Treatment Of Lead Poisoning Research Articles

Effect of Dietary Calcium and Phosphorus on Toxicity of Lead in the Rat: Rationale of Phosphate Therapy.

Since the introduction of calcium salts or calcium containing foods, by Aub and his associates,1 in the treatment of lead poisoning, numerous papers have appeared in the literature advocating such therapy. The rationale of the procedure was based on the following facts: First, the solubility of lead phosphate was found to be analogous to that of calcium phosphate; hence Aub and his associates believed that lead might be deposited in the bones in the same manner that lime salts are and thus be removed from the circulation. Second, when diets low in calcium were fed to cats, the trabeculae of the bones of the animals were diminished in size and in number as compared to those of animals fed diets to which calcium had been added. This was interpreted to mean that the addition of calcium salts to diets in general results in an increased storage of lime salts in the trabeculae; and since lead was supposed to behave like calcium, its deposition in the bones could be hastened or increased by furthering the proces...

Significance of Bone Trabeculae in the Treatment of Lead Poisoning

T has been found easier to control the metabolism of lead in the human organism since it was learned that the lead stream runs parallel to the calcium stream.' It is now generally agreed that lead is stored in the bones for long periods of time. From this storage place it is gradually liberated, just as calcium is liberated, and therefore may be found in the excreta over a period of months and probably in small quantities for years. This gradual elimination of lead is the result of normal exchange of the inorganic salt content of bone. In periods of metabolic emergency such as occur during pneumonia, alcoholic debauches, operations, etc., it has been observed that toxic lead episodes develop in individuals exposed to lead but who have previously had no symptoms. In such metabolic emergencies, therefore, the organism may be exposed to an increased stream, which must be derived from the bones. This lead stream can also be liberated, as shown by Aub and Minot,1 and Hunter and Aub,2 by using other methods which draw calcium from the bones. Since this treatment was devised, the question has often been asked whether it is preferable to withdraw lead by such therapy or whether it would be wiser to allow it to be excreted in the natural course of metabolic events over a long period of time. The work here reported presents further evidence in favor of removing this stored lead. Inasmuch as lead metabolism runs parallel to that of calcium, the -lead problem becomes essentially a problem of calcium metabolism. In recent work upon the function of bones, Bauer, Aub, and Albright' and later, Gyorgy,4 demonstrated that bone structure could obviously

"ARSPHENAMIN DERMATITIS, MERCURIAL POISONING AND LEAD INTOXICATION"

To the Editor: —I wish to comment briefly on a letter written by Dr. Harry Lutz, Augusta, Kan., published January 17. Physicians who have had little or no experience with sodium thiosulphate might believe what Dr. Lutz has said. I have had little experience with the use of sodium thiosulphate in the treatment of lead poisoning; therefore I know little about its merits in this condition. I would consider, however, that it is just as important to use sodium thiosulphate in the treatment of acute arsenic and mercury poisoning as it is to sterilize one's instruments before an abdominal operation. Sodium thiosulphate is as much a specific in mercury poisoning as quinin is in malaria. We cannot expect medicine to restore to an individual his kidney after a nephrectomy, and because a medicine does not restore an organ after it has been removed or destroyed by disease or poison is

Treatment of Lead Poisoning

Treatment of Lead Poisoning

Treatment of Lead Poisoning

Treatment of Lead Poisoning

The Treatment of Lead Poisoning

The Treatment of Lead Poisoning

A New Treatment of Lead Poisoning

A New Treatment of Lead Poisoning

Chloroform for the Treatment of Lead Poisoning

Chloroform for the Treatment of Lead Poisoning