Transport Measurements Research Articles

Development of the Gravel Pressure and Voice Synchronous Observation System and Application in Bedload Transport Measurement

Bedload sediment transport is critical in the natural river environmental and ecological system. It is quite challenging to measure the bedload sediment transport rate in rivers with any degree of accuracy. In this study, the authors developed the Gravel Pressure and Voice Synchronous observation system (GPVS) to estimate the bedload sediment transport rate in rivers. The core of the GPVS includes an underwater high-fidelity audio recorder and pressure sensor. The audio recorder is intended to monitor the low bedload sediment transport rate, whereas the pressure sensor is utilized to detect relatively substantial bedload sediment transport. The GPVS is tested by running flume experiments with natural gravel to evaluate the system’s reliability and feasibility. Results reveal that the GPVS has a very high sensitivity for detecting bedload transport. When the bedload sediment transport rate is relatively low, the audio recorder can measure it quantitatively, showing that the system is not impacted by ambient noise.

SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia

Neutropenia and neutrophil dysfunction in glycogen storage disease type 1b (GSD1b) and severe congenital neutropenia type 4 (SCN4), associated with deficiencies of the glucose-6-phosphate transporter (G6PT/SLC37A4) and the phosphatase G6PC3, respectively, are the result of the accumulation of 1,5-anhydroglucitol-6-phosphate in neutrophils. This is an inhibitor of hexokinase made from 1,5-anhydroglucitol (1,5-AG), an abundant polyol in blood. 1,5-AG is presumed to be reabsorbed in the kidney by a sodium-dependent-transporter of uncertain identity, possibly SGLT4/SLC5A9 or SGLT5/SLC5A10. Lowering blood 1,5-AG with an SGLT2-inhibitor greatly improved neutrophil counts and function in G6PC3-deficient and GSD1b patients. Yet, this effect is most likely mediated indirectly, through the inhibition of the renal 1,5-AG transporter by glucose, when its concentration rises in the renal tubule following inhibition of SGLT2. To identify the 1,5-AG transporter, both human and mouse SGLT4 and SGLT5 were expressed in HEK293T cells and transport measurements were performed with radiolabelled compounds. We found that SGLT5 is a better carrier for 1,5-AG than for mannose, while the opposite is true for human SGLT4. Heterozygous variants in SGLT5, associated with a low level of blood 1,5-AG in humans cause a 50–100% reduction in 1,5-AG transport activity tested in model cell lines, indicating that SGLT5 is the predominant kidney 1,5-AG transporter. These and other findings led to the conclusion that (1) SGLT5 is the main renal transporter of 1,5-AG; (2) frequent heterozygous mutations (allelic frequency > 1%) in SGLT5 lower blood 1,5-AG, favourably influencing neutropenia in G6PC3 or G6PT deficiency; (3) the effect of SGLT2-inhibitors on blood 1,5-AG level is largely indirect; (4) specific SGLT5-inhibitors would be more efficient to treat these neutropenias than SGLT2-inhibitors.

On-chip electrocatalytic microdevices.

On-chip electrocatalytic microdevices (OCEMs) are an emerging electrochemical platform specialized for investigating nanocatalysts at the microscopic level. The OCEM platform allows high-precision electrochemical measurements at the individual nanomaterial level and, more importantly, offers unique perspectives inaccessible with conventional electrochemical methods. This protocol describes the critical concepts, experimental standardization, operational principles and data analysis of OCEMs. Specifically, standard protocols for the measurement of the electrocatalytic hydrogen evolution reaction of individual 2D nanosheets are introduced with data validation, interpretation and benchmarking. A series of factors (e.g., the exposed area of material, the choice of passivation layer and current leakage) that could have effects on the accuracy and reliability of measurement are discussed. In addition, as an example of the high adaptability of OCEMs, the protocol for in situ electrical transport measurement is detailed. We believe that this protocol will promote the general adoption of the OCEM platform and inspire further development in the near future. This protocol requires essential knowledge in chemical synthesis, device fabrication and electrochemistry.

Electrical detection of the flat-band dispersion in van der Waals field-effect structures

Two-dimensional flat-band systems have recently attracted considerable interest due to the rich physics unveiled by emergent phenomena and correlated electronic states at van Hove singularities. However, the difficulties in electrically detecting the flat-band position in field-effect structures are slowing down the investigation of their properties. In this work, we use indium selenide (InSe) as a flat-band system due to a van Hove singularity at the valence-band edge in a few-layer form of the material without the requirement of a twist angle. We investigate tunnelling photocurrents in gated few-layer InSe structures and relate them to ambipolar transport and photoluminescence measurements. We observe an appearance of a sharp change in tunnelling mechanisms due to the presence of the van Hove singularity at the flat band. We further corroborate our findings by studying tunnelling currents as a reliable probe for the flat-band position up to room temperature. Our results create an alternative approach to studying flat-band systems in heterostructures of two-dimensional materials.

