Trend Of Bone Mineral Density Research Articles

Global research trends in bone mineral density in children with diabetes: a bibliometric and visualization study

Research on bone density in children with diabetes has attracted increasing attention, and this study aims to investigate the global status and trends in this field.From the Web of Science's Science Citation Index, research papers related to bone density in children with diabetes from 1984-2022 were retrieved. Source data were studied and indexed using bibliometric methods. The visualization study used VOS viewer software for literature coupling, co-authorship, co-citation and co-occurrence analysis to analyze the publication trend of bone density in children with diabetes.A total of 1074 articles were included. Globally, the number of related research interests and publications is increasing every year. The United States contributes the most to global research, receives the most citations, and has the highest h-index. The Journal of Clinical Endocrinology and Metabolism has the highest number of publications.The university of pennsylvania,Childrens hospital of philadelphia,Pennsylvania medicine,Harvard university and university of Sydney are the largest contributors. Research can be divided into four categories: mechanistic research, animal research, clinical trials, and tissue engineering. Mechanism research is expected to be the next hot topic in this field.From the current global research trend, the number of papers on bone density in children with diabetes will continue to increase. The United States is the largest contributor in this area. Much of the effort is devoted to the mechanisms of changes in bone density in children with diabetes, which could be the next hot spot in research.

Trends in Bone Mineral Density in US 6-80 Years Old: Findings from 2005-2020 NHANES Surveys

<h3>Research Objectives</h3> The bone mineral density (BMD) reflects bone health and is associated with the risk of developing osteoporotic fractures. This study aimed to examine the trends in BMD values in US 6-80 years old, and the changes in BMD values between 2005 and 2020. <h3>Design</h3> This is a cross-sectional observational study. <h3>Setting</h3> General community. <h3>Participants</h3> Data from 28,514 noninstitutionalized participants, aged 6 to 80, were obtained from the 2005-2020 National Health and Nutrition Examination Survey (NHANES) study. We described the distributions of BMD values by sex, age group (6-8, 9-11, 12-15, 16-19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, 75-79, 80+ yr), and compared the trends in six cross-sectional surveys during 2005-2006, 2007-2008, 2009-2010, 2013-2014, 2017-2018, 2017-2020. <h3>Interventions</h3> N/A. <h3>Main Outcome Measures</h3> BMD at the lumbar spine and femur was assessed using Dual-Energy X-ray Absorptiometry (DEXA). <h3>Results</h3> BMD changed by age and differed by sex. For males, mean femur BMD values (g/cm2) increased from 0.71 (6-8 yr), to 0.93 (12-15 yr), to 1.11 (16-19 yr), and decreased gradually to 0.92 (80+ yr) by age. For females, mean femur BMD values (g/cm2) increased from 0.66 (6-8 yr), to 0.93 (12-15 yr), to 0.98 (16-19 yr), and decreased gradually to 0.74 (80+ yr) by age. For males, mean spine BMD values (g/cm2) increased from 0.58 (6-8 yr), to 0.82 (12-15 yr), to 1.07 (25-29 yr), and maintained the levels by age (mean BMD = 1.07 at 80+ yr). For females, mean spine BMD values (g/cm2) increased from 0.60 (6-8 yr), to 0.94 (12-15 yr), to 1.08 (35-39 yr), and decreased gradually to 0.90 (80+ yr) by age. Males had higher femur BMD values in the age group 16-80 years old, and higher spine BMD values in the age group 50-80 years old, compared to females (p<.001). Mean BMD values (g/cm2) were relatively stable across data releasing cycles 2005-2020. <h3>Conclusions</h3> Between 2005 and 2020, stable trends in BMD values were observed among noninstitutionalized residents in the US. <h3>Author(s) Disclosures</h3> The authors declare no conflict of interest.

Risk factors for future osteoporosis in perimenopausal Japanese women.

