Triggering Event Research Articles

PM2.5 and its components and respiratory disease healthcare encounters – Unanticipated increased exposure-response relationships in recent years after environmental policies

Prior studies reported excess rates (ERs) of cardiorespiratory events associated with short-term increases in PM2.5 concentrations, despite implementation of pollution-control policies. In 2017, Federal Tier 3 light-duty vehicle regulations began, and to-date there have been no assessments of population health effects of the policy. Using the NYS Statewide Planning and Research Cooperative System (SPARCS) database, we obtained hospitalizations and ED visits with a principal diagnosis of asthma or chronic obstructive pulmonary disease (COPD) for residents living within 15 miles of six urban PM2.5 monitoring sites in NYS (2014–2019). We used a time-stratified case-crossover design and conditional logistic regression (adjusting for ambient temperature, relative humidity, and weekday) to estimate associations between PM2.5, POC (primary organic carbon), SOC (secondary organic carbon), and rates of respiratory disease hospitalizations and emergency department (ED) visits from 2014 to 2019. We evaluated demographic disparities in these relative rates and compared changes in ERs before (2014–2016) and after Tier 3 implementation (2017–2019). Each interquartile range increase in PM2.5 was associated with increased ERs of asthma or COPD hospitalizations and ED visits in the previous 7 days (ERs ranged from 1.1%–3.1%). Interquartile range increases in POC were associated with increased rates of asthma ED visits (lag days 0–6: ER = 2.1%, 95% CI = 0.7%, 3.6%). Unexpectedly, the ERs of asthma admission and ED visits associated with PM2.5, POC, and SOC were higher during 2017–2019 (after Tier 3) than 2014–2016 (before Tier-3). Chronic obstructive pulmonary disease analyses showed similar patterns. Excess Rates were higher in children (<18 years; asthma) and seniors (≥65 years; COPD), and Black, Hispanic, and NYC residents. In summary, unanticipated increases in asthma and COPD ERs after Tier-3 implementation were observed, and demographic disparities in asthma/COPD and PM2.5, POC, and SOC associations were also observed. Future work should confirm findings and investigate triggering of respiratory events by source-specific PM.

Dynamic event-triggered dual-channel quantized sliding mode control for uncertain networked control systems under DoS attacks

This paper introduces a dynamic event-triggered sliding mode control method to address the issue of quantized stability in uncertain networked control systems (NCSs) subjected to random Denial-of-Service (DoS) attacks. Firstly, a dynamic event-triggered mechanism is utilized to compensate for the damage caused by DoS attacks while effectively reducing network bandwidth pressure. Subsequently, a sliding mode controller is designed to ensure the robustness of uncertain NCSs with external disturbances. Additionally, we construct a novel control framework that considers network delays and incorporates quantizers for state and control signals, respectively. Based on this framework, both a sufficient condition for exponential stabilization of NCSs and a co-design method for dynamic event trigger and controller are given. Finally, the effectiveness of the proposed method is verified with two generalized simulation examples.

Dynamic event-triggered time-varying formation control for heterogeneous unmanned swarm systems with scaling attacks

This paper addresses the problem of time-varying formation control for heterogeneous unmanned swarm systems (USSs) consisting of multiple unmanned aerial vehicles (UASs) and unmanned surface vehicles (USVs) based on a directional switching topology. Firstly, a novel USSs model is established, involving the effect of multiple network attacks, network bandwidth constraints and input saturation. In particular, a scaling attack model is proposed to account for denial-of-service (DoS) and deception attacks. Secondly, a distributed controller based on a dynamic event triggering mechanism is designed to reduce the communication load by adjusting the communication frequency between individuals, and the Zeno phenomenon is effectively avoided. Finally, the Lyapunov function is used to obtain sufficient conditions for system stability and bounds on the frequency and duration of network attacks. The experiments and comparison results verify the proposed strategy's effectiveness and superiority.

