Analysis Tools Research Articles

MPNG: A MATPOWER-Based Tool for Optimal Power and Natural Gas Flow Analyses

MPNG is an open-source simulation package for solving Optimal Power and Natural Gas Flow (OPNGF) problems. It is coded in <small>Matlab</small> and developed using the widely-used tool for power systems research and education, <small>Matpower</small>. MPNG assembles a nonlinear steady state OPNGF formulation for analyzing the integration of electricity and natural gas networks with order-of-priority classes of consumers and gas nodal price-controlled storage facilities. This paper presents the details of the nonlinear optimization model behind MPNG, as well as several features that were designed into it for the purpose of achieving robustness. These include an approximation of the Weymouth equation for handling bi-directional gas flows in pipelines, a per-unit representation for the natural gas network, and penalized slack variables for power and gas balances. Simulation results using a test case and the Colombian power and natural gas networks are presented to highlight MPNG&#x0027;s capabilities to solve OPNGF problems.

3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression.

Cancer genomes are composed of many complex structural alterations on chromosomes and extrachromosomal DNA (ecDNA), making it difficult to identify non-coding enhancer regions that are hijacked to activate oncogene expression. Here, we describe a 3D genomics-based analysis called HAPI (Highly Active Promoter Interactions) to characterize enhancer hijacking. HAPI analysis of HiChIP data from 34 cancer cell lines identified enhancer hijacking events that activate both known and potentially novel oncogenes such as MYC, CCND1 , ETV1 , CRKL , and ID4 . Furthermore, we found enhancer hijacking among multiple oncogenes from different chromosomes, often including MYC , on the same complex amplicons such as ecDNA. We characterized a MYC - ERBB2 chimeric ecDNA, in which ERBB2 heavily hijacks MYC 's enhancers. Notably, CRISPRi of the MYC promoter led to increased interaction of ERBB2 with MYC enhancers and elevated ERBB2 expression. Our HAPI analysis tool provides a robust strategy to detect enhancer hijacking and reveals novel insights into oncogene activation.

Refining ChatGPT-Generated Code: Characterizing and Mitigating Code Quality Issues

Since its introduction in November 2022, ChatGPT has rapidly gained popularity due to its remarkable ability in language understanding and human-like responses. ChatGPT, based on GPT-3.5 architecture, has shown great promise for revolutionizing various research fields, including code generation. However, the reliability and quality of code generated by ChatGPT remain unexplored, raising concerns about potential risks associated with the widespread use of ChatGPT-driven code generation. In this article, we systematically study the quality of 4,066 ChatGPT-generated programs of code implemented in two popular programming languages, i.e., Java and Python, for 2,033 programming tasks. The goal of this work is threefold. First, we analyze the correctness of ChatGPT on code generation tasks and uncover the factors that influence its effectiveness, including task difficulty, programming language, time that tasks are introduced, and program size. Second, we identify and characterize potential issues with the quality of ChatGPT-generated code. Last, we provide insights into how these issues can be mitigated. Experiments highlight that out of 4,066 programs generated by ChatGPT, 2,756 programs are deemed correct, 1,082 programs provide wrong outputs, and 177 programs contain compilation or runtime errors. Additionally, we further analyze other characteristics of the generated code through static analysis tools, such as code style and maintainability, and find that 1,930 ChatGPT-generated code snippets suffer from maintainability issues. Subsequently, we investigate ChatGPT’s self-repairing ability and its interaction with static analysis tools to fix the errors uncovered in the previous step. Experiments suggest that ChatGPT can partially address these challenges, improving code quality by more than 20%, but there are still limitations and opportunities for improvement. Overall, our study provides valuable insights into the current limitations of ChatGPT and offers a roadmap for future research and development efforts to enhance the code generation capabilities of artificial intelligence models such as ChatGPT.

Precisely Extracting Complex Variable Values from Android Apps

Millions of users nowadays rely on their smartphones to process sensitive data through apps from various vendors and sources. Therefore, it is vital to assess these apps for security vulnerabilities and privacy violations. Information such as to which server an app connects through which protocol, and which algorithm it applies for encryption, are usually encoded as variable values and arguments of API calls. However, extracting these values from an app is not trivial. The source code of an app is usually not available, and manual reverse engineering is cumbersome with binary sizes in the tens of megabytes. Current automated tools, however, cannot retrieve values that are computed at runtime through complex transformations. In this article, we present ValDroid , a novel static analysis tool for automatically extracting the set of possible values for a given variable at a given statement in the Dalvik byte code of an Android app. We evaluate ValDroid against existing approaches (JSA, Violist, DroidRA, Harvester, BlueSeal, StringHound, IC3, and COAL) on benchmarks and 794 real-world apps. ValDroid greatly outperforms existing tools. It provides an average F 1 score of more than 90%, while only requiring 0.1 s per value on average. For many data types including Network Connections and Dynamic Code Loading, its recall is more than twice the recall of the best existing approaches.