ObjectiveThe aims of this study were to investigate trends in bone mineral density (BMD) loss and related factors in early postmenopausal women in Japan, identify risk factors for future osteoporosis, and predict osteoporosis before it occurs.MethodsThe study population consisted of women who were 50 to 54 years old at the time of the survey in 2002 or 2006. The study included a questionnaire and physical measurement findings (BMD, height, body weight [WT], body mass index [BMI], and handgrip strength). One hundred sixty-seven women continued to participate in the study and had BMD measurements at the 9- or 10-year follow-up of the Japanese Population-based Osteoporosis study. Statistical analyses were performed using Pearson correlation to examine each factor of physical measurement and BMD for lumbar spine (LS) and femoral neck (FN). The receiver operating characteristic curve of this data was also predictive of osteoporosis in 2011 for 2002 data; BMD at the age of 50 to 54 years was then used to predict the likelihood of being diagnosed with osteoporosis 9 and 10 years later.ResultsAt the baseline in 2002 and 2006, WT, BMI, height, and handgrip strength were positively correlated with BMD. The optimal cutoff values for BMD in 2006 to predict osteoporosis in 2016 were LS less than 0.834 g/cm2 and FN less than 0.702 g/cm2. These data were also predictive of osteoporosis in 2011 for 2002 data; applying this to the 2002 data, LS/FN had a sensitivity of 92%/100%, a specificity of 87%/81%, a positive predictive value of 55%/48%, and a negative predictive value of 98%/100%. The larger WT and BMI also resulted in a greater decrease in BMD of FN after 9 or 10 years.ConclusionsWe have identified a cutoff value for BMD to predict future osteoporosis in menopausal women and found a negative correlation between WT and BMI in menopausal women and changes in BMD of the FN over the next 10 years.

Trends in Bone Mineral Density, Osteoporosis, and Osteopenia Among U.S. Adults With Prediabetes, 2005-2014.

We aimed to evaluate trends in bone mineral density (BMD) and the prevalence of osteoporosis/osteopenia in U.S. adults with prediabetes and normal glucose regulation (NGR) and further investigate the association among prediabetes, osteopenia/osteoporosis, and fracture. We collected and analyzed data from the U.S. National Health and Nutrition Examination Surveys during the period from 2005 to 2014. Femoral neck and lumbar spine BMD data were available for 5,310 adults with prediabetes and 5,162 adults with NGR >40 years old. A shift was observed toward a lower BMD and a higher prevalence of osteopenia/osteoporosis at the femoral neck and lumbar spine in U.S. adults >40 years old with prediabetes since 2005, especially in men <60 and women ≥60 years old. A shift toward a higher prevalence of osteopenia/osteoporosis at the femoral neck was also observed in adults >40 years old with NGR. Moreover, prediabetes was associated with a higher prevalence of hip fracture, although participants with prediabetes had higher BMD and a lower prevalence of osteopenia/osteoporosis at the femoral neck. There was a declining trend in BMD from 2005 to 2014 in U.S. adults >40 years old with prediabetes and NGR, and this trend was more significant in men <60 years old. Populations with prediabetes may be exposed to relatively higher BMD but a higher prevalence of fracture.

Trends in bone mineral density among nutritional status categories of Vojvodina elderly population

Introduction/Objective. Low bone mineral density (BMD) is commonly associated with alterations of nutritional status. The aims of the present study were to evaluate the prevalence of low BMD and its associated nutritional risk factors in Vojvodina population and to use linear regression equations to predict the BMD by using a simple marker of nutritional status, body mass index (BMI). Methods. In this retrospective, cross-sectional study, the study population included subjects who were undergoing assessment of BMD between January and December 2017, and who have met the study inclusion criteria. A total of 1974 patients (1866 women and 108 men) were included in this analysis of nutritional status according to anthropometry and BMI index, and dual-energy X-ray absorptiometry (DEXA) measurements of BMD of the femoral neck and lumbar spine. The relationship between BMI and BMD was analyzed by linear regression equation. Results. Median age was 63 (56?70) years. Considering nutritional status category, there were 40% overweight, 31% obese and 29% normal weight subjects. In most of the sample, the subjects had low BMD, 37% had osteopenia, and 25% had osteoporosis. In both bone areas we observed trends of lowering BMD as the subjects BMI decreased. Subjects with osteoporosis are more prone to BMI depended BMD changes, concerning subjects with osteopenia and normal BMD. In addition, normal weight subjects compared to overweight and obese had the highest prediction coefficients of BMI-depended changes on BMD. Conclusion. High prevalence of low BMD coexists with overweight and obese elderly females in Vojvodina. Prediction equations for the calculation of BMD can be used to evaluate the effect of BMI changes on BMD in clinical settings.

