Objective of the study: To assess prescribing pattern of antihypertensive drugs use and adherence to various clinical guidelines in the Hospital. Materials and methods: A prospective observational study was carried out for a period of six months in the IPD and OPD tertiary care hospital. Prescriptions were analyzed during the study period. All the patients of age ≥ 20 (20-70 age) years with or without comorbidities, including males and females, who were diagnosed with hypertension as per JNC 8, ESH/ESC, NICE, STG, IHG, and receiving antihypertensive drugs were included. Discussion: The results of our study suggested that out of the total number of hypertensive patients (202) males were 54.45% witch females were 45.55%. Therefore, there was immensely need of proper awareness about the hypertension and its etiologies among the population especially of younger generation. In this scenario, clinical pharmacist could do a lot more for the patients and overall society because of their expertise in Pharmaceutical Care. Conclusion: Calcium channel blockers, Diuretics, ARB as monotherapy and ARB with CCB as combination therapy were the choices for the treatment of Hypertensive patients as a single drug and combination drug therapy. As per the JNC 8 & ESC/ESH guidelines majority of the prescription patterns were achieved and found optimal at the study site.