Tube Type Research Articles

Type of enteral feeding tube predicts readmission in patients receiving home enteral nutrition

Type of enteral feeding tube predicts readmission in patients receiving home enteral nutrition

Research on engineering technology of compact thermoacoustic air conditioner for vehicles

Thermoacoustic refrigeration technology presents a promising solution for sustainable and efficient air conditioning in vehicles. However, traditional thermoacoustic systems typically employ rigid resonant tubes, which pose challenges in terms of assembly and spatial layout during experimentation. Additionally, electric heating is predominantly utilized as the heat source in most experimental setups.To address the need for compact thermoacoustic air conditioning systems suitable for vehicle applications, this paper introduces the concept of employing flexible resonant tubes in heat-driven thermoacoustic refrigeration systems. Our study begins by constructing a heat-driven thermoacoustic refrigeration platform designed to simulate real automotive exhaust conditions. The DeltaEC software is employed to optimize the design of each component within the system.Both flexible and rigid resonant tubes are used in experimental research. Our findings reveal that the pressure amplitudes measured from experiments using both types of tubes closely match the simulated sound field. Operating at 8.7 MPa, the cooling capacity of the thermoacoustic system with flexible tube is 3.4 kW at 10 ℃. Using more gentle bending of flexible resonant tubes can reduce small losses caused by bending in rigid resonant tubes. Consequently, under similar working conditions, the cooling capacity generated by the system employing flexible resonant tubes slightly exceeds that of systems employing rigid resonant tubes. Furthermore, our study demonstrates a thermoacoustic conversion efficiency of 20.8 % and a refrigerator refrigeration efficiency of 2.34.These findings provide empirical validation for the use of flexible resonant tubes within vehicle exhaust heat-driven thermoacoustic refrigeration systems. The experimental results clearly demonstrate the ability of vehicle exhaust as a heat source to provide heat for thermoacoustic systems, and the ability of flexible thermoacoustic systems to generate sufficient cooling capacity. Ultimately, this research contributes to the advancement and practical implementation of thermoacoustic air conditioning within vehicles.

The holomorphic discrete series contribution to the generalized Whittaker Plancherel formula II. Non-tube type groups

For every simple Hermitian Lie group G, we consider a certain maximal parabolic subgroup whose unipotent radical N is either abelian (if G is of tube type) or two-step nilpotent (if G is of non-tube type). By the generalized Whittaker Plancherel formula we mean the Plancherel decomposition of L2(G/N,ω), the space of square-integrable sections of the homogeneous vector bundle over G/N associated with an irreducible unitary representation ω of N. Assuming that the central character of ω is contained in a certain cone, we construct embeddings of all holomorphic discrete series representations of G into L2(G/N,ω) and show that the multiplicities are equal to the dimensions of the lowest K-types. The construction is in terms of a kernel function which can be explicitly defined using certain projections inside a complexification of G. This kernel function carries all information about the holomorphic discrete series embedding, the lowest K-type as functions on G/N, as well as the associated Whittaker vectors.

Simulation of heat and pressure transfer in concentric heat exchangers for small industrial scale

Abstract A Heat exchanger is a tool in industry which aims to transfer energy from hot fluid to cold fluid. The amount of heat transferred is an important parameter of the design and performance of heat exchangers. Concentric tube is a type of heat exchanger that is widely used in industries such as material processing and food preparation. One way to get the value of heat transfered before manufacturing a heat exchanger is to carry out computational fluid dynamic simulations. This simulation will make it easier for us to understand the heat transfer phenomenon that occurs from hot fluid to cold fluid. The aim of this study is to calculate how much heat transfer and pressure drop there is in a laboratory scale cocentric tube type heat exchanger. We also get a picture of the pressure drop that occurs due to fluid friction with the inner pipe walls. Experiments and simulations carried out in this study will then be validated. Variations in flow rate on the tube and shell sides are applied. the greater the flow rate, the greater the transfer of heat. The same trend is shown by variations in pressure. The greater the pressure, the greater the pressure drop that occurs. In this study, the pressure drop from the heat exchanger inlet to the heat exchanger outlet was 0.015%.

Method of home tube feeding and 2-3-year neurodevelopmental outcome.

