Abstract
Background: Breast cancer has recently become one of the most obsessing and life threatening issues in the world. Globally, females suffered mostly by breast cancer. Breast cancer is multifactorial etiological disorder. Trace elements are acts as cofactors and biological catalyst. They play a very essential role in the metabolic pathways.
 Methods: A cross sectional study with two hundred (200) subjects and divided into two groups. 50 females were normal healthy as a control while 150 females were patient with breast cancer. Blood was collected from all participant after taking history, clinical data, mammographic and histopathological findings. Consent and predesign porforma were filled by all participants of study. The trace elements (Na, K, Zn, Fe, Ca) were determined through atomic absorption spectrophotometer (ASS) and other biochemical analysis such as Total Protein, serum albumin and Total cholesterol were analyzed on Micro Lab.300. Data was entered on SPSS 22.0 version, and applied student t-test for continuous variables. Results were analyzed as Mean and standard deviation.
 Results: The results of serum Na+, K+, Ca++, Zn++, Cu++ and Fe in breast cancer patient were observed and found significantly fluctuated in breast cancer patients as compared to normal healthy subjects. Serum Total Protein significantly increased whereas serum Albumin decreased in patient with breast cancer.
 Conclusions: in Present study we found significantly abnormal concentration of Na+, K+, Ca++, Zn++, Cu++ and Fe in breast cancer these elements may contribute in early diagnosis of breast cancer. Increased body weight and total cholesterol are also risk factors of Ca breast.
Highlights
Breast cancer is most common and second leading cause of mortality in female worldwide [1,2]
The BMI, serum albumin, Total Protein and serum cholesterol analyzed in breast cancer patient as compared to normal healthy females
The biochemical parameters were analyzed, BMI and Total cholesterol and Total Protein level significantly increased in breast cancers patients, whereas albumin level was declined as compared to control subjects shown in Table 1 respectively
Summary
Breast cancer is most common and second leading cause of mortality in female worldwide [1,2]. Trace elements acts a cofactor in metabolic pathways in the human body [6]. Abnormal levels of trace elements lead to develop the breast cancer and responsible for the generation of reactive oxygen species (ROS). Fluctuation in the concentration of K+ either decreased or increased can cause adverse effect in human body, such as delayed reflex response, muscle weakness and paralytic disorders [9]. Many researchers observed higher concentration of albumin and total protein in diverse types of malignancies including breast and ovarian cancer [18,19]. The BMI, serum albumin, Total Protein and serum cholesterol analyzed in breast cancer patient as compared to normal healthy females. Trace elements are acts as cofactors and biological catalyst They play a very essential role in the metabolic pathways. Lakhan et al.; JPRI, 33(57B): 156-160, 2021; Article no.JPRI.78338
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
