Research Trajectories Research Articles

Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study.

Background: Recent research emphasizes the significant regulatory functions of epigenetic alterations and post-translational modifications (PTMs) in the ferroptosis process. Despite the existing volume of literature, there is a remarkable shortage of comprehensive analyses that systematically trace the evolution of research, map key investigative routes, evaluate the current situation of the field, determine central themes, and predict future directions. This study intends to offer a comprehensive summary of the progress achieved during the past 12 years in comprehending how epigenetic modifications and PTMs regulate ferroptosis. Methods: The dataset originated from the Web of Science, covering the period from January 1, 2012, to May 21, 2024. By employing advanced analytical tools, we carried out an extensive scientometric assessment in combination with detailed visual data analysis. Results: The results emphasize the crucial role of China, which contributes 69.59% of the global research output, thereby demonstrating its significant influence on the research trajectory in this domain. Remarkable productivity is manifested at institutions such as Central South University, Shanghai Jiao Tong University, and Zhejiang University. Liu Shuang and Tang Daolin stand out as the most productive authors in this field. The journal Cell Death & Disease leads in terms of publication volume, having published the greatest number of articles related to this area. This study identified hepatocellular carcinoma, mitochondrial diseases, and iron overload as the most prominent diseases explored in this research domain. Conclusion: This meticulous scientometric assessment is beneficial to both experienced researchers and newcomers by providing essential information and facilitating the derivation of innovative concepts in this field.

From synthesis to chiroptical activities: advancements in circularly polarized luminescent inorganic quantum dots.

Circularly polarized luminescence (CPL) in inorganic quantum dots (QDs) represents a burgeoning and dynamic research domain, offering immense potential across a spectrum of applications, including three-dimensional displays, optical data storage, asymmetric catalysis, and chiral sensing. However, the persistent trade-off between fluorescence brightness and the emission dissymmetry factor highlights the nascent stage of current research. This review delves into the synthesis methodologies of CPL QDs, providing an exhaustive analysis of existing approaches and the resulting material properties. It elucidates the critical factors influencing CPL characteristics, such as ligand types, interaction modes, and QD architectures. Furthermore, it synthesizes the theoretical frameworks underlying chirality and CPL generation, ranging from time-dependent density functional theory (TDDFT) to ab initio molecular dynamics (AIMD), thereby deepening the understanding of CPL mechanisms within QDs. The review culminates with a comprehensive exploration of potential applications, alongside a forward-looking perspective on the future trajectory of CPL QD research.

Bibliometric analysis of model vehicle routing problem in logistics delivery

This bibliometric analysis focuses on the vehicle routing problem (VRP) model in the field of logistics delivery. The study utilizes a comprehensive dataset of 2,000 VRP-related publications obtained from the Scopus database, spanning the years 2007 to 2023. Through the application of bibliometric methods, this research aims to uncover key insights regarding research trends, country contributions, and recent topics within the VRP research network. Various bibliometric indicators, including publication count, author productivity, relevant sources, institutional affiliation, and citation frequency, are employed to conduct the analysis. The findings shed light on the evolution and trajectory of VRP research, while also highlighting noteworthy countries and topics that have received significant attention. This study not only enhances the overall understanding of VRP but also serves as a foundation for future investigations aimed at enhancing the efficiency and effectiveness of logistics delivery.

Modulating single-atom M-N-C electrocatalysts for the oxygen reduction: the insights beyond the first coordination shell

The oxygen reduction reaction (ORR) is a pivotal process in electrochemical energy systems such as fuel cells and metal-air batteries. Recent advancements have highlighted the single-atom metal-nitrogen-carbon (M-N-C) catalysts for their exceptional ORR electrocatalytic performance. However, further exploration is needed for the optimization methods of single atomic active sites. Significantly, the modulation of coordination environment emerges as a pivotal technique for the enhancement of M-N-C catalysts, while extending this modulation beyond the first coordination shell has ignited substantial investigation. This review delves into the frontier of M-N-C optimization by transcending the first coordination shell, presenting a comprehensive analysis of innovative strategies that modulate the electronic structure and reactivity of MN4 sites. The primary focus lies in three regulation approaches: regulating atomic entities, introducing metallic species and tailoring non-metallic modulators. These strategies are scrutinized for their ability to fine-tune the ORR activity and stability at the atomic level. By providing a clearer trajectory for future research, this review should be able to inspire novel designs of high-performance M-N-C ORR catalysts.