Decreasing trend of bone mineral density in US multiethnic population: analysis of continuous NHANES 2005-2014.

Osteoporosis prevalence in the USA declined between 1988 and 2006, while the declining trend in hip fracture may have plateaued in 2013-2014. We aimed to examine whether there has been a corresponding change in BMD trajectory for the US population. Continuous National Health and Nutrition Examination Survey (NHANES) data from 2005-2006 to 2013-2014 were analyzed to examine BMD trends among US men and women aged 30years and older and among different race/ethnicity subgroups. ANOVA and Bonferroni adjustments were used to examine the differences in mean BMD, and multiple linear regressions adjusting for potential confounding effects were employed to examine BMD trends. After age standardization, the mean BMD of the femur neck for the first three NHANES cycles was stable (all p > 0.1) in both men and women, but significantly decreased in 2013-2014, from 0.864g/cm2 to 0.846g/cm2 (p = 0.0025) in men and from 0.789 to 0.771g/cm2 (p = 0.03) in women. The overall mean femur neck BMD in 2013-2014 was significantly lower than that in earlier survey cycles in both men and women, even after adjusting for multiple covariates, including age, race, physical activity, previous fracture, BMI, and other variables. Similar results were observed in subgroup analyses of race and sensitivity analyses. Age-adjusted mean BMD decreased in 2013-2014 in both men and women, and this significant decrease was also observed in sensitivity and subgroup analyses. The decreased BMD in 2013-2014 still remained significant even after being adjusted for multiple potentially confounding effects.

Biological sex variation in bone mineral density in the cranium and femur

ObjectivesSex and age trends in bone mineral density (BMD) play an important role in the estimation of age-at-death (AAD) of unidentified human remains. Current methodologies lack the ability to precisely estimate age in older individuals. In this study, BMD of the cranium and femur measured by DXA were examined to establish their applicability for age estimation in older adults. BMD as measured by DXA, is most commonly used clinically for prediction of osteoporotic fracture risk. We hypothesized that weight-bearing and non-weight-bearing bones, the femur and cranium, respectively, would provide valuable insights for aging. MethodsThe sample consists of 32 sets of excised cranial fragments from the Regional Forensic Center, Johnson City, Tennessee and 41 associated crania and femora from the North Carolina Office of the Chief Medical Examiner. All crania and femora were scanned using a Hologic (R) DXA scanner and data were analyzed using Student t-tests, Loess regression, and ANOVA. ResultsStudent t-tests indicate a significant relationship between the sexes and cranial BMD and a significant relationship between age cohorts and femoral neck BMD. The Loess regression showed different aging patterns in the cranium for females and males older than 55. And the ANOVA showed changes in femoral neck after age 55. ConclusionsThese results indicate age and sex dependent changes in BMD especially for individuals over the age of 55, which offers improvement from current aging methods for older individuals. Further research using a larger sample size could improve the predictive capabilities of the model.

