Traditional Medicine For Treatment Research Articles

The Elementary School Student’s Achievements in Usada Bali ‘Balinese Traditional Medicine’ Lexicon (Gender Study and Language Revitalization)

Usada Bali is a traditional Balinese healing practice that uses natural materials like plants for medicine. This practice is recorded in Balinese script on lontar leaves. Modern technology and synthetic medicine have reduced the use of some traditional medicinal plants and caused a language shift from Balinese to Indonesian, even for traditional medicine terminology. Now, these materials are often written in Indonesian to describe their usage. This study aims to analyze the language strategies regarding the Usada Bali lexicon applied by the student's parents at elementary school at Denpasar and Klungkung Regency. It examines students' proficiency in traditional medicine types, treatment techniques, and related medical problems, and factors influencing their understanding. Using qualitative methods and surveys, the study found that most parents (66.3% in Denpasar and 83.3% in Klungkung) use Strategy 7-a language strategy involving Balinese Language with their children, the same as that employed in the neighborhood domain. As a result, 59.2%-81.9% of students understand the traditional medicine lexicons. The study concludes that besides Strategy 7, other factors such as family demographics and the presence of multiple generations play significant roles in maintaining the Balinese language and Usada Bali lexicons, as part of oral traditions and Balinese Culture, which are crucial for preserving Balinese cultural identity.

Metagenomic Analysis of Gut Microbiome in Gout Patients with Different Chinese Traditional Medicine Treatments.

Introduction Changes in eating habits have made gout a metabolic disease of increasing concern. Previous studies have indicated that there are significant differences in species composition and abundance of gut microbiome in gout patients compared with average. Considering that traditional Chinese medicine has a momentous effect in treating gout, the research study aimed to explore the differences of genomic and metabolomics of gut microbiome before and after traditional Chinese medicine treatment in patients with gout. Method 30 patients with gout and 29 matched controls were recruited of which 16 patients took H treatment and 14 patients took T treatment. Stools were collected twice for patients before and after treatment and only once for controls. A total of 89 samples were annotated with metagenomic species and functions, and the enrichment analysis of differential genes and KO pathway was carried out. Result The results showed a decrease in the diversity of gut microbiome in gout patients and the gene abundance and metabolomics had great differences among study groups. The number of bacterial genera also had significant differences among treatment groups. Moreover, among different groups, the regulation of different species was variously correlated. The correlation between species and clinical laboratory indicators in the rising group was stronger than that in the decreasing group and the upregulation of some strain was related to the content of urea nitrogen. Conclusion After the traditional Chinese medicine treatment, the glutathione pathway was significantly enriched and some pathogenic bacteria were significantly inhibited. The study suggests that traditional Chinese medicine treatment may exert its therapeutic effect by inhibiting relevant pathways.

Development and Validation of a New Analytical HPLC-PDA Method for Simultaneous Determination of Cucurbitacins B and D from the Roots of Trichosanthes kirilowii

Trichosanthes kirilowii, one of the herbal formulas named SH003, has been used for treatment in traditional medicine. This paper aimed to analyze the marker compounds from the roots of T. kirilowii and evaluate a validation method for cucurbitacins B and D using high-performance liquid chromatography-photodiode array detector (HPLC-PDA). Two marker compounds were identified as cucurbitacin B (1) and cucurbitacin D (2) from the roots of T. kirilowii by spectroscopic analyses. Cucurbitacins B and D peaks were well separated and were detected at 15.4 min and 12.4 min, respectively, by a UV detector at 230 nm with the linearity (R2 > 0.999) range between 5 and 250 μg/mL, limit of detections (LODs) were 1.87 μg/mL and 1.30 μg/mL, respectively, while limit of quantifications (LOQs) were 5.66 μg/mL and 3.93 μg/mL, respectively. The established method offered good precision with overall intra- and inter-day variations of 0.34–1.26 and 0.26–1.35%, respectively, for % relative standard deviation (RSD, acceptance limit %RSD <3%). The cucurbitacins B and D recoveries ranged from 99.2 to 101.7% and 98.6 to 102.0%, respectively. These results suggest that cucurbitacins B and D could be a valuable candidate for marker compounds of the extract from T. kirilowii, and the proposed method was shown applicability for quality control of SH003.

