Objective: To consider the requirements for the train control system (SUDP) at “Moscow-Kazan-Yekaterinburg” high-speed network (VSM). To develop system-wide requirements for SUDP, including the selection of the structure and composition of subsystems. Methods: Computer-based interlocking with contactless control of vehicles should be applied at the stations as the main means for train traffic control. Vocal frequency track circuits were determined as the major means for free and busy status control of track at stations and blocks, an information channel giving an update of a track ahead, and the means for a rail integrity test. Stationary equipment for train collision avoidance via radio channel is to provide train traffic with speeds up to 400 km/h, multiple-aspect ALS-YEN (integrated continuous automatic cab signaling system), depending on control technology with speeds up to 250 km/h and ALS (automatic locomotive signaling system) – up to 160 km/h. Results: The issues of providing reliable and safe functioning of SUDP were considered, as well as liveness and interoperability. Practical importance: Control system realization in the suggested configuration with combined data communication via radio channel and conventional ALS and ALS-YEN facilities will make it possible to provide train traffic collision avoidance backup, as well as interoperability with high-speed transport lines. Keywords: High-speed network, train control system, centralized traffic control, computer- based interlocking, train traffic collision avoidance, radio-block center.