Trace Elements In Patients Research Articles

Low serum manganese as a noninvasive marker predicting the presence of myosteatosis among hospitalized patients with cirrhosis

Emerging evidence expands on a close connection between trace elements and muscular abnormalities, mostly focusing on sarcopenia. We hypothesized an association between concentrations of serum trace elements and myosteatosis, given that myosteatosis has a more pronounced clinical implication relative to sarcopenia, but there is a paucity of data in patients with cirrhosis. Consecutive patients were hospitalized for cirrhosis-associated complications. Serum trace elements (zinc, copper, manganese [Mn], magnesium, calcium, and iron) were measured by inductively coupled plasma mass spectrometry. The presence of myosteatosis was defined according to computed tomography–demarcated intramuscular adipose tissue content. In total, the 295 patients with cirrhosis analyzed had a median age of 63 years and 53.6% were male. Among them, 42 patients presented with myosteatosis (14.2%) and concomitant higher Model for End-stage Liver Disease-Sodium and triglyceride concentrations and lower neutrophil counts and serum Mn concentrations (all P < .05). No differences were found regarding other 5 trace elements in patients with versus without myosteatosis. The median serum Mn concentrations were 1.16 µg/L, and this population was categorized into high-Mn and low-Mn groups. The proportion of myosteatosis was significantly lower in high-Mn group than that in low-Mn group (8.1% vs 20.4%, P < .001). Univariable binary logistic regression indicated that low Mn was associated with myosteatosis (odds ratio, 2.906; 95% confidence interval, 1.424–5.932; P = .003) in the context of cirrhosis. This result was validated according to multivariable analysis by adjusting for confounding factors. In conclusion, low serum Mn can be predictive of myosteatosis, a novel muscular abnormality representing more clinical relevance and close relation to inferior outcomes among cirrhosis.

Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma

Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma

A Meta-Analysis of Essential Trace Elements in Patients with Coronary Heart Disease

There is growing evidence that presence of essential trace elements that pose risk for coronary heart disease (CHD) patients. A meta-analysis was conducted on the levels of trace elements Copper (Cu), Zinc (Zn), Iron (Fe), Manganese (Mn), Cobalt (Co) and Chromium (Cr) in CHD patients. Eligible articles from the databases of Web of Science, Scopus, PubMed, EBSCOHost and Ovid were searched based on PRISMA guidelines. English articles published between 2011 to 2021 were included and analysed by descriptive statistics and RevMan 5.4. Quality assessment was assessed with Newcastle-Ottawa scale. There were six studies selected with 322 participants’ data. Trace elements Cu (SMD=-0.13, 95%CI=[-0.99, 0.73], I2=92%, p=0.77), Zn (SMD=-0.38, 95%CI=[-0.81, 0.06], I2=71%, p=0.09), Fe (SMD=0.47, 95%CI=[-1.19, 2.13], I2=97%, p=0.58) and Mn (SMD=0.11, 95%CI=[-0.11, 0.33], I2=0%, p=0.33) levels were not significant. Sensitivity analysis revealed significant Cu level among patients with CHD (SMD=-0.54, 95%CI=[-0.85, -0.22], I2=0%, p=0.0008) and Fe level among the controls (SMD=1.41, 95%CI=[0.08, 2.73], I2=95%, p=0.04). Whereas Co and Cr levels varied according to dietary and smoking behaviours. Overall quality assessment was medium-to-high quality. Elements Cu was found significant in CHD patients and Fe was found significant among the controls, while other findings were inconclusive.

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder.

The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance. Our research revealed consistently higher manganese concentrations in the OCD group compared to healthy volunteers associated with a higher EEG ratio of amplitude transformation and symptom severity. The dynamics of salivary microelements and resting-state EEG, possibly influenced by cognitive and emotional load during the anticsaccade task, differed between groups. In healthy volunteers, there was a decrease in salivary iron level with an increase in high-frequency power spectral density of EEG. The OCD group showed a decrease in salivary copper with an increased Hjorth mobility of EEG.