A Review of Research Trends in Traditional Korean Medicine for Nonalcoholic Fatty Liver Disease

Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine.Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were “nonalcoholic fatty liver disease”, “non-alcoholic fatty liver”, “nonalcoholic hepatitis”, “herb”, “herbal medicine”, “acupuncture”, and “traditional medicine”. The studies were analyzed according to the type of research.Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify.Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.

East Asian Traditional Medicine Treatment for Patients after Heart Valve Replacements: A Systematic Review with Meta-Analysis

Objectives: To compare the effectiveness and safety of East Asian traditional medicine treatments (EATMT) versus conventional management in patients following heart valve replacement surgery.Methods: We searched several databases, including the Korean Studies Information Service System, PubMed, China National Knowledge Infrastructure, and Citation Information by NII. The search range included randomized controlled trials from each first issue until June 27, 2021. Two review authors independently extracted the data. We assessed the risk of systematic errors by evaluating risk domains using the “Risk of bias” tool.Results: We included 5 trials in the review. In the EATMT, the investigators reported significant improvements in reshaping of the heart structure: left ventricular end diastolic diameter (MD -4.43, 95% CI -6.06 to -2.79; 130 participants; 2 studies; high evidence). Comparisons with usual care revealed a significant decrease in gastrointestinal complications rate (OR 0.30, 95% CI 0.20 to 0.47; 503 participants; 2 studies; high evidence). We assessed 4 studies as having a low risk of bias and 1 study as having a high risk of bias.Conclusion: This systematic review suggests that East Asian traditional medicine interventions may be effective in preventing and alleviating complications, but we found evidence of important trade-offs between known benefits and known adverse effects in cardiac dysfunction and inflammation following heart valve replacement. Consequently, additional high-quality studies should be conducted.

Pharmacological studies of sumac plant on COVID-19

Since 2019, the COVID-19 virus has caused severe lung damage and acute respiratory syndrome, leading to global epidemics with high morbidity and mortality. The world health organization has declared it a cause of the pandemic. At the beginning of 2020, many national and international organizations urgently took action to develop vaccines, and dozens of approved vaccines have been developed so far. Despite the significant effectiveness of vaccines, the continuation of deaths because of COVID-19 has increased people’s interest in traditional medicine. The uncertainty in the diagnosis, prevention, and treatment of many diseases, especially chronic diseases, has increased the interest in treatment methods other than modern medicine all over the world. It is stated that over 85% of the population in Africa, Asia, and the Middle East use herbal medicines as the first treatment option. Some compounds are obtained from plants, especially flavonoids; the quercetin, silymarin, polyphenolic compound glycyrrhizin, and curcumin have shown antiviral activity. Sumac is the common name for a genus (Rhus) in the Anacardiaceae family that includes over 250 species of flowering plants. Many compounds such as fatty acids, phenolics, organic acids, essential oils, proteins, fibers, vitamins, and minerals have been isolated from different parts of the sumac plant. It is considered a reasonable treatment in traditional medicine because of its analgesic, anorexic, antidiarrheal, antiseptic, and antihyperglycemic properties. Djakpo and Yao reported that sumac contains potent antiviral properties. The bioactive compound of sumac with antiviral activity is polyphenol tetra-O-galloyl-β-d-glucose (TGG), a tannin. Ling et al. found that TGG exhibited significant inhibition against severe acute respiratory syndrome coronavirus (SARS-CoV). Sherif et al. identified six polyphenolic compounds of Rhus spp as potential inhibitors to the SARS-CoV-2 major protease enzyme (Mpro; 6LU7). Keywords: Sumac, COVID-19, traditional medicine

Case report: Treatment with Pien-Tze-Huang for prolonged positive SARS-CoV-2 test results in COVID-19 patients: A report of five cases

Coronavirus disease 2019 (COVID-19) has rapidly spread around the world since December 2019, becoming a global pandemic. Atypical cases of COVID-19, manifesting as prolonged positive SARS-CoV-2 test results during the convalescence period, have been encountered. These cases increase the difficulty of COVID-19 prevention and treatment. Here, we report five cases of COVID-19 patients who demonstrated prolonged positive SARS-CoV-2 tests after regular traditional Chinese medicine and western medicine treatments. After administration of Pien-Tze-Huang and cessation of previous treatments, SARS-CoV-2 tests results of the patients turned and remained negative. We believe the finding will contribute to a better understanding of atypical COVID-19 cases and hope to offer a potential therapy. Since this is a preliminary case series, larger-scale clinical trials are warranted.