Visualization of dynamic metastable states evolution in TiO2 memristor during electroforming by electroluminescence

The electroforming process, transforming a homogeneous insulating oxide into localized conductive filaments, is crucial for memristive devices. However, it is still unclear how the intermediate phases develop microscopically throughout the transient forming process. Here, we investigate the nonequilibrium dynamic phase transition in the conductive region of TiO2 memristors during electroforming. Synchronous electroluminescence emission and transport measurements demonstrate that the application of pulse fields primarily causes a gradual reduction in the conducting area, accompanied by the reversible field-dependent evolution of metastable phases at the cathode region. As a result of positive feedback between the lateral gradient of oxygen vacancies and the electric field, the self-reinforcing process eventually facilitates the final filament generation. This study offers insights into the physical mechanisms governing the metastable phase evolution during electroforming and raises implications for optimizing the forming process of memristive devices.

Coordination of public-private transport and sustainability measurement: A futuristic perspective in transport

Coordination in providing sustainable and effective transport services can be beneficial for both the public and private sectors. Although there is considerable research in each of public and private transport, the literature shows that research on public-private coordination is rare. Furthermore, performance measurement of public-private transport has been another less explored topic in transport systems. Based on these knowledge gaps, we make contributions to the transportation field by performance measurement and coordination of public-private transport within multimodal transport networks. In this paper, we model public-private transport networks by developing a novel network data envelopment analysis (NDEA) with some distinctive features. The model is built based on the directional distance function (DDF) and provides detailed insights into the sustainability and coordination of public-private transport networks operating in a supply chain. It also provides resource allocation among decision making units (DMUs).

In situ Raman characterization of the stability of blueberry anthocyanins in aqueous solutions under perturbations in temperature, UV, pH

Blueberry anthocyanin (BA) is a functional ingredient to enhance the biological activity of food, and the stability of BA is of great interest. BA stability in aqueous solutions stored in polypropylene and glass bottles was analyzed in-situ using confocal Raman spectroscopy, and the acceptable depth of focus was optimized. The Raman characteristics of BA degradation were explained by multivariate analysis. The degradation rate of BA was significantly accelerated by heating above 65 °C for 2 h or ultraviolet irradiation (10 W) for 96 h. The first order kinetic reaction rate was accelerated with the increase of pH value and temperature and the prolongation of ultraviolet irradiation time. The synergistic effect of multiple factors promoted BA degradation. This study provides an in-situ, nondestructive method for the analysis of anthocyanin stability, which has great utility in the food industry to optimize processing, storage, and transportation measures to reduce the degradation of BA.

Electron transport measurements in liquid xenon with Xenoscope, a large-scale DARWIN demonstrator

The DARWIN observatory is a proposed next-generation experiment with 40 tonnes of liquid xenon as an active target in a time projection chamber. To study challenges related to the construction and operation of a multi-tonne scale detector, we have designed and constructed a vertical, full-scale demonstrator for the DARWIN experiment at the University of Zurich. Here, we present the first results from a several-months run with 343,hbox {kg} of xenon and electron drift lifetime and transport measurements with a 53,hbox {cm} tall purity monitor immersed in the cryogenic liquid. After 88,hbox {days} of continuous purification, the electron lifetime reached a value of (664,pm ,23),upmu hbox {s}. We measured the drift velocity of electrons for electric fields in the range (25–75) V/cm, and found values consistent with previous measurements. We also calculated the longitudinal diffusion constant of the electron cloud in the same field range, and compared with previous data, as well as with predictions from an empirical model.