Salivary trace elements in patients with ulcerative colitis on different treatment modalities

The nutritional status of patients with inflammatory bowel disease is considered less than ideal. This study aimed to compare the salivary levels of some trace elements (Zinc, copper, and magnesium) in patients with ulcerative colitis (UC) on two different therapeutic modalities to control subjects. Materials and methods: This cross-sectional study was performed in 2021-2022 on 53 diagnosed UC patients (27 UC patients on oral immunosuppressant therapy and 26 UC patients on combination therapy). All subjects were randomly selected from gastroenterology and Hepatology teaching hospitals in Baghdad city; twenty-five subjects were also recruited as controls. Demographic data were recorded through a checklist. Salivary levels of zinc (Zn), copper (Cu) and magnesium (Mg) were measured by atomic absorption spectroscopy. Data were analyzed using SPSS-28 at a significance level of 0.05. The results: Salivary Zn mean was significantly lower in monotherapy and combination therapy patients than in controls (p&lt;0.001). Mean salivary Cu levels were significantly higher in monotherapy and combination therapy patients than in controls (p&lt;0.001). Similarly, the salivary Mg mean was significantly lower in both groups of ulcerative colitis patients than in controls (p&lt;0.001). The mean of salivary Cu was higher in UC patients, while the men of Zn and Mg were lower in UC patients compared to controls. Conclusions: The results showed that UC patients have significantly lower Zn and Mg levels than healthy individuals and were lower inpatient on monotherapy than in combination. At the same time, salivary Cu in UC patients was higher than in control individuals and was higher in UC patients on monotherapy. Keywords: Inflammatory bowel diseases, Ulcerative colitis, Trace elements

Evaluation of liver enzymes activity and some trace elements in sickle cell anemia patients in Basrah Governorate – Iraq.

Sickle cell anemia is one of genetic diseases caused by hemoglobin biochemical disorder in especially in polypeptidic chain of this protein. The study was conducted from October 2019 to December 2020 and included two sets of samples Patient and Healthy .The current study was curried out to evaluate some enzymes and trace elements in patients with sickle cell anemia. The levels of copper (Cu) were estimated spectrophotometrically by reaction of copper with 4 – (3,5 – dibromo – 2- pyridylazo) – N – ethyl sulphopropylaniline to produce a chelating complex.The determination was carried out at wavelength equal to 520 nm. Finally, absorbances were recorded and they are proportional to concentration of copper in the sample . Also, the levels of zinc in serum of blood belonging to sickle cell anemia (SCA) were investigated and estimated by reaction of zinc with chromogen existing in the characteristic kit to produce coloured complex. The absorbances were recorded spectrophotometrically which are proportional to concentration of zinc in blood sample . The levels of biochemical variables were estimated using ARCHITECT c4000 systems provided by ABBOTT Company, which are designed with advanced technology, accuracy in clinical results and ease of handling. The device uses a sample size at a rate of 6µL in all measurements of chemical variables.The total values of the current results were made and expressed by calculation of the mean ± standard deviation. Analysis of all results data were carried out by using a statistical procedure according to analysis of variance univariate . Statistical programmer of social science (SPSS ,v.23 ) was depended for calculation of significant differences for the different groups of patients infected by SCA disease and healthy persons . The correlation regression coefficient (r) was used and depended to distinguish between the means of groups belonging to all patients and healthy individuals ( control group ) .The p-value was agreed for less than 0.05 to the limit of lowest significance . A highly significant difference was recorded belong to levels of GPT, ALP and GOT in patients compared with healthy individuals (control group) according to age and sex factor.

