Group Of Trainees Research Articles

Physical fitness of young Greco-Roman athletes under the restrictions of the COVID-19 pandemic

Background and Study Aim. The physical training of young athletes is the basis for future success in competitions. Its effectiveness depends on many factors, among which safe conditions for life support stand out. In the context of the COVID-19 pandemic, there are significant restrictions on the training of young athletes. The aim of the study is the physical training of young Greco-Roman wrestlers in the context of the COVID-19 pandemic.
 Material and Methods. The study involved young athletes (boys, n=20, age 5-7 years (Kharkiv, Ukraine). The experimental group of initial training (n=10) consisted of young athletes of the first year of study (children's sports school). The control group (n=10) consisted of children in the first year of primary school education. The study was conducted for 12 weeks. At the beginning and at the end of the study, a final testing of the level of physical fitness of boys was carried out. Tests were used to determine strength abilities, speed-strength abilities, coordination readiness and flexibility development. The study included all students whose parents agreed to participate in the study. This study was conducted by the Declaration of Helsinki and approved by the Ethics Committee of University.
 Results. Positive changes in the experimental group were observed in tests characterizing the level of development of coordination abilities. During repeated testing, the experimental group was much better oriented in space when performing three rolls. This was manifested in a reduction in the time of their implementation (t=4.091; р˂0.001) and a longer balance in static conditions (t=4.11; р˂0.01). In tests for the manifestation of strength and coordination abilities, there is a tendency to positive changes. However, there was no confirmation of a likely difference between pre-test and post-test (p>0.05). In tests for flexibility, the result remained almost unchanged and even deteriorated slightly. There were very slight positive changes in other studied indicators.
 Conclusions. For the formation of basic physical fitness, it is effective to provide a greater variety of training means and to maximize the focus on the game method of training. The process of training wrestlers of this age should be directed mainly to the development of coordination abilities.

The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome

Background: Irisin is a myokine suggested to exert anti-obesity benefits. On the other hand, paraxonase-1 (PON 1) is one of the most important free radical scavenging enzymes and is among the main protectors of lipoproteins against oxidizing compounds. This study aimed to evaluate the effect of 8 weeks of concurrent training on serum levels of irisin, PON 1, lipid profile, and insulin resistance in men with metabolic syndrome. Methods: In this quasi-experimental study, 30 men with metabolic syndrome (aged 25-35 years and with body mass>25 kg.m-2) were purposefully selected and randomly divided into two groups of concurrent training (n=15) and control (n=15). Three sessions of the training program were held per week over an 8-week interval. Concurrent training included warm-up, resistance (20 minutes of resistance training), and endurance (25 minutes of activity on a stationary bike with an intensity of 50%-80% of maximum heart rate). Blood samples were collected before and 24 hours after exercise to measure serum levels of variables. Data were analyzed using independent and dependent t-tests. Results: At baseline, serum levels of PON 1, irisin, and high-density lipoprotein (HDL) were higher in the concurrent training group. The results of the study also indicated that 8 weeks of concurrent training significantly reduced the levels of insulin resistance, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), systolic, and diastolic blood pressure in men with metabolic syndrome. Conclusion: Eight weeks of concurrent training improves the levels of irisin, insulin resistance, PON 1, and lipid profile of men with metabolic syndrome.

Using ultrasonography to improve fluoroscopic needle navigation in PM&R residents and medical students; a Randomised study

BackgroundFluoroscopy guided interventions are widely used procedures in the treatment of musculoskeletal conditions. Understanding the movement of the needle is part of a resident's initial training when performing these procedures. Needle navigation training is largely gained with fluoroscopy. ObjectiveThe purpose of this study is to determine whether the use of ultrasound training can lead to a decrease in time to reach a target under fluoroscopy. Methods32 medical students or residents. Exposure of one group of trainees to a practice session of needle navigation using ultrasound. The control group did not participate in ultrasound training. Time to reach the target during a fluoroscopy guided needle navigation test was measured in both groups. ResultsThe mean time to reach the target under fluoroscopy of the students unexposed to an ultrasound training (group 1 control group) was 183 ​s (standard deviation ​= ​160 ​s), while that after ultrasound training (group 2 experimental group) was 150,81 ​s (standard deviation ​= ​96 ​s) (p ​= ​0,483) ConclusionFluoroscopy needle navigation training was not improved by a 1-h group practice session with in-plane ultrasound needle navigation practice. Further studies need to be done with exposure for residents to a group practice session longer than 1-h

