Total Number Of Subjects Research Articles

P-412. Staphylococcus aureus Hand Colonization in 321 Adult Inpatients

Abstract Background Staphylococcus aureus (SA) hand colonization is understudied. Table 1. shows the total number of subjects with each stated characteristic, as well as the number and percent of subjects with each characteristic stratified among those with positive enrollment hand cultures and those with negative hand enrollment cultures. Methods We tested 328 adults in 2 general medicine hospital units < 3 days after admission, and for 219 of them < 2 days before discharge, for SA colonization of hands, nares, inguinal skin, and oropharynx, by direct plating and broth enrichment. Comorbidities were assessed by ICD-10 codes.Figure 1.Venn Diagram showing distribution of positive S. aureus enrollment cultures from 4 body sites in 138 colonized adult inpatients Venn diagram showing 138 of 328 (42.1%) study subjects who were found to have colonization with S. aureus at one or more of the following 4 body sites: throat (T), inguinal skin/groin (G), hand (H), or nares (N). Shows each study subject in a mutually exclusive group of single-site or multibody-site colonization. For example, 15 (4.6%) had only hand (H) colonization, while 26 (7.9%) had colonization at all 4 body sites. Results The median age was 57.5 years (IQR 39.5-70.5), 55.8% were male, 32.9% had diabetes mellitus, 78.4% had a cardiovascular diagnosis, median study enrollment was for 3 days (IQR 1-7) and 42.1% had SA colonization at 1 or more site. 36.0% (118/328) were administered 1 or more antimicrobial drug; IV vancomycin (32%) and cefepime (25%) were most common (Table 1). SA grew from 28.4% (91/321) of enrollment and 25.6% (56/219) of discharge hand cultures. Enrollment hand colonization (HCe) was associated with carriage at each other tested body site (p< 0.001). The nose was most (65/91, 71%) and the groin, least (42/91, 46%) commonly co-colonized with HCe (Fig. 1). Of those with groin colonization, 85% (42/49) also had HCe (Fig. 1). HCe was more common in younger patients (median 49 vs. 60 years, p=0.045) and in patients without circulatory disease (26/67, 38%, p=0.03). There was a non-significant trend toward lower rates of HCe among patients with an infectious diseases diagnosis (25/113, 22.1%, p=0.064). For those with HCe, hand colonization was present in 67% (37/55) tested at last culture, with a mean LOS of 7.6 days. Additionally, 11% (18/161) gained hand colonization at last culture (GHCLC) which was not associated with age, sex, race, any specific comorbid condition, duration of stay, nor IV vancomycin, cefepime, or metronidazole use. GHCLC was less likely for those who received ceftriaxone (0/40 vs. 17/115, p=0.007) during their hospital stay. Among 100 subjects tested at enrollment and 7 days, HCe persisted in 13/22 (59%) and was acquired by 8/78 (10%) others; 5/8 who gained hand colonization at 7 days were colonized at enrollment at another body site. Conclusion Hand S. aureus colonization is common in hospitalized adults, particularly among patients who were younger, had groin colonization, and those without circulatory disease. New hand colonization occurred before discharge and was less common in those who received ceftriaxone. Disclosures Michael Z. David, MD PhD, Covance: Grant/Research Support|GSK: Grant/Research Support|Johnson & Johnson: Advisor/Consultant

Comparing General Anesthesia-Based Regimens for Endovascular Treatment of Acute Ischemic Stroke: A Systematic Review and Network Meta-Analysis.

