This paper presents preliminary results of laboratory tests conducted on small block samples of Topopah Spring tuff, in support of the Yucca Mountain Site Characterization Project. The overall objective of these tests is to investigate the thermal-mechanical, thermal-hydrological, and thermal-chemical response of the rock to conditions similar to the near-field environment (NFE) of a potential nuclear waste repository. We present preliminary results of deformation and elastic wave velocity measurements on a 0.5-m-scale block of Topopah Spring tuff tested in uniaxial compression to 8.5 MPa and at temperatures to 85°C. The Young's modulus was found to be about 7 to 31 GPa for vertical measurements (parallel to the stress direction) across parts of the block containing no fractures or a few fractures, and 0.5 to 0.9 GPa for measurements across individual fractures, at ambient temperature and 8.5 MPa maximum stress. During stress cycles between 5 and 8.5 MPa, the deformation modulus values for the matrix with fractures were near 15–20 GPa at ambient temperature but dropped to about 10 GPa at 85°C. Compressional wave velocities were found to be about 3.6 to 4.7 km/s at ambient temperature and stress. After the stress was cycled, velocities dropped to values as low as 2.6 km/s in the south end of the block where vertical cracks developed. Heating the block to about 85°C raised velocities to as much as 5.6 km/s in the upper third of the block.