Trial In Primary Biliary Cirrhosis Research Articles

A test of fit for a semiparametric additive risk model

SUMMARY Kolmogorov-Smirnov and Cramer-von Mises type test statistics based on the standardised cumulative hazard process are proposed. It is very difficult to evaluate their asymptotic distributions, but they can be approximated by the use of the bootstrap. The advantages of the goodness-of-fit test are that arbitrary partitions of the time axis and covariate spaces are not needed for evaluating test statistics and that it has excellent consistency properties. The test is applied to data from the Mayo Clinic trial in primary biliary cirrhosis of the liver. A simulation study indicates that the proposed test is suitable for practical use.

Therapeutic trials in primary biliary cirrhosis

Journal Article Therapeutic trials in primary biliary cirrhosis Get access S. SHERLOCK S. SHERLOCK Department of Surgery, Royal Free HospitalLondon, UK Address correspondence to Professor Dame Sheila Sherlock, Department of Surgery, Royal Free Hospital, Pond Street. London NW3 2QG Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume 87, Issue 11, November 1994, Pages 701–703, https://doi.org/10.1093/oxfordjournals.qjmed.a068886 Published: 01 November 1994