Transmission Setup Research Articles

Metal-Semiconductor-Metal Photodiode Fabricated With an AlGaN/AlN Superlattice for UV Light Detection

Abstract We designed and fabricated a nonplanar metal-semiconductor-metal (MSM) ultraviolet (UV) photodetector (PD), incorporating a 30-pair Al0.5Ga0.5N/AlN superlattice (SL) absorption layer on a GaN on a sapphire substrate. In contrast to conventional PDs featuring a 100-nm-thick Al0.25Ga0.75N epilayer, our proposed PDs with the higher Al content of Al0.5Ga0.5N/AlN SLs did not exhibit degradation in epiwafer quality. Furthermore, we observed that the use of Al0.5Ga0.5N/AlN SLs resulted in a higher optical gain, specifically achieving voltage-dependent photoresponsivity in the MSM PDs. This improvement was observed with both the ohmic-type Ti/Al/Ni/Au (top) and the Schottky-type Ni/Au (bottom) electrodes, as well as with two Ni/Au Schottky metal electrodes. With the incorporation of Al0.5Ga0.5N/AlN SLs, our proposed MSM PDs with an Ohmic/Schottky-type electrode configuration showcased an enhanced photoresponsivity of 1129.8 A/W at ‒5 V in comparison to MSM PDs employing two Schottky-type electrodes. Moreover, by utilizing the Al0.5Ga0.5N/AlN SL absorption layer, we achieved an increased light current to dark current ratio, reaching 3.66 × 105 biasing at a ‒7 V. Following the implementation of our proposed MSM PDs with an Ohmic/Schottky-type electrode configuration, the gain ratio improvement underscores the efficacy of this approach. Subsequently, the fabricated device's transient response, demonstrating enhanced output performance, was analyzed using an in-house optical transmission setup. The estimated 3-dB cut-off frequency of this proposed MSM PD was found to be approximately 1.2 MHz.

Ventilation does not affect close-range transmission of influenza virus in a ferret playpen setup

Sustained community spread of influenza viruses relies on efficient person-to-person transmission. Current experimental transmission systems do not mimic environmental conditions (e.g., air exchange rates, flow patterns), host behaviors, or exposure durations relevant to real-world settings. Therefore, results from these traditional systems may not be representative of influenza virus transmission in humans. To address this pitfall, we developed a close-range transmission setup that implements a play-based scenario and used it to investigate the impact of ventilation rates on transmission. In this setup, four immunologically naive recipient ferrets were exposed to a donor ferret infected with a genetically barcoded 2009 H1N1 virus (H1N1pdm09) for 4 h. The ferrets interacted in a shared space that included toys, similar to a childcare setting. Transmission efficiency was assessed under low and high ventilation, with air exchange rates of ~1.3 h-1 and 23 h-1, respectively. Transmission efficiencies observed in three independent replicate studies were similar between ventilation conditions. The presence of infectious virus or viral RNA on surfaces and in air throughout the exposure area was also not impacted by the ventilation rate. While high viral genetic diversity in donor ferret nasal washes was maintained during infection, recipient ferret nasal washes displayed low diversity, revealing a narrow transmission bottleneck regardless of ventilation rate. Examining the frequency and duration of ferret physical touches revealed no link between these interactions and a successful transmission event. Our findings indicate that exposures characterized by frequent, close-range interactions and the presence of fomites can overcome the benefits of increased ventilation.

Inhomogeneity mitigation for diffusion weighted MRI at 7T using TR-FOCI pulses.

The purpose of this study is to improve the image quality of diffusion-weighted images obtained with a single RF transmit channel 7 T MRI setup using time-resampled frequency-offset corrected inversion (TR-FOCI) pulses to refocus the spins in a twice-refocused spin-echo readout scheme. We replaced the conventional Shinnar-Le Roux-pulses in the twice refocused diffusion sequence with TR-FOCI pulses. The slice profiles were evaluated in simulation and experimentally in phantoms. The image quality was evaluated in vivo comparing the Shinnar-Le Roux and TR-FOCI implementation using a b value of 0 and of 1000 s/mm2. The b0 and diffusion-weighted images acquired using the modified sequence improved the image quality across the whole brain. A region of interest-based analysis showed an SNR increase of 113% and 66% for the nondiffusion-weighted (b0) and the diffusion-weighted (b = 1000 s/mm2) images in the temporal lobes, respectively. Investigation of all slices showed that the adiabatic pulses mitigated inhomogeneity globally using a conventional single-channel transmission setup. The TR-FOCI pulse can be used in a twice-refocused spin-echo diffusion pulse sequence to mitigate the impact of inhomogeneity on the signal intensity across the brain at 7 T. However, further work is needed to address SAR limitations.