Phage-Displayed SH2 Domain Libraries: From Ultrasensitive Tyrosine Phosphoproteome Probes to Translational Research.

Tyrosine phosphorylation is a critical regulator of cell signaling. A large fraction of the tyrosine phosphoproteome, however, remains uncharacterized, largely due to a lack of robust and scalable methods. The Src homology 2 (SH2) domain, a structurally conserved protein domain present in many intracellular signal-transducing proteins, naturally binds phosphorylated tyrosine (pTyr) residues, providing an ideal scaffold for the development of sensitive pTyr probes. Its modest affinity, however, has greatly limited its application. Phage display is an in vitro technique used for identifying ligands for proteins and other macromolecules. Using this technique, researchers have been able to engineer SH2 domains to increase their affinity and customize their specificity. Indeed, highly diverse phage display libraries have enabled the engineering of SH2 domains as affinity-purification (AP) tools for proteomic analysis as well as probes for aberrant tyrosine signaling detection and rewiring, and represent a promising class of novel diagnostics and therapeutics. This review describes the unique structure-function characteristics of SH2 domains, highlights the fundamental contribution of phage display in the development of technologies for the dissection of the tyrosine phosphoproteome, and highlights prospective uses of SH2 domains in basic and translational research.

PLUME: Record, Replay, Analyze and Share User Behavior in 6DoF XR Experiences.

From education to medicine to entertainment, a wide range of industrial and academic fields now utilize eXtended Reality (XR) technologies. This diversity and growing use are boosting research and leading to an increasing number of XR experiments involving human subjects. The main aim of these studies is to understand the user experience in the broadest sense, such as the user cognitive and emotional states. Behavioral data collected during XR experiments, such as user movements, gaze, actions, and physiological signals constitute precious assets for analyzing and understanding the user experience. While they contribute to overcome the intrinsic flaws of explicit data such as post-experiment questionnaires, the required acquisition and analysis tools are costly and challenging to develop, especially for 6DoF (Degrees of Freedom) XR experiments. Moreover, there is no common format for XR behavioral data, which restrains data-sharing, and thus hinders wide usages across the community, replicability of studies, and the constitution of large datasets or meta-analysis. In this context, we present PLUME, an open-source software toolbox (PLUME Recorder, PLUME Viewer, PLUME Python) that allows for the exhaustive record of XR behavioral data (including synchronous physiological signals), their offline interactive replay and analysis (with a standalone application), and their easy sharing due to our compact and interoperable data format. We believe that PLUME can greatly benefit the scientific community by making the use of behavioral and physiological data available for the greatest, contributing to the reproducibility and replicability of XR user studies, enabling the creation of large datasets, and contributing to a deeper understanding of user experience.

A cognitive level evaluation method based on machine learning approach and Bloom of taxonomy for online assessments

Adaptive online learning can be realized through the evaluation of the learning process. Monitoring and supervising learners’ cognitive levels and adjusting learning strategies can increasingly improve the quality of online learning. This analysis is made possible by real-time measurement of learners’ cognitive levels during the online learning process. However, most of the currently used techniques for evaluating cognitive levels rely on labour-intensive and time-consuming manual coding. In this study, we explore the machine learning (ML) algorithms and taxonomy of Bloom’s cognitive levels to explore features that affect learner’s cognitive level in online assessments and the ability to automatically predict learner’s cognitive level and thus, come up with a recommendation or pedagogical intervention to improve learner’s acquisition. The analysis of 15,182 learners’ assessments of a specific learning concept affirms the effectiveness of our approach. We attain an accuracy of 82.21% using ML algorithms. These results are very encouraging and have implications for how automated cognitive-level analysis tools for online learning will be developed in the future.