To describe the Bayley Scales of Infant Development 3rd Edition (Bayley-III) of infants discharged home receiving tube feeds. Retrospective review of infants discharged with nasogastric or gastrostomy tube feeds and completed a Bayley-III assessment at 2-3-years of age through a neonatal follow-up program. Results were reported using descriptive statistics. Of infants discharged with nasogastric feeds, median Bayley-III scores were in the low-average to average range, and full oral feeds were achieved in 75%. Of infants discharged with gastrostomy tube feeds, median Bayley-III scores were in the extremely low range, and full oral feeds were achieved in 36%. Our data set did not demonstrate a distinct patient demographic that correlated to the type of feeding tube at discharge. Neurodevelopmental outcome at 2-3 years does not appear to be negatively impacted by the decision to discharge an infant from the NICU with home NG feedings.

Comparative analysis on melting performance of PCM using rectangular and branching fin configurations in a shell and tube type thermal energy storing unit

Phase change materials (PCMs) are widely used in various applications, however, their low conductivity and long phase transition time hinder thermal energy supply. Thus, numerous researchers have studied various fin designs to solve this problem. In this study, with the unique combinations of two, three and four rectangular fins and straight, curved and angled branching fins, nine novel cases have been proposed to examine the melting enhancement of PCM in shell and tube-type heat exchangers. A numerical two-dimensional analysis has been conducted in a transient state using N-eicosane PCM, considering the natural convection effect. The CFD of this numerical model has been validated with pertinent literature work. The evolution of the solid-liquid interface and natural convection has been visualized by liquid fraction, isotherm expansion and velocity streamlines. At first, three proposed branching designs are compared for different numbers (two, three and four) of rectangular fins. Following the methodology, evaluating the impact of branching fins for two and four rectangular fins, the best branching design was the angled fins with 8.25 % and 28.58 % melting time improvement, respectively, compared to the curved fins, which performed the worst. For three rectangular fins, straight branching fins were identified as the best with a 21.2 % melting time improvement compared to the angled branching fins as the worst performer. Lastly, among all the nine cases, two rectangular fins with angled branching perform the best, with 84.6 % melting time savings. The worst performer is four rectangular fins with curved branching, saving 40 % melting time compared to no fin case. In addition to that, the cases with two rectangular fins significantly outperform other cases in terms of energy storage rate.

Assessment of Preanalytical Cerebrospinal Fluid Handling and Storage Factors on Measurement of Aβ1-42, Aβ1-40, and pTau181 Using an Automated Chemiluminescent Platform.

Standardizing cerebrospinal fluid (CSF) laboratory protocols will improve the reliability and availability of clinical biomarker testing required for prescription of novel Alzheimer disease (AD) therapies. This study evaluated several preanalytical handling and storage factors common to β-amyloid1-42 (Aβ1-42), β-amyloid1-40 (Aβ1-40), and phosphorylated tau (pTau181) concentrations including storage at different temperatures, extended cap contact, various mixing methods, and multiple freeze-thaw cycles. Aβ1-42, Aβ1-40, and pTau181 concentrations were measured using LUMIPULSE G1200 automated assays. Samples were collected in polypropylene tubes of various volumes. Sample cap-contact was evaluated by storing samples in upright and inverted positions at either 4°C for 1 week or -80°C for 1 month. To assess mixing methods, samples were freeze-thawed and mixed by inversion, vortex, horizontal roller, or unmixed prior to assay sampling. The impact of successive freeze-thaw cycles was assessed through freezing, thawing, and analyzing CSF samples. Short-term storage at 4°C did not affect Aβ1-42, Aβ1-40, or pTau181 measurements in any tube type. Tube cap contact affected Aβ1-42 in 2.5 mL tubes and pTau181 levels in 10 mL tubes. No difference was observed between mixing methods. After 4 freeze-thaw cycles, Aβ1-42 significantly decreased but Aβ1-40 remained unchanged. Utilizing the Aβ1-42/Aβ1-40 ratio, Aβ1-42 values normalized, maintaining ratio values within ±5% of baseline measurements. Storage of CSF at 4°C for 1 week or -80°C for 1 month did not significantly affect Aβ1-42, Aβ1-40, pTau181, or associated ratio measurements. Tube cap-contact impacted pTau181 and pTau181/Aβ1-42 values in larger tubes. Mixing methods are equivalent. The Aβ1-42/Aβ1-40 ratio compensates for freeze-thaw variability up to 4 cycles.