Self-Confined Dewetting Mechanism in Wafer-Scale Patterning of Gold Nanoparticle Arrays with Strong Surface Lattice Resonance for Plasmonic Sensing.

A self-confined solid-state dewetting mechanism is reported that can fundamentally reduce the use of sophisticated nanofabrication techniques, enabling efficient wafer-scale patterning of non-closely packed (ncp) gold nanoparticle arrays. When combined with a soft lithography process, this approach can address the reproducibility challenges associated with colloidal crystal self-assembly, allowing for the batch fabrication of ncp gold arrays with consistent ordering and even optical properties. The resulting dewetted ncp gold nanoparticle arrays exhibit strong surface lattice resonance properties when excited in inhomogeneous environments under normal white-light incidence. With these SLR properties, the sensitive plasmonic sensing of molecular interactions is achieved using a simple transmission setup. This study will advance the development of miniaturized and portable devices.

Airborne transmission efficiency of SARS-CoV-2 in Syrian hamsters is not influenced by environmental conditions

Several human respiratory viruses display a clear seasonal pattern with a higher incidence in the winter season in temperate regions. We previously determined that SARS-CoV-2 is more stable at low-temperature and low-humidity conditions compared to warmer temperature and higher-humidity. To determine if this translates into differential airborne transmission rates in vivo, we performed airborne transmission experiments in the Syrian hamster model under three different environmental conditions (10 °C, 45% relative humidity (RH), 22 °C, 45% RH, and 27 °C, 65% RH). We compared the ancestral SARS-CoV-2 Lineage A with the more transmissible Delta Variant of Concern (VOC). Airborne transmission was evaluated using SARS-CoV-2 infected donor animals at 24 h post inoculation. Sentinels were placed at a 90 cm distance in a transmission set-up and exposed for 1-h to infected donor animals. While environmental conditions moderately impacted lung RNA titers, the shedding kinetics of the donors were not affected by the environmental conditions and did not differ significantly between variants on day 1. Overall, the highest transmission efficiency was observed at 22 °C, 40%RH for Delta (62.5%, based on seroconversion), and ranged between 37.5 and 50% for all other conditions. However, these differences were not significant. To elucidate this further, we performed aerosol stability comparisons and found that infectious virus remained stable during a 1-h time window across all conditions. Our data suggest that even when environmental conditions affect the stability of SARS-CoV-2, this may not directly be translatable to measurable impacts on transmission in an experimental setting when exposure time is restricted.

Low-cost and high-performance channel access strategies for Internet of Nano-Things applications

Nanodevices, which are only a few nanometers (nm) in size, are interconnected to form the Internet of Nano-Things (IoNT) that performs complex operations. One of the key challenges is ensuring efficient channel access control for nanodevices, especially when dealing with large network sizes. Medium access control (MAC) protocols serve this purpose, but traditional approaches are not practical due to the inherent constraints of nanodevices. In this paper, we propose two novel MAC protocols for IoNT applications. The first protocol, Slot Assignment-Based (SAB) MAC, is a contention-free method relying on scheduling. In contrast to its counterparts, it enables simultaneous packet transmission through Time Spread On-Off Keying (TS-OOK), effectively minimizing the collision probability and end-to-end delay. The second protocol, Receiver-Initiated and Directed (RID) MAC, adopts a contention-based approach to reduce unnecessary transmissions caused by flooding. It achieves this by limiting the number of active nanodevices within a time interval using directional antennas without incurring scheduling overhead. We evaluated the performance of these protocols through comprehensive simulations, comparing them with counterparts in terms of packet transmission success, energy consumption, end-to-end delay and setup overhead. In dense topologies, SAB-MAC outperforms Transparent (TRN) MAC by approximately twice the packet transmission success reaching up to 95.73%. It accomplishes this with 1000 times lower end-to-end delay and reduced setup overhead than Time Division Multiple Access (TDMA). Conversely, RID-MAC achieves twice the packet transmission success of TRN-MAC and ten times that of unicast-based methods, all with lower end-to-end delay and nearly equivalent energy consumption. Consequently, due to its superior performance SAB-MAC is the optimal choice for communication between nanorouters (NRs). However, RID-MAC is more suitable for communication between nanosensors (NSs), as it incurs no setup overhead.