#2947 COMPARISON OF TRACE ELEMENT CONCENTRATIONS IN PREDIALYSIS, HEMODIALYSIS AND PERITONEAL DIALYSIS PATIENTS

Abstract Background and Aims Regulation of many trace elements (TE) is critically dependent on kidney functions. Dialysis modality, duration of dialysis, equipment, purity of water and nutrition also impacts TE balance. There are inadequate data on comparison of TE in patients with different stages of kidney disease. We aimed to compare TE levels in a restricted geographical area across a wide range of glomerular filtration rate (GFR) including end stage kidney disease. We assumed that this kind of design might be beneficial for understanding TE balance and impact of dialysis. Method Hemodialysis (HD), peritoneal dialysis (PD) and chronic kidney disease (CKD) patients with reduced GFR were included in this cross-sectional study. A sample of plasma was analyzed by inductively coupled plasma mass spectrometry (ICP-MS) (Thermo Scientific™ iCAP Q ICP-MS, USA). Sensitivity was on the order of ppb (µg/L). A control group (CG) with glomerular filtration rate ≥ 90 ml/min were used for comparison of plasma levels of TE. Results Results of TE are presented in the Table 1. Significant number of both patients and controls lack a valid TE measurement because of the concentrations below limit of the detection (LoD). Copper, in CKD patients, is negatively correlated with hospitalization within the last six months (r= - 0,315, p= 0.005). Conclusion Our data suggest that TE levels except Zn and Mn deviate from that of CG in a statistically significant manner in renal patients. Existing data on TE in renal patients are inconsistent and there is some confusion. Similarly, our results are consistent with some data and conflicting with others. In future studies, this confusion could be eliminated by evaluating each trace element separately and minimizing methodological problems. (This study is realized with support of Cumhuriyet University CUBAP)

Trace Element Imbalances in Acquired Hepatocerebral Degeneration and Changes after Liver Transplant.

Brain manganese (Mn) accumulation is a key feature in patients with acquired hepatocerebral degeneration (AHD). The role of trace elements other than Mn in AHD needs to be clarified. In this study, using inductively coupled plasma mass spectrometry, we aimed to evaluate blood levels of trace elements in patients with AHD before and after liver transplantation (LT). Trace element levels in the AHD group were also compared with those of healthy controls (blood donors, n = 51). Fifty-one AHD patients were included in the study (mean age: 59.2 ± 10.6 years; men: 72.5%). AHD patients had higher levels of Mn, Li, B, Ni, As, Sr, Mo, Cd, Sb, Tl and Pb and a higher Cu/Se ratio, and lower levels of Se and Rb. Six patients (two women; mean age 55 ± 8.7 years) underwent LT, and there was an improvement in neurological symptoms, a significant increase in the Zn, Se and Sr levels, and a decrease in the Cu/Zn and Cu/Se ratios. In summary, several trace element imbalances were identified in AHD patients. Liver transplantation resulted in the improvement of neurological manifestations and the oxidant/inflammatory status. It is possible that observed changes in trace element levels may play a role in the pathophysiology and symptomatology of AHD.

Assessment of trace elements, systemic inflammation, and electrolytes in patients with chronic obstructive pulmonary disease

BackgroundSystemic inflammation, electrolytes, and trace element derangements are thought to be involved, directly or indirectly, in chronic obstructive pulmonary diseases (COPD).AimOur aim is to evaluate systemic inflammation and disturbance in serum electrolytes and trace elements in patients with COPD.MethodsThis study was conducted in the Chest Department, Cardiothoracic Minia University Hospital. One hundred COPD patients and 40 healthy controls were included in the study. Sixty patients were in a stable state, while 40 patients were in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Serum C-reactive protein (CRP), TNF-α, copper (Cu), zinc (Z), Na, K, and Mg levels were measured for all participants.ResultsCRP, TNF, Cu, and Z were significantly higher in the stable group than in the control group (p-value 0.0002*, 0.0018*, 0.04*, 0.034*, respectively) with significantly higher levels during exacerbation (8.47 ± 6.3, 24.36 ± 9.53, 201 ± 39.02, 192 ± 32.3). The Cu/Z ratio was significantly lower in the exacerbation group than in the stable group (p-value 0.042*). Serum levels of Na, K, and Mg were significantly lower in the patients group than in the control group (p-value 0.024*, 0.039*,0.044*, respectively), with more reduction observed in the exacerbation group (132 ± 5.45, 3.24 ± 0.52, 1.67 ± 0.38).ConclusionCRP, TNF-α, Cu, and Z levels were significantly higher in stable COPD patients, with higher levels during exacerbation. The Cu/Z ratio was lower in the exacerbation group than in the stable group. Na, K, and Mg levels were lower in patients than in the control group with more reduction during exacerbation.