Abstract P2-07-16: Alcohol consumption increases mammographic density in women aged ≥55 years

Abstract Background: Incresed mammographic density is a significant risk factor for breast cancer and decreses the sensitivity of mammography screening. The aim of this study is to examine the factors affecting breast density in Japanese women. Data sources and methods: Between Apr. 2014 and Mar. 2016, 3492 women were received mammography screening. According to the results of mammography, breast density was categorized as non-dense(BI-RADS 1 and 2, n=1670) and dense(BI-RADS 3 and 4, n=2222) . Logistic regression was used to estimate the odds of having dense breasts by age, body mass index(BMI), alcohol consumption, smoking, parity, menopausal status, dysmenorrhea, hormone use, family history of breast cancer, physical activity, fried foods intake, brightly colored vegetables intake, coffee intake and tea or green tea intake. All statistical tests were two-sided. Results: There was a statistically significant negative interaction of age(OR=0.97, &amp;lt;0.001), BMI(OR=0.78, &amp;lt;0.001), number of live birth (one; OR=0.77, &amp;lt;0.030, two or more; OR0.37, &amp;lt;0.001), post-menopause(OR=0.6, &amp;lt;0.001) on breast density. On the other, there was a statistically significant positive interaction of alcohol intake(20g or more a day, OR=1.62, 0.026) in dense breast women aged ≥55 years. A trend of bone mineral density ≥80% and dense breast was seen in women aged ≥40 years(OR=0.63, &amp;lt;0.086, n=510). Results of analysis of factors influencing breast density among all study participants Odds ratio95% CIPAgeContinuoous variables0.970.95-0.98&amp;lt;0.001BMIContinuoous variables0.780.76-0.80&amp;lt;0.001Alcohol intakenone1.00 0.325 &amp;lt;20g a day1.120.94-1.350.209 ≥20g a day1.210.91-1.600.186Smokingno1.00 yes0.940.71-1.230.644Birth01.00 &amp;lt;0.001 once0.770.61-0.970.030 ≥20.370.31-0.45&amp;lt;0.001Menopausepre1.00 post0.600.47-0.77&amp;lt;0.001Dysminorrheano1.00 yes0.780.41-1.480.446Family history of breast cancerno1.00 yes1.000.81-1.240.991Physical activityno1.00 yes0.890.74-1.070.207Fried foods intakenone1.00 0.087 once two days0.780.60-1.020.068 ≥once a day0.760.51-1.120.166Brightly coloredd vegetablesnone1.00 0.910 once two days0.950.70-1.280.737 ≥once a day0.950.73-1.220.666Coffee intakenone1.00 0.105 once two days1.060.75-1.510.729 ≥once a day1.221.01-1.470.040Tea/Green tea intakenone1.001.01-1.470.098 once two days0.760.55-1.050.097 ≥once a day0.840.70-1.000.055bone mineral density(n=510)&amp;lt;80%1.00 ≥80%0.630.38-1.070.068 Results of analysis of factors influencing breast density in women aged ≥55 years (n=1382) Odds ratio95% CIPBMI&amp;lt;25kg/m21.00 ≥25kg/m20.300.21-0.44&amp;lt;0.001Birth0 Trend P&amp;lt;0.001 once0.690.46-1.040.0076 ≥two0.310.23-0.41&amp;lt;0.001Alcohol intakenone 0.052 &amp;lt;20g/day1.260.98-1.620.074 ≥20g/day1.621.06-2.480.026 Conclusion: Alcohol consumption increase mammographic breast density in women aged ≥55 years. As both of increased breast density and alcohol consumption have been suggested to increase risk of breast cancer, more cautious mammographic screening should be considered for those women aged ≥55 years. Citation Format: Uchida K, Ohashi H, Kitano N, Tsunoda K, Nagamatsu T, Sekine C, Imawari Y, Nogi H, Takeyama H. Alcohol consumption increases mammographic density in women aged ≥55 years [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P2-07-16.