Monitoring acoustic vibrations in optical fibers by estimating polarization matrix variation with the integration of coherent optical communication and sensing.

In this paper, we propose a novel architecture called as the Direct-Computation-Sensing Architecture (DCSA) to directly calculates the polarization state changes caused by optical fiber vibrations with training data, offering a more accurate and responsive method than that with adaptive filter-based sensing architectures. We detected the distinct fiber vibration induced by piezoelectric ceramics in an established experimental platform, and recovered a song melody played near the optical fiber buddle from the fiber's polarization changes. We locate the source of the vibration by comparing data from both ends of a bidirectional transmission setup. Lastly, we conducted field tests under conditions involving machine-induced vibrations and natural cable movements.

Custom Hyperspectral Imaging System Reveals Unique Spectral Signatures of Heart, Kidney, and Liver Tissues

The rapid advancement of diagnostic and therapeutic optical techniques for oncology demands a good understanding of the optical properties of biological tissues. This study explores the capabilities of hyperspectral (HS) cameras as a non-invasive and non-contact optical imaging system to distinguish and highlight spectral differences inbiological soft tissuesof three structures (kidney, heart, and liver) for use inendoscopic interventionoropen surgery. The study presents an optical system consisting of two individual setups, the transmission setup, and the reflection setup, both incorporating anHS camerawith apolychromatic light sourcewithin the range of 380 to 1050 nm to measure tissue's light transmission (Tr) and diffuse light reflectance (Rd), respectively. The optical system was calibrated with a customizedliquid optical phantom, then 30 samples from various organs were investigated fortissue characterizationby measuring both Tr and Rd at the visible and near infrared (VIS-NIR) band. We exploited the ANOVA test, subsequently by a Tukey's test on the created three independent clusters (kidney vs. heart: group I / kidney vs. liver: group II / heart vs. liver: group III) to identify the optimum wavelength for each tissue regarding their spectroscopic optical properties in the VIS-NIR spectrum. The optimum spectral span for the determined light Tr of the three groups was 640 ∼ 680 nm, and the ideal range was 720 ∼ 760 nm for the measured light Rd for mutual group I and group II. However, the group III range was different at a range of 520 ∼ 560 nm. Therefore, the investigation provides vital information concerning theoptimum spectral scalefor the computed light Tr and Rd of the investigatedbiological tissues(kidney, liver, and heart) to be employed in diagnostic andtherapeutic medical applications.

Towards simultaneous determination of tablet porosity and height by terahertz time-domain reflection spectroscopy

The quality control of pharmaceutical tablets is still based on testing small sample numbers using at- and off-line testing methods. Traditional in-process controls, such as tablet mass, height, mechanical strength, and disintegration time are time- and resource-consuming and poorly suited to support an effective transition towards continuous manufacturing. Another suitable parameter to monitor during production would be tablet porosity. Porosity can be linked to mechanical strength and disintegration but typically requires knowledge of tablet dimensions and mass. Tablet porosity measurements based on terahertz time-domain spectroscopy (THz-TDS) offer a fast and non-destructive approach to in-process control testing for physical tablet properties. This study presents THz-TDS reflection measurements as an alternative to the previously reported transmission setup. It is shown that the proposed method can determine porosity based on the reflected amplitude from the tablet surface, but also allows for precise determination of tablet height in the same measurement. The tablet mass can be estimated by combining the height and porosity measurements. This opens up for the opportunity to determine the tablet's mechanical strength by using the possible correlation to the determined porosity.