Predicting Tumor Perineural Invasion Status in High-Grade Prostate Cancer Based on a Clinical–Radiomics Model Incorporating T2-Weighted and Diffusion-Weighted Magnetic Resonance Images

To explore the role of bi-parametric MRI radiomics features in identifying PNI in high-grade PCa and to further develop a combined nomogram with clinical information. 183 high-grade PCa patients were included in this retrospective study. Tumor regions of interest (ROIs) were manually delineated on T2WI and DWI images. Radiomics features were extracted from lesion area segmented images obtained. Univariate logistic regression analysis and the least absolute shrinkage and selection operator (LASSO) method were used for feature selection. A clinical model, a radiomics model, and a combined model were developed to predict PNI positive. Predictive performance was estimated using receiver operating characteristic (ROC) curves, calibration curves, and decision curves. The differential diagnostic efficiency of the clinical model had no statistical difference compared with the radiomics model (area under the curve (AUC) values were 0.766 and 0.823 in the train and test group, respectively). The radiomics model showed better discrimination in both the train cohort and test cohort (train AUC: 0.879 and test AUC: 0.908) than each subcategory image (T2WI train AUC: 0.813 and test AUC: 0.827; DWI train AUC: 0.749 and test AUC: 0.734). The discrimination efficiency improved when combining the radiomics and clinical models (train AUC: 0.906 and test AUC: 0.947). The model including radiomics signatures and clinical factors can accurately predict PNI positive in high-grade PCa patients.

Personality Determinants of Eating Behaviours among an Elite Group of Polish Athletes Training in Team Sports

The nutritional behaviours of athletes are determined by environmental and individual factors. The aim of the research was to analyse the personality determinants of the eating behaviour among an elite group of Polish athletes training in team sports. The research was conducted among 213 athletes, using a proprietary validated nutritional behaviour questionnaire and the Neuroticism Extraversion Openness-Personality Inventory-Revised (NEO-PI-R Personality Inventory). Statistical analysis was performed with the use of Pearson's linear and Spearman's signed rank correlation coefficients, as well as multiple regression evaluation, assuming the significance level of α = 0.05. It was shown that the overall index of proper eating behaviour increased with increasing neuroticism (r = 0.132) and decreased with increasing openness to experience (r = -0.143). When assessing individual nutritional behaviours, it was indicated, among others, that with increasing neuroticism, athletes more often avoided energy drinks (R = 0.173), and with increasing extraversion, they more frequently consumed vegetables at least twice a day (R = 0.154). At the same time, the consumption of raw vegetables (R = -0.153), 2-3 portions of vegetables and fruit per day (R = -0.157) and the limitation of sweet and salty snacks (R = -0.152) decreased along with an increase in openness. On the other hand, with increasing conscientiousness, the regular consumption of meals (R = 0.186), dairy products (R = 0.143) and the reduction of sweet and salty snacks (R = 0.148) increased. The model built on the basis of the Big Five personality traits explained, to a very large extent (approx. 99%), variance concerning the general index of normal eating behaviour among athletes. The predictive significance of the personality traits presented in the Big Five model was demonstrated in relation to the quality of nutritional choices among Polish athletes competitively training in team sports, which may be used to personalise the dietary education of athletes.

Mining Housing Features to Classify Housing Unit Price

In data mining, classification builds an interdisciplinary field upon from statistics, computer science, mathematics and many other disciplines. There are numerous statistical applications where parametric and non-parametric methods are frequently used to train data to estimate mapping function. In this study, two of the most widely used techniques are applied to a real dataset. The goal of the study is to compare the classification success of ordinal logistic regression and the classification trees and to predict a categorical response. For this purpose, the potential factors affecting the housing unit price for sale as being the dependent variable with three classes in Eskişehir were examined. The real data set was split into three as train, validation and test groups. The classification performance of the techniques was demonstrated with 5-fold cross validation technique. According to the results, a more successful classification was made with the classification trees algorithm.