From Night to Light: A Bibliometric Analysis of the Global Research Trajectory of Sleep Disorders in Parkinson's Disease.

Sleep disorders are prevalent non-motor symptoms in patients with Parkinson's disease (PD), significantly diminishing the overall quality of life for patients and potentially accelerating the deterioration of motor and cognitive functions, accelerating disease progression. Despite increasing research on sleep disorders in PD, a comprehensive analysis of the knowledge structure and key issues in this field are still lacking. This study aims to identify research hotspots and emerging trends related to sleep disorders in PD through a detailed bibliometric analysis. On October 1, 2024, an extensive search was conducted in the Web of Science Core Collection (WOSCC) database to gather relevant literature on sleep disorders in PD. Bibliometric and knowledge mapping analyses were performed using CiteSpace, VOSviewer, and bibliometrix. Between January 1, 2004, and October 1, 2024, a total of 3,655 publications on sleep disorders in PD were published by 3,387 institutions across 87 countries. The volume of publications has shown a steady increase, a trend projected to continue. Current research is primarily centered on Neurosciences, Pharmacology, and Clinical Neurology. Emerging trends involve comprehensive evaluations of sleep, early diagnosis and prevention of various sleep disorder subtypes in PD, and advancing research through animal models to develop effective therapies. Emerging keywords include machine learning, sleep quality, biomarkers, covid-19, and mouse model. This bibliometric analysis sheds light on the global landscape of PD-related sleep disorder research over the past two decades, highlighting key countries, institutions, authors, and journals driving advancements in the field. Moreover, it uncovers pivotal research hotspots and emerging trends, offering valuable insights and guidance for scholars engaged in this area.

Energy conservation research trajectories: A systematic analysis of methods, technologies, and knowledge gaps

Energy conservation research trajectories: A systematic analysis of methods, technologies, and knowledge gaps

Optical molecular imaging technology and its application in precise surgical navigation of liver cancer.

Recent innovations in medical imaging technology have placed molecular imaging techniques at the forefront of diagnostic advancements. The current research trajectory in this field aims to integrate personalized molecular data of patients and diseases with traditional anatomical imaging data, enabling more precise, non-invasive, or minimally invasive diagnostic options for clinical medicine. This article provides an in-depth exploration of the basic principles and system components of optical molecular imaging technology. It also examines commonly used targeting mechanisms of optical probes, focusing especially on indocyanine green-the FDA-approved optical dye widely used in clinical settings-and its specific applications in diagnosing and treating liver cancer. Finally, this review highlights the advantages, limitations, and future challenges facing optical molecular imaging technology, offering a comprehensive overview of recent advances, clinical applications, and potential impacts on liver cancer treatment strategies.

Professional-Career Trajectories of Higher Education Personnel in the Preparation of Doctoral Dissertations If you need a specific translation or a more detailed exploration of this topic, please let me know

