In this paper, a frame structural topology optimization methodology for the generation of moment resisting braced frames for tall buildings, considering dynamic seismic loading, is presented. Real-world loading conditions along with standardized steel profiles of Euronorm are employed. In the literature, the studies that employ the ground structure topology optimization method are limited mostly to truss structures under static loading conditions. The dynamic response in the framework of structural topology optimization remains a challenging problem, especially when the ground structure method is used for deriving the structural system of tall buildings. The contribution of this study to the state of the art, relies on the implementation of the proposed methodology in the conceptual design phase of civil engineering frame structures, where both axial and flexural stiffness is considered. Direct time integration methods are used, to implement forced vibrations and real recorded earthquake data in the topology optimization procedure, resulting to novel layouts for lateral resisting systems of tall buildings. Aiming to aid the engineer to the final design phase, the response spectrum modal analysis is employed and the seismic loading is applied according to the Eurocode 8.