Total intravenous anesthesia (TIVA)-based and volatile-based general anesthesia have different effects on cerebral hemodynamics. The current work compares these 2 regimens in acute ischemic stroke patients undergoing endovascular therapy. We conducted a systematic literature search across MEDLINE, Embase, Cochrane, CINAHL, Web of Science, and Scopus. We identified English language studies including adult acute ischemic stroke patients managed with endovascular therapy under general anesthesia delineable into TIVA only and/or volatile only, and obtained categorical data for favorable functional outcomes using the modified Rankin scale (mRS ≤2), at 90 days after endovascular therapy. Odds ratios (OR) and standardized mean differences were calculated to inform a network meta-analysis approach, which permitted the inclusion of studies comparing a form of general anesthesia (ie, TIVA only or volatile only) to conscious sedation. The search rendered 6235 articles, of which 15 met inclusion criteria. Three studies directly investigated TIVA versus volatile, whereas 12 studies compared general anesthesia to conscious sedation. The total number of subjects was 3015 (conscious sedation: n = 1067; general anesthesia: n = 1948 [TIVA: n = 1212, volatile: n = 736]). No significant differences were identified between TIVA and volatile groups in 90-day neurological outcome (OR = 1.25, 95% confidence interval [CI], 0.81-1.91; P = .31), 90-day mortality (OR = 0.72, 95% CI, 0.42-1.24; P = .24), successful recanalization (OR = 1.33, 95% CI, 0.70-2.52; P = .39), or recanalization time (standardized mean difference = 0.03, 95% CI, -0.35 to 0.41; P = .88). Additionally, no significant differences were identified between the conscious sedation group and the TIVA group in 90-day neurological outcome (OR = 1.14, 95% CI, 0.84-1.53; P = .40), 90-day mortality (OR = 0.87, 95% CI, 0.62-1.23; P = .43), successful recanalization (OR = 0.76, 95% CI, 0.52-1.10; P = .15), or recanalization time (standardized mean difference = -0.18, 95% CI, -0.47 to 0.11; P = .23), and between the conscious sedation group and the volatile group in 90-day neurological outcome (OR = 1.42, 95% CI, 0.92-2.17; P = .11), 90-day mortality (OR = 0.63, 95% CI, 0.36-1.12; P = .11), successful recanalization (OR = 1.01, 95% CI, 0.52-1.94; P = .98), or recanalization time (standardized mean difference = -0.15, 95% CI, -0.52 to 0.23; P = .44). This network meta-analysis showed that the perioperative use of either general anesthesia-based regimen, or sedation, did not significantly impact various endovascular therapy-related outcomes. However, the current work was underpowered to detect differences in anesthetic agents, clinico-demographic characteristics, or procedural factors.

A systematic review of the clinicopathological characteristics of oral leiomyomatous hamartoma

BackgroundOral leiomyomatous hamartoma (OLH) corresponds to an abnormal, benign and disorganized overgrowth of mature smooth muscle tissue, which can develop in any site where this tissue is found in healthy conditions. The present systematic review aimed to analyze the clinicopathological characteristics of OLH.Materials and methodsThe protocol of this study was constructed following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and was registered in the Open Science Framework (OSF): OSF.IO/BMPUX. Five electronic databases were used to identify studies for this systematic review: PubMed, Web of Science, Dentistry & Oral Science Source, Scopus and ScienceDirect, from January 15th, 1945 to January 10th, 2024. The Joanna Briggs Institute (JBI) tool was used to assess the risk of bias and the quality of the included reports and case series.ResultsA comprehensive search yielded 5,562 articles, of which 55 met the inclusion criteria. The total number of subjects studied in the included investigations was sixty-six. The subjects’ ages varied from newborns to 61 years, with a mean age ± standard deviation of 71.23 ± 123.01 months. 50.7% were males and 49.3% were females. Most lesions presented normochromic color (24.24%), pedunculated base (31.81%), firm consistency (22.72%), with an average size of 1.20 cm, present on the dorsum of the tongue (31.81%) or anterior part of the alveolar border of the maxilla (30.30%). Treatment was carried out by surgical excision (78.46%) and half of the studies report that there were no recurrences.ConclusionsThe cases described in the medical-dental literature provide valuable information to date on the clinicopathologic and immunohistochemical profile of OLH. Although it is a rare lesion, it should be considered as part of the differential diagnosis in newborns, infants, children and young adults with lingual and/or maxillary masses present in the midline.

Minimally Invasive Distal Metatarsal Osteotomies for Metatarsalgia Treatment: A Review

Introduction: Metatarsalgia is a very common pathology in podiatric consultations, whose main aetiological factor is biomechanical alterations. Given the failure of conservative treatments, minimally invasive osteotomies of the distal metatarsal are becoming more popular, providing comparable results to open surgical techniques and with a lower rate of complications. Objectives: To determine clinical improvement and patient satisfaction after minimally invasive distal metatarsal osteotomy (DMMO) as a surgical treatment for central metatarsalgia at present. Methodology: The databases used for this systematic review were PubMed, Scielo, Cochrane Library, WOS and Scopus. We included articles that studied the efficacy of DMMO for primary metatarsalgia and excluded studies whose patients had more than one pathology or used other surgical techniques. Results: We identified 10 articles, 5 prospective studies, 4 retrospective studies and 1 cross-sectional, non-randomized, analytical study published between 2015 and 2021. The total number of subjects was 366, with a mean age of 61 years. The majority of subjects were women. They presented with symptomatology compatible with primary metatarsalgia for a minimum of 6 months and had failed conservative treatment. Conclusions: DMMO osteotomies for central metatarsals offer excellent post-surgical results for the treatment of central metatarsalgia in the assessment scales (AOFAS, MOXFQ etc.) of the articles analyzed and therefore an evident clinical improvement with benefits in terms of MTF mobility and reduction of surgical time, as well as a high degree of satisfaction in the patients who received this intervention that can be considered as excellent.