Faktor yang Mempengaruhi Tingkat Kecurangan Karyawan PT. BUM Pabrik Perikanan Samudera Kendari

The purpose of this study is to provide empirical evidence of the influence of employee attitudes toward fraud on PT. BUM Kendari ocean fisheries, provide empirical evidence of the effect of pressure on the employee to fraud PT. BUM Kendari ocean fisheries, provide empirical evidence influence employees the opportunity to fraud at PT. BUM Kendari ocean fisheries, provide empirical evidence of the influence of employee capability to fraud at PT. BUM Kendari ocean fisheries, provide empirical evidence influence attitudes, the pressure occasion, and employee capability simultaneously to fraud on PT. BUM Kendari ocean fisheries. The population in this study were employees of PT. BUM Kendari ocean fisheries as many as 42 employees. The sampling technique using census method. Census method is sampling technique when all members of the population used as a sample. The analysis tool used is the Multiple Linear Regression Analysis. The results showed that There is a significant influence on the attitude (Rationalization) against fraud with a significance value of 0.045. There is a significant influence of pressure against fraud with a significance value of 0.008. There is a significant influence of opportunities against fraud with a significance value of 0.027. There is a significant influence on the capability of the fraud with a significance value of 0.002. There is a significant influence on the attitude (Rationalization), Pressure, opportunity and capability against fraud with a significance value of 0.009.

Optimizing the Performance and Governance of MSMEs in the Special Region of Yogyakarta Through Digitalization

A significant feature of technology is its capacity to change the routines and behavior of business players, especially MSMEs actors. MSMEs players in the Special Area have been impacted by the Covid-19 outbreak and are now looking to the MSMEs sector for business opportunities. It is necessary to overcome the difficulty of attaining the digitization of MSMEs. The fact that the MSMEs actors are not fundamentally and mentally equipped is another problem. The study's objective is to evaluate the effectiveness of using digital literacy, e-commerce, and skills as a tactic to enhance MSMEs governance and performance. The main sources of data for the study were imaginative MSMEs Daerah Istimewa Yogyakarta actors. The analytical unit of the study is the manager or owner of MSMEs in Daerah Istimewa Yogyakarta. In this study, primary data are gathered by a questionnaire. The sample size was established using a simple proportionate random sampling approach. The AMOS SEM analysis tool and a sample of 20% of all MSMEs in each district and city of the Daerah Istimewa Yogyakarta are used to achieve this. According to the study's findings, E-Commerce affects the MSMEs Governance, Digital Expertise affects MSMEs Governance and Performance, MSMEs Governance the performance of MSMEs. However, E-Commerce has no effect on the performance of MSMEs.

An improved IPA approach driven by big data and its application to customer satisfaction research of energy-saving appliance

Against the backdrop of increasing global demand for reducing greenhouse gas emissions, promoting the use of energy-saving and environmentally friendly products has become a crucial aspect of low-carbon economic development. Customer satisfaction plays a vital role in the promotion of these products. To address the challenges of dealing with big data in the conventional customer satisfaction analysis tool, Importance Performance Analysis (IPA), a machine learning-based method is proposed to improve IPA. Firstly, the Latent Dirichlet Allocation (LDA) model is used to capture users’ opinions on different product topics. Then, the Support Vector Machine (SVM) and Random Forest (RF) algorithms are employed respectively to assess the satisfaction and importance of product attributes, enabling an objective measurement of customer satisfaction and adapting to the current trend of big data. The proposed method is applied to the analysis of water heater satisfaction on the JD platform, obtaining satisfaction levels for 10 topics. The research findings demonstrate that the improved IPA method based on SVM-RF effectively explores customer satisfaction and can provide some improvement strategies for platform managers and manufacturers.

Linearized Models of the Coupled Rotorcraft Flight Dynamics and Acoustics for Real-Time Noise Prediction

This article demonstrates the linearization of the coupled rotorcraft flight dynamics and aeroacoustics to provide realtime acoustic predictions in generalized maneuvering flight. To demonstrate the methodology, the study makes use of a nonlinear simulation model of a generic utility helicopter (PSUHeloSim) that is coupled with an aeroacoustic solver based on a marching cubes algorithm. A periodic equilibrium of the coupled rotorcraft flight dynamics and acoustics is first found at a desired flight condition using a modified harmonic balance trim solution method. Next, the nonlinear time-periodic dynamics are linearized about that periodic equilibrium and transformed into an equivalent higher order linear time-invariant system in harmonic decomposition form. Composite aeroacoustic measures are included as an output of this system. To speed up runtime and make control design tractable, the order of these harmonic decomposition models is reduced via residualization to an 8-state model where the states are representative of the rigid-body dynamics of the aircraft. This 8-state model is shown to provide accurate acoustic response predictions for small-amplitude pilot inputs and to abate runtime by a factor of approximately 104, thus enabling acoustic predictions in generalized maneuvering flight that are significantly faster than real time. The 8-state model is subsequently used to demonstrate the use of linear system tools for the dynamic analysis of the coupled rotorcraft flight dynamics and acoustics.

