Agro-waste geopolymers are being significantly researched as sustainable substitutes to traditional construction materials for structural performance. However, a thorough assessment of their energy, environment, and economic (E3) performance is still questioned to facilitate in-situ building applications. This study first opts for a novel method of pressure catalysis for rice husk ash (RHA)-based geopolymers to enhance physico-mechanical performance with a low alkali activator dose. Afterward, the thermal conductivity of the optimized specimen was evaluated experimentally. Then, to assess its practical application, an E3 performance investigation was conducted on masonry brick/blocks as a pioneering approach for geopolymers. Distinct wall scenarios were simulated using Building Information Modeling (BIM) in a digital residential building. The experimental results showed that geopolymers with 50 % RHA, catalyzed under 20 MPa pressure, achieved 26.8 MPa compressive strength, lower density (1510 kg/m3), reduced water absorption (6.8 %), and 0.552 W/(m·K) thermal conductivity, outperforming traditional fired-clay brick and concrete block. The BIM analysis revealed that walls with RHA material had 53 % lower energy consumption and 30 − 41 % lesser CO2 emissions, respectively. Despite the higher cost, the RHA block has advantages as a masonry unit due to a high economic index. The significant energy and environmental gains suggest the potential for optimizing the production process of RHA-based geopolymer to enhance cost-effectiveness and amplify benefits.