DEVIANT BEHAVIOR, SOCIAL FRUSTRATION, LOCUS OF CONTROL AND MEANINGFULNESS OF THE LIFE OF STUDENTS OF UNIVERSITY

The study focuses on identifying deviant behavior tendencies and personality traits of university technical students. The methods of “Tendency to deviant behavior” by A. N. Orel were used; “The level of social frustration” by L. I. Wasserman in the modification of V. V. Boyko; “Level of subjective control” by E. F. Bazhin, S. A. Golynkina, A. M. Etkind; Test “Meaningful orientations” by D. A. Leontyev. Data processing was carried out using primary statistics, Student’s t-test, Pearson correlation analysis. The study sample was made up of students of the 2nd and 3rd courses of technical specialties of the university. The total number of subjects was 59 people, of which 28 were girls and 31 were young men, the average age was 19 years. Differences are presented between indicators of deviant behavior, social frustration, locus of control and meaningfulness of life in university students and female students, as well as in students with high and low levels of meaningfulness of life. The relationships of the listed psychological phenomena among students and university students have been identified. The results show that girls have a greater tendency to demonstrate socially acceptable responses, to positive self-presentation. Young men manage their emotions more successfully, but show greater susceptibility to dependent, auto-aggressive and violent behavior. Young men have a higher internality in relationships with other people, which indicates their greater confidence in the ability to manage interpersonal relationships. Students with a high level of meaningfulness of life are more likely to show international personality traits, taking responsibility for their relationships and production activities. Students with a low level of meaningfulness of life have higher rates of social frustration. No common relationships were found in the female and male samples. Specific relationships for boys and girls were highlighted.

THE RELATIONSHIP BETWEEN ISOLATION, ACTIVITIES AND URBAN MOBILITY FOR THE ELDERLY DURING THE COVID-19 PANDEMIC

Objective: to identify the impact that the elderly population had during the quarantine on issues of social isolation, urban mobility and performance of instrumental activities of daily living. And as specific objectives: to carry out a comparative analysis between the mobility patterns of the elderly before and during the COVID-19 pandemic, to verify the impact of the reduction in urban mobility during the pandemic on the performance of their IADLs and to investigate symptoms of depression. Method: cross-sectional and quantitative study, carried out with 43 subjects from the interior of the state of São Paulo, with inclusion criteria of active individuals, with chronological age equal to or greater than 60 years, of both genders and, as exclusion criterion, diagnosis related to cognitive or physical impairments that compromised their functional independence. The instruments used for data collection were a questionnaire and the Yesavage Geriatric Depression Scale Abbreviated (GDS-15). Data analysis performed using statistics using the Statistical Package for the Social Sciences (SPSS version 18), McNemar's test and Pearson's chi-square test, with Yates' continuity correction, with a significance level of 5% (p < 0.05). Results: there was a predominance of female participants, 28 (65.12%), most aged between 70 and 79 years, totaling 23 (53.49%) and 25 (58.14%) married. Regarding education, 16 (37.21%) had higher education and 15 (34.88%) had elementary education. For 37 (86.05%) of the elderly, the frequency of visits to the places decreased during the pandemic, while for 4 (9.30%) it remained the same and for 2 (4.65%) it increased. With the pandemic, fewer individuals used the bus as a means of transportation, with the percentage going from 34.88% to 18.6%. Regarding car use, the number went from 72.09% to 79.07%. Regarding essential activities and social interaction, there was a decrease in individuals attending these places (p-0.04123) and (p-0.37110), respectively. The number of women with some indication of depression was higher during the pandemic (p-0.01333). Of the total number of subjects with depressive symptoms, 41.7% lived alone, while 58.3% lived with someone. Conclusions: The COVID-19 pandemic changed the daily lives of older adults, and this study contributed to identifying the impact of social isolation on urban mobility patterns and activity performance for the subjects. Highlighting the importance of seeking strategies and actions to overcome the possible consequences of this context for the health of older adults.

