One of the important parts of the in-core fuel management is loading pattern optimization (LPO). The loading pattern optimization as a reasonable design of the in-core fuel management can improve both economic and safe aspects of the nuclear reactor. This work proposes the hybrid of fuzzy logic controller with harmony search algorithm (HS) for loading pattern optimization in a pressurized water reactor. The music improvisation process to find a pleasing harmony is inspiring the harmony search algorithm. In this work, the adjustment of the harmony search algorithm parameters such as the bandwidth and the pitch adjustment rate are increasing performance of the proposed algorithm which is done through a fuzzy logic controller. Hence, membership functions and fuzzy rules are designed to improve the performance of the HS algorithm and achieve optimal results. The objective of the method is finding an optimum core arrangement according to safety and economic aspects such as reduction of power peaking factor (PPF) and increase of effective multiplication factor (Keff). The proposed approach effectiveness has been tried in two cases, Michalewicz's bivariate function problem and NEACRP LWR core. The results show that by using fuzzy harmony search algorithm the value of the fitness function is improved by 15.35%. Finally, with regard to the new solutions proposed in this research it could be used as a trustworthy method for other optimization issues of engineering field.