Sliding-window cross-correlation and mutual information methods in the analysis of solar wind measurements

Context. When describing the relationships between two data sets, four crucial aspects must be considered, namely: timescales, intrinsic lags, linear relationships, and non-linear relationships. We present a tool that combines these four aspects and visualizes the underlying structure where two data sets are highly related. The basic mathematical methods used here are cross-correlation and mutual information (MI) analyses. As an example, we applied these methods to a set of two-month’s worth of solar wind density and total magnetic field strength data. Aims. Two neighboring solar wind parcels may have undergone different heating and acceleration processes and may even originate from different source regions. However, they may share very similar properties, which would effectively “hide” their different origins. When this hidden information is mixed with noise, describing the relationships between two solar wind parameters becomes challenging. Time lag effects and non-linear relationships between solar wind parameters are often overlooked, while simple time-lag-free linear relationships are sometimes insufficient to describe the complex processes in space physics. Thus, we propose this tool to analyze the monotonic (or linear) and non-monotonic (or non-linear) relationships between a pair of solar wind parameters within a certain time period, taking into consideration the effects of different timescales and possible time lags. Methods. Our tool consists of two parts: the sliding-window cross-correlation (SWCC) method and sliding-window mutual information (SWMI) method. As their names suggest, both parts involve a set of sliding windows. By independently sliding these windows along the time axis of the two time series, this technique can assess the correlation coefficient (and mutual information) between any two windowed data sets with any time lags. Visualizing the obtained results enables us to identify structures where two time series are highly correlated, while providing information on the relevant timescales and time lags. Results. We applied our proposed tool to solar wind density and total magnetic field strength data. Structures with distinct timescales were identified. Our tool also detected the presence of short-term anti-correlations coexisting with long-term positive correlations between solar wind density and magnetic field strength. Some non-monotonic relationships were also found. Conclusions. The visual products of our tool (the SWCC+SWMI maps) represent an innovative extension of traditional numerical methods, offering users a more intuitive perspective on the data. The SWCC and SWMI methods can be used to identify time periods where one parameter has a strong influence on the other. Of course, they can also be applied to other data, such as multi-wavelength photometric and spectroscopic time series, thus providing a new tool for solar physics analyses.

Learning Aligned Vertex Convolutional Networks for Graph Classification.

Graph convolutional networks (GCNs) are powerful tools for graph structure data analysis. One main drawback arising in most existing GCN models is that of the oversmoothing problem, i.e., the vertex features abstracted from the existing graph convolution operation have previously tended to be indistinguishable if the GCN model has many convolutional layers (e.g., more than two layers). To address this problem, in this article, we propose a family of aligned vertex convolutional network (AVCN) models that focus on learning multiscale features from local-level vertices for graph classification. This is done by adopting a transitive vertex alignment algorithm to transform arbitrary-sized graphs into fixed-size grid structures. Furthermore, we define a new aligned vertex convolution operation that can effectively learn multiscale vertex characteristics by gradually aggregating local-level neighboring aligned vertices residing on the original grid structures into a new packed aligned vertex. With the new vertex convolution operation to hand, we propose two architectures for the AVCN models to extract different hierarchical multiscale vertex feature representations for graph classification. We show that the proposed models can avoid iteratively propagating redundant information between specific neighboring vertices, restricting the notorious oversmoothing problem arising in most spatial-based GCN models. Experimental evaluations on benchmark datasets demonstrate the effectiveness.

Agile fusion: developing 'Eat at Right Place' sentiment analysis tool

This study presents the development and validation of the "Eat at Right Place Initiative," a sentiment analysis tool for restaurant reviews. Combining a user-centric approach with the Scrum framework, the mHealth agile development and evaluation framework was implemented, deviating from the initially considered Scrum framework. A multidisciplinary team navigated three phases, aligning sprints, goals, and backlogs. Phase 1 focused on product identification through interviews and surveys. Phase 2 involved development and alpha testing using a bidirectional encoder representation from transformers (BERT) rule-based sentiment analysis model. The final phase, beta testing, incorporated user feedback for usability enhancements. Ethical considerations were prioritized, ensuring participant consent and confidentiality. The study culminated in a robust aspect-based sentiment analysis model, effective in capturing nuanced insights from diverse restaurant aspects. Beta testing revealed actionable insights, marking the tool as fit for release. This sentiment analysis tool addresses consumer and owner needs, with iterative development and real-world testing laying the groundwork for future enhancements.

InVADo: Interactive Visual Analysis of Molecular Docking Data.