Design and Integration of a Robotic Welding Parameterized Procedure for Industrial Applications

This paper explores the development of an effective motion planning strategy for robotics welding in tube to tubesheet joints, a critical process in heat exchanger manufacturing. The research methodology follows an experimental paradigm, investigating two distinct approaches to tackle the intricacies of this task. The initial approach, involving a welding torch affixed to the robotic arm's flange, proved ineffective due to the complexity of continuous 360° orbital welding. This led to the adoption of a custom end effector in the second approach, designed to enhance adaptability and precision. Key tools and materials employed in this research include the Robot Operating System (ROS), Rviz for 3D visualization, MoveIt for motion planning, SolidWorks for CAD modelling, and the xArm7 Robotic Arm. These tools facilitated the creation of a comprehensive planning environment. The motion planning process relies on three essential parameters: tube diameter, type of tube to tubesheet joint (flush or protruding), and the 3D coordinates of tube centers. A Python scripts control the robot's movements, with specific joint state and pose goals for precise positioning. Finally, this study contributes to present a program that orchestrates the robotic arm's motion, simulating the welding process for tube to tubesheet joints. This comprehensive research endeavor contributes to the optimization of motion planning strategies in the context of tube to tubesheet welding, with practical applications in the manufacturing industry.

Analysis of Heat Transfer in Shell and Tube Type Condensers

Analysis of Heat Transfer in Shell and Tube Type Condensers

Comparative study of the effectiveness of time series and arima modeling x RNA approach in a Multi Layer Perceptron (MLP) model in predicting fouled in petroleum pre-processing heat exchangers

This work presents a comparison between two approaches based on Artificial Intelligence techniques to predict critical deposition in the battery of shell and tube heat exchangers, used in petroleum pre-processing. Deposition or incrustation, which occurs on the thermal exchange surfaces of heat exchangers, during operation, can reduce the efficiency of this equipment and generate an increase in the cost of refining for the petrochemical plant due to the modification of ideal operating parameters and changes. process variables, such as flow, pressure and temperature, input and output of heat exchangers, as well as thermodynamic parameters, such as fouling resistance coefficient and global heat transfer coefficient. The proposed methods for comparing results used the analysis and prediction of time series based mainly on integrated autoregressive moving average (ARIMA) and Deep Learning models and, on the other hand, an artificial neural network (ANN) model based on the Multi Layer architecture. Perceptron (MLP) with the Backpropagation error backpropagation algorithm. The data was collected in exchangers of a petroleum preheating battery in the years 2014 to 2021. The general objective of this work is to present the results of both approaches and compare, since they aim to predict the deposition in the heat exchanger of the shell and tube type, thus helping to minimize maintenance costs and increase the energy efficiency of the petrochemical plant, making operations safer and more efficient, bringing significant benefits to the petroleum industry.

Study on the Effect of Bifurcation Position on Spontaneous Ignition and Shock Wave Propagation Characteristics in High-pressure Hydrogen Leakage Tubes

Hydrogen safety issues constrain the development and diffusion of hydrogen energy technologies. The current research on tube types in high-pressure hydrogen storage and transportation links is insufficient. In this paper, the spontaneous combustion law and the propagation characteristics of the shock wave in the tube after accidental leakage of high-pressure hydrogen in a bifurcated tube with a blocking structure are investigated by experimental means. By changing the relative position of the bifurcation structure, it is found that moving the bifurcation position upstream can effectively reduce the intensity of the shock wave at the nozzle of the tube, the propagation velocity of the shock wave inside the tube and the critical ignition pressure. There are three ignition possibilities in the bifurcated tube with blocking structure, and quenching can be realized in the tube under lower pressure.

Machine learning-based Nusselt number prediction for falling-film evaporators in absorption refrigeration systems

The evaporator serves as a pivotal component of an absorption refrigeration system (ARS), bolstered by improved wettability and mitigation of the irregular arrangement of the liquid film. The complexities of the evaporation heat transfer characteristics of falling films have led to numerous empirical correlations for falling-film Nusselt number (Nu) estimation, demanding substantial computational resources and experimental expenses and limiting their universal applicability. This study used machine learning to predict Nu of a falling-film evaporator. Artificial neural network (ANN) and random forest regression (RFR) models were used to predict heat transfer characteristics and establish a novel Nu correlation using an experimentally derived dataset. Correlations of falling-film Nu were established for six tube types using empirical data, ANN, and RFR predictions and then compared based on experimental falling-film Nu. The ANN and RFR provided high prediction performance within 10 % error and an R2 of 0.985 and 0.999, respectively. The Nu correlations derived from ANN and RFR demonstrated satisfactory agreement, typically within ±15 % error of experimental results lower than that of the empirical correlations. The optimized ANN and RFR demonstrates their promising ability to predict heat transfer characteristics and establish Nu correlations, thereby reducing the need for immense experimental efforts.