Consumption of fish and seafood in patients with type 2 diabetes mellitus according to nutritional status in Copiapó (Chile)

Chile has the third highest prevalence of diabetes mellitus America, with 12.7% of the population aged 20-79 years, whose 90% have type 2 diabetes mellitus(T2DM)(1). Diet plays an important role in the management of this disease(2). According to the 2016-17 National Health Survey in Chile, only 9.2% of the population consume fish and seafood (9.5% women and 8.8% men)(3). However, no studies have investigated the frequency of fish and seafood consumption in T2DM population from Chile, or whether consumption differs between normal weight, overweight, and obese subjects. This study aims to compare the frequency of fish and seafood consumption in normal weight, overweight, and obese subjects with T2DM in primary health care centres (PHCC) in CopiapóChile.A descriptive cross-sectional study was conducted in patients with T2DM, of both sexes, aged 3065 years, from the CODIACO cohort, recruited in PHCCs, during 2023. Pregnant and lactating women, diabetic neuropathy or nephropathy, cancer, and severe inflammatory or infectious diseases patients were excluded. Participants were administered a food consumption frequency questionnaire (never/rarely, occasionally and usually) of oily and white fish, and seafood. The nutritional status (normal-weight, overweight, and obese) was defined based on WHO criteria(4). The results on the frequency of food consumption were expressed as percentages and the age of the participants as mean and standard deviation. Chi-square test was used to study the relationship between the frequency of fish and seafood consumption and nutritional status. A Pvalue less than 0.05 was considered statistically significant. The CODIACO project was approved by the Scientific Research Ethics Committee of the Universidad de Atacama. Project funded by FONDECYT N°11180794.The mean age of the 153 participants, 106 women and 47 men, was 55.45 ± 7.56 years. Of the participants 9.8% were normal-weight, 32.0% were overweight and 58.2% were obese. Those who reported an usually consumption of oily fish according normal-weight (53.3%), overweight (28.6%) and obese patients (29.2%), were significant (P = 0.021). From the total number of subjects who never/rarely consumed oily fish, 2.2 % were normal-weight, 26.1% were overweight and 71.7% were obese. Regarding white fish, it was usually consumed by 46.7% of normal-weight, 32.7% of overweight and 29.2% of obese patients, but not significant (P = 0.059). Furthermore, white fish was never/rarely consumed by 5.1% of normal-weight, 23.1% of overweight and 71.8 % of obese subjects. Finally, seafood consumption reported was not significant (P = 0.571). Those who declare a never/rarely seafood consumption, 6.0% had a normal-weight, 30% were overweight and 64% were obese subjects.The results suggest that obese patients with T2DM in the PHCCs of Copiapó consume significantly less fish, especially oily fish, than normal-weight and overweight diabetic patients. A better oily fish consumption could be a protector factor to prevent obsesity in T2DM.

Comparison of oral disease symptoms according to eating habits of adolescents from Korean families and adolescents from multicultural families

Objectives: This study used the 18th Youth Online Health Behavior Data to compare oral disease symptoms according to the eating habits of adolescents from Korean families and adolescents from multicultural families. The total number of subjects was 40,913. Methods: The Rao-Scott chi-square test was used to compare general characteristics, eating habits, and experience with oral disease symptoms. In the final multiple logistic regression analysis, general characteristics and eating habits-related characteristics were used as correction variables to investigate eating habits related to oral disease symptoms in Korean adolescents and adolescents from multicultural families. Results: In Korean family the experience of oral disease symptoms was found to be lower when sweet drink 5-6 times a week 0.89 times, 3-4 times a week 0.77 times, 1-2 times a week 0.65 times, and 0.56 times when not consuming them than when consuming them daily. In multicultural families, the incidence of experiencing oral disease symptoms was 0.47 times lower in those who sweet drink daily than in those who consumed them 1-2 times a week, and 0.32 times lower in those who did not consume them. Conclusions: Based on the above research results, it is thought that customized nutrition education and oral health education programs should be continuously developed and utilized to promote oral health among adolescents from Korean families and multicultural families and to change their eating habits.