Generalized uniform optimization for robust adaptive Buck converter with uncertain perturbations

This paper presents an event-triggered impulse (ETI) control mechanism with generalized uniform optimization, endowing robust adaptive for various uncertain Buck converter perturbations. An impulse compensates for the state fluctuation error, and the event triggering mechanism (ETM) is introduced into the control process of the stochastic model of the Buck converter. The mean square stability theory of linear matrix inequality (LMI) stochastic systems is provided, wherein the cost function incorporates uncertain perturbation-induced state feedback impulses and adaptive system tuning. Unlike traditional event-triggered control with manually determined triggering times, ETI is activated only when events conform to the optimal design, significantly enhancing error-tracking accuracy and adaptive capability. Moreover, the parameters of the optimal controller remain independent of the statistical characteristics of uncertain noise, ensuring globally optimal operational control and model generality. Namely, the proposed method demonstrates versatility by extending its application to DC motor control, addressing various perturbations Buck converters encounter. Finally, the designed controller can closely track the required angular velocity trajectory across sudden changes in system uncertain perturbation.

Event-Triggered Collaborative Fault Diagnosis for UAV–UGV Systems

The heterogeneous unmanned system, which is composed of unmanned aerial vehicles (UAV) and unmanned ground vehicles (UGV), has been broadly applied in many domains. Collaborative fault diagnosis (CFD) among UAVs and UGVs has become a key technology in these unmanned systems. However, collaborative fault diagnosis in unmanned systems faces the challenges of the dynamic environment and limited communication bandwidth. This paper proposes an event-triggered collaborative fault diagnosis framework for the UAV–UGV system. The framework aims to achieve autonomous fault monitoring and cooperative diagnosis among unmanned systems, thus enhancing system security and reliability. Firstly, we propose a fault trigger mechanism based on broad learning systems (BLS), which utilizes sensor data to accurately detect and identify faults. Then, under the dynamic event triggering mechanism, the network communication topology between the UAV–UGV system and BLS is used to achieve cooperative fault diagnosis. To validate the effectiveness of our proposed scheme, we conduct experiments on a software-in-the-loop (SIL) simulation platform. The experimental results demonstrate that our method achieves high diagnosis accuracy for the UAV–UGV system.

The domino effect of teacher cognitive presence triggering events and resolution on student’s grit

The aim of this current study is to assess the essential role of teacher cognitive presence within the context of the community of inquiry framework in relation to enhancing students’ academic perseverance, more specifically this type of presence influences the most students’ academic perseverance. In order to test this hypothesis, an online questionnaire was created, including the community of inquiry scale and the grit scale. A total of 529 valid and consented answers were collected. We have further analyzed the structure of the variables network with network analysis and then we have employed several sequential mediation analyses testing the impact of cognitive presence triggering events and resolution on the relationship between all the other presences and students’ academic perseverance. A circular structure has emerged in network analysis and eight significant full complementary sequential mediation analysis. Results confirm the domino effect of teacher cognitive presence triggering events and resolution on student’s grit under the community of inquiry framework.

Monitoring the physiological inflammatory alertness in horse after road transport.

The aim of this study was to assess the changes of pro-inflammatory interleukins in 10 horses subjected to road transport practices (distance of 150km) from the training site (Messina, Sicily) to the competition centre in Syracuse (Sicily). Blood sampling and interleukins analysis were performed during a round trip transportation (transport 1 and transport 2). In particular, blood samples were collected before the transport took place (Pre), five minutes later (Post) and one hour later (Post 1h), for each transport, in order to assess the serum concentration of IL-1α, IL-1β, IL-2 and IL-6. The results showed that the serum concentration of IL-1α decreased at Post and Post 1h compared to the values obtained at rest condition (P < 0.05). The other interleukins analysed (i.e. IL-1β, IL-2 and IL-6) showed increased levels at Post than Rest and Post 1h in transport 1 (P < 0.05). In transport 2 the analysed parameters showed no change throughout the analysed time points (P > 0.05); however, higher levels of IL-1α at Pre and higher IL-1β, IL-2 and IL-6 values at Post were found in transport 1 than transport 2 (P < 0.05). The increase in pro-inflammatory cytokines after transport 1 suggests the triggering of the inflammatory event and this may show that, although horses are animals accustomed to transport, this is a stressful event that could activate the well-orchestrated inflammation cascade, albeit physiological and temporary, as highlighted by the lower serum concentrations of the investigated interleukins found in transport 1 than transport 2 and by the lack of significant differences in the serum concentrations of the investigated interleukins among the time points of transport 2. It must be taken into account that enrolled animals are well-trained and healthy athletic horses participating to a jumper competition, thus, such inflammation did not occur thanks to a good balance between pro-inflammatory and anti-inflammatory cytokines which allowed a prompt restoration of homeostasis eventually impaired by the stressful event.