Field Measurements of Longshore Sediment Transport along Denu Beach, Volta Region, Ghana

Field measurements of longshore sediment transport have been performed in the surf zone along Denu Beach, located in the Volta Region of Ghana, West Africa. This study consisted of measuring sediment transport rates by the deployment of modified versions of Kraus streamer traps on a cross-shore distance, which was about half the average surf zone width. In addition to the measured transport rates, data on waves, longshore currents, and other morphological parameters were collected with simple and low-cost instrumentation. In total, about 22 datasets were obtained through several days of data collection spanning a period of 5 months. Mathematical formulae proposed by CERC (1984), Kamphuis (1991), and the new van Rijn (2014) were used to compute theoretical transports for the entire surf zone, which were validated by measured data. Applying the CERC equation with a K-value of 0.39, the theoretical transports were about one order of magnitude higher than the measured rates. The rates computed by the Kamphuis formula were slightly higher than those yielded by the van Rijn equation. They produced values that were, on average, about 3.5 and 2.9 times higher than the measured rates, respectively. This study then confirmed the capabilities of both the Kamphuis and van Rijn equations to provide closer estimates of longshore sediment transport on Denu Beach. It especially sheds light on the new van Rijn formula, which has not been used extensively in LST quantification across the world. We, therefore, concluded that both the Kamphuis and van Rijn equations could be particularly useful to local engineers in the prediction of LST prior to the design of coastal protection structures. Further long-term studies employing available cutting-edge technologies were also recommended to provide more information on longshore transport not only in Ghana but also in the entire Gulf of Guinea and for the establishment of a reliable sediment budget for the country and the entire region.

Sn/InAs Josephson Junctions on Selective Area Grown Nanowires with in Situ Shadowed Superconductor Evaporation.

Superconductor-semiconductor nanowire hybrid structures are useful in fabricating devices for quantum information processing. While selective area growth (SAG) offers the flexibility to grow semiconductor nanowires in arbitrary geometries, in situ evaporation of superconductors ensures pristine superconductor-semiconductor interfaces, resulting in strong induced superconductivity in the semiconducting nanowire. In this work, we used high-aspect-ratio SiOx dielectric walls to in situ evaporate islands of superconductor tin on in-plane InAs SAG nanowires. Our technique enables customization in the designs of such hybrid nanostructures, while simultaneously performing the nanowire and superconductor growth without breaking vacuum. Using this technique, we grew super(S)-normal(N)-super(S), NS, and SNSNS junctions. We performed cryogenic electron transport measurements revealing the presence of gate and field tunable supercurrents. We further measured the superconducting gap and critical fields in the hybrid nanostructures and the crossover from 2e to 1e periodicity in the SNSNS junctions as a proof of the usability of these hybrid nanostructures.

Identifying Pauli spin blockade using deep learning

Pauli spin blockade (PSB) can be employed as a great resource for spin qubit initialisation and readout even at elevated temperatures but it can be difficult to identify. We present a machine learning algorithm capable of automatically identifying PSB using charge transport measurements. The scarcity of PSB data is circumvented by training the algorithm with simulated data and by using cross-device validation. We demonstrate our approach on a silicon field-effect transistor device and report an accuracy of 96% on different test devices, giving evidence that the approach is robust to device variability. Our algorithm, an essential step for realising fully automatic qubit tuning, is expected to be employable across all types of quantum dot devices.

High field magnetic transport measurements of FeGe thin plates

Magnetic skyrmions have garnered considerable attention due to their topological properties and potential applications in information storage. These unique structures can be found in chiral magnets, including well-known compounds like MnSi and FeGe with a B20-type crystal structure. In this study, we utilized Lorentz transmission electron microscopy to investigate the influence of magnetic skyrmions on the Hall effect in FeGe under low magnetic fields. Additionally, we examined the magnetoresistance (MR) and Hall effect of FeGe under a high magnetic field of 28 T. Our findings reveal distinct mechanisms governing the MR at low and high temperatures. Notably, the anomalous Hall effect plays a significant role in the Hall resistivity observed at low magnetic fields. Meanwhile, the contribution of the skyrmion-induced topological Hall signal in the FeGe is ignorable. Furthermore, by employing a two-carrier model and fitting the carrier concentration of FeGe under high magnetic fields, we demonstrate a transition in the dominant carrier type from electrons to holes as the temperature increases. These results contribute to a deeper understanding of the intrinsic magnetic properties of FeGe.

Statistical modeling of mRNP transport in dendrites: A comparative analysis of β-actin and Arc mRNP dynamics.