The association between dietary quality index- international and metabolic risk factors in RaNCD cohort study

BackgroundNon-communicable diseases (NCDs) are the leading cause of death around the world. The Dietary Quality Index-International (DQI-I) is one of the indicators that shows changes in diet and its association with NCDs. The aim of this study is to measure the association between the DQI-I and major metabolic risk factors.MethodsThis study is a cross-sectional study based on data collected in the first phase of the prospective cohort study on Ravansar non-communicable diseases (RaNCD). To perform clinical and biochemical tests such as lipid profile, blood glucose and liver enzymes, blood samples were collected using standard vacutainer blood collection techniques. Information from the food frequency questionnaire containing 118 food items was used to score each person’s DQI-I. Binary logistic regression was used to determine the association between the DQI-I tertile and the metabolic risk factors. Linear regression was also used for the association between subgroups of DQI-I score and the metabolic risk factors.ResultsThe total number of subjects in this study was 7,115, with a mean age of 47.14 ± 8.29 years. Dietary quality was generally poor, with 37.03% in the lowest tertile. Men had better dietary quality than women. Anthropometric measures, blood pressure, triglycerides and blood glucose were lower in the lowest tertile of dietary quality. A one-unit increase in the total DQI-I resulted in a 0.19 decrease in total cholesterol. Higher dietary quality was associated with a 22% increased risk of high triglycerides, a 19% increased risk of low high-density density lipoprotein, a 5% decreased risk of elevated low-density lipoprotein, a 42% increased risk of high blood pressure, and a 99% increased risk of high fasting blood glucose. Higher dietary quality was also associated with a 33% increased risk of overweight/obesity.ConclusionThe study found that participants had poor dietary quality, with some favorable metabolic outcomes in the lowest tertile, but concerning associations in the highest tertile, including increased risk for high triglycerides, blood pressure, and obesity. The complex associations suggest that balanced, multifaceted interventions are needed.

Correlation study between lipid profile parameters and liver function enzymes in Babylon province

Objective: The present study was an observational case control design. The data of study were collected in the period from first of January 2024 to March 2024. The study was conducted from clinical Laboratory private in Hilla City, Babylon province, Iraq. Material and methods: A total number of subjects involved in this study was 150 patients, from both sex (male and female) with age range (5-85). Blood samples were taken from each one to determination lipid profile tests (total cholesterol, total triglyceride, High and Low-density lipoprotein cholesterol and liver function tests (ALT, AST, ALP, TSB) and investigation the correlation between them. Results: The results showed that, these were significant correlation between these tests according to male groups, the strength and direction of the correlation between TC and TG levels. The value being significant suggests that there was a moderate strong relationship between these variables (0.491). A strong positive correlation between TC and LDL levels (0.799), HDL and ALP levels (0.290), ALT and AST levels (0.777). In addition, a positive association between AST and ALP levels (0.125), TC and LDL levels (0.799). On the other hand, a weak negative association TC and AST levels (0.045), TC and TSB levels (-0.185), TG and HDL levels (-0.04). TG and AST levels (-0.065), TG and TSB levels (-0.184), HDL and ALT levels (0.123), HDL and AST levels (-0.133), ALT and TSB levels (-0.08) and between ALP and TSB levels (-0.08). However, a moderate negative association between TG and LDL levels (-0.32) and a very weak negative association between HDL and TSB (-0.016). Conclusion: In male group, a strong positive correlation between TC and LDL levels, HDL and ALP levels, ALT and AST levels. A positive association between AST and ALP levels, TC and LDL levels, these were significant correlation between these tests according to female groups, the strength and direction of the correlation between TC and TG levels, a moderate strong relationship between these variables, TC and LDL levels, ALT and AST levels, ALT and ALP levels, ALT and TSB levels, AST and ALP levels, AST and TSB levels and ALP and TSB levels. And moderately strong negative correlation between HDL and ALT levels. So, a relatively weak positive correlation between LDL and AST levels in female group. Moderately positive correlation between LDL and ALP levels and between LDL and TSB levels.

