Abstract P2-07-16: Alcohol consumption increases mammographic density in women aged ≥55 years

Abstract

Abstract Background: Incresed mammographic density is a significant risk factor for breast cancer and decreses the sensitivity of mammography screening. The aim of this study is to examine the factors affecting breast density in Japanese women. Data sources and methods: Between Apr. 2014 and Mar. 2016, 3492 women were received mammography screening. According to the results of mammography, breast density was categorized as non-dense(BI-RADS 1 and 2, n=1670) and dense(BI-RADS 3 and 4, n=2222) . Logistic regression was used to estimate the odds of having dense breasts by age, body mass index(BMI), alcohol consumption, smoking, parity, menopausal status, dysmenorrhea, hormone use, family history of breast cancer, physical activity, fried foods intake, brightly colored vegetables intake, coffee intake and tea or green tea intake. All statistical tests were two-sided. Results: There was a statistically significant negative interaction of age(OR=0.97, <0.001), BMI(OR=0.78, <0.001), number of live birth (one; OR=0.77, <0.030, two or more; OR0.37, <0.001), post-menopause(OR=0.6, <0.001) on breast density. On the other, there was a statistically significant positive interaction of alcohol intake(20g or more a day, OR=1.62, 0.026) in dense breast women aged ≥55 years. A trend of bone mineral density ≥80% and dense breast was seen in women aged ≥40 years(OR=0.63, <0.086, n=510). Results of analysis of factors influencing breast density among all study participants Odds ratio95% CIPAgeContinuoous variables0.970.95-0.98<0.001BMIContinuoous variables0.780.76-0.80<0.001Alcohol intakenone1.00 0.325 <20g a day1.120.94-1.350.209 ≥20g a day1.210.91-1.600.186Smokingno1.00 yes0.940.71-1.230.644Birth01.00 <0.001 once0.770.61-0.970.030 ≥20.370.31-0.45<0.001Menopausepre1.00 post0.600.47-0.77<0.001Dysminorrheano1.00 yes0.780.41-1.480.446Family history of breast cancerno1.00 yes1.000.81-1.240.991Physical activityno1.00 yes0.890.74-1.070.207Fried foods intakenone1.00 0.087 once two days0.780.60-1.020.068 ≥once a day0.760.51-1.120.166Brightly coloredd vegetablesnone1.00 0.910 once two days0.950.70-1.280.737 ≥once a day0.950.73-1.220.666Coffee intakenone1.00 0.105 once two days1.060.75-1.510.729 ≥once a day1.221.01-1.470.040Tea/Green tea intakenone1.001.01-1.470.098 once two days0.760.55-1.050.097 ≥once a day0.840.70-1.000.055bone mineral density(n=510)<80%1.00 ≥80%0.630.38-1.070.068 Results of analysis of factors influencing breast density in women aged ≥55 years (n=1382) Odds ratio95% CIPBMI<25kg/m21.00 ≥25kg/m20.300.21-0.44<0.001Birth0 Trend P<0.001 once0.690.46-1.040.0076 ≥two0.310.23-0.41<0.001Alcohol intakenone 0.052 <20g/day1.260.98-1.620.074 ≥20g/day1.621.06-2.480.026 Conclusion: Alcohol consumption increase mammographic breast density in women aged ≥55 years. As both of increased breast density and alcohol consumption have been suggested to increase risk of breast cancer, more cautious mammographic screening should be considered for those women aged ≥55 years. Citation Format: Uchida K, Ohashi H, Kitano N, Tsunoda K, Nagamatsu T, Sekine C, Imawari Y, Nogi H, Takeyama H. Alcohol consumption increases mammographic density in women aged ≥55 years [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P2-07-16.