Purpose: This article investigates the primary determinants of Turkish-American relations during the Cold War, focusing on key events and policies that influenced bilateral interactions. It aims to understand the impact of the Truman Doctrine, the Marshall Plan, NATO alliances, the Cyprus issue, and the Kurdish conflict on these relations. The study also critically assesses the role of ethnic lobbies, such as the Armenian and Greek communities, in shaping U.S. foreign policy towards Turkey. Method: Utilizing a comprehensive historical analysis, this research draws on different sources including speeches, and official correspondences, as well as secondary sources such as academic books, journal articles, and theses. This methodological approach allows for an in-depth exploration of the complex interplay between domestic politics and international diplomacy. Conclusion: The study reveals that Turkish-American relations during the Cold War were shaped by a combination of strategic alliances, regional conflicts, and domestic political influences. Key policies like the Truman Doctrine and the Marshall Plan were instrumental in solidifying Turkey as a critical ally, while events such as the Cyprus issue and the Kurdish conflict presented significant challenges. The influence of ethnic lobbies also played a crucial role in shaping bilateral relations. Implication of the Research: The insights gained from this analysis provide valuable lessons for future diplomatic efforts, emphasizing the need for cooperation, diversification of partnerships, and strategic alignment. Understanding the historical context of Turkish-American relations can inform current and future diplomacy, helping to navigate the complexities of this bilateral relationship. Originality of the Research: This research offers a unique and comprehensive examination of Turkish-American relations during the Cold War, incorporating a critical assessment of both strategic policies and the influence of ethnic lobbies. By providing a nuanced understanding of these factors, the study contributes original insights to the field of international relations and foreign policy analysis.