Spinal cord injury (SCI) influences approximately 1000 individuals per million in the general population, and almost 12,000 newcases of SCI occur every year in theUnited States, which is a heavy social and economic burden for the society and involved families. A series of therapies exist for functional recovery following SCI, including surgery, prescription drugs, physical therapy, and supportive treatment. Acupuncture, which is based on traditional Chinese medicine theory, has been widely used for pain relief or neurological dysfunction in China. A recent systematic review demonstrated that the acupuncture treatment was beneficial for the functional recovery based on the motor American Spinal Injury Association scores and total Functional Independence Measure scores. Both basic research and clinical study have demonstrated the effect of acupuncture on SCI. The combination of implanted electroacupuncture electric stimulation and bone marrow-derived mesenchymal stromal cells transplantation obviously promotes functional improvements for animals with SCI, indicating that this combination method has the potential to treat SCI in humans. Electroacupuncture treatment may increase the expression of neurotrophin-3, and promote the cell number and differentiation of endogenous oligodendrocyte precursor cells, along with the functional improvement of demyelinated