Ionization and fragmentation have been measured for C 60 molecules bombarded in the vapor phase by Xe 35+ and Xe 18+ ions with energies in the range 420–625 MeV. The CM energies exceeded those used in previous studies by several orders of magnitude. We present the observed mass distribution of positively charged fragments together with a theoretical model indicating that the total interaction cross section contains roughly equal contributions from (a) excitation of the giant plasmon resonance, and (b) large-energy-transfer processes that lead to multiple fragmentation of the molecule.