Special physical fitness factors of athletes involved in pole sports

Purpose: to determine the peculiarities of training female athletes engaged in Pole Sports on the basis of the factor analysis of physical, special physical qualities and functional capabilities.
 Material and methods: the study involved 15 female athletes (age 12-13 years), who are engaged in the sports club "Atmosphere" in Pole Sport and aerial acrobatics, Kharkov. Athletes are in the group of initial training (amateur level) and have the experience of sports activity 1-1,5 years. The study was conducted in September 2021. All participants and their parents agreed to participate in the experiment. Methods: theoretical analysis of literary sources; methods of testing physical development (height, weight); physical fitness (Push-ups 30 s, jumping rope for 3 min, lifting the trunk in sitting position in 1 minute, dynamometry of right and left arms, tilt of the body forward from the sitting position); special physical condition (chopper, pulling up on the pole, jumping rope for 3 min, jumping " Heels back", jumps with turning 180°, jumps with turning 360°, jumping into grouping); methods of functional capabilities (Genchi and Ruffier tests), mathematical and statistical methods using "EXCEL" and "SPSS" computer programs (factor analysis by principal component method was used). Results. A factor analysis of physical development indicators, physical training, functional athletes specializing in Pole Sport. It was found that in the structure of preparation of the athletes of this group overcomes the first factor "Special endurance" (15,21% of the total total dispersion), then the second "Functional abilities" (14,54% of the total total dispersion), the third factor "Power capabilities" (14,12% of the total cumulative variance) and the fourth factor " Coordination abilities" (14,02% of the total cumulative variance), the fifth factor " Flexibility " (13,52% of the total cumulative variance), the sixth factor "Technical capabilities" (12.37% of the total cumulative variance). The percentage contribution of these factors indicates the equivalent importance of these factors.
 Conclusions. The training means for the development of special physical qualities and techniques, the dosage of the volume and intensity of loads for athletes 12-13 years old involved in Pole Sports are presented.

Clustering of Librarians' Initial Knowledge on the Theme of Training

Background of study: The implementation of librarian competency development through training in Sidenreng Rappang Regency, South Sulawesi Province, was carried out by dividing librarians based on the location of their agency's work area. In practice, there are training barriers, namely differences in absorption of the material due to limited training time and differences in initial knowledge of the training material. Purpose: According to the librarian's prior knowledge of the training to be held in future, this study attempts to determine the best grouping and number of participants. Method: The methodology used in this research is Cross Industry Standard Process for Data Mining (CRISP-DM) which consists of 6 stages. The data collection technique used a questionnaire with a linear numerical scale from a score of 0 to 10 to 97 librarians in Sidenreng Rappang Regency. Data were analyzed using the K-Means algorithm to determine the number of groups and the number of librarians in each group and evaluated using the Davies-Bouldin index (DBI) algorithm to determine the most optimal group division. Findings: According to this study, the best number of groups for training in the processing of library materials is two under a DBI value of 0.68983. With a DBI value of 0.69431, the best number of groups is two in the library promotion training. Conclusion: the library service training had the best number of groups of 2 with a DBI value of 0.65698. Meanwhile, for INLISLite-based automation training, the best number of groups is two groups with a DBI value of 0.65500.

Effects of near-fault pulse-type ground motion on train–track–bridge coupled system with nonlinear supports

Researches have revealed that the excitations of near-fault pulse-type (NFPT) earthquakes lead to significant challenge of high-speed railway. This paper mainly focuses on the dynamic responses of train–track–bridge coupled system (TTBCS) under NFPT ground motions. An innovative effective TTBCS model (TTBCM) considering nonlinearities of supports is proposed herein, and with that model, numerical simulation and data analysis are conducted to reveal the potential effect on TTBCS arisen by NFPT ground motion from both qualitative and quantitative perspectives. Conclusions can be summarized below: The comparison between linear model and nonlinear model reveals the necessity of nonlinearity when conducting TTBCS numerical simulation under NFPT ground motions. Moreover, the analysis of pulse parameters of NFPT ground motions reveals that the relationship between dynamic responses of train group and amplitude of velocity pulse is approximately to the linear positive correlation relationship, while the dynamic responses of train group and period of velocity pulse exhibits negative correlation as inverse proportional function. Based on parameters analysis, a multiple-parameter regression between spectral intensity and pulse parameters is conducted, with the combination of running safety assessment (RSA) criteria including Nadal, wheel unloading, and wheel lift, suggestion from RSA perspective under NFPT ground motions are proposed as well.