Optimized planar printed UCA configurations for OAM waves and the associated OAM mode content at the receiver

SummaryUtilization of planar printed uniform circular antenna arrays (UCA) to generate the orbital angular momentum (OAM) carrying waves in the millimeter‐wave (mmWave) frequency band is advantageous from the viewpoints of easy signal modulation and mode reconfiguration, low cost, low profile, and straightforward integration with the existing broadband wireless infrastructure. The OAM mmWave UCA are highly promising as the enablers of very high transmission data rates required by hybrid 5G/6G optical and wireless communication systems by complementing and enhancing other technologies currently in use. Therefore, we here contribute a detailed electromagnetic analysis of important constraints of such antenna arrangements aimed at short‐range multimode OAM wave transmission. We investigate (i) the required antenna array dimensions and optimized UCA arrangements for a particular link range and (ii) the corresponding mode structure of OAM waves in the plane of receiving arrays. Four relatively simple antenna configurations operating in the 60‐GHz band are compared. Theoretical assumptions based on ideal OAM modes are critically assessed and, using state‐of‐the‐art numerical electromagnetic analysis, compared to realistically generated OAM waves. The proposed “cyclic transmission setup” resulted in much lower unwanted field components in the region of receiving arrays. RMS magnitudes of unwanted modes are on average about 64% of the received mode, in comparison with 80% (up to 94%) for sequential transmission. The observed mode impurities and mode mixing effects at the receiver indicate the need to dedicate more attention to the system‐level design, the development of efficient receiving arrays, the MIMO processing, and the stream separation.

APPLICATION OF CROSS-SHORE MORPHOLOGICAL MODELS FOR PERCHED BEACHES

Perched beaches are beaches that are supported at the offshore side by a submerged structure. The advantages of such design schemes are that less dredged material is required, and more protected waters are created in front of the beach. Apart from the hydraulic stability of the submerged structure itself, the stability of the beach needs to be studied in order to make sure it fulfils the requirements during its design lifetime. Aspects that play a role here are the expected sand losses over the submerged structure, the (dynamic) equilibrium profile of the beach and the performance during storm conditions. In order to study the morphological responses of such beaches, morphological models should be applied that can take into account the influence of the submerged structure. This paper discusses two cross-shore models that have been used to study a large perched beach project that is under construction in unusually deep waters, severe wave climate (mostly unidirectional) and small tidal range. The models applied are SBEACH (Larson et al., 1989) and CROSMOR (Van Rijn et al., 2003). First the models are validated and calibrated hydrodynamically by comparing the wave transmission and wave setup with measurements from 2D flume tests. Next, the models have been used to predict the future cross-shore development of the beach.

Temperature-Induced Contrast Enhancement for Radar-Based Breast Tumor Detection at K-Band Using Tissue Mimicking Phantoms

Conventional approaches for microwave breast tumor detection are limited by the imaging resolution due to the low operating frequency. The objective of this work is to provide a proof of concept for radar-based detection of breast tumors in K-band using the temperature-dependent permittivity of the tissue for contrast enhancement. The innovation of this work is given by i) investigating higher microwave frequencies for breast cancer diagnostics and improved resolution; ii) exploiting variations in tissue temperature as a non-invasive approach for contrast-induced radar imaging eliminating the need for contrast agents such as nanoparticles; iii) using a well-defined setup with the breast compressed similar to mammography; iv) eliminating the need for coupling liquid through the usage of ultra-wideband bow-tie antennas operating from 16.55 to 40 GHz for a reflection coefficient lower than −10 dB; v) validating the experimental findings through numerical modelling. The experimental setup in this work consists of a single-pixel transmission setup with the antennas placed in a 3D printed container. Two different tissue mimicking phantoms have been studied that both model the temperature-dependent permittivity of biological tissue. The first phantom represents homogeneous fatty tissue properties and the second phantom simulates fatty tissue with a tumor inclusion. A uniform phantom warming is realized through a water bath combined with a continuous monitoring of the phantoms temperature. We show that a homogeneous phantom without tumor can be distinguished from a heterogeneous phantom with tumor in the temperature range of 28 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$^\circ$</tex-math></inline-formula> C to 38 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$^\circ$</tex-math></inline-formula> C.

FeCoNiMnCr high-entropy alloys (HEAs): Synthesis, structural, magnetic and nuclear radiation absorption properties