Swarm of Drones for Surveillance Monitoring of a Grounded Target: An event-triggered approach

In this paper, we present a novel formation control approach in the framework of Event-Triggered (ET) control to provide a solution to the surveillance problem. To do this, we identify two main challenges which are the switching topology of the drones and the limited bandwidth of the communication network, which are also valid in formation applications. To provide a solution to switching topologies, we propose a networked continuous controller that is robust in the presence of connection switching between drones and the target. Then, we propose a networked controller with ET communication in some aperiodic instants which reduces the required bandwidth and load within the communication network. We guarantee the stability of the developed ET controller and prove that the Zeno behavior cannot occur. To validate the method, we present realistic 3D simulation results conducted in the Simulink environment of Matlab® for different scenarios. The results of the study show the effectiveness of the proposed controller, especially for limited bandwidth channels as the ETC scheme has decreased the load within the communication network while resulting in a robust and efficient formation performance. We also considered moving target scenarios with missing possibilities to validate the robustness of the proposed method.

P-242 ICSI, the sooner, the better

Abstract Study question What is the impact of different ICSI timing on the efficiency of egg reception cycles concerning both denudation and trigger events? Summary answer The interval between denudation and ICSI significantly compromises cycle efficiency, particularly blastocyst quality. Delayed ICSI impairs this impact relative to the trigger event. What is known already The established consensus on the optimal ICSI timeframe, spanning 2-6 hours post-oocyte retrieval, has been extensively documented. However, the acknowledged variability within this window has prompted a critical review. Recent studies highlight the need for a more nuanced understanding, suggesting that phenomena affecting ICSI outcomes can be better elucidated by adopting stable models such as oocyte reception cycles. By removing the oocyte factor, these models offer a more precise perspective, addressing the temporal intricacies integral to successful ICSI procedures. The present research underscores the imperative of refining the temporal dimension for optimal reproductive results. Study design, size, duration This retrospective study encompassed 1,275 egg reception ICSI-cycles conducted between January 2019 and July 2023. Donors underwent stimulation using a short antagonist protocol, and oocytes were collected 35.5h post-trigger. The impact of both, the time between denudation-ICSI (D-ICSI time) and the time between trigger-ICSI (T-ICSI time) on reproductive outcomes were analysed. Six comparable groups were established by 30-minute intervals, segmenting the sample based on D-ICSI time (0.5h to 3h) and T-ICSI time (38h to 40.5h). Participants/materials, setting, methods A total of 1,275 cycles, involving 11,333 MII-oocytes, were