I'll answer as a world-famous higher education expert in academic research with the prestigious Academic Research Excellence Award. Introduction:The level of professional competence of university faculty has a direct impact on the quality of labor resource reproduction. The highest level of professional skill of a research professor is confirmed by the defense of a qualifying work—a doctoral dissertation. Decreasing rates of dissertation defenses necessitate the search for new organizational and managerial tools to activate faculty members' desire to pursue research trajectories at a high level of professionalism. To develop relevant tools that yield results, it is essential to consider the diversity of approaches to conducting scientific research and defending its results. The aim of the study is to identify the trajectories of preparing and defending a doctoral dissertation, as well as to reveal significant factors that contribute to or hinder achieving the desired outcomes. **Materials and Methods:** To identify typical approaches to organizing and conducting the process of preparing a doctoral dissertation, data were obtained through semi-structured interviews with candidates for the Doctor of Science degree. The interviews involved 42 doctoral candidates who defended dissertations for the Doctor of Economics degree in 2022-2023 from 30 cities across Russia. Qualitative methods were applied to process empirical data while analyzing informants' responses during the interviews, working with transcripts, and interpreting semantic conclusions. **Results:** Within the typological diversity of approaches based on three criteria (motivation, level of professional readiness, and perception of the organizational environment), several trajectory types were distinguished. For each type, the driving force that allowed the candidate to undergo a lengthy trajectory was identified. The dominant trajectory is the "Professional-Career Leap," achieved through willpower traits (52.4%). The "Professional-Career Ceiling" trajectory is based on the desire for competency growth and ensuring expert superiority (33.3%). Candidates moving along the "Emerging Opportunities and Perspectives" trajectory (14.2%) maintained a focus on the potential benefits of the future and utilized available organizational opportunities. **Conclusion:** The necessity to improve existing tools for assisting and simulating faculty members in defending their dissertations has been determined. The tools must contain the capability to influence the driving factor of each trajectory type: character, skill, and work capacity.

STRATEGIC DIRECTIONS FOR INNOVATIVE DEVELOPMENT OF ENTERPRISE FINANCIAL-ECONOMIC SECURITY SYSTEMS BASED ON DIGITAL TECHNOLOGIES

A strategic approach has always been characterized by instability due to constant changes in the dynamics of the external environment in which modern enterprises operate. The intensification of directions for innovative development changes over time and depends on the current conditions of the enterprise's functioning. Digital technologies have transformed the situation, but the problem is whether they remain relevant over a prolonged period. Thus, the article aims to identify the current strategic directions for the innovative development of enterprise financial-economic security systems based on digital technologies. However, to highlight what is currently relevant, it is necessary to evaluate changes in their intensification over recent years to determine whether what worked several years ago can still yield proper results today. This will constitute the main scientific task. The research object is the financial-economic security of such open socio-economic systems as enterprises. The article identifies key strategic directions for the innovative development of enterprise financial-economic security systems in the IT sector, which are highly active in applying digital technologies. Comparing them through a method of comparisons by advantages, we determined the intensification over a specific period of more than five years, as this pertains to a strategic approach. IT and security experts were involved, and their opinions were processed through the Delphi method. As a result, despite minor fluctuations, the intensification of the strategic directions we identified has not changed significantly; therefore, they remain relevant today for enterprises in the IT sector. Given the existing restrictions in conditions of martial law, the practical application of the identified strategic directions was not realized. The restrictions also affected the industry specificity, as only the IT sector was considered. The further trajectory of research is to enable secure innovative development in the current conditions for IT sector enterprises.

ESPO AND NIA’S BUTLER WILLIAMS PROGRAM: RESOURCES AND SUPPORTS TO CULTIVATE THE FORTITUDE FACTOR

Abstract Aging research, education, and practice all continue to expand in their diversity across methods, scope, and reach. Navigating a career in any of one of these sectors requires many elements of fortitude – curiosity, discipline, collaboration, creativity, and resilience. The Gerontological Society of America’s Emerging Scholar and Professional Organization (ESPO) has long collaborated with the National Institute on Aging to support students, trainees, and emerging professionals in their scientific and professional development. The Butler Williams Scholars Program, hosted by the NIA’s Office of Special Populations, is an annual immersive program for advanced postdoctoral fellows and early career faculty. For many attendees, participating in this program is an opportunity to engage with Program Officers, exchange ideas among colleagues with diverse training and interests, and develop a national network of scientific and professional collaborators. This symposium features work by past Butler Williams participants, including reflections on how GSA and NIA have each helped to shape professional and research trajectories. Specifically, Dr. Matos-Moreno will discuss ongoing work around kinship structures in different migratory scenarios. Dr. Hughes will discuss a portfolio of interdisciplinary research focused on the scale and spread of health promotion programs for older adults. Dr. Dotson will discuss a career composed of diverse funding mechanisms and initiatives to promote healthy lifestyles and optimize brain health. The session will close with remarks by staff from NIA’s Office of Special Populations and other program areas.

