In order to improve the surface performance of the key components of Ti-6Al-4 V titanium alloy and meet its requirements for surface performance and life in complex service environments, this study combines traditional mechanical rolling with high-frequency ultrasonic vibration, and achieves high-speed impact on the surface of titanium alloy and traditional rolling at the same time. Numerical simulation of ultrasonic rolling processing of titanium alloy workpiece is carried out, the residual stress and surface roughness of the workpiece after processing are analyzed, and the influence of different process parameters on it is explored. The results show that ultrasonic rolling processing can effectively improve the surface properties of Ti-6Al-4 V titanium alloy, so that the residual stress distribution of the workpiece is more uniform and increases with the increase of static force and amplitude. When the static force is 1000 N and the amplitude is 8 μm, the surface finishing effect is the best.