Purpose of the study: The hospitality industry is undergoing a transformation with the advent of blockchain technology, especially in hotel keys management. This chapter explores the use of blockchain to manage hotel guest room keys, focusing on its applications, benefits, and future ramifications. Methodology: The chapter begins by clarifying the basic concepts of blockchain, outlining its functionality as a decentralized distributed ledger system and then explores the challenges of traditional core system design and introduces blockchain-based key management solutions. This solution uses cryptographic encryption and decentralized access control mechanisms, integrating smart contracts to automate processes. Main Findings: Blockchain-based key management systems generate and distribute secure digital keys to guest smartphones, protecting it from unauthorized access and tampering blockchain’s immutable recordkeeping for a tamper-proof audit trail, enhancing security and accountability. Hotel networks allow guests to use digital keys in multiple ways, and connecting IoT devices allows for remote control and personalized experiences. Applications of the study: Blockchain technology provides a robust alternative to traditional hotel key management systems, improving security, transparency, and operational efficiency. Future trends, including artificial intelligence and machine learning, promise new innovations. A strategic and collaborative approach is recommended to maximize the benefits of blockchain in the hospitality industry. Novelty/Originality of the study: This chapter provides valuable insights for practitioners and researchers aiming to harness the transformative power of blockchain.