Phytochemical profile and pharmacological activities of hemigraphis colorata: a review

The use of herbal plants in the medical system plays an important role in the treatment of illnesses. Researchers all over the globe are exploiting the medicinal plants because of their least side effects, high efficacy and safety. Advancement in science technology has led to the development of a novel formulation from the medicinal plants. Exploitation of such medicinal plants has helped in treatment of ailments and it management. Even though researchers are discovering the hidden potentials of the medicinal plants still there are many underutilized medicinal plant with potent remedies. Amoung such plants Hemigraphis colorata is a plant that has significant part in the medicine system and has made a remarkable impact in traditional medicine treatment. The plant has been used in treatment of bloody dysentery, bacterial infection, fungal infection, haemorrhoids and as a wound healing agent. Along with these several pharmacological studies also suggest that the plant has potent antibacterial activity, anti-inflammatory activity, anticancer activity, antidiabetic activity, antidiarrheal activity etc. these activities can be a results of its vast phytochemical composition which includes alkaloids, tannins, glycosides, steroids, flavonoids etc. the present review is an effort made to collect all the available information regarding the phytochemistry, traditional usage and pharmacological activities.

Indigenous Medicinal Plants of Tripura used by the Folklore Practitioners for the Treatment of Bone Fractures

Traditional medicine is the oldest form of medicine and modern medicine has its roots in it. The experienced folklore practitioners are very scientific in their approach and understand well the mind and body relationship. This has enabled them to treat their patients in an integrated and holistic manner. Indian system of medicine has identified around medicinal plants, of which 500 species are used in preparation of drug formulations. KiratDesh an ancient name of Tripura was well known as a land of hills and dates in the past and was very rich in flora and fauna diversity. Almost all the plants contain some chemical compounds that are beneficial to mankind and many of them are used for medicinal values. In Tripura, about 266 species have been found to have medicinal properties. Folklore practitioners of Tripura were studied for the use of indigenous medicinal plants in the treatment of bone fractures. They use a combination of herbal, physical and natural process for treatment. They know that natural resources that have nurtured the human race the secret of healing. Knowledge of Traditional medicine is like a family heirloom and is transferred by means of inheritance. This precious knowledge should be conserved and all of indigenous medicinal plants should be protected from unauthorized use for monetary gain. We recorded 23 numbers of wild indigenous medicinal plant species and formulations of 12 types of traditional medicine treatments for the cure of bone fractures. This is a preliminary study and there is more scope for further extensive research and documentation.

Traditional medicine treatment in addressing the issue of women's stress and depression: A policy implementation perspective

The aim of this article is to highlight the importance of traditional treatment as a complimentary method of treatment for women with postpartum depression and stress. Even though the modern treatment and medicine have been recognised in improving the society’s health and well-being, the traditional medicine and treatment have been part of the society since the very old days. Having said this, the government has developed a National Policy of Traditional and Complementary Medicine (TCM) to facilitate the development of traditional and complementary medicine in order to achieve the quality and safety level of treatment practices recognized by the Helath Ministry by promoting the correct and reasonable use of the medicine, especially in primary health care. The way forward is discussed.

무릎 내측측부인대 손상의 한의학적 치료에 대한 국내외 임상연구 동향 분석

Objectives : This study aimed to review clinical studies on traditional Korean medicine treatment for medial collateral ligament injury of the knee. Methods : Clinical studies on Korean traditional medicine treatment of medial collat- eral ligament injury were conducted. We used five Korean online databases (OASIS, KISS, RISS, DBPia, and ScienceOn) and three foreign databases (PubMed, Cochrane Library, and CNKI). Out of 99 studies that were found, we excluded repeated articles, studies that were not related to Korean medicine, and those not relevant to the topic of the study. Results : Ten randomized controlled trials and 20 case studies were selected. Eight traditional Korean medicine treatments, including acupuncture, herbal medicine, chuna, and herbal ointment, were used in these studies. The most commonly used treatment was found to be acupuncture. Conclusions : Our study showed that traditional Korean medicine for medial collateral ligament injuries was effective. However, there were some limitations. Further clin- ical studies and randomized controlled clinical trials are needed for more evidence on Korean traditional medicine.