We report the synthesis and structural, magnetic and Radiation shielding properties of High Entropy Alloy (HEA) produced through mechanical alloying method. Using an X-Ray Diffractometer (PanalyticalEmpryan) with CuK radiation at 45 kV and 40 mA, the phase identification starting elements and as-milled powders are identified. Scanning electron microscopy (SEM) equipped with energy dispersive X-ray spectroscopy (EDX), morphological and microstructural investigations were conducted (FEI Quanta FEG 450). EDX and elemental mapping analyses are conducted to assess the purity and elemental distributions of the synthesized alloys. Using the Quantum Design Physical Characteristics Measurement System (PPMS) with vibrating sample magnetometer (VSM) and a magnetic field of 30 kOe at room temperature, magnetic properties are examined. Using 137Cs radioisotope and mathematical methods, gamma-ray and neutron shielding properties of HEA are investigated in a conventional transmission setup using experimental and theoretical approaches. In the presence of a 3 T applied field, the sample exhibits a low magnetization of 5.30 emu/g at 300 K. Moreover, Ms is raised to 22 emu/g at 10 K owing to decreased thermal effects. The temperature dependence of the magnetization is recorded in the presence of a 1 T applied field. HEA exhibits superior neutron attenuation properties than conventional absorption materials such as B4C, graphite, and water. Our results showed that the synthesized HEA has superiority over other alloys and conventional neutron absorption materials. It can be concluded that the proposed novel HEA might be investigated further in terms of broadening its characterization and clarifying its other crucial properties to extend the scope of the current investigation.

Uncovering solvent-engineering mechanisms in Y6:PM6 solar cells

Additives, like 1-chloronaphtalene (CN), are commonly used in Y6:PM6 solar cells as they lead to an increased power conversion efficiency. In this work, we investigate the influence of CN during spin coating of Y6:PM6 dissolved in chloroform via an in situ transmission setup. We show that, in the presence of CN, the film formation of Y6:PM6 can be divided into two parts: one related to the evaporation of chloroform and one related to the evaporation of CN. This is mostly related to Y6 being dissolved in CN. We find that even for low CN concentration, the film formation is not completed for several minutes after the spin coating process. Furthermore, the removal of CN is needed to achieve a smooth film surface. We demonstrate that this fast removal can be achieved by spin coating the electron transport layer PDINN from methanol. The methanol is acting as an anti-solvent for the CN, leading to its removal from the film. Using this approach, solar cells fabricated with a high CN concentration of 5% feature a comparable performance to ones with more common concentrations between 0.5% and 1%.

A Free-Space Transmission Setup for Material Parameters Estimation with Affordable and Non-Synchronized Software-Defined Radios in the 0.85–1.55 GHz Band

This paper describes a prototype of a free-space transmission setup for dielectric parameters estimation. The transmitter and receiver, both configurable by software and working in the range 0.85–1.55 GHz, are not synchronized, as they use different clocks. An estimation of the dielectric permittivity of a planar sample was obtained by comparing our measurements with a numerical model. A parametric study with different variables was conceived in order to find the best fit between measurements and simulations. Customized techniques were applied to deal with noise and inconsistencies found in the measurements. The genetic algorithm was used to adjust the constants that minimized the error between simulated and experimental data. Results for a reference sample of polymethylmethacrylate are presented and discussed. Although the accuracy of the proposed approach in recovering the dielectric parameters of the sample was relatively low, the simplicity and cost-effectiveness of this setup make it interesting for scenarios where a rough characterization of the material is sufficient.

Demonstration of Uncoupled 4-Core Multicore Fiber in Submarine Cable Prototype With Integrated Multicore EDFA

We developed a 15.2-km submarine cable prototype which can accommodate up to 16 fiber pairs (FPs) of 125 μm standard cladding diameter 4-core uncoupled multicore fiber (UC-MCF). Fiber properties such as loss, chromatic dispersion, and inter-core crosstalk were measured and compared before and after cabling. We found that the cabling process, such as fiber rewinding, copper tubing and polyethylene coating completion, did not significantly change the fiber properties such as loss. To verify the influence of cabling process on long-haul transmission performance, we fabricated a 60.8-km length 4-core UC-MCF transmission span by serially splicing four FPs from the 15.2-km length cabled 4-core UC-MCF. An experimental loop transmission setup was established using the cabled transmission span, and Q-value was measured in real-time. The 120 wavelength multiplexed channels were transmitted. The five channels were modulated by 100 Gbps 34.7 GBd polarization multiplexed quadrature phase shift keying (PM-QPSK) signal and the other channels were loading channels shaped from amplified spontaneous emission (ASE). We changed the transmission direction one core at a time in the 4-core UC-MCF based transmission line to examine the effect of inter-core crosstalk on the transmission line. The −25-dB inter-core crosstalk caused negligible signal degradation in the 4-core UC-MCF and fan-in fan-out (FIFO) a total of 88 spans. Furthermore, we found that the 5,350-km transmission using cabled 4-core UC-MCF was limited by optical signal to noise ratio (OSNR). We integrated the transmission 4-core UC-MCF with the 4-core UC-MC-erbium doped fiber amplifier (EDFA) without using FIFO and clarified experimentally a Q-value improvement of 0.6 dB by removing half number of the FIFOs.

Introducing 4D Geometric Shell Shaping for Mitigating Nonlinear Interference Noise

Four dimensional geometric shell shaping (4D-GSS) is introduced as an approach for closing the nonlinearity-caused shaping gap. This format is designed at the spectral efficiency of 8 b/4D-sym and is compared against polarization-multiplexed 16QAM (PM-16QAM) and probabilistically shaped PM-16QAM (PS-PM-16QAM) in a 400ZR-compatible transmission setup with high amount of nonlinearities. Reach increase and nonlinearity tolerance are evaluated in terms of achievable information rates and post-FEC bit-error rate. Numerical simulations for a single-span, single-channel show that 4D-GSS achieves increased nonlinear tolerance and reach increase against PM-16QAM and PS-PM-16QAM when optimized for bit-metric decoding ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{R}_\text{BMD}$</tex-math></inline-formula> ). In terms of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{R}_\text{BMD}$</tex-math></inline-formula> , gains are small with a reach increase of 1.7% compared to PM-16QAM. When optimizing for mutual information, a larger reach increase of 3% is achieved compared to PM-16QAM. Moreover, the introduced GSS scheme provides a scalable framework for designing well-structured 4D modulation formats with low complexity.

Digital Residual Spectrum-Based Generalized Soft Failure Detection and Identification in Optical Networks

Machine learning is regarded as an attractive solution for soft failure management in optical networks; however, the performance of trained models working on unseen data is of growing concern, due to scarce historical data and high training costs. Hence, the issues of reducing training data and improving generalization have received considerable attention. In this paper, a soft failure detection (SFD) and identification scheme is proposed based on digital residual spectrum that leverages auto-encoder (AE) and support vector machine. The digital residual spectrum acquired by the coherent receiver is computed by subtracting the averaged spectrum of multiple normal digital spectra from the digital spectrum. The scheme features: (i) high generalization, i.e., a model trained for a specific transmission setup performs well in other setups with different fiber lengths; (ii) low cost, i.e., the digital residual spectrum is easily obtained from a coherent receiver without additional hardware; and (iii) easy training, i.e., only normal samples are needed to train the SFD model (less pressure on the collection of rare soft-failure data). Using the model trained for any specific setup, we demonstrated an area under the curve and identification accuracy above 99.24% and 96.45%, respectively, for five experimental setups.

Mobile multi-configuration clinical translational Raman system for oral cancer application.

Early diagnosis of oral cancer is critical to improve the survival rate of patients. Raman spectroscopy, a non-invasive spectroscopic technique, has shown potential in identifying early-stage oral cancer biomarkers in the oral cavity environment. However, inherently weak signals necessitate highly sensitive detectors, which restricts widespread usage due to high setup costs. In this research, the fabrication and assembly of a customised Raman system that can adapt three different configurations for the in vivo and ex vivo analysis is reported. This novel design will help in reducing the cost required to have multiple Raman instruments specific for a given application. First, we demonstrated the capability of a customized microscope for acquiring Raman signals from a single cell with high signal-to-noise ratio. Generally, when working with liquid samples with low concentration of analytes (such as saliva) under a microscope, excitation light interacts with a small sample volume, which may not be representative of whole sample. To address this issue, we have designed a novel long-path transmission set-up, which was found to be sensitive towards low concentration of analytes in aqueous solution. We further demonstrated that the same Raman system can be incorporated with the multimodal fibre optical probe to collect in vivo data from oral tissues. In summary, this flexible, portable, multi-configuration Raman system has the potential to provide a cost-effective solution for complete screening of precancer oral lesions.

Fractional dual-phase-lag heat conduction with periodic heating and photo-thermal response

We apply an extension of dual-phase-lag in thermal systems to predict the photoacoustic signal for transmission configuration and characteristics of the open photoacoustic cell technique. For this, we consider a particular case from Jeffrey?s equation as an extension of the generalized Cattaneo equations. In this context, we obtain the temperature distribution under the effects of fractional differential operators, allowing the calculation of the Photoacoustic signal for the transmission set-up. The results show a rich class of behaviors related to the anomalous diffusion connected to these fractional operators.