The tooth bending fatigue fracture is caused by the alternating loads for the heavy-duty transmission gears. The crack initiation and propagation are the two major parts in the failure process. The crack propagation behavior is mainly affected by initial crack position except for the load and material properties. In this paper, the crack propagation model of a gear is established under the considering of crack initiation location by using extended finite element method (XFEM). The model accuracy is verified by testing results of strain and fractography by conducting the single-tooth bending fatigue experiment. The influence of crack initiation locations on subsequent crack propagation behavior is analyzed. The crack length in the tooth width direction and depth direction is faster when the initial crack is located in the middle of root surface. The crack growth rate is lower for the initial crack located in the surface close to the end surface of the gear.