The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS

Ethnopharmacological relevanceAccording to the Compendium of Materia Medica, honey has been used as a traditional medicine in treatment against mucositis, tinea, hemorrhoids and psoriasis. In complementary medicine, due to its significant antimicrobial activity, honey has been widely used as a remedy for skin wounds and gastrohelcosis for thousands of years. Aim of the studyThis study is aimed at exploring the antimicrobial activity and mechanisms of honey sourced from medicinal plants, and revealing the composition-activity relationship, to facilitate their complementary and alternative application in the therapy of bacterial infectious diseases. Materials and methodsEight kinds of medicinal plant-derived uniflorous honey, native to China, were gathered. Their antimicrobial activities were evaluated in vitro, and then in vivo with the systemically infected mouse model and the acute skin infection model. SYTOX uptake assay, scanning electron microscopy, DNA binding assay, and quantitative real-time PCR, were carried out to elucidate the antibacterial mechanisms. This was followed by an investigation of the componential profile with the UPLC-MS/MS technique. ResultsIt was found that Scrophularia ningpoensis Hemsl. (figwort) honey (S. ningpoensis honey) exhibited broad-spectrum and the strongest antibacterial potency (MICs of 7.81–125.00%, w/v), comparable to manuka honey. In the in vivo assays, S. ningpoensis honey significantly decreased the bacterial load of the muscles under the acute MRSA-infected skin wounds; the sera level of TNF-α in the S. aureus and P. aeruginosa-infected mice decreased by 45.38% and 51.75%, respectively, after the treatment of S. ningpoensis honey (125 mg/10 g). It was capable of killing bacteria through disrupting the cell membranes and the genomic DNA, as well as down-regulating the expression of genes associated with virulence, biofilm formation and invasion, including icaA, icaD, eno, sarA, agrA, sigB, fib and ebps in S. aureus, and lasI, lasR, rhlI, rhlR and algC in P. aeruginosa. Apart from H2O2, some other nonperoxide compounds such as adenosine, chavicol, 4-methylcatechol, trehalose, palmitoleic acid and salidroside, might play a vital role in the antibacterial properties of S. ningpoensis honey. ConclusionsThis is the first study to thoroughly investigate the antibacterial activity, mode of action, and componential profile of S. ningpoensis honey. It suggested that S. ningpoensis honey might be a potential supplement or substitute for manuka honey, for the prevention or treatment of bacterial infections. It will facilitate the precise application of medicinal plant-sourced honey, provide a new thread for the development of antibacterial drugs, and assist in the distinction of different kinds of honey.

Clinical Effectiveness of Conservative Treatments on Lumbar Spinal Stenosis: A Network Meta-Analysis

Objective: To systematically evaluate the clinical effectiveness of conservative treatments including pharmacological treatments and nonpharmacological treatments on patients with lumbar spinal stenosis. Methods: We searched six electronic databases systematically for randomized clinical trials published between January 2000 and July 2021, including the China National Knowledge Infrastructure, WanFang Data, PubMed, MEDLINE, Embase, and the Cochrane library. The studies focused on the therapeutic effects of pharmacological treatments including calcitonin, antiepileptics, neurotrophic drugs, nonsteroidal anti-inflammatory drugs, Chinese Traditional Medicine, limaprost, and nonpharmacological treatments like physiotherapy for treating lumbar spinal stenosis were included. The outcome was measured using the visual analog scale, Oswestry Dysfunction Index, Japanese Orthopaedic Association Score, and EuroQol Five Dimensions Questionnaire. The quality of eligible studies was assessed by using the Cochrane recommended bias risk assessment tool. Stata was used to conduct the network meta-analysis. Results: A total of 12 randomized control trials with 1,194 patients were included. The network meta-analysis showed that for the visual analog scale, a better therapeutic effect was noted while using Chinese Traditional Medicine and physiotherapy, followed by analgesics drugs and limaprost. Limaprost and calcitonin were better in decreasing the Oswestry Dysfunction Index. In terms of the Japanese Orthopaedic Association Score, the use of traditional Chinese Medicine and limaprost were associated with a better improvement than other treatments. Meanwhile, limaprost combined with analgesics drugs was found to be effective to improve the EuroQol Five Dimensions Questionnaire. Conclusion: Among the commonly used conservative treatments for the treatment of lumbar spinal stenosis, limaprost may have better efficacy in improving the Japanese Orthopaedic Association Score and decreasing the Oswestry Dysfunction Index, with a beneficial effect on decreasing the visual analog scale and improving the EuroQol Five Dimensions Questionnaire. Systematic Review Registration: website, identifier registration number.