Evaluation of Hearing Impairment and Levels of Trace Elements in Patients with Oral Submucous Fibrosis

Introduction: Oral Submucous Fibrosis (OSMF) is a slowly progressive premalignant condition. Trace elements like Copper (Cu) and Zinc (Zn) were found to have diagnostic and prognostic values in malignancies. Disease activity at in an earlier stage by determining the exact stage of OSMF based on eustachian tube dysfunction and serum Cu, Zn, and Iron (Fe) levels. Aim: To assess the Eustachian tube dysfunction and level of trace elements in OSMF patients. Materials and Methods: This case-control study was carried out in VSPM Dental College and Research Centre Nagpur and Department of Ear, Nose and Throat (ENT) and Biochemistry of NKP Salve Medical College, Nagpur, Maharashtra, India, from March 2018 to February 2019. Two hundred patients were equally divided into individuals without OSMF and with OSMF. A Pure Tone Audiometry (PTA) was used to measure degree of hearing impairment while estimation of trace elements Cu, Zn and Fe was done by atomic absorption spectrophotometry. The unpaired t-test, Chi-square test and one-way Analysis of Variance (ANOVA) test were used for statistical analysis. Results: All 200 individuals were matched with age and sex in both the groups. Normal hearing was found in 61% of the ears and Conductive Hearing Loss (CHL) in 39% of the ears with OSMF. A positive association of hearing loss in both the ears with stages of OSMF were seen which was statistically significant with p-value of 0.001. The level of Cu (103.44 mg/dL) was found increased in OSMF individuals while the levels of Zn (78.93 mg/ dL) and Fe (84.05 mg/dL) was reduced. Conclusion: Within the limitations of the study, there was association between the severity of OSMF, degree of hearing loss and levels of trace elements. One of the most serious sideeffects of OSMF is hearing loss. Level of copper increased while level of zinc and iron were reduced in OSMF patients.

Role of microelements in the development of endocrine pathology

Due to the continual increase in the incidence of endocrine diseases in the world, their prevention and treatment have become topical. Diseases of the endocrine system are often accompanied by the development of comorbidities and complications, which negatively affect the quality of life and survival of patients. Currently, research is focused on the status of trace elements in patients with various diseases. Numerous current studies are devoted to investigating the influence of the balance of trace elements on the etiology and pathogenesis of diabetes mellitus, obesity, and some thyroid diseases, including autoimmune ones. The role of iodine, selenium, iron, zinc, and copper in the development and progression of these diseases has been established, but the findings of these studies are sometimes contradictory.&#x0D; This review focuses on national and foreign studies on the role of trace elements in the development of endocrine pathology, and gives a brief description of the most significant mineral substances, as well as the effect of their imbalance on the structure and function of the organs of the endocrine system. This review recommends further studies on this issue incorporating concomitant diseases, as well as the mutual influences of mineral substances on each other, which can lead to a change in the concentration of trace elements in the body.

Evaluation of Trace Elements in Patients with Senile Cataract

Background: Senile cataract is a common cause of blindness among older people. The problem is common among adults of age 40 and older. There are various factors that cause senile cataracts among adults. These factors include protein and lipid variations, genetic role, and the existence of trace elements like magnesium, zinc and copper. Aim and objectives: To evaluate the level of zinc and relationship between copper, and magnesium in patients with senile cataract by comparing with healthy subjects. Material and Methods: This study has a key focus on examining the effect of trace elements on senile cataract patients. We conducted experiments when 100 people (50 patients and 50 non-patients). Absorption spectrometry was used to examine the blood samples of the people who took part in the research. Results: It was noted during the results that most of the patients developed senile cataracts after crossing the age of 50. It was also noted from the results that the concentration of copper and zinc was higher in the patients as compared to the non-patients, while the concentration of magnesium was lower in the patients as compared to the non-patients. Based on these results, it can be stated that an increase in the concentration of copper and zinc increases the chances of senile cataracts. The decline in the concentration of magnesium increases the chances of senile cataracts. Also, out of these patients, a majority of them were females. Therefore, there are chances of biased results in this study that can be improved in future studies with the number of patients and an equal number of males and females. Conclusion: The concentrations of copper and zinc were significantly higher in patients than in the non-patients, whereas the concentration of magnesium was lower in the patients than in the non-patients. Based on these findings, it may be concluded that an increase in copper and zinc concentrations increases the risk of senile cataracts. Keywords: zinc, copper, magnesium, senile cataract, healthy subjects.