Simulation and Analysis of π-Type Rectifier Filter

This paper analyzes the principles of the π-type rectifier filter circuit and conducts simulations on both the π-type LC rectifier filter circuit and the π-type RC rectifier filter circuits respectively, compares the π-type LC rectifier filter circuit with the π-type RC rectifier filter circuit, analyzes the working principle and performance characteristics of the π-type rectifier filter circuit, and deeply understands the circuit's working mechanism and the overall performance; Through the simulated evaluation of the circuit, key parameters are improved, such as the size selection of capacitors and inductors, and the type of rectifier tubes, in order to optimize the performance of the circuit.

STUDY OF THE PROCESS OF PLANT RAW MATERIAL EXTRACTION IN A STATIC-TYPE CAVITATION INLINE MIXER

Abstract. The flowering heads of calendula have a significant content of biologically active substances (BAS) with a wide range of pharmacological activities. Traditional methods for obtaining their aqueous extracts include maceration or percolation. However, these methods have significant drawbacks. The rational choice of equipment and the study of the influence of thermophysical conditions on the extraction process of specific plant raw materials to intensify mass transfer processes are relevant. The aim of the study is to investigate the transition of solid substances of calendula flowers into a soluble state in a flow cavitation mixer of a static type to intensify mass transfer processes in obtaining aqueous extracts. For the research, previously ground dry calendula flower heads, swollen in distilled water at a hydro module of 1:15 and reduced to 0,1-2 mm, were used. The work was carried out on an experimental cavitation mixer of the Venturi tube type with a variable cavitation reactor with a nozzle throat diameter ranging from 0,006 m to 0,12 m. The efficiency of extraction was determined by the amount of water-soluble substances, and the cavitation phenomenon was characterized by the cavitation number. Results: The overall design of the cavitation apparatus, the profile and geometric parameters of the nozzle, the flow parameters, as well as the properties of the plant material, significantly affect the hydrodynamic conditions and the development of cavitation effects during processing. The Venturi-type flow cavitation mixer used in the research showed high efficiency in processing mass transfer processes during the extraction of a water suspension of calendula flower heads. The results obtained indicate that the most significant impact of cavitation effects is observed at nozzle throat diameters of 0,08 m and 0,10 m, with cavitation numbers χ = 0,53 and χ = 0,84, respectively. In this case, the process duration can be limited to 60 seconds. The obtained conclusions are confirmed by microstructure studies.

Effect of Buoyancy Force in Phase Change Material-Based Metal Hydride Reactor

Abstract In Phase Change Material (PCM) simulations, buoyancy force is used to capture the melting contour. However, for the sake of simplicity, most of the PCM-based Metal Hydride (MH) simulations have ignored the influence of buoyancy in PCM which is crucial in analyzing the heat flow within PCM. This study incorporates the buoyancy term in mathematical models to capture the contour of a melted PCM and also its heat transfer capacity during the hydrogen absorption process. A PCM model with buoyancy force is validated against the experimental values and applied to the MH-PCM models. Incorporating the buoyancy force improves the heat transfer rate in the PCM during melting which benefits in better heat removal from the MH bed. Two designs of MH-PCM models having PCM placed in ring-type and tube-type configurations are discussed. Further, the design optimization in ring-type models was done by changing the PCM-MH volume and sandwiching ratios.

Performance assessment of phase change material-based thermal energy storage

Phase change material (PCM) based thermal energy storage (TES) offers high energy density and better heat transfer performance by encapsulating PCM within a specifically designed container, i.e., shell and tube type TES. In this work, the PCM is packed in multiple cylindrical tubes, and heat transfer fluid (HTF) flows in the annulus. Such arrangement of PCM and HTF in the TES system is termed a cylindrical model, and the one opposite to the cylindrical model is called a pipe model. This work conducts the performance evaluation for PCM-based shell and tube TES using an experimentally validated numerical model. The 3D cyclic periodic model for TES has been developed based on hexagonal circle packing, and the effective energy storage ratio as a performance index under varying geometrical and operating parameters has been investigated. The variation in parameters includes tube length (0.5–7 m), diameter (10–50 mm), initial temperature (293.15–303.15 K), volumetric flow rate (10–500 l/min), inlet temperature (323.15–393.15 K). Using a conjugate heat transfer model, the influence of parameters was investigated, and the performance index was evaluated using the effectiveness-NTU theory. It was found that TES was effective for geometrical parameters diameter d≤ 30 mm and length L≥ 2 m. The performance index of 1.54 was optimum and achieved when the inlet temperature was 333.15 K. This optimum performance index value was compared with existing work and found to be performing comparatively well.

