ABSTRACT The twisting force arm (TFA) is an important part of the pillar landing gear, anti-fatigue optimization on its structure can improve the reliability of the landing gear. However, the optimization accuracy of the conventional optimization method is limited by the basic topological structure from the views of topological theory. Besides that, the optimization efficiency of the conventional method is also relatively low because of the high computational cost of the fatigue life estimation. In this paper, an anti-fatigue optimization method of the TFA was developed to improve the optimization accuracy and efficiency by using the approximate sequential optimization method after an optimal basic topological structure was obtained. To verify its effectiveness, the proposed method was introduced to the anti-fatigue optimization of a pillar landing gear TFA. The results show that the optimization accuracy of the proposed method is higher than the conventional method, and the computational cost can be reduced 82.35%. This indicates that the proposed method can improve the optimization accuracy and efficiency of the anti-fatigue optimization.