Elbow to digit measurements as a preoperative adjunct tool to aid intramedullary femoral nail selection – the rule of thumb

BackgroundIntramedullary femoral nails are measured intraoperatively using fluoroscopy. This study aims to investigate whether distance from the olecranon to fingertips can be used to estimate nail length preoperatively by evaluating agreement of the two measurements. Such preoperative measurements may provide a likely range of nails needed for theatre and serve as an adjunct to intraoperative measurements. MethodsIn 70 patients, long leg radiographs were used to make linear measurements from the piriformis fossa and greater trochanter to the distal physeal scar of the femur. These were compared to measurements from the olecranon to the tip of each digit and Bland-Altman agreement analysis was performed. Train and Trial groups were formed to develop models for estimation and to then test their accuracy. ResultsBland-Altman analysis revealed a fixed bias, indicative of average difference between measurements, of 1.4 cm when comparing the elbow-thumb length to maximum femoral nail length for piriformis fossa entry and 3.5 cm using greater trochanter entry, informing the “rule of thumb”. Elbow-thumb length plus 1.4 cm or 3.5 cm predicts nail length to a range of ± one nail increment. The rule can be used to preoperatively predict a range of three nails from which there is a 94–97% likelihood the appropriate intramedullary nail would be selected. ConclusionsThe “rule of thumb” may serve as a simple to use tool for preoperative planning and a technical check to assess the “reasonableness” of intraoperative measurements before implantation of the device. It has the potential to reduce operating time and nail wastage.

Development and Examination of a Trainee-Led ECHO Autism Network for Rural Healthcare Providers

ABSTRACT Rural healthcare providers face numerous challenges in caring for autistic individuals. Some of the most common obstacles to optimal services include lack of specialized training and expertise, resources, and collaborators, as well as large physical distances between providers and those they serve, region-specific cultural factors, and others. Recent methodologies, such as Extensions for Community Healthcare Outcomes (ECHO), use videoconferencing technology to connect subject-matter experts with community providers to remediate disparities in 1) provider access to knowledge and consultation relevant to evidence-based practices (EBP) and, thereby, 2) patient access to quality care. Despite such advances, few projects have targeted rural communities in the same geographic area as network personnel. Additionally, to date, ECHO networks have been staffed with senior personnel, who have provided their experience and expertise to attendees. We, a multidisciplinary group of trainees and faculty, developed and piloted an ECHO Autism network for healthcare providers across the rural Western United States. In preparation for the launch of this network, trainees polled prospective participants regarding their disciplines and interests. Then, ECHO sessions were developed and implemented over several months. Finally, attendees provided feedback about their experiences. We report information regarding each of these phases and initial results of the post-session feedback to assist those who desire to develop a similar network in their area, and to provide preliminary examination (i.e., formative evaluation) of its benefit in view of the needs of rural providers caring for autistic individuals. We posit that our trainee-led model has unique value for cost-effectiveness and sustainability of implementation.

Fostering guardians for frontline medical disputes: a government-led medical dispute mediator training program in Taiwan