Design and optimization analysis of a new double-layer tube type heat exchanger for lead-bismuth reactors

Double-layer heat tubes have been designed to effectively reduce the occurrence of heat pipe rupture accidents. However, inter-tube thermal contact resistance can decrease heat transfer efficiency, thus hampering the heat dissipation in the primary loop system of lead-bismuth reactors. Therefore, optimizing the design of double-layer heat tubes is necessary. This work focuses on the double-layer heat exchanger of a lead-bismuth reactor and utilizes gallium-based graphene nanofluids as a thermal interface material to fill the gap between the heat tubes. Furthermore, the impact of the length, wall thickness, outer diameter, and spacing of heat tubes on the heat transfer performance of the double-layer heat exchanger with and without the nanofluids has been analyzed. The study aims to optimize the JF factor and cost-effectiveness ratio (CER). Genetic algorithms are employed to optimize and evaluate the heat transfer performance of the main heat exchanger based on the four aforementioned parameters. Consequently, a new design scheme is obtained for the double-layer heat exchanger, which increases the optimized overall heat transfer coefficient of the main heat exchanger by 5.79%, pressure drop in the primary loop by 2.32%, JF factor by 5%, and CER by 24.62%. These results demonstrate that the gallium-based graphene nanofluids can effectively enhance the heat transfer performance of the double-layer heat exchanger while reducing the likelihood of steam generator tube rupture accidents.

Evaluation of Collection and Processing Conditions for Gene Expression Analysis Using Human Myeloid Cells.

Background: The population of blast cells among peripheral blood mononuclear cells (PBMCs) obtained from patients is a desirable specimen for analyzing gene expression in diseases including acute myeloid leukemia. Although the enrichment of blast cells often needs to be performed at a central laboratory, acceptable conditions for sample transport from clinical sites remain to be established. Methods: We evaluated storage temperature, duration, and tube type before initiating sample processing for the analysis of cluster of differentiation (CD)33+ myeloid cells among PBMCs as an alternative to CD34+/CD33+ blast cells. Results: CD33+ myeloid cells were successfully purified by MACS. The cell viability and the RNA integrity were sustained during storage up to 48 hours before sample processing. Storage at 4°C had minimal effects on gene expression, whereas storage at room temperature induced the senescence pathway, characterized by the expression of stress-inducible genes. A CPT tube was also better than an ethylenediaminetetraacetic acid tube for minimizing gene expression change. Conclusions: Our study provided important clues for establishing a sample handling approach for gene expression analysis with purified cell fractions from human PBMCs. To keep the variation of gene expression to a minimum, samples should be delivered at 4°C within 48 hours before processing.

Abstract 5030: Evaluation of different blood collection tubes for liquid biopsy NGS applications