191.2 Trends in bone mineral density on DXA scan over a 12 year period in the Regional CF Paediatric Centre in Northern Ireland

191.2 Trends in bone mineral density on DXA scan over a 12 year period in the Regional CF Paediatric Centre in Northern Ireland

Trends in bone mineral density in young adults with cystic fibrosis over a 15 year period

BackgroundImprovements in clinical care have led to increased life expectancy in patients with cystic fibrosis (CF) over the past several decades. Whether these improvements have had significant effects on bone health in patients with CF is unclear. MethodsThis is a cross-sectional study comparing clinical characteristics and bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) in adults with CF evaluated in 1995–1999 to age-, race-, and gender-matched patients with CF evaluated in 2011–2013 at the same center on calibrated DXA machines. ResultsThe cohorts were similar in terms of age, BMI, pancreatic insufficiency, presence of F508del mutation, and reproductive history. In the most recent cohort, pulmonary function was superior, and fewer patients had vitamin D deficiency or secondary hyperparathyroidism. Areal BMD measures of the PA spine, lateral spine, and distal radius were similarly low in the two cohorts. ConclusionsAlthough pulmonary function and vitamin D status were better in patients in the present-day cohort, areal BMD of the spine was reduced in a significant number of patients and was no different in patients with CF today than in the late 1990s. Further attention to optimizing bone health may be necessary to prevent CF-related bone disease.

Temporal Trends in Bone Mineral Density, Body Mass Index and Fracture Rates: Implications for Osteoporosis Diagnosis and FRAX

Temporal Trends in Bone Mineral Density, Body Mass Index and Fracture Rates: Implications for Osteoporosis Diagnosis and FRAX

Bone mineral density in adults in Taiwan: results of the Nutrition and Health Survey in Taiwan 2005-2008 (NAHSIT 2005-2008).

Osteoporosis is one of the most prevalent global health problems in the elderly. A nationwide representative sample of 1121 adult subjects, aged 19 years and older, were scanned by a dual-energy X-ray absorptiometry in the third survey year of Nutrition and Health Survey in Taiwan 2005-2008. There was an apparent gender difference in the trend of bone mineral density (BMD) with age. In males, the decrease in BMD with age at lumbar spine and at femoral neck were statistically significant in those younger than 50 years, whereas the decrease in BMD at forearm was significant only in those aged 50 years and older (β= -0.005, p<0.0001). In females there was a significant negative correlation between BMD at femoral neck and age (β= -0.004, p<0.0001). In the 236 subjects aged 50 years and older, the prevalence rates of osteoporosis were 4.3% at lumbar spine, 12.0% at femoral neck, and 11.6% at forearm in males, and 12.6% at lumbar spine, 18.1% at femoral neck, and 25.0% at forearm in females, respectively. The prevalence rates of osteoporosis at any site were 23.9% in males and 38.3% in females, respectively. The prevalence rates of low bone mass at lumbar spine, femoral neck, and forearm were 28.8%, 57.5%, and 22.7% in males and 34.7%, 45.9%, and 26.1% in females, respectively. Effective measures to maintain bone health and/or to reduce excessive bone loss may be important in the prevention of osteoporotic fractures in Taiwanese adults.

Trends in bone mineral density in children with Duchenne Muscular Dystrophy before and after glucocorticoid therapy

Trends in bone mineral density in children with Duchenne Muscular Dystrophy before and after glucocorticoid therapy

Medium-to-long Term DEXA Analysis of an Uncemented (AML) Femoral Component

We present medium-to-long-term bone mineral density studies assessing bone resorption and remodelling around the cementless femoral component of a total hip arthroplasty (Depuy AML prosthesis). Bone mineral densities were compared with the unoperated side at a time interval of eight years between scans using dual energy X-ray absorptiometry. Initial proximal stress shielding is known but we show that this response continues into the medium to long term in relative terms. We have also found an overall trend for bone mineral density to increase around the prosthesis with the greatest changes occurring distally. The greatest real increase in bone mineral density occurred in Gruen zones 2, 3 and 5 with smaller increases in zones 1, 4, 6 and 7. However, when compared with the contralateral unoperated femur (thus considering systemic changes in bone mineral density), we found these changes only reached statistical significance in Gruen zones 5, 6 and 7.