BackgroundMediation is increasingly used for medical dispute resolution, and the particularity of such mediation necessitates specialized training. In response to the promotion of compulsory mediation ahead of a legislation in Taiwan, we invited experts with an interdisciplinary team to design a case-based mediator training workshop. Our study aimed to investigate the learning outcomes of trainees and analyze their perspectives.MethodsWe recruited 129 trainees of a non-probability convenience sample who served as mediators or have dealt with medical dispute-related cases to undergo 2.5 h of lectures (introduction; procedure; roles of two mediators; principles and techniques of mediation; dispute arrangement; and issue analysis) and 1.5 h of case-based exercises. An after-class survey was conducted using a 4-point Likert-type scale to evaluate trainees’ viewpoints and learning outcomes. A total of 104 questionnaires were collected (response rate: 80.6%).ResultsThe professions of the participants were medical (56%), law (16%), and administration and others (28%). Males considered the course more helpful (3.79 vs. 3.63, p = 0.053) and more important (3.88 vs. 3.74, p = 0.042) than did females. Participants with a legal background scored the highest in helpfulness (3.84), followed by medical (3.74) and administrative (3.63) professionals. Medical and administrative professionals scored the highest (3.85) and lowest (3.76), respectively, on importance. Respondents with more than 10 years (3.81) and less than 1 year (3.79) of experience produced higher scores in helpfulness. Respondents with 1–5 years of experience (3.68) were found to be less likely to agree with the practical importance of course content compared with other groups of trainees. Administrative professionals obtained the highest scores (89.68) in written examinations.ConclusionsThere are variations in mediators’ perspectives based on gender, occupation, and work experience. Our nationwide mediation training workshop can be utilized to cultivate capabilities of mediators for handling medical disputes to achieve the goal of non-litigation in medical disputes.

Predictors and outcomes in primary depression care (POKAL) – a research training group develops an innovative approach to collaborative care

BackgroundThe interdisciplinary research training group (POKAL) aims to improve care for patients with depression and multimorbidity in primary care.POKAL includes nine projects within the framework of the Chronic Care Model (CCM). In addition, POKAL will train young (mental) health professionals in research competences within primary care settings. POKAL will address specific challenges in diagnosis (reliability of diagnosis, ignoring suicidal risks), in treatment (insufficient patient involvement, highly fragmented care and inappropriate long-time anti-depressive medication) and in implementation of innovations (insufficient guideline adherence, use of irrelevant patient outcomes, ignoring relevant context factors) in primary depression care.MethodsIn 2021 POKAL started with a first group of 16 trainees in general practice (GPs), pharmacy, psychology, public health, informatics, etc. The program is scheduled for at least 6 years, so a second group of trainees starting in 2024 will also have three years of research-time. Experienced principal investigators (PIs) supervise all trainees in their specific projects. All projects refer to the CCM and focus on the diagnostic, therapeutic, and implementation challenges.ResultsThe first cohort of the POKAL research training group will develop and test new depression-specific diagnostics (hermeneutical strategies, predicting models, screening for suicidal ideation), treatment (primary-care based psycho-education, modulating factors in depression monitoring, strategies of de-prescribing) and implementation in primary care (guideline implementation, use of patient-assessed data, identification of relevant context factors). Based on those results the second cohort of trainees and their PIs will run two major trials to proof innovations in primary care-based a) diagnostics and b) treatment for depression.ConclusionThe research and training programme POKAL aims to provide appropriate approaches for depression diagnosis and treatment in primary care.

Effects of Individualized Training and Respiratory Muscle Training on Pulmonary Function among Collegiate Swimmers: an Experimental Study

The study aimed to examine the effect of individualized (IT) and respiratory muscle training (RMT) on pulmonary function among collegiate swimmers.
 Materials and methods. The study recruited 43 healthy collegiate swimmers aged 18 to 25, and they were freestyle non-elite swimmers who swam at least three days a week. The participants were divided into three groups of Usual training (Control Group A), Respiratory muscle training (Experimental Group B) and Combination of respiratory muscle training and individualized training (Experimental Group C). The repeated measures two-way ANOVA was used to evaluate the differences within and between (time x group) the groups upon completion of the four-week intervention.
 Results. Both experimental groups (Group B and C) showed significant improvement within the groups. Whereas in between-group comparison, Group C (RMT and IT) showed tremendous improvement with significant differences in FVC value, predicted FVC value (percent), FEV1, FEV (percent), and predicted MVV, with the exception of the FEV1/FVC predicted ratio percent.
 Conclusions. When RMT and IT are used combined, swimmers’ performance increases more than when RMT and usual training are used separately. The findings suggest that training instructors may adapt RMT and IT techniques to fit the individual demands of swimmers in order to increase progress and performance efficiency, especially among competitive swimmers.