Психологические барьеры инклюзивного взаимодействия как фактор риска для учащихся начальных классов

Introduction. The risks of an inclusive educational environment are associated with the emergence of psychological barriers to the interaction of its subjects. In this study, we provided the results of cluster analysis characterizing the psychological barriers to interaction between students and teachers. Methods. The total number of subjects is 192 people (128 children aged 8–10 years (primary school students - both with disabilities and limited health, and ordinary children from educational organizations in Stavropol); 64 teachers of educational organizations (schools)). As the main method we used J. Kelly's method of repertory lattices. Factor, cluster and correlation analysis were used to process the obtained data. Results. As a result of the study, the presence and essence of psychological barriers to interaction in dyads of subjects of the inclusive educational process were revealed: teachers-children, children-children. The qualitative characteristics of psychological barriers in these dyads are shown in the context of the types of barriers we have identified: communicative, activity and personal. In the teacher-children dyad, all types of barriers were identified, the sources of which are the teachers themselves. In the child-child dyad, communication and activity barriers predominate. The degree of severity of psychological barriers to interaction among teachers is concentrated in the range from excessive to average, and in the sample of children from above average to low. Discussion. The results obtained were considered as risk factors for the safety of the educational environment. For subjects of the inclusive educational process, the presence of psychological barriers leads to risks that hinder the success of educational outcomes and social integration.

Concurrent Validity of The U21 Men's Soccer Physical Test Battery

This study aims to test the validity of the U-21 men’s soccer physical test battery. The method used in this research is an evaluation approach. Data collection techniques in this research used tests and measurements. The subjects involved in this research were U-21 male soccer athletes in Papua. The total number of subjects participating in concurrent validity testing was 31 athletes. The instruments used in this research are body mass index (BMI) to measure body composition, sit and reach to measure flexibility, 30-meter sprint to measure speed, shuttle run to measure agility, leg and back dynamometer to measure muscle strength, and standing board. jump to measure explosive power, and the Multistage Fitness Test (MFT) to measure cardiovascular endurance. Validity testing uses a concurrent validity approach. The data analysis technique used in concurrent validity testing is using correlation product moment. This test is carried out by looking at the relationship between the tests on the first day and the second day. The results showed that each test item on the U-21 men’s soccer physical test battery had a calculated r value greater than the r table. Thus, it can be concluded that the U-21 Putra football physical test battery has a high validity value. Further research needs to test the reliability of the instrument to get a physical test instrument that meets the standards.

Fast algorithms of computing admissible intervals for discrete distributions with single parameter

It is of great interest to compute optimal exact confidence intervals for the success probability (p) in a binomial distribution, the number of subjects with a certain attribute (M) or the total number of subjects (N) in a hypergeometric distribution, and the mean λ of a Poisson distribution. In this paper, efficient algorithms are proposed to compute an admissible exact interval for each of the four parameters when the sample size (n) or the random observation X is large. The algorithms are utilized in four practical examples: evaluating the relationship between two diseases, certifying companies, estimating the proportion of drug users, and analyzing earthquake frequency. The intervals computed by the algorithms are shorter, and the calculations are faster, demonstrating the accuracy of the results and the time efficiency of the proposed algorithms.

Analysis of Maximal Volume of Oxygen for Gorontalo Contingent Martial Arts Athletes

This research analyzes Maximal Volume of Oxygen (VO2 Max) as the main variable to measure the aerobic capacity of martial arts athletes from the Gorontalo Contingent. This variable is important for understanding the level of cardiovascular fitness and physical endurance capabilities of athletes in facing training and competition. This research uses descriptive analytical research methods. The total number of subjects was nine athletes including four Taekwondo athletes, two Wushu athletes, one athlete Kickboxing, one athlete Karate and one athlete Muaythai. The instrument used in this research is the Bleep Test with classification norms using a bleep test calculator. Meanwhile, descriptive data analysis used SPSS 25 software. The results of this research for Taekwondo athletes were two above average, two were good. Wushu one average, one below average. Average kickboxing. Good karate. Muay Thai is average. In conclusion, Taekwondo athletes show a VO2 max that is generally higher compared to athletes from other disciplines. These results demonstrate the importance of personalized training programs to optimize cardiovascular fitness and performance in athletes. Further research with a more comprehensive approach is needed to strengthen and expand understanding of the influence of VO2 max on the performance of martial arts athletes.

A randomized, multicenter, open-label phase III trial of hyperthermic intraperitoneal chemotherapy in platinum-resistant recurrent ovarian cancer (KOV-HIPEC-02).