Medium-to-long term DEXA analysis of an uncemented (AML) femoral component

We present medium-to-long-term bone mineral density studies assessing bone resorption and remodelling around the cementless femoral component of a total hip arthroplasty (Depuy AML prosthesis). Bone mineral densities were compared with the unoperated side at a time interval of eight years between scans using dual energy X-ray absorptiometry. Initial proximal stress shielding is known but we show that this response continues into the medium to long term in relative terms. We have also found an overall trend for bone mineral density to increase around the prosthesis with the greatest changes occurring distally. The greatest real increase in bone mineral density occurred in Gruen zones 2, 3 and 5 with smaller increases in zones 1, 4, 6 and 7. However, when compared with the contralateral unoperated femur (thus considering systemic changes in bone mineral density), we found these changes only reached statistical significance in Gruen zones 5, 6 and 7.

Low bone mineral density in the femoral neck of medieval women: a result of multiparity?

An archaeological investigation of a medieval cemetery gave us the opportunity to investigate 49 Danish skeletons dating from 1000 to 1250 A.D. and to compare them with 298 contemporary Danes (aged 19–79 years) and assess the millennial trend in bone mineral density (BMD) in populations considered genetically closely related. BMD and bone mineral apparent density (BMAD) of the femoral neck were measured by dual-energy X-ray absorptiometry (DEXA) and transformed into z scores. BMD zscore was significantly lower in medieval women (−0.54 ± 0.25, p = 0.04), whereas BMD zscore in medieval men was significantly higher (0.55 ± 0.22, p = 0.02). In medieval women, BMD zscore tended to increase with age ( r = 0.42, p = 0.07), whereas no change was seen in men ( r = 0.19, not significant [n.s.]). Also, BMAD zscore was significantly elevated in medieval men (1.00 ± 0.28, p < 0.01), but in medieval women no difference was found (−0.28 ± 0.21, n.s.). However, the correlation between BMAD zscore and age was significant in the medieval women where it increased with advancing age ( r = 0.49, p = 0.03). In conclusion, medieval women had lower BMD when compared with contemporary women, but this relationship was reversed in women who survived to older ages. In contrast, medieval men had significantly higher BMD as compared with contemporary men at all ages. The observed lower BMD in medieval women can be explained by the well-known selective mortality among the younger women. A high birth rate and prolonged periods of lactation are the main reasons for the observed increased mortality, and therefore can also very likely explain the associated low BMD. The increase in the incidence of osteoporosis in modern elderly women could possibly, or partially, be explained by the survival of women who would have died prematurely had they lived in earlier centuries.

Milk consumption and bone mineral density in middle aged and elderly women.

To study the effects of historical milk consumption on current bone mineral density at the hip and spine. Cross sectional study. 284 community based women aged 44-74 years recruited from four general practice age-sex registers in Cambridge. Subjects categorised their average milk consumption up to age 25, from age 25-44, and from age 44 to the present time as > or = 1 glass/day, < 1 glass/day but > 1 glass/week, or < 1 glass/week. Bone mineral density at the hip and spine measured by dual energy x ray absorptiometry. Data on milk consumption up to age 25 years were available for 252 women. There was a consistent upward trend in bone mineral density at all sites with increasing historical milk consumption (total hip, femoral neck, trochanter, intertrochanter, P < 0.05; Ward's triangle, P = 0.005). Adjustment for age and body size did not alter these trends. Milk consumption up to age 25 was a significant independent predictor of bone mineral density at all sites in multiple linear regression analyses controlling for age, body mass index, menopausal status, smoking, ever use of hormone replacement therapy or oral contraceptives, physical activity, and alcohol intake. The effects of milk consumption from age 25-44 and from age 44 to the present were similar in direction though not statistically significant. Frequent milk consumption before age 25 favourably influences hip bone mass in middle aged and older women.