Metalloprotein status in Indian patients with beta thalassemia trait

Introduction and Aim: Beta Thalassemia trait (BTT) is the most prevalent heterozygous hemoglobinopathy in Asian population. The current study aims to evaluate plasma antioxidant metalloproteins like SOD, ceruloplasmin, ferritin and correlate them with the trace elements in patients with BTT. Materials and Methods: The subjects included in the study were divided into two groups comprising of 40 BTT patients in group I and 40 age and sex matched normal individuals in group II. Cation exchange HPLC was used for hemoglobin variant analysis. Plasma iron, copper, ceruloplasmin and SOD were assayed using the spectrophotometric method while zinc was determined by atomic absorption spectrometry and ferritin by ECLIA. Results: There was a marked reduction in plasma trace elements in BTT compared to healthy controls. The decrease in zinc (p&lt;0.001) and copper (p&lt;0.04) was statistically significant. Both SOD and ferritin levels were significantly lower in BTT patients (p&lt;0.001). However, an apparent decrease was observed in ceruloplasmin levels. Iron and ferritin showed a significant positive correlation (r=0.84 p=0.01), similarly copper and ceruloplasmin correlated positively (r=0.92 p=0.001) in BTT patients. Interestingly HbF correlated negatively with all the three trace elements. Conclusion: It can be concluded that decreased antioxidant metalloproteins may lead to free radical toxicity in BTT. The study highlights the indirect role of trace elements in oxidative stress and draws attention on the requirement for regular and timely assessment of metalloenzymes and periodic administration of trace elements in reduction of free radical damage and associated complications in BTT patients.

Assessment of serum level of selected essential trace elements in patients with renal disorders

Levels of some trace elements in the sera of patients (male and female) with kidney diseases were determined. The patients were twelve (12) in number, aged between 45-65 years and were having occupation traceable to heavy metal exposure. The trace elements determined were iron, manganese, copper and zinc. The investigation was conducted at the in-and-out patient unit of the University College Hospital, Ibadan, Oyo State, Nigeria and the results obtained were compared with the corresponding values obtained in control subjects. The results of this study revealed a significant (P&lt;0.05) increase in serum iron and manganese levels where mean serum iron levels of [(92.9±16.5), (45.0±150.9)] mg/100 ml were obtained in patients (both sexes) compared to [(82.5±5.14), (50.8±100.3)] mg/10 0 ml obtained in control subjects respectively. Mean serum manganese levels of [(2.39±1.30), (0.05±6.90)] mg/100 ml were also obtained in patients (both sexes) compared to [(1.20±0.22), (0.70±1.90)] mg/100 ml in control subjects respectively. However, there was significant (P&lt;0.05) decrease in serum copper and zinc levels in the patients compared to the control subjects. Mean serum copper levels of [(49.3±12.4), (20.5±92.2)] mg/100 ml were obtained from patients compared to [(82.5±47.3), (50.8±89.2)] mg/100 ml obtained in control subjects while mean serum zinc levels of [(54.3±15.9), (16.5±100.0)] mg/100 ml were obtained from patients compared to [(66.1±5.17), (40.8±84.0)] mg/10 0 ml in control subjects. The results suggest heavy metal interference with the essential trace elements in physiological system of the patients due to occupational exposure.

Evaluation of Vitamin D and trace element level in sera of patients with Rheumatoid arthritis

Objective: The purpose of this research was to assess the serum concentration of (1,25-(OH)2D3) and trace elements in patients with rheumatoid arthritis as compared to healthy individuals. Methods: This research was performed on 72participants, 37 cases of RA and 35 healthy individuals, with age range 39-67 years. Serum (1,25-(OH)2D3) levels was determined and compared in cases and healthy controls. Results: The serum (1,25-(OH)2D3) levels were significantly lower in the RA patients (13.24 ± 1.06 ng/ml), when compared to the healthy individuals (26.9 ± 1.7 ng/ml). The examination of data revealed that the levels of (Magnesium, Manganese, Nickel and Rubidium) were remarkably elevated in RA patients when compared to healthy control , serum levels of (Chromium, Cobalt and Germanium) were remarkably decreased in RA patients when compared to healthy control. Conclusions: (1,25-(OH)2D3) insufficiency is more widespread among patients with RA and may be one of the reasons leading to evolution of rheumatoid arthritis. Supplementation with (1,25-(OH)2D3) may be required both for the avoidance of bone loss besides for painkilling in patients suffering from rheumatoid arthritis. Current results propose that alterations in the serum concentration of trace elements may yield good indication to their role in the pathogenesis of rheumatoid arthritis.