stratified based on D-ICSI time (0.5h:89-cycles/761-MII; 1h:128/1,186; 1.5h:269/2,385; 2h:270/2,415; 2.5h:340/3,064; 3h:179/1,522) and T-ICSI time (38h:183/1,631; 38.5h:131/1,158; 39h:246/2,205; 39.5h:219/1,952; 40h:173/1,534; 40.5h:323/2,853). Comparative analyses were conducted for fertilization, abnormal fertilization, ICSI degeneration, and useful day 5/6 blastocyst outcomes (transferred or cryopreserved; &amp;gt;3BB-top and ≤3BB-good quality by Gardner score), as well as pregnancy and live birth rates (1,594 SET). Statistical methods employed included ANOVA, Chi-square tests, and Pearson’s correlation. Main results and the role of chance Several parameters showed stability across different time intervals of D-ICSI time: fertilization (0.5h:74.6%; 1h:72.6%; 1.5h:74.0%; 2h:75.9%; 2.5h:74.8%; 3h:74.4%; r = 0.3707; p = 0.469), blastocyst (0.5h:65.3%; 1h:62.6%; 1.5h:61.7%; 2h:60.1%; 2.5h:64.8%; 3h:63.8%; r= -0.068; p = 0.898), and live birth rates (0.5h:39.5%; 1h:35.9%; 1.5h:36.6%; 2h:40.2%; 2.5h:39.9%; 3h:39.7%; r = 0.474; p = 0.342). However, an extended interval significantly correlated with increased oocyte ICSI-degeneration (0.5h:5.5%; 1h:6.7%; 1.5h:6.7%; 2h:6.5%; 2.5h:7.4%; 3h:8.5%; r = 0.903; p &amp;lt; 0.05) and a decreased proportion of top-quality blastocysts (0.5h:86.8%; 1h:89.2%; 1.5h:86.4; 2h:85.3%; 2.5h:81.2%; 3h:75.2%; r= -0.879; p &amp;lt; 0.05). Extended culture of cumulus cell-free oocytes may promote oocyte aging and, consequently, compromise optimal development (consistent with findings in other studies). In evaluating T-ICSI time, similar trends to those observed in D-ICSI time persist in fertilization (r = 0.275, p = 0.598), blastocyst (r = 0.233, p = 0.657), live birth (r = 0.516, p = 0.295), and ICSI-degeneration rates (r = 0.864, p &amp;lt; 0.05). The negative correlation in the quality of generated useful blastocysts significantly intensifies (38h:90.6%; 38.5h:87.5%; 39h:84.7%; 39.5h:82.4%; 40h:80.1%; 40.5h:79.7%; r= -0.982, p &amp;lt; 0.05). In a separate analysis, we observed that undetected in vitro matured oocytes, stemming from delayed denudations, lead to a reduction in the top-quality blastocyst ratio. This concept, along with D-ICSI time, seems to synergize, emphasizing the adverse trend when evaluating blastocyst qualities concerning T-ICSI times. Limitations, reasons for caution This study has inherent limitations as a retrospective analysis. Additionally, the potential effects of ICSI earlier than 0.5 hours post denudation and 38 hours post-trigger, not yet standardized in the laboratory, were not assessed. Wider implications of the findings Extended incubation of denuded and non-injected oocytes fosters oocyte aging. Consequently, cycle efficiency is compromised with prolonged incubation times. The reduction of these times holds promise for improving the efficiency of IVF treatments. Additionally, shortening or eliminating incubation periods would enhance the automated sequence of diverse processes during an IVF. Trial registration number not applicable

Fully Distributed Hierarchical ET Intrusion- and Fault-Tolerant Group Control for MASs With Application to Robotic Manipulators