Supplemental Material for Self-Disclosure in a Self-Practice/Self-Reflection CBT Group in Professional Psychology Training

Supplemental Material for Self-Disclosure in a Self-Practice/Self-Reflection CBT Group in Professional Psychology Training

Incidence of Respiratory Pathogens in Naval Special Warfare Sea, Air, and Land Team Candidates With Swimming-Induced Pulmonary Edema

Swimming-induced pulmonary edema (SIPE) is a respiratory condition frequently seen among Naval Special Warfare (NSW) trainees. The incidence of positive respiratory panel (RP) findings in trainees with a diagnosis of SIPE currently is unknown. Does a significant difference exist in the incidence of respiratory pathogens in nasopharyngeal samples of NSW candidates with SIPE and a control group? Retrospective analysis of clinical information from NSW Sea, Air, and Land (SEAL) team candidates with a diagnosis of SIPE over a 12-month period. Candidates who demonstrated the common signs and symptoms of SIPE underwent a nasopharyngeal swab and RP test for common respiratory pathogens. SIPE diagnoses were supported by two-view chest radiography. RP tests were obtained for a selected control group of first-phase trainees without SIPE. Forty-five of 1,048 SEAL team candidates received a diagnosis of SIPE (4.3%). Five had superimposed pneumonia. Thirty-six of 45 showed positive results for at least one microorganism on the RP (80%). In the study group, human rhinovirus/enterovirus (RV/EV) was the most frequently detected organism (37.8%), followed by coronavirus OC43 (17.8%), and parainfluenza virus type 3 (17.8%). Sixteen of 68 candidates from the control group showed positive RP (24%) findings. Patients with SIPE and positive RP results reported dyspnea (94%), pink frothy sputum (44%), and hemoptysis (22%) more frequently than the control participants with positive RP results. Those who reported respiratory infection symptoms in both the study and control groups showed higher incidences of positive RP results (P= .046). We observed that 80%of trainees with a diagnosis of SIPE showed positive results on a point-of-care RP. This positivity rate was significantly higher than that of RP test results from the control cohort. These findings suggest an association between colonization with a respiratory pathogen and the development of SIPE in NSW candidates.

Http://medrehab.sbmu.ac.ir/article_1101715_d7641b2cbbd4f9e28db58f78a16fcd8c.pdf?lang=en

Background and Aims: Running sport is one of the basic and medal-winning sports. For success in this sport, it requires to improve the performance of athletes in young ages. This study aims to assess the effect of eight weeks of two plyometric and resistance training methods on selected biomechanical variables (flexibility, balance, power, and speed) of adolescent male runners. Methods: This is a quasi-experimental study with a pre-test/post-test design using a control group. The study population consists of all adolescent male runners aged 12-17 years attending the training sessions of youth teams active in the league competitions in Tehran, Iran. Of these, 45 were selected and randomly divided into three groups of plyometric training (n=15), resistance training (n=15) and control (n=15). The training programs were presented to the training groups for eight weeks, three sessions per week, each for 45 minutes, while the control group participated in their routine training of their teams. The Sargent jump test was used to evaluate their power; the 30-m sprint test was used to evaluate their speed; the star excursion balance test was used to evaluate their dynamic balance, and the sit and reach test was used to evaluate their flexibility. To analyze the collected data, descriptive statistics (mean and standard deviation) and analysis of covariance and Bonferroni post hoc test were used in SPSS software, version 24. Results: The eight weeks of two plyometric and resistance training methods had a significant effect on the selected biomechanical variables of adolescent male runners in the training groups compared to the control group. The results of post hoc test showed that the plyometric training was more effective than the resistance training. Conclusion: Plyometric and resistance training methods can be helpful in improving the physical performance of adolescent male runners and increase their records.

The prognosis of bladder cancer is affected by fatty acid metabolism, inflammation, and hypoxia.