Trace elements content in the hair of patients at the maxillofacial surgery department

Relevance. The urgency of the problem of traumatism is constantly increasing, which is associated with an increase in road accidents, an increase in the number of interpersonal conflicts, the availability of firearms and cold steel weapon, etc. In addition, the proportion of victims with injuries of the maxillofacial region in a state of alcoholic intoxication is constantly growing. The aim of the study is to conduct a comparative analysis of trace elements in hospitalized patients with maxillofacial trauma, intoxicated, acute traumatic stress and the study of the effect of trauma on the balance of trace elements in patients of the Department of Maxillofacial Surgery with various alcohol history. Materials and Methods. The study involved 30 male patients of the department of maxillofacial surgery of the Moscow city clinical F.I. Inozemtseva hospital located in the city of Moscow. All patients were joined to the department for trauma of the maxillofacial tract and were divided into two groups: 15 of them regularly took alcohol and were in a state of alcoholic intoxication at the time of injury (group 1), 15 - without alcohol history (comparison group 2). All patients carried a general clinical blood test, a biochemical blood test, and the content of essential and conditionally essential elements in the hair were also determined. Results and Discussion. As a result, significant differences were revealed in the content of micro elements between the groups of patients: the content of copper (p = 0.013) and zinc (p = 0.000) in the hair examined of the first group was 1.4 lower than in the comparison group 2. The manganese content (p = 0.05), on the contrary, was also increased by 1.4 times in the hair of group 1 patients. Besides, leukocytosis was detected in the blood in patients with a history of alcohol and an increase in AST levels. Conclusion. The study showed an increase in the content of manganese and a decrease in the content of selenium, zinc and copper in the hair of patients with an alcoholic history. Diselementosis was accompanied by a significant increase in aspartate aminotransferase activity, as well as leukocytosis and lymphocytosis. Such an imbalance of chemical elements, together with a changes of peripheral blood and an increase in the activity of ASaT, can be reflected on the period the timing and peculiarities of the course of the reparative process.

Trace elements content in the hair of patients at the maxillofacial surgery department

Relevance. The urgency of the problem of traumatism is constantly increasing, which is associated with an increase in road accidents, an increase in the number of interpersonal conflicts, the availability of firearms and cold steel weapon, etc. In addition, the proportion of victims with injuries of the maxillofacial region in a state of alcoholic intoxication is constantly growing. The aim of the study is to conduct a comparative analysis of trace elements in hospitalized patients with maxillofacial trauma, intoxicated, acute traumatic stress and the study of the effect of trauma on the balance of trace elements in patients of the Department of Maxillofacial Surgery with various alcohol history. Materials and Methods. The study involved 30 male patients of the department of maxillofacial surgery of the Moscow city clinical F.I. Inozemtseva hospital located in the city of Moscow. All patients were joined to the department for trauma of the maxillofacial tract and were divided into two groups: 15 of them regularly took alcohol and were in a state of alcoholic intoxication at the time of injury (group 1), 15 - without alcohol history (comparison group 2). All patients carried a general clinical blood test, a biochemical blood test, and the content of essential and conditionally essential elements in the hair were also determined. Results and Discussion. As a result, significant differences were revealed in the content of micro elements between the groups of patients: the content of copper (p = 0.013) and zinc (p = 0.000) in the hair examined of the first group was 1.4 lower than in the comparison group 2. The manganese content (p = 0.05), on the contrary, was also increased by 1.4 times in the hair of group 1 patients. Besides, leukocytosis was detected in the blood in patients with a history of alcohol and an increase in AST levels. Conclusion. The study showed an increase in the content of manganese and a decrease in the content of selenium, zinc and copper in the hair of patients with an alcoholic history. Diselementosis was accompanied by a significant increase in aspartate aminotransferase activity, as well as leukocytosis and lymphocytosis. Such an imbalance of chemical elements, together with a changes of peripheral blood and an increase in the activity of ASaT, can be reflected on the period the timing and peculiarities of the course of the reparative process.