TPS5635 Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) during cytoreductive surgery has emerged to achieve a higher concentration of chemotherapeutic agents and treat micro-metastases on peritoneal surfaces. At advanced staged ovarian cancer treated with neoadjuvant chemotherapy, HIPEC during interval cytoreductive surgery with cisplatin 75-100mg/m2 increases progression-free survival and overall survival (OV-HIPEC-01 and KOV-HIPEC-01). In chemotherapy-naïve ovarian cancer patients, survival benefit is not identified with HIPEC (KOV-HIPEC-01). And the meta-analysis revealed the survival benefit after recent exposure of chemotherapy. In ovarian cancer, HIPEC is thought to overcome chemotherapy resistance. Methods: This trial (KOV-02) is currently actively enrolling, a multicenter, open-label, 1:1 randomized, phase III trial that will enroll 140 patients in platinum-resistant recurrent epithelial ovarian cancer. The trial is registered on ClinicalTrials.gov (NCT05316181). Institutional review board approval was obtained. The first patient was enrolled on April 07, 2022. The experimental arm will receive cytoreductive surgery and HIPEC (Doxorubicin 35mg/m2 and mitomycin 15mg/m2, 41.5-42.0°C) followed by physician-choice chemotherapy, and the control arm will receive physician-choice chemotherapy until disease progression or intolerable toxicity. The primary objective of the trial is to evaluate progression-free survival (PFS) between the HIPEC group and the control group. Secondary objectives are overall survival (OS), cancer-specific survival, safety, and quality of life. Assuming that the enrollment period is three years and the follow-up period is two years, the total number of events required is 121. Based on the log-rank test, the total number of subjects required to prove HR 0.6 with a two-sided alpha of 0.05 and 80% power is 126. Considering 10% drop-out, 140 patients are finally studied. Clinical trial information: NCT05316181 .

Rationale and study design of the KOV-HIPEC-04: A phase III randomized controlled trial in primary stage III and IV ovarian cancer after interval cytoreductive surgery (FOCUS).

TPS5636 Background: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) during interval cytoreductive surgery increases progression-free and overall survival for patients with stage III ovarian cancer in two randomized controlled trials (OV-HIPEC-01 and KOV-HIPEC-01) in the era of platinum. The aim of this trial is to identify the survival benefit of HIPEC in stage III & IV ovarian cancer with maintenance therapy of bevacizumab and/or PARP inhibitor. Methods: The KOV-HIPEC-04 trial is the international, multicenter, 1:1 randomized, phase III trial that will enroll 520 patients with stage III & IV ovarian cancer who received neoadjuvant chemotherapy. Patients with residual tumor < 2.5mm after interval cytoreductive surgery will be randomized to the trial arm (HIPEC, 41.0-42.0°C cisplatin 75mg/m2, 90 minutes) or control arm. After recovery from surgery, patients will receive postoperative platinum-based adjuvant chemotherapy followed by maintenance therapy with PARP inhibitor or bevacizumab by the institutional guideline based on BRCA/HRD status. The primary endpoint is to evaluate overall survival (OS); secondary objectives are progression-free survival (PFS), cancer-specific survival, time to the first subsequent therapy, safety, and quality of life. Assuming that the enrollment period is 5 years and the follow-up period is 3 years, the total number of events required is 263. Based on the log-rank test, the total number of subjects required to prove HR 0.67 with a two-sided alpha of 0.05 and 90% power is 494. Considering 5% drop-out, 520 patients are finally enrolled. ClinicalTrials.gov (NCT05827523). Clinical trial information: NCT05827523 .

From pediatric to adult care: a survey on the transition process in type 1 diabetes mellitus and the diabetes services in Italy.

The present study assessed the transitioning process of young adults with type 1 diabetes mellitus (T1D) in Italy. We asked Pediatric Diabetes Centers (PDC) and Adult Diabetes Centers (CAD) to fill in a web-based survey on the current state of services, the number of transitioning adolescents with T1D within the last year, observations on limitations, and future directions. 93 centers (46 PDCs, 47 CADs) joined the study. The total number of subjects with T1D being followed by a PDC was 16,261 (13,779 minors and 2483 young adults), while CADs had 25,500 patients. The survey showed an uneven situation. Only some services had a dedicated diabetes team (78% of PDCs, 64% of CADs). 72% of PDCs and 58% of CADs reported a protocol dedicated to transition. The median age for transition was 19 (range 16-25years); the time required for preparing transition, indicated by both PDCs and CADs, was 5.5months. A high percentage of CADs (80%) confirmed receiving sufficient clinical information, mainly through paper or computerized reports. The transition process is hampered by a lack of resources, logistical facilities, and communication between services. While some services have a protocol, monitoring of results is only carried out in a few cases. Most specialists expressed the need to enhance integration and continuity of treatment. The current situation could be improved. Applying standard guidelines, taking into consideration both clinicians' and patients' necessities, would lead to a more successful transition process.