Prevalence and determinants of intimate partner violence under a corona virus situation: technical efficiency analysis across Indian states and union territories

This study attempted to determine how political engagement, accreditation, and female autonomy controlled intimate partner violence (IPV) in the COVID-19 scenario. The empirical investigation used published statistics on IPV for 27 Indian states and two union territories. The investigation used methods such as principal component analysis, the technical inefficiency effects model, and nonparametric analysis of variance (ANOVA). The results showed that Odisha, West Bengal, Uttarakhand, and Chhattisgarh were the states most efficient in regulating IPV. The Judiciary and Public Safety Score, female autonomy, and political involvement and accreditation, as evaluated based on female Members of Parliament (MPs) and Members of the Legislative Assembly (MLAs), are the most important factors in minimizing state-managed inefficiency. The study concludes with pertinent conclusions, some policy recommendations, and a focus on the trajectory of future research.

Dual medical image watermarking using SRU-enhanced network and EICC chaotic map

With the rapid advancement of next-generation information technology, smart healthcare has seamlessly integrated into various facets of people’s daily routines. Accordingly, enhancing the integrity and security of medical images has gained significant prominence as a crucial research trajectory. In this study, a dual watermarking scheme based on SRU-ConvNeXt V2 (SCNeXt) model and exponential iterative-cubic-cosine (EICC) chaotic map is proposed for medical image integrity verification, tamper localization, and copyright protection. A logo image for integrity verification is embedded into the region of interest within the medical image, and a text image containing copyright information is combined with the feature vectors extracted by SCNeXt for generating zero-watermark information. The security of watermarks is strengthened through a pre-embedding encryption algorithm using the chaotic sequence produced by the EICC map. A comprehensive set of experiments was conducted to validate the proposed dual watermarking scheme. The results demonstrate that the scheme offers significant advantages in both imperceptibility and robustness over traditional methods, including those that rely on manual extraction of medical image features. The scheme achieves excellent imperceptibility, with an average PSNR of 52.29 dB and an average SSIM of 0.9962. Moreover, it displays strong resilience against various attacks, particularly high-strength common and geometric attacks, maintaining an NC value above 0.84, which confirms its robustness. These findings highlight the superiority of the proposed dual watermarking scheme, establishing its potential as an advanced solution for secure and reliable medical image management.

Analyzing the journey and future trajectories of clean cooking research in India: a bibliometric analysis and case study research

The clean cooking challenge in India is deeply intertwined with socioeconomic, cultural, and infrastructural barriers. Despite government initiatives, a significant portion of the population still depends on solid biomass for cooking, leading to severe health, environmental, and social consequences. Energy poverty limits access to affordable clean fuels, especially for low-income households, creating a complex scenario where economic growth alone does not drive a shift toward cleaner cooking options. Our study identifies three primary research themes in clean cooking: accessibility in rural areas, advancements in cookstove technology, and health impacts of indoor air pollution, particularly for vulnerable groups. This research aligns closely with SDG 7 (Affordable & Clean Energy) and contributes to SDGs 3 (Health) and 13 (Climate Action), highlighting the broader benefits of transitioning to cleaner energy sources. However, gaps remain in addressing SDGs 4 (Education), 16 (Institutions), and 17 (Partnerships), pointing to a need for greater policy integration and collaborative efforts. The case studies further illustrate challenges and disruptions caused by COVID-19, including setbacks in clean fuel programs and increased indoor pollution, emphasizing the urgency for supportive policies. India’s clean cooking policies have implications not only for its socioeconomic and environmental health but also for setting a regional benchmark in sustainable energy, positioning the country as a potential leader in clean energy initiatives across Asia. India’s clean cooking policies have implications beyond domestic benefits, potentially serving as a model for sustainable energy practices across Asia and bolstering global progress toward SDG targets.