This paper studies group synchronization tracking problem for a class of high-order multi-agent systems (MASs) with nonidentical and unknown direction faults (NUDFs) under multiple cyber attacks (i.e., denial-of-service (DoS) attacks and false data injection attacks (FDIAs)). Be motivated by this, a fully distributed hierarchical (cyber layer and physical layer) Zeno-free event-triggered (ET) intrusion-and fault-tolerant controller is presented based on Nussbaum-type gain technique, where a positive inter-event time exists in the state-dependent asynchronous ET mechanism (ETM). The constructed virtual cyber layer realizes the interaction among different agents so as to avoid the interaction in physical processes and thus reduce the error propagation. This two layer controller greatly increase the flexibility of the controller design compared with single-layer control strategies. In addition, a novel Nussbaum function stability lemma (Lemma lem4lem4) is developed for the first time. Based on this lemma, the fully distributed adaptive controller can adjust the direction of the input to match the fault direction with the help of Nussbaum function. Finally, a robotic manipulator example demonstrates the effectiveness and merit of the proposed control scheme. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —In industrial processes, NUDFs and cyber attacks often occur in many different systems, which usually lead to performance degradation or even serious accidents. Typically, NUDFs affect the performance of chemical and industrial processes, circuits, and sensors. Meanwhile, in driverless vehicle platoon, attackers change the control signal through the wireless network, and then issue emergency braking commands, etc. Therefore, this paper designs a fully distributed hierarchical ET intrusion-and fault-tolerant scheme for high-order MASs that are usually used to model ship dynamics, robotic manipulators, and quarter-car active suspension. The control scheme gives solutions to the problem of NUDFs, multiple cyber attacks, and network bandwidth limitations at different layers, and effectively integrates the physical and cyber layers to achieve group synchronization. Meanwhile, a new event-triggered mechanism under the framework of group synchronization is developed to save communication resources. Robotic manipulator simulation studies verify the validity of the proposed scheme.

Event-Triggered Control of Switched Nonlinear Time-Delay Systems With Asynchronous Switching.

This article investigates the event-triggered switching control (ETSC) of switched nonlinear time-delay systems (SNTDSs) with asynchronous switching. First, we study the input-to-state stability (ISS) and integral ISS (iISS) for SNTDSs with asynchronous switching, where switching instants are generated based on the designed event-triggered mechanism. Among existing works on the ETSC, systems behavior at event-triggered instants is neglected. In fact, whenever an event is triggered, the systems mode will jump suddenly such that a switch is imposed to the systems, leading to the change of subsystems. Moreover, asynchronous switching behavior may occur between the actual subsystem and its corresponding controller. These facts bring great challenges for the event-triggered mechanism design and ISS analysis. To tackle these problems, a new Lyapunov-based event-triggered mechanism with adjustable parameters is designed to establish the relationship between systems switches and event triggers, and exclude the Zeno phenomenon. The analysis of the asynchronous switching behavior can be implemented and some ISS and iISS criteria of SNTDSs are derived utilizing the merging switching technique. Finally, two numerical examples, including a practical stirred tank reactor system, are presented to show the validity of the proposed methods.

Protocol-based control for semi-Markov reaction-diffusion neural networks

This paper addresses the asynchronous control problem for semi-Markov reaction–diffusion neural networks (SMRDNNs) under probabilistic event-triggered protocol (PETP) scheduling. A semi-Markov process with a deterministic switching rule is introduced to characterize the stochastic behavior of these networks, effectively mitigating the impacts of arbitrary switching. Leveraging statistical data on communication-induced delays, a novel PETP is proposed that adjusts transmission frequencies through a probabilistic delay division method. The dynamic adjustment of event trigger conditions based on real-time neural network is realized, and the responsiveness of the system is enhanced, which is of great significance for improving the performance and reliability of the communication system. Additionally, a dynamic asynchronous model is introduced that more accurately captures the variations between system modes and controller modes in the network environment. Ultimately, the efficacy and superiority of the developed strategies are validated through a simulation example.

Clinical use of CRT‐D devices with left ventricular sensing: Impact of the desynchronization‐detection algorithm

AbstractThe use of CRT‐D devices with left ventricular (LV) sensing has created controversy about programming various parameters especially the left ventricular T wave protection (LVTP) designed to prevent the delivery of a pacing stimulus into the LV vulnerable period. Such devices are available from two manufacturers. This review focuses only on those provided by Biotronik. As the LVTP controls LV sensing, some investigators have advocated turning off the LVTP to prevent episodic desynchronization known a CRT pacing interrupt. However, LVTP off reduces but does not eliminate this type of desynchronization if triggering of an LV stimulus upon right ventricular sensing (RVs) is programmed on. Deactivation of the LVTP incurs loss of diagnostic data provided by CRT pacing interrupt itself. By choice, the occurrence of CRT pacing interrupt can be totally eliminated by appropriate programming of the LV upper rate interval, LVTP and triggering of an LV pacing event upon RVs. Various programmability options are available according to clinical circumstances. As a rule, clinical judgement must weigh the potential diagnostic benefit of preserving the LVTP capable of recording of episodic CRT pacing interrupt against the loss of diagnostic benefit when LVTP is programmed off (with or without triggering of an LV stimulus upon RVs).

Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells.

Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis and limited therapeutic options. Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II (ATII) cells, has recently been identified as a potential trigger event for the progressive disease cycle. Targeting ATII senescence and the senescence-associated secretory phenotype (SASP) is an attractive therapeutic strategy; however, translatable primary human cell models that enable mechanistic studies and drug development are lacking. Here, we describe a novel system of conditioned medium (CM) transfer from bleomycin-induced senescent primary alveolar epithelial cells (AEC) onto normal human lung fibroblasts (NHLF) that demonstrates an enhanced fibrotic transcriptional and secretory phenotype compared to non-senescent AEC CM treatment or direct bleomycin damage of the NHLFs. In this system, the bleomycin-treated AECs exhibit classical hallmarks of cellular senescence, including SASP and a gene expression profile that resembles aberrant epithelial cells of the IPF lung. Fibroblast activation by CM transfer is attenuated by pre-treatment of senescent AECs with the senolytic Navitoclax and AD80, but not with the standard of care agent Nintedanib or senomorphic JAK-targeting drugs (e.g., ABT-317, ruxolitinib). This model provides a relevant human system for profiling novel senescence-targeting therapeutics for IPF drug development.

Protocol-based SMC for singularly perturbed systems with switching parameters and deception attacks

This research paper investigates a protocol-based sliding mode control (SMC) approach for singularly perturbed systems with switching parameters and random occurring deception attacks. The mode switching behavior of the original system is regulated using a semi-Markov process, and a novel and more efficient mode monitoring method is proposed, distinct from the conventional hidden Markov model. Furthermore, to reduce the triggering rate while maintaining control performance, a probability-based event triggering protocol is introduced. By employing the proposed scheme along with Lyapunov theory, sufficient criteria for parameter correlation are established to ensure asymptotic stability. The designed sliding mode control incorporates a convergence factor to enhance the control performance. Finally, the feasibility and practicality of the proposed control strategy are verified through simulations using two practical models.

Can a one-day event trigger interest in quantum physics at the university level?

The ongoing second quantum revolution and the growing impact of quantum technologies on our society and economy are making quantum physics education even more important. Consequently, there is a lot of research on quantum physics education for university students and even the general public. However, studying quantum physics or any other topic is primarily voluntary and thus a matter of personal interest—and it can only grow from a seed planted earlier. Here, we describe and test how a one-day event designed to trigger interest and change perceptions about quantum physics among physics and mathematics students at the University of Turku, Finland succeeded in meeting its goals. The data was collected from participants through questionnaires and complementary interviews. We found that the event made attitudes and views toward quantum physics more positive, versatile, and realistic. Although the event was too short to notably or permanently elevate the phase of interest when evaluated externally on a four-level scale, self-evaluations still reported an increased interest for most participants. Thus, it appears that even a short event can cultivate the ground to make it fertile for maintaining and developing interest further, for example, by well-designed and -timed quantum physics curriculum.