The prognosis of bladder cancer (BC) is poor, and there is no effective personalized management method for BC patients at present. Developing an accurate model is helpful to make treatment plan and prognosis analysis for BC patients. Endogenous fatty acid metabolism causes cancer cells to become hypoxic, and the coexistence of hypoxia and inflammation is often characteristic of cancer. All three together influence the tumor immune microenvironment, treatment, and prognosis of BC. We used The Cancer Genome Atlas-Bladder Urothelial Carcinoma (TCGA-BLAC) cohorts as a train group to build a risk model based on fatty acid metabolism, hypoxia and inflammation-related gene signatures and performed external validation with GSE13507, GSE31684, and GSE39281 cohorts. We validated the model to correlate with the clinicopathological characteristics of patients, created an accuracy nomogram, and explored the differences in immune microenvironment and enrichment pathways. We found significant differences in overall survival and progression-free survival between high- and low-risk groups, and patients in the low-risk group had a better prognosis than those in the high-risk group. In the train group, the AUCs for predicting overall survival at 1, 3, and 5 years were 0.745, 0.712, and 0.729, respectively. The 1-, 3-, and 5-year overall survival AUCs were 0.589, 0.672, and 0.666 in the external validation group, respectively. The risk score independently predicted the prognosis of BC patients with AUCs of 0.729. In addition, there was a significant correlation between risk scores and BC clinicopathological features and, in the GSE13507 cohort, we observed that BC progression and deeper invasion were associated with higher risk scores. Risk scores were highly correlated with coproptosis, pyroptosis, m7G, immune checkpoint-related genes, and immune microenvironment. In addition, we found that patients in the low-risk group responded better to immunotherapy, whereas patients in the high-risk group were more sensitive to commonly used chemotherapy drugs. Our findings provide new treatment decisions for BC, and can effectively predict the prognosis of BC patients, which is helpful for the management of BC patients.

De perspectiefgerichte benadering

In late 2019, the Dutch Expert Centre Worldview and Religion in Secondary Education (Expertisecentrum Levensbeschouwing en Religie in het Voortgezet Onderwijs; LERVO) tasked a group of teachers and teacher trainers to work out a national curriculum for the subject area ‘worldview and religion’ (levensbeschouwing en religie). In this article, I outline the progress made so far. In the first section of the article, I discuss the general educational vision of LERVO that we have developed in dialogue with Gert Biesta’s theoretical pedagogy, Wolfgang Klafki’s theory of Bildung, and Fred Janssen’s ‘perspectives approach’ (perspectiefgerichte benadering). The second part of the article presents a new framework for the national curriculum, consisting of nine perspectives on worldview and religion (e.g., the meaning-making and phenomenological perspectives), and three additional learning lines focused, respectively, on dimensions of worldviews and religions, important traditions, and societal challenges.

A delta-radiomics model for preoperative prediction of invasive lung adenocarcinomas manifesting as radiological part-solid nodules.

This study aims to explore the value of the delta-radiomics (DelRADx) model in predicting the invasiveness of lung adenocarcinoma manifesting as radiological part-solid nodules (PSNs). A total of 299 PSNs histopathologically confirmed as lung adenocarcinoma (training set, n = 209; validation set, n = 90) in our hospital were retrospectively analyzed from January 2017 to December 2021. All patients underwent diagnostic noncontrast-enhanced CT (NCECT) and contrast-enhanced CT (CECT) before surgery. After image preprocessing and ROI segmentation, 740 radiomic features were extracted from NCECT and CECT, respectively, resulting in 740 DelRADx. A DelRADx model was constructed using the least absolute shrinkage and selection operator logistic (LASSO-logistic) algorithm based on the training cohort. The conventional radiomics model based on NCECT was also constructed following the same process for comparison purposes. The prediction performance was assessed using area under the ROC curve (AUC). To provide an easy-to-use tool, a radiomics-based integrated nomogram was constructed and evaluated by integrated discrimination increment (IDI), calibration curves, decision curve analysis (DCA), and clinical impact plot. The DelRADx signature, which consisted of nine robust selected features, showed significant differences between the AIS/MIA group and IAC group (p < 0.05) in both training and validation sets. The DelRADx signature showed a significantly higher AUC (0.902) compared to the conventional radiomics model based on NCECT (AUC = 0.856) in the validation set. The IDI was significant at 0.0769 for the integrated nomogram compared with the DelRADx signature. The calibration curve of the integrated nomogram demonstrated favorable agreement both in the training set and validation set with a mean absolute error of 0.001 and 0.019, respectively. Decision curve analysis and clinical impact plot indicated that if the threshold probability was within 90%, the integrated nomogram showed a high clinical application value. The DelRADx method has the potential to assist doctors in predicting the invasiveness for patients with PSNs. The integrated nomogram incorporating the DelRADx signature with the radiographic features could facilitate the performance and serve as an alternative way for determining management.