Effect-Directed Profiling of Monofloral Honeys from Ethiopia by High-Performance Thin-Layer Chromatography and High-Resolution Mass Spectrometry.

Ethiopian honey is used not only as food but also for treatment in traditional medicine. For its valorization, bioactive compounds were analyzed in nine types of monofloral Ethiopian honey. Therefore, a non-target effect-directed profiling was developed via high-performance thin-layer chromatography combined with multi-imaging and planar effect-directed assays. Characteristic bioactivity profiles of the different honeys were determined in terms of antibacterial, free-radical scavenging, and various enzyme inhibitory activities. Honeys from Hypoestes spp. and Leucas abyssinica showed low activity in all assays. In contrast, others from Acacia spp., Becium grandiflorum, Croton macrostachyus, Eucalyptus globulus, Schefflera abyssinica, Vernonia amygdalina, and Coffea arabica showed more intense activity profiles, but these differed depending on the assay. In particular, the radical scavenging activity of Croton macrostachyus and Coffea arabica honeys, the acetylcholinesterase-inhibiting activity of Eucalyptus globulus and Coffea arabica honeys, and the antibacterial activity of Schefflera abyssinica honey are highlighted. Bioactive compounds of interest were further characterized by high-resolution mass spectrometry. Identifying differences in bioactivity between mono-floral honey types affects quality designation and branding. Effect-directed profiling provides new insights that are valuable for food science and nutrition as well as for the market, and contributes to honey differentiation, categorization, and authentication.

Serum Scavenging Capacity and Folliculogenesis Impact following Flaxseed Consumption in the First-Generation Mice Pups.

Flaxseed is a source of antioxidants utilized for female infertility treatment in traditional medicine. This study investigated the effects of flax hydroalcoholic extract and flaxseeds during prenatal and postnatal (PND) periods on folliculogenesis and serum total antioxidant capacity (TAC). Pregnant NMRI mice received 500 and 1000 mg/kg of flax extract (LE) and the same doses of flaxseed (LS). Female pups received the same regimen for 56 days. The body, ovarian morphometry, follicle development, and TAC levels were evaluated. The ovarian weight significantly increased in the LE1000 group compared to the LS500 group. The LE500 group had a considerably lower number of primary and antral follicles compared to the CTL and LS1000 groups. The number of antral follicles significantly increased in the LE1000 group compared to the LS500 and LE500 groups. The number of preovulatory follicles was higher in the LE1000 group. A significant increase in the TAC levels was detected in the LS500, LS1000, and LE1000 groups. LE showed a dose-dependent protective effect on the folliculogenesis in F1, which is more evident with the dosage of 1000 mg/kg. This could be related to the strongest antioxidant property of LE1000, as shown by the highest levels of TAC.

Review of the Literature on Oral Cancer: Epidemiology, Management and Evidence-based Traditional Medicine Treatment

Oral cavity cancers are part of the upper aerodigestive tract cancers and represent a significant burden worldwide. Its epidemiology varies from country to country with high frequencies in South East Asian countries. Tobacco and alcohol are the main risk factors. Survival of oral cancer is low i.e., less than 40% in the advanced stage (stage III and IV), diagnosis of oral cavity cancer is based on a complete clinical examination of the oral cavity complete with biopsy, bio-markers are an adjunct to screening and diagnosis of oral cavity cancers, surgery, radiotherapy, chemotherapy and immunotherapy are part of the therapeutic armamentarium of oral cancer but also have limitations. Traditional medicine is an important and proven alternative in the treatment and support of patients with oral cavity cancer. Prevention of oral cavity cancers includes not only early detection of precancerous and cancerous lesions but also control of risk factors and education of the population. Surgery, radiotherapy, chemotherapy and immunotherapy are part of the therapeutic strategy of oral cancer treatment but also have limitations. Traditional Medicine is an important and proven alternative in the treatment and support of patients with oral cavity cancer. It is thus desirable to scientifically validate phytochemicals in order to integrate alternative medicine as part of national cancer management strategy. In silico advanced studies on secondary metabolites of medicinal plants traditionally used to treat oral cancer are in progress.

