Background: Comprehensive Stroke Center (CSC) identified tPA transfers were missing documentation of treatments and vital signs from transferring facilities (TFs) and during transfer by Emergency Medical Services (EMS). A patient who became hypertensive and had hemorrhagic transformation (HT) arrived without documentation. Purpose: Implement transfer guidelines to ensure documentation is received and blood pressures (BP) are monitored and treated during transfer to avoid HT. Method: Guidelines developed included required documentation from TFs to be sent with patients; parameters for BP monitoring and treatment during EMS transfer; and receiving nurse checklist to verify receipt of documented care prior to arrival. Guidelines were communicated to TFs, EMS, and CSC nurses. Results: Review of 293 tPA records, excluding endovascular interventions, were compared pre-guidelines 2016 (Pre-G) and post-guidelines January 2017-June 2018 (Post-G). Transfer volumes Pre-G were 37 of 129 and Post-G 54 of 164. Rate of hemorrhage on brain imaging within 36 hours after tPA was higher on transfers for both review periods 19%(7/37) and 15%(8/54) compared to non-transfers 8%(7/92) and 8%(9/110). Of the Pre-G HTs that were symptomatic, transfers had a higher rate 71%(5/7) than non-transfers 29%(2/7) and decreased to a rate of 50%(4/8) Post-G. Blood pressures were controlled on 60% of 2016 cases versus 75% in 2017. There were zero transfer symptomatic HTs in 2018. Pre-G and Post-G transfers with symptomatic HT had dispositions of Hospice 60%(3/5) and 25%(1/4), Rehab 40%(2/5) and 25%(1/4), Home 0%(0/5) and 50%(2/4), respectively. Pre-G and Post-G modified Rankin Score (mRS) at discharge for symptomatic HT transfers were mRS 4-5 = 100%(5/5) and 50%(2/4) and mRS 2-3 = 0%(0/5) and 50%(2/4), respectively. mRS at 90 days hospice or expired was Pre-G 60%(3/5) and Post-G 25%(1/4). Conclusion: Prior to implementing transfer guidelines for tPA patients, this population had higher rates of HT, symptomatic HT, and mRS at discharge. Transfer guidelines improved acquisition of documentation for continuum of care and BP management with decreased rates of symptomatic HT and improved outcomes.
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