Abstract Intro: Liquid biopsy is fast becoming a standard practice in oncology research due to recent advancements in Next Generation Sequencing (NGS). To detect genetic variants, whole blood samples are collected in blood collection tubes (BCTs) and fractionated to obtain plasma which is then used to isolate cell free nucleic acid (cfNA) for analysis. While the limited availability of cfNA is a challenge in liquid biopsy, storage condition and duration between blood collection and fractionation have a significant impact on the quantity and quality of the cfNA due to degradation and genomic DNA and RNA contamination. There are several BCTs available on the market offering stabilization of cfNA profiles to overcome the above challenges. Methods: Here we compare the NGS performance of cfNA derived from three commonly used BCTs on the market, BD Vacutainer™ K2EDTA Tubes, Streck™ Cell-Free DNA, and PAXgene® Blood ccfDNA tubes. Matched whole blood samples collected in the above-mentioned tube types were obtained from commercial vendors which were derived from 38 healthy donors as well as 6 cancer research samples. Whole blood samples were fractionated as per manufacturer recommendations and cfNA was isolated and quantified using Genexus™ Cell-Free Total Nucleic Acid Purification Kit on Genexus™ purification system. Isolated cfNA was then sequenced using Ion Ampliseq™ HD target amplification assay on Genexus™ Integrated sequencer. Results: Data shows that K2EDTA collected samples contain slightly higher amounts of cfNA compared to PAXgene® and Streck™ samples. When the cfDNA profiles were analyzed by Agilent™ BioAnalyzer™, K2EDTA derived cfDNA showed varying degrees of genomic DNA contamination which can inflate the cfDNA concentration. However, both Streck™ and PAXgene® derived cfDNA showed little to no detectable genomic DNA contamination. As a result, a higher percentage of PAXgene® and Streck™ samples did not meet the minimum input requirement (5ng) for the sequencing assay. Sequencing data for DNA showed that K2EDTA samples had higher total reads and median molecular coverage compared to the other two BCT types. However, all samples had passing QC metrics, and mean read length, on target reads, and uniformity were comparable between the three tube types. When DNA variant detection was evaluated using cancer research samples, no significant difference was observed in performance between K2EDTA and PAXgene® samples. Interestingly, sequencing data for RNA shows that PAXgene® samples had slightly higher mapped reads on average, and significantly higher internal process control coverage compared to both K2EDTA and Streck™ samples. Whereas Streck™ samples had significantly lower internal process control coverage. Conclusion: In summary, this study demonstrates the advantages and disadvantages of using different BCTs for liquid biopsy applications, in terms of cfNA yields, isolated DNA profiles, and sequencing performance. Citation Format: Nicholas Siepert, Emilia Ostrowska, Luming Qu He, Madhuri Jasti, Kris Lea, Thilanka Jayaweera, Angie Cheng. Evaluation of different blood collection tubes for liquid biopsy NGS applications [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5030.

Abstract 2292: Impact of delayed processing on cfDNA quantity and quality using STRECK cfDNA tubes: Connect Pilot Study

Abstract Interest in cell-free DNA detection for multi-cancer early detection and tumor monitoring is growing.1 Prospective evaluations of liquid biopsy assays are critical, and knowledge gaps in standard collection and preparation practices must be addressed for adequate assay execution.2 The NCI Connect for Cancer Prevention Cohort Study (Connect) aims to study new approaches in early detection. A pilot study was conducted with the STRECK Cell-Free DNA BCT tube to determine the impact of processing time on cfDNA quantity and quality utilizing two complementary quality control assays. 4 STRECK DNA BCT tubes were drawn from 40 donors. Plasma samples were analyzed, with half processed immediately and the other half stored for five days before processing. Two QC assays were performed to compare results at the two processing time points. The Alu EFIRM assay measured Alu element concentration (copies/mL). The Cell-free DNA ScreenTape assay evaluated Qubit DNA concentration (μg/mL) and %cfDNA. Descriptive statistics and paired sample t-tests were performed to compare mean concentrations at the two processing time points, with and without identified samples with cytolysis. Median, mean, and range were recorded for each assay measure (Table 1). A reduction in cfDNA quantity was observed at the 5-day processing time point. Five 5-day processing samples were identified with high DNA quantity and a high Alu element concentration. The five samples experienced hemolysis and clotting as a result of handling and processing at odds with standard protocol. There was a significant difference between the mean DNA quantities of the processing time points following exclusion of the five samples. There was no change in significance between the mean Alu concentration and %cfDNA following exclusion (Table 2). Both assays successfully detected samples with high nuclear DNA, a major contaminant for cfDNA assays, and identified a reduction in cfDNA at the 5-day processing time point. Proper handling and processing procedures are necessary to avoid cell lysis and maximize cfDNA quality and yield. This pilot establishes a starting point for future evaluations of liquid biopsy tube types, processing delays, and preanalytical cfDNA quality variables. Citation Format: Jazmyn Bess, Domonique Hopkins, Norma Diaz Mayoral, Heather Cooley, Angela de Palatis, David T. Wong, Stephanie Weinstein Oshinsky, Christian Abnet, Marie-Josephe Horner, Amanda Black, Michelle Brotzman, Kathleen Wyatt, Lynn Sorbara, Matthew Young, Mia Gaudet, Nicolas Wentzensen, Mickey Williams, Christopher Karlovich, Eric Greenbank, David Elashoff, Fang Wei, Feng Li. Impact of delayed processing on cfDNA quantity and quality using STRECK cfDNA tubes: Connect Pilot Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2292.