. The purpose of the research is to evaluate the effect of organic and mineral fertilizers and their combination on the yield and quality indicators of potato tubers during irrigation on chernozem soils of the Republic of Tatarstan. The research was carried out in 2021-2022 in Kama zone on leached chernozem of medium loamy granulometric composition. The medium-early variety of Gala potatoes served as the material for research. The experiment was performed to study the effect of organic and mineral fertilizers and their combination by creating the following nutrition backgrounds: mineral fertilizers with a rate of application of N60P60K90 d.v. kg/ha (general background); organic fertilizer (manure 60 t/ha); general background + manure 60 t/ha; general background + organic fertilizer (siderate); general background + siderate + straw; general background + organic matter (manure 60 t/ha) + straw; organic fertilizer (manure 60 t/ha + siderate + straw); natural background (control). The weather conditions in both years of research were both satisfactorily favorable for the growth and development of potatoes. In the budding and tuber formation phase, artificial sprinkling was carried out at the rate of 300 m3 of water per 1 ha, thereby the potato agrocenosis was fully provided with productive moisture. On average, over two years, the highest yield was achieved in variant 7 (background + manure + straw), and it amounted to 38.8 t/ha, which is 20.6 t/ha more than in the control, in other experimental variants this difference ranged from 10.46-18.8 t/ha. The dry matter content in tubers during the application of various types of fertilizers was lower by 0.49...1.49% than in the control, starch – by 0.25...0.79%. On average, over 2 years, the highest protein and vitamin C content was in variant 6 – 2.95% and 21,24 mg%, respectively, which is higher than the control by 0.37% and 3.03 mg%.