Experience of pre-suicidal suffering: insights from suicide attempt survivors

ABSTRACT Purpose Psychache significantly contributes to the suicidal process. However, the transition from pre-suicidal suffering to a suicide crisis remains one of the least explored stages in suicidology. Methods We retrospectively explored experience of pre-suicidal suffering through semi-structured, in-depth interviews with 12 individuals recruited from the Vilnius City Mental Health Center, Lithuania. Interpretative phenomenological analysis was employed to identify recurring patterns. Results Nine primary group experiential themes emerged: Certain adverse life events occurring during the suicidal process were not immediately perceived as connected; Complex traumatic events laid the groundwork for a profound sense of lack; A compensatory mechanism balanced the experience of profound lack; Exhaustion ensued from efforts to sustain the compensatory mechanism; The main trigger directly challenged the compensatory mechanism; The affective state followed the experience of the main triggering event; Dissociation served to isolate psychache; Thoughts of suicide experienced as automatic; Suicide was perceived as a means to end suffering. Conclusion The findings suggest that the suicidal process unfolds over an extended period of suffering, culminating in a crisis to alleviate unbearable psychological pain. In clinical practice, identifying the main triggering event discussed in this study can be pivotal in understanding the essence of suffering characterized by profound lacking and developed compensatory mechanisms.

Shrinking the 13D disclosure window will benefit non-activist investors

PurposeThis study aims to examine the Securities and Exchange Commission’s final rule in Modernization of Beneficial Ownership Reporting, which reduced the time for significant public company shareholders to file Schedule 13D (effective February 5, 2024). The authors corroborate prior results under the historic 10-day maximum reporting regime and provide updated academic analysis regarding how the five-day deadline between the “triggering” event, accumulating 5% of the outstanding shares and public disclosure of that event will affect abnormal returns.Design/methodology/approachThis empirical archival study uses publicly available data.FindingsThe analyses show that changing from a 10-day to a 5-day Schedule 13 disclosure window will reduce activist investors’ opportunity to profit by legally delaying the filing of Schedule 13D. These excess returns for delay exist regardless of the profitability or size of the target firm or the shareholder’s disclosed reason for filing. The authors conclude that accelerating the timing of the disclosure window is an improvement that is in the best interest of the general investing public.Originality/valueTo the authors’ knowledge, this is the only academic study of Schedule 13D filings to include the postpandemic period. As such, the authors establish an updated “baseline projection” for expectations regarding how the Modernization final rule will impact activist investors and stock returns under a five-day reporting regime. In addition, the authors measure and test abnormal returns after considering differences between “triggering” events and filing dates of Schedule 13Ds in the sample rather than grouping all filings. This approach allows the authors to account for the time difference between the triggering event and the filing date.

Characteristic Slow‐Slip Events on the Superstition Hills Fault, Southern California

AbstractThe Superstition Hills Fault (SHF) exhibits a rich spectrum of slip modes, including M 6+ earthquakes, afterslip, quasi‐steady creep, and both triggered and spontaneous slow slip events (SSEs). Following 13 years of quiescence, creepmeters recorded 25 mm of slip during 16–19 May 2023. Additional sub‐events brought the total slip to 41 mm. The event nucleated on the northern SHF in early‐May and propagated bi‐laterally at rates on the order of kilometers per day. Surface offsets reveal a bi‐modal slip distribution, with slip on the northern section of the fault being less localized and lower amplitude compared to the southern section. Kinematic slip models confirm systematic variations in the slip distribution along‐strike and with depth and suggest that slip is largely confined to the shallow sedimentary layer. Observations and models of the 2023 SSE bear a strong similarity to previous slip episodes in 1999, 2006, and 2010, suggesting a characteristic behavior.

Regulatory T cells as a possible new target in epilepsy?

Epilepsy is a complex chronic brain disorder with diverse clinical features that can be caused by various triggering events, such as infections, head trauma, or stroke. During epileptogenesis, various abnormalities are observed, such as altered cellular homeostasis, imbalance of neurotransmitters, tissue changes, and the release of inflammatory mediators, which in combination lead to spontaneous recurrent seizures. Regulatory T cells (Tregs), a subtype of CD4+Foxp3+ T cells, best known for their key function in immune suppression, also seem to play a role in attenuating neurodegeneration and suppressing pathological inflammation in several brain disease states. Considering that epilepsy is also highly associated with neuronal damage and neuroinflammation, modulation of Tregs may be an interesting way to modify the disease course of epilepsy and needs further investigation. In this review, we will describe the currently available information on Tregs in epilepsy.