In the field of respiratory physiology, it seems interesting to evaluate the change of respiratory pattern as the results of alteration of the respiratory route before and after the closure of tracheostoma.Tracheostomized patients breathe without the upper airway such as the nose, the mouth and the larynx. When tracheostoma is closed, the patients are suddenly forced to breathe through the upper airway. As the result, an anatomical dead space, a respiratory resistance and a humidifying function are added to their airway abruptly. The purpose of this study was to examine the above-mentioned change of respiratory pattern before and after the closure of tracheostoma.The subjects were seven tracheostomized patients with normal lung function. Tidal volume, respiration time and blood gases were measured before and just after, 1 hour and 2 hours after the closure of tracheostoma.The results were as follows: 1) When tracheostoma was closed, tidal volume and respiration time increased and respiratory minutes volume tended to decrease gradually in the course of time. 2) While Pao2 did not change in the course of time before and after the closure of tracheostoma, Paco2 was increased slightly after the closure and the value continued in 2 hours almost constantly.These changes were statistically significant except for minutes volume.It is obvious that the anatomical dead space increases when the tracheostoma is closed. As the results, the efficiency of ventilation would decrease.Our results showed, however, Pao2 did not decrease after closing the tracheostoma. On the other hand, respiratory minutes volume tended to decrease, and Paco2 increased just after the closing it and the value continued constantly for two hours.These results confirm that the ventilatory efficiency would be improved sometimes after the closure of tracheostoma in spite of the increased dead space, suggesting that the humidifying function and the resistance of the upper airway play a significant role in the respiration.