#2947 COMPARISON OF TRACE ELEMENT CONCENTRATIONS IN PREDIALYSIS, HEMODIALYSIS AND PERITONEAL DIALYSIS PATIENTS

Abstract

Abstract Background and Aims Regulation of many trace elements (TE) is critically dependent on kidney functions. Dialysis modality, duration of dialysis, equipment, purity of water and nutrition also impacts TE balance. There are inadequate data on comparison of TE in patients with different stages of kidney disease. We aimed to compare TE levels in a restricted geographical area across a wide range of glomerular filtration rate (GFR) including end stage kidney disease. We assumed that this kind of design might be beneficial for understanding TE balance and impact of dialysis. Method Hemodialysis (HD), peritoneal dialysis (PD) and chronic kidney disease (CKD) patients with reduced GFR were included in this cross-sectional study. A sample of plasma was analyzed by inductively coupled plasma mass spectrometry (ICP-MS) (Thermo Scientific™ iCAP Q ICP-MS, USA). Sensitivity was on the order of ppb (µg/L). A control group (CG) with glomerular filtration rate ≥ 90 ml/min were used for comparison of plasma levels of TE. Results Results of TE are presented in the Table 1. Significant number of both patients and controls lack a valid TE measurement because of the concentrations below limit of the detection (LoD). Copper, in CKD patients, is negatively correlated with hospitalization within the last six months (r= - 0,315, p= 0.005). Conclusion Our data suggest that TE levels except Zn and Mn deviate from that of CG in a statistically significant manner in renal patients. Existing data on TE in renal patients are inconsistent and there is some confusion. Similarly, our results are consistent with some data and conflicting with others. In future studies, this confusion could be eliminated by evaluating each trace element separately and minimizing methodological problems. (This study is realized with support of Cumhuriyet University CUBAP)