Localization of messenger RNA (mRNA) in dendrites is crucial for regulating gene expression during long-term memory formation. mRNA binds to RNA-binding proteins (RBPs) to form messenger ribonucleoprotein (mRNP) complexes that are transported by motor proteins along microtubules to their target synapses. However, the dynamics by which mRNPs find their target locations in the dendrite have not been well understood. Here, we investigated the motion of endogenous β-actin and Arc mRNPs in dissociated mouse hippocampal neurons using the MS2 and PP7 stem-loop systems, respectively. By evaluating the statistical properties of mRNP movement, we found that the aging Lévy walk model effectively describes both β-actin and Arc mRNP transport in proximal dendrites. A critical difference between β-actin and Arc mRNPs was the aging time, the time lag between transport initiation and measurement initiation. The longer mean aging time of β-actin mRNP (~100 s) compared with that of Arc mRNP (~30 s) reflects the longer half-life of constitutively expressed β-actin mRNP. Furthermore, our model also permitted us to estimate the ratio of newly generated and pre-existing β-actin mRNPs in the dendrites. This study offers a robust theoretical framework for mRNP transport, which provides insight into how mRNPs locate their targets in neurons.

Realizing metallicity in Sr2IrO4 thin films by high-pressure oxygen annealing

Perovskite iridates are a promising material platform for hosting unconventional superconductivity. Transport measurements of Sr2IrO4 thin-film field-effect transistors are expected to provide irrefutable evidence for the existence of superconductivity. However, these experiments have revealed a remarkably robust insulating state over wide electron and hole doping ranges; this finding is in contrast to the case of the bulk material, in which metallicity appears upon moderate electron doping by substituting cations in place of Sr. The nature of this robust insulating state and whether any metallic state can be realized in the Sr2IrO4 thin film are two remaining challenges that preclude further progress in the search for superconductivity in this system. Here, we show that this insulating state is enhanced in Sr2IrO4 thin films by thermal annealing under vacuum conditions, while it can be destroyed upon annealing in an oxygen atmosphere within restricted ranges of oxygen pressure, annealing temperature and ion substitution levels. The resulting films exhibit metallic transport behavior near room temperature and a metal–insulator crossover at ~200 K. Our results point to the potentially important roles of the oxygen vacancies at different atomic sites in the formation of the robust insulating state and the new metallic state and to their interplay in the Sr2IrO4 thin film. This finding opens new possibilities in the search for unconventional superconductivity by further tailoring the as-found metallic state in properly oxygen-annealed Sr2IrO4 thin films.

Direct visualization of electronic transport in a quantum anomalous Hall insulator.

A quantum anomalous Hall (QAH) insulator is characterized by quantized Hall and vanishing longitudinal resistances at zero magnetic field that are protected against local perturbations and independent of sample details. This insensitivity makes the microscopic details of the local current distribution inaccessible to global transport measurements. Accordingly, the current distributions that give rise to transport quantization are unknown. Here we use magnetic imaging to directly visualize the transport current in the QAH regime. As we tune through the QAH plateau by electrostatic gating, we clearly identify a regime in which the sample transports current primarily in the bulk rather than along the edges. Furthermore, we image the local response of equilibrium magnetization to electrostatic gating. Combined, these measurements suggest that the current flows through incompressible regions whose spatial structure can change throughout the QAH regime. Identification of the appropriate microscopic picture of electronic transport in QAH insulators and other topologically non-trivial states of matter is a crucial step towards realizing their potential in next-generation quantum devices.

Environmental contaminants modulate transport activity of zebrafish (Danio rerio) multidrug and toxin extrusion protein 3 (Mate3/Slc47a2.1)

Zebrafish Mate3 is one of six co-orthologs of human multidrug and toxin extrusion proteins. It is highly expressed in the kidneys, intestine, testes, and brain of males. Initial interaction studies showed its interaction with xenobiotic compounds, suggesting a role in the efflux of toxic compounds. In this study, we aimed to test various environmental contaminants for their interaction with zebrafish Mate3. We developed a stable zebrafish Mate3 cell line and optimized a high-throughput screening assay using DAPI and ASP+ as fluorescent model substrates. To gain insight into the structure and function of the Mate3 protein and relate these to the results of the DAPI and ASP+ transport measurements, we predicted its 3D structure using the AlphaFold2 algorithm. A 3D structure with high per residue confidence scores with 13 transmembrane segments (TMs) was obtained, with topology and mutual positioning characteristic of the Mate protein family in a shape open to the extracellular part. Molecular docking methods were used to identify DAPI and ASP+ binding sites on the surface and in the center of the protein cavity. Because our kinetics experiments combined with molecular docking indicated that there may be additional active sites in zebrafish Mate3, additional cytotoxicity experiments were performed and highly potent Mate3 interactors were identified from a set of 55 different environmental contaminants. Our results suggest that some of the identified interactors may be of environmental concern, as their interaction with Mate3 could lead to an impairment of its normal efflux function, making fish more sensitive to harmful substances commonly released into the aquatic environment. Finally, the quality of zebrafish Mate3 structures predicted by the AlphaFold2 algorithm opens up the possibility of successfully using this tool for in silico research on transport preferences of other Mate proteins.