Estimation of some vital trace elements in patients with acute pancreatitis: A case-control study

Trace elements have an important influence on the living system and play a major role in a variety of processes necessary for life. This case study was conducted as an attempt to expand our knowledge of the relationship between trace elements and their effect on acute pancreatitis. Sixty-five patients diagnosed with acute pancreatitis with mean age 43.6 years, along with sixty-five healthy volunteers with a mean age 45.7 years, were included in this study. The obtained results indicated a significant increase in the Cu, Ni and Cr levels, and a significant decrease in the Zn, Mg and Fe levels for acute pancreatitis patients compared with the control group (p <0.001). In addition, a remarkable increase in the Cu/Zn ratio was observed in patients. The current work provides important evidence of correlation between changes in copper and zinc levels and the risk of acute pancreatitis. Also, an increased Cu/Zn ratio may be a useful indication for the diagnosis and monitoring of acute pancreatitis. Moreover, the current study concluded that there is a possible relationship of Mg, Fe, Ni and Cr with acute pancreatitis. Thus, it can be suggested that these elements are reliable to provide indications for warning of the risk of acute pancreatitis.

Attentive Evaluation of Trace Elements in Patients with Breast Cancer-A Cross Sectional Study of Nawabshah, Sindh, Pakistan

Background: Breast cancer has recently become one of the most obsessing and life threatening issues in the world. Globally, females suffered mostly by breast cancer. Breast cancer is multifactorial etiological disorder. Trace elements are acts as cofactors and biological catalyst. They play a very essential role in the metabolic pathways.&#x0D; Methods: A cross sectional study with two hundred (200) subjects and divided into two groups. 50 females were normal healthy as a control while 150 females were patient with breast cancer. Blood was collected from all participant after taking history, clinical data, mammographic and histopathological findings. Consent and predesign porforma were filled by all participants of study. The trace elements (Na, K, Zn, Fe, Ca) were determined through atomic absorption spectrophotometer (ASS) and other biochemical analysis such as Total Protein, serum albumin and Total cholesterol were analyzed on Micro Lab.300. Data was entered on SPSS 22.0 version, and applied student t-test for continuous variables. Results were analyzed as Mean and standard deviation.&#x0D; Results: The results of serum Na+, K+, Ca++, Zn++, Cu++ and Fe in breast cancer patient were observed and found significantly fluctuated in breast cancer patients as compared to normal healthy subjects. Serum Total Protein significantly increased whereas serum Albumin decreased in patient with breast cancer.&#x0D; Conclusions: in Present study we found significantly abnormal concentration of Na+, K+, Ca++, Zn++, Cu++ and Fe in breast cancer these elements may contribute in early diagnosis of breast cancer. Increased body weight and total cholesterol are also risk factors of Ca breast.

Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias.

Trace elements such as cadmium, arsenic, zinc or selenium increase or decrease risk of a wide range of human diseases. Their levels in toenails may provide a measure of mid-term intake of trace elements for studies in humans. However, in biologically and clinically aggressive diseases as pancreatic cancer, the progression of the disease could modify such concentrations and produce reverse causation bias. The aim was to analyze the influence of specific time intervals between several clinical events and the collection of toenails upon concentrations of trace elements in patients with pancreatic cancer. Subjects were 118 incident cases of pancreatic adenocarcinoma prospectively recruited in eastern Spain. Toenails were collected at cancer diagnosis, and soon thereafter interviews were conducted. Information on cancer signs and symptoms was obtained from medical records and patient interviews. Levels of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. General linear models adjusting for potential confounders were applied to analyze relations between log concentrations of trace elements and the time intervals, including the interval from first symptom of cancer to toenail collection (iST). Toenail concentrations of the 12 trace elements were weakly or not influenced by the progression of the disease or the diagnostic procedures. Concentrations of aluminum were slightly higher in subjects with a longer iST (age, sex and stage adjusted geometric means: 11.44 vs. 7.75 µg/g for iST > 120 days vs. ≤ 40 days). There was a weak inverse relation of iST with concentrations of zinc and selenium (maximum differences of about 20 and 0.08 µg/g, respectively). Conclusions: concentrations of the trace elements were weakly or not influenced by the development of the disease before toenail collection. Only concentrations of aluminum increased slightly with increasing iST, whereas levels of zinc and selenium decreased weakly. Even in an aggressive disease as pancreatic cancer, toenail concentrations of trace elements may provide a valid measure of mid-term intake of trace elements, unaffected by clinical events and disease progression.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12403-021-00436-2.