A Review of the Korean Traditional Medicine Treatment for Meniscus Injury

Objectives: The purpose of this study was review the current clinical studies about the effect of Korean traditional medicine treatment for meniscus injury.Methods: Clinical studies on Korean traditional medicine treatment of meniscus injury were searched through 11 online databases. We analyzed the authors, publication year, country, study design, subjects, treatment methods, treatment effects, evaluation tools and adverse events of the selected studies.Results: 23 studies which included 9 randomized controlled trials, 8 case reports, 4 retrospective observational studies, 2 non-randomized controlled trials were selected through the databases. A total of 9 Korean traditional medicine treatments were used, among them, acupuncture treatment was the most used. The most commonly used outcome was effective rate.Conclusions: Through this study, we could confirm that Korean traditional medicine is an effective treatment for meniscus injury. It was suggested that various clinical studies on the effects of Korean traditional medicine for meniscus injury are needed and it is necessary to establish more scientific evidence through studies with a high level of evidence.

Effects of Korean Traditional Medicine Treatment on Spontaneous Osteonecrosis of the Knee: A Case Report

Spontaneous osteonecrosis of the knee (SONK) is a common form of osteonecrosis of the knee and mainly affects the medial condyle due to localized vascular insufficiency. We report a case of SONK in a 65-year-old woman who had severe knee pain in her left knee whichimpeded her capacityto walk beyond 10 minutes. Bilateral knee X-rays revealed degenerative osteoarthritis of both knees and magnetic resonance imaging revealed R/O SONK in the lateral aspect of the medial femoral condyle, as well as a medial meniscal posterior horn root tear, and a Grade 1 medial collateral ligament injury. She was hospitalized at Jaseng Hospital of Korean Medicine for 21 days and receivedcombination therapy includingacupuncture, pharmacopuncture, and herbal medicine. Patient-reported scales indicated that her pain and physical functional limitations were alleviated. Combination therapy consisting of Korean traditional medicine may bean alternative non-operative treatment approach for patients with SONK.

Chemical Structures of Phenylbutanoids From Rhizomes of Zingiber cassumunar

Zingiber cassumunar is widely distributed in Asia, and its rhizomes are used for asthma treatment in traditional medicine and as a spice. Five new phenylbutanoids, cassumunols I–M (1-5), were isolated from Z cassumunar rhizomes collected in Thailand, and their structures were characterized on the basis of physiochemical and chemical evidence.

Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and ClinicalTrials.gov: a narrative review.

To analyze the current status of clinical trial registration of Traditional Chinese Medicine (TCM) for the treatment of neurological diseases. Interventional clinical trials of TCM treatment for ischemic stroke, hemorrhagic stroke, vascular cognitive impairment, tension-type headache before September 22, 2020 on the platform of Chinese Clinical Trial Registry (ChiCTR), and ClinicalTrials.gov were searched. Two researchers independently selected the literature and extracted data. A total of 180 interventional clinical trials were included for analysis. Out of 180 trials, 127 were from ChiCTR and 53 from ClinicalTrials.gov. The countries primary sponsoring the included trials were China (176, 97.8%), and the common categories of primary sponsors were hospital (131, 72.8%). Among the study design, the largest proportion of allocation was randomized (172, 95.6%), interventional model assignment was parallel (163, 90.6%), masking was double blind 49 (27.2%), and the sample size was ≤ 400 (144, 80.0%). The trials were most carried out at a single center (102, 56.7%). Among the included studies, 112 (62.2%) registered on ChiCTR attached the ethical approval documents. In terms of trial stages, 50 (27.7%) studies were in phase IV. The mostly used intervention was Chinese herbal medicines (99, 55%), acupuncture (68, 37.8%) was the second. By searching the registration number on China National Knowledge Infrastructure Database and PubMed, 38 (21.1%) registered trials were published, including 25 protocol studies and 14 research results with one (NCT02275949) published both the protocol and the results. Irregular and inadequate reporting, untimely update and publication, insufficient information on traditional medicine unique characteristics, and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases. More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials.