Abstract
<h3>Research Objectives</h3> The bone mineral density (BMD) reflects bone health and is associated with the risk of developing osteoporotic fractures. This study aimed to examine the trends in BMD values in US 6-80 years old, and the changes in BMD values between 2005 and 2020. <h3>Design</h3> This is a cross-sectional observational study. <h3>Setting</h3> General community. <h3>Participants</h3> Data from 28,514 noninstitutionalized participants, aged 6 to 80, were obtained from the 2005-2020 National Health and Nutrition Examination Survey (NHANES) study. We described the distributions of BMD values by sex, age group (6-8, 9-11, 12-15, 16-19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, 75-79, 80+ yr), and compared the trends in six cross-sectional surveys during 2005-2006, 2007-2008, 2009-2010, 2013-2014, 2017-2018, 2017-2020. <h3>Interventions</h3> N/A. <h3>Main Outcome Measures</h3> BMD at the lumbar spine and femur was assessed using Dual-Energy X-ray Absorptiometry (DEXA). <h3>Results</h3> BMD changed by age and differed by sex. For males, mean femur BMD values (g/cm2) increased from 0.71 (6-8 yr), to 0.93 (12-15 yr), to 1.11 (16-19 yr), and decreased gradually to 0.92 (80+ yr) by age. For females, mean femur BMD values (g/cm2) increased from 0.66 (6-8 yr), to 0.93 (12-15 yr), to 0.98 (16-19 yr), and decreased gradually to 0.74 (80+ yr) by age. For males, mean spine BMD values (g/cm2) increased from 0.58 (6-8 yr), to 0.82 (12-15 yr), to 1.07 (25-29 yr), and maintained the levels by age (mean BMD = 1.07 at 80+ yr). For females, mean spine BMD values (g/cm2) increased from 0.60 (6-8 yr), to 0.94 (12-15 yr), to 1.08 (35-39 yr), and decreased gradually to 0.90 (80+ yr) by age. Males had higher femur BMD values in the age group 16-80 years old, and higher spine BMD values in the age group 50-80 years old, compared to females (p<.001). Mean BMD values (g/cm2) were relatively stable across data releasing cycles 2005-2020. <h3>Conclusions</h3> Between 2005 and 2020, stable trends in BMD values were observed among noninstitutionalized residents in the US. <h3>Author(s) Disclosures</h3> The authors declare no conflict of interest.
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