Variations in Using Diagnosis Codes for Defining Age-Related Macular Degeneration Cohorts

Data harmonization is vital for secondary electronic health record data analysis, especially when combining data from multiple sources. Currently, there is a gap in knowledge as to how studies identify cohorts of patients with age-related macular degeneration (AMD), a leading cause of blindness. We hypothesize that there is variation in using medical condition codes to define cohorts of AMD patients that can lead to either the under- or overrepresentation of such cohorts. This study identified articles studying AMD using the International Classification of Diseases (ICD-9, ICD-9-CM, ICD-10, and ICD-10-CM). The data elements reviewed included the year of publication; dataset origin (Veterans Affairs, registry, national or commercial claims database, and institutional EHR); total number of subjects; and ICD codes used. A total of thirty-seven articles were reviewed. Six (16%) articles used cohort definitions from two ICD terminologies. The Medicare database was the most used dataset (14, 38%), and there was a noted increase in the use of other datasets in the last few years. We identified substantial variation in the use of ICD codes for AMD. For the studies that used ICD-10 terminologies, 7 (out of 9, 78%) defined the AMD codes correctly, whereas, for the studies that used ICD-9 and 9-CM terminologies, only 2 (out of 30, 7%) defined and utilized the appropriate AMD codes (p = 0.0001). Of the 43 cohort definitions used from 37 articles, 31 (72%) had missing or incomplete AMD codes used, and only 9 (21%) used the exact codes. Additionally, 13 articles (35%) captured ICD codes that were not within the scope of AMD diagnosis. Efforts to standardize data are needed to provide a reproducible research output.

Habits of healthy living in adults former athletes of federated competition in the modality of volleyball in the province of Jaen

The main objective of this research is to know the healthy lifestyle habits of people who participated in federated competitions in volleyball in the province of Jaén once their competitive stage has ended. Therefore, to investigate whether people who in their adolescence and youth practiced a federated competitive sport in volleyball, maintain healthy lifestyle habits, referring to diet, quality of sleep, level of physical activity practice and their physical condition, in their stage of adulthood and seniority. This research has been carried out though a descriptive, cross-sectional, single measurement (Ato et al., 2013), and interpretive research; in which former athletes responded to a questionnaire about their daily habits related to health; In addition, to know the information through self-completed surveys by those who were captains and technicians of the volleyball clubs, in order to better understand their current healthy habits. The total number of subjects studied was 199 people, of which 18 were captains and 21 were coaches. When asking people about their eating habits, the majority values correspond to the response option “good”, both in women (61.5%) and in men (48.8%). The different groups of participants in the research state that they attach great importance to eating habits, nutrition, and diet quality in their daily lives. 84.6% of women and 91.9% of men consider that their current level of physical fitness is based on the sports practice of their youth. Physical-sports practice as a healthy lifestyle habit is incorporated as a healthy lifestyle habit mostly in the former athletes and sports technicians participating in this research.

Effect of Random, Blocked, and Mixed Practice Order on Upper Extremity Motor Learning in Subjects with Parkinson’s Disease

Background: Random practice order has been shown to improve motor learning in normal individuals as well as sports players. The purpose of this study is to investigate which practice order is beneficial in subjects with Parkinson’s disease. Methodology: The total number of Subjects included in this study was 32. Blocked practice order followed by random followed by mixed practice order was given. In between washout period of 1 week was given. Response time during acquisition and retention was assessed. Data were analyzed statistically by using one-way ANOVA. Results: The mean time taken by the subjects was maximum with Random practice order with (p=0.001, SD= 10.73) during Acquisition and (p=0.003, SD=8.88). The mean time difference was maximum with random (p= 0.001) in both the acquisitions as well as retention phases. On comparing the difference between the 1st and 10th trials of all three practice orders by using Analysis of Variance (ANOVA) post hoc analysis by using Tukey’s test, we observed that in subjects with PD Random practice order is more beneficial than mixed and blocked respectively. Discussion: On comparing all three practice orders we can infer that Upper Extremity motor learning skill was superior with Random practice orders followed by Mixed and blocked practice orders respectively in both the acquisition and retention phases. KEYWORDS: Parkinson’s Disease, Motor Learning, Practice Order, Acquisition, Retention.