Improving Appraisal Methodology for Land Use Transport Measures to Reduce Risk of Social Exclusion

Enabling people to be socially included is a high-priority goal for many governments but monetised benefit measures applicable to initiatives intended to reduce social exclusion risk are lacking in land use transport, and other, policy arenas. In settings where the decision-making process seeks guidance from cost-benefit analysis, this is likely to disadvantage initiatives intended to reduce exclusion. This is a particular problem for public transport services intended to enable people to access more of the opportunities available in their society (‘social transit’). This paper develops a monetised measure of the value of improved mobility as it contributes to reducing risk of social exclusion, showing this to make a material difference to benefit estimates from social transit service improvements. It also develops monetised benefit estimates for some other potential pathways for reducing risk of social exclusion, particularly changes in bridging and bonding social capital, sense of community, subjective wellbeing and neighbourhood disadvantage. The research thus provides an opportunity to significantly strengthen appraisal tools linked to reducing social exclusion, which should encourage more integrated approaches to reducing exclusion and improve implementation prospects for initiatives with that purpose. Reduced social exclusion is a likely outcome.

Sub-micrometer four-point probe transport measurements on graphene

Usually, electronic transport measurements on two-dimensional materials, such as graphene and transition metal dichalcogenides, require deposition of electrodes on top of the material, in, for instance, the form of a Hall bar device. In this work, we show that by making use of a collinear micro-four-point probe, electrical transport measurements on small flakes of graphene can be performed without having to fabricate electrodes on top of the flakes. Using probes with probe pitches down to sub-micrometer scale, we show back-gate tuned transport measurements in graphene on silicon oxide and on hexagonal boron nitride. The charge carrier mobilities and the minimum conductivity of graphene are in good agreement with conventional transport measurements. In addition, we assess the possible damage caused by landing these probes on graphene.

Longitudinal Critical Current Profiles in Coated Conductors Examined by Transport and Magnetization Measurements

Critical current ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_c</i> ) variations along the coated conductor (CC) have a significant impact on the conductor stability and quench behavior. In the direct current (DC) transport case, localized <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_c</i> minimum can lead to the formation of a region with a higher electric field. Joule heating in such a region can disable the operational functionality of the device. Then a sufficiently detailed knowledge of the longitudinal profile of the conductor <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_c</i> is in the first place necessary in assessing the conductor eligibility for a specific application. In the second place, it serves to design appropriate electro-thermal stabilization, securing an effective operation, and reducing the probability of conductor degradation during the quench. We report on the experimental investigation of longitudinal <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_c</i> homogeneity of <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</i> observed by means of transport and magnetization measurements. Basic information is the CC data from the producer on <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_c</i> profiles obtained with ∼1-milimeter spatial resolution by Tapestar <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> XL. We compare it with the result obtained by multi-channel DC transport measurement with 3-millimeter spatial resolution between neighboring contacts on a multiprobe device. Then the whole sample is characterized by a complex AC susceptibility experiment. We analyze possible causes of observed discrepancies between respective methods and discuss the relevance of various techniques for the determination of longitudinal <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I_c</i> profiles in commercial CC.

Gate-Tunable Lifshitz Transition of Fermi Arcs and Its Transport Signatures

One hallmark of Weyl semimetals is the emergence of Fermi arcs (FAs) in surface Brillouin zones, where FAs connect the projected Weyl nodes of opposite chiralities. Unclosed FAs can give rise to various exotic effects that have attracted tremendous research interest. Configurations of FAs are usually thought to be determined fully by the band topology of the bulk states, which seems impossible to manipulate. Here, we show that FAs can be simply modified by a surface gate voltage. Because the penetration length of the surface states depends on the in-plane momentum, a surface gate voltage induces an effective energy dispersion. As a result, a continuous deformation of the surface band can be implemented by tuning the surface gate voltage. In particular, as the saddle point of the surface band meets the Fermi energy, the topological Lifshitz transition takes place for the FAs, during which the Weyl nodes switch their partners connected by the FAs. Accordingly, the magnetic Weyl orbits composed of the FAs on opposite surfaces and chiral Landau bands inside the bulk change their configurations. We show that such an effect can be probed by the transport measurements in a magnetic field, in which the switch-on and switch-off conductances by the surface gate voltage signal the Lifshitz transition. Our work opens a new route for manipulating the FAs by surface gates and exploring novel transport phenomena associated with the topological Lifshitz transition.