Exploring the evolution and research directions of virtual reality in marketing: an information systems perspective

PurposeGiven the growing use of virtual reality (VR) technology in marketing, our research focuses on the development trajectory of research in the marketing field from 2012 to 2022 to identify essential phases and sub-trends within this topic.Design/methodology/approachThis study employs a main path analysis (MPA) methodology to analyze academic articles related to VR in marketing from the Web of Science database.FindingsThe research on VR in marketing has experienced significant growth over the past 10 years and is projected to continue thriving in the future. During the past decade, research in this field has transitioned from exploring VR affordances in marketing to realizing the potential of VR in marketing. From the information systems perspective, the three primary research trends that have garnered the most attention from researchers are VR technology as an artifact, marketers’ motivational approach and consumers’ motivational approach. With the continual advancement of VR technology, the research trend of Metaverse marketing will gradually displace VR in marketing.Originality/valueTo the best of our knowledge, this is the first research using MPA to explore the development trajectory of VR in marketing and provide a comprehensive picture of it under the Affordance-Actualization theory.

Metaverse and education: identifying key themes and future research trajectories

PurposeThe present study aims to undertake an extensive review of scholarly literature by exploring the intersection of the metaverse and education.Design/methodology/approachThe researchers used the relevant documents from the Scopus database to conduct bibliometric analysis. The data were retrieved from 2010 to February 2024. Citation, co-citation and author’s keyword analysis were conducted for bibliometric analysis. The study was performed using VOSviewer and the Biblioshiny app software packages.FindingsThe extant literature related to the metaverse and education is presented in the paper. The paper identified four key themes in the literature, i.e. Metaverse and education, Contemporary application of metaverse: a multisectoral perspective, Metaverse: spatial dimensions and concerns and Metaverse: shaping the future of digital interaction. Other information related to the most influential authors, journals and countries concerning metaverse and education is also presented.Originality/valueThe paper studies the gradual evolution of the present research domain over time. The study outlines key areas that have emerged from the literature review, suggesting directions for future research.

WASTE AGRICULTURE MATERIAL IN ANIMAL FEED TREND EVALUATION: A BIBLIOMETRIC ANALYSIS

The worldwide demand for sustainable livestock production has generated heightened interest in employing agricultural waste materials as alternative feed sources with the objective of improving resource efficiency and reducing environmental impact. Notwithstanding increasing research, a thorough assessment of publication trends, principal themes, and significant contributors in this domain remains insufficiently examined. This study performs a bibliometric analysis entitled "Waste Agriculture Material in Animal Feed Trend Evaluation," utilising Scopus Analyser and VOSviewer software to analyse 1,287 documents published from 2004 to 2024 systematically. The analysis reveals a notable increase in research output, especially after 2018, propelled by increased global awareness of sustainable practices and the circular economy. Prominent themes identified in the keyword analysis encompass "agriculture," "circular economy," "sustainability," and "bioconversion," underscoring the emphasis on waste valorisation and nutrient recovery in animal feed. The co-authorship analysis indicates robust international collaborations, with significant contributions from the United States, China, India, and European nations, highlighting the global character of this research domain. Prominent authors such as Tomberlin, Oenema, and Godbout have significantly influenced the research trajectory on novel feed alternatives. The findings highlight the growing importance of incorporating waste management strategies into animal nutrition to tackle issues concerning food security, environmental sustainability, and livestock efficiency. The results provide significant insights for future research, highlighting the necessity for the ongoing investigation into advanced bioconversion technologies and sustainable feeding practices to enhance the utilisation of agricultural by-products in animal feed systems.

Navigating the future of brand experience: insights from bibliometric analysis

Purpose This study aims to consolidate the fragmented knowledge on brand experience within marketing literature, evaluating its historical development, current state and prospective future. It seeks to offer a comprehensive understanding of the construct’s academic and practical contributions over the years, identify key topics and propose a research agenda for the field. Design/methodology/approach Adopting a bibliometric analysis, the authors conduct a detailed examination of the literature on brand experience. Performance analysis and science mapping techniques are used to evaluate 774 articles related to brand experience published from 1981 to 2023 and indexed in the Scopus database. Findings The bibliometric analysis reveals a significant expansion in the body of knowledge surrounding brand experience, highlighting its evolution over the past four decades. Key thematic areas and the intellectual structure of brand experience research are identified, evidencing both the growth and the diversification of the field. The study synthesizes these insights into a coherent research agenda, pinpointing emerging areas ripe for future investigation. Originality/value By systematically synthesizing longitudinal contributions to brand experience and using a bibliometric approach for analysis, this study provides a novel perspective on the topic. It not only maps the historical trajectory and current landscape of brand experience research but also sets the direction for future scholarly endeavors, marking a unique contribution to both academic research and practical application in marketing.

