Grouped multilevel space-time trellis codes (GMLSTTCs) utilize multilevel coding (MLC), antenna grouping and space time trellis codes (STTCs) for simultaneously providing coding gain, diversity improvement and increased spectral efficiency. The performance of GMLSTTCs is limited due to predefining of the antenna groups. It has been shown that when perfect or partial channel state information is available at the transmitter, the performance and capacity of space-time coded system can be further improved. In this paper, we present a new code designed by combining MLC, STTCs, antenna grouping and channel state information at transmitter, henceforth referred to as adaptively grouped multilevel space time trellis codes (AGMLSTTCs). AGMLSTTCs use a single full-diversity STTC at initial some levels and multiple STTCs at some later levels. The single full diversity STTC at each initial level spans all transmit antennas and the STTC at each later level spans a group of transmit antennas. The channel state information at the transmitter is used to adaptively group the transmit antennas for the later levels. Instantaneous channel power gain is calculated between each transmit antenna and all the receive antennas. A subset of transmit antennas having maximum channel power gain is selected to form a group. The simulation results show that AGMLSTTCs enable to transmit more than one data symbol per time slot with improved error performance over GMLSTTCs with predefined transmit antenna grouping.