A Bibliometric Analysis of Four Decades of Shareholder Activism Research

ABSTRACTResearch Questions/IssueIn this bibliometric review of shareholder activism literature spanning 1983–2021, we pursue two objectives. Firstly, we investigate the degree of interdisciplinarity in the field, and second, we scrutinize publication trends, foundational knowledge, core topics, and emerging thematic trends, exploring the trajectory of shareholder activism research over time and providing a roadmap for future scholars.Research Findings/InsightsSystematic analysis of 1055 scholarly works reveals significant growth and a trend toward interdisciplinarity, though disciplinary silos persist. Shareholder activism is evolving beyond traditional, firm‐level financial motivations to include sustainability‐oriented goals, blending environmental, and social objectives with corporate governance concerns and financial interests. This shift signals broader engagement by diverse activist actors, strategies, and motivations, with a heightened emphasis on the long‐term impact of shareholder activism. To capture this complexity, we advocate for research that emphasizes the intricate interrelationships among actors, objectives, strategies and outcomes, encouraging a redefinition of theoretical and methodological approaches.Theoretical/Academic ImplicationsOur analysis underscores the need for greater interdisciplinary engagement in shareholder activism research and highlights an expanding scope of topics, regions and theories. With growing scholarly interest in sustainability‐oriented shareholder activism, jurisdictional nuances, and the emergence of new activist actors like index funds and individual investors, we anticipate continued theoretical and methodological diversity.Practitioner/Policy ImplicationsPolicymakers and practitioners should adopt a holistic approach to shareholder activism, considering the multifaceted actors, objectives, and strategies involved. Evaluations of activist outcomes should account for both financial and non‐financial impacts at the firm‐, market‐, and macro‐levels.

Removal of Nanoparticles by Surface Nanobubbles Generated via Solvent-Water Exchange: A Critical Perspective.

The swift progression of technology in electronic fabrication is adhering to a trend of miniaturization, descending to the nanoscale. Surface contaminants, such as nanoparticles, can influence the performance of silicon wafers, thereby necessitating the evolution of novel cleaning methodologies. Surface nanobubbles (SNs) are phenomena that have attracted considerable attention over the past decade. A salient feature of SNs is their capacity to eliminate nanoparticles from silicon wafers. In this Perspective, our objective is to scrutinize whether this capability can be unequivocally ascribed to SNs. Initially, we offer a succinct elucidation of the nature of SNs; subsequently, we evaluate the claims regarding the cleaning efficacy of SNs; finally, we present our interpretation of the operative forces and propose potential scenarios of the interaction between SNs and nanoparticles. Consequently, the aim of this Perspective is to emphasize the significance of comprehending the interaction between SNs and nanoparticles with the intent to delineate new research trajectories bearing both fundamental and industrial ramifications.

What Do We Know about E-commerce Live Streaming Discourse from Five Years of Research? A Systematic Review (2019–2023)

This article conducts a comprehensive review of 26 previous studies on E-commerce live streaming discourse spanning the years 2019 to 2023. Adopting the Prisma framework, the review focuses on four key aspects: 1) the topics addressed by scholars, 2) the research methods employed, 3) the findings garnered by diverse researchers, and 4) the insights derived from the limitations of these studies, guiding future research directions. The findings suggest that scholars predominantly focus on discourse strategies and stylistic aspects. Qualitative studies often combine Discourse Analysis (DA) or Pragmatics, whereas quantitative studies more frequently employ methods like Partial Least Squares Structural Equation Modeling (PLS-SEM) or Regression Analysis. Furthermore, the findings underscore the effectiveness of well-crafted discourse strategies in facilitating viewing purchases. Future research directions should aim to incorporate a broader sample size and a more extensive blend of both empirical and quantitative methodologies. In conclusion, this study pioneers the synthesis of e-commerce live streaming discourse research, offering timely and reliable insights that establish a robust foundation for future investigations and point towards potential research trajectories.