Molecular docking is a key technique in various fields like structural biology, medicinal chemistry, and biotechnology. It is widely used for virtual screening during drug discovery, computer-assisted drug design, and protein engineering. A general molecular docking process consists of the target and ligand selection, their preparation, and the docking process itself, followed by the evaluation of the results. However, the most commonly used docking software provides no or very basic evaluation possibilities. Scripting and external molecular viewers are often used, which are not designed for an efficient analysis of docking results. Therefore, we developed InVADo, a comprehensive interactive visual analysis tool for large docking data. It consists of multiple linked 2D and 3D views. It filters and spatially clusters the data, and enriches it with post-docking analysis results of protein-ligand interactions and functional groups, to enable well-founded decision-making. In an exemplary case study, domain experts confirmed that InVADo facilitates and accelerates the analysis workflow. They rated it as a convenient, comprehensive, and feature-rich tool, especially useful for virtual screening.

Функционально-трудоемкостный анализ кадровых процессов системы менеджмента качества организации

The article discusses an approach to improving personnel (supporting) processes in the organisation’s quality management system based on the methodology tool modification of the functional-cost analysis (FCA) and the qualimetric substantiation of critical indicators of the studied process function parameters. The paper analyses tools and technologies for structuring, correcting, and improving personnel processes in the organization’s quality management system as well as problems associated with their application in practice. The expediency for operational determination of the direction for improving the personnel process quality is substantiated by studying a limited number of their parameters. Importance (significance) and labour intensity of personnel process functions are considered as the studied parameters. A procedure for functional and labour-intensive analysis (FLIA) is proposed, which is the personnel process improvement based on analysing the importance-labour intensity ratio of function implementation, allowing the process owner to quickly obtain information about the process state. The procedure of functional and labour-intensive analysis is considered through the approbation on the example of the personnel process “Personnel Recruitment.” Critical indicators of “Personnel Recruitment” structure are compared with similar indicators obtained based on applying functional-cost analysis to the process under consideration. The article argues for the promising use of the proposed procedure for enhancing the personnel processes of the organization’s quality management system, aimed at identifying the direction for their improvement.

Impact of internal pre-damage due to drying shrinkage under various humidity conditions on DEF expansion in cement paste and mortar

This study explores the impact of internal pre-damage from early drying shrinkage on the delayed ettringite formation (DEF) expansion behavior of cement-based materials subjected to high-temperature processes. Specimens of cement paste and mortar with water-cement (W/C) ratios of 0.4, 0.5, and 0.6 were characterized after curing under relative humidity (RH) conditions of 50, 70, and 100 for 56 days. The parameters assessed were drying shrinkage, dynamic elastic modulus, and free water content. Subsequent DEF expansion over time was quantified, and the underlying mechanism was analyzed using XRD and SEM techniques after 270 days of underwater curing. Results indicate that: (1) a lack of adequate early curing humidity significantly reduces the dynamic elastic modulus with more than a 10% drop in cement paste following 56 days at RH50; (2) a higher W/C ratio and lower early curing humidity lead to more internal damage due to shrinkage, thereby promoting DEF expansion; (3) drying intensifies internal pre-damage in the interfacial transition zone (ITZ), causing an earlier deterioration of DEF expansion in mortar compared to cement paste. However, the presence of aggregates constrains this, leading to lesser DEF expansion in mortar; (4) dynamic elastic modulus changes as measured by ultrasonic methods can quantitatively characterize the extent of deterioration caused by DEF expansion, thus offering a tool for non-destructive testing and DEF expansion deterioration analysis.

Misuse of XPS in Analyzing Solid Polymer Electrolytes for Lithium Batteries

One of the most powerful spectroscopic tools for battery analysis is X-ray photoelectron spectroscopy (XPS); however, its great power, must be accompanied by great responsibility for authenticity. Fluorine is documented to be unstable under XPS conditions, and fluorinated salts used in Li batteries show photodecomposition. As all-solid-state batteries advance, demand for surface characterization is increasing. Here, a popular solid polymer electrolyte comprising a fluorinated salt in a PEO matrix was measured by XPS. Rapid photodecomposition after few minutes produced mainly LiF, initially not found on the surface. Not being aware of such artifacts may lead to an erroneous analysis of the characterized electrochemical system.

Abstract 7426: The GenePattern ecosystem for cancer bioinformatics

Abstract As the availability of genomic data and analysis tools from large-scale cancer initiatives continues to increase, with single-cell studies adding new dimensions to the potential scientific insights, the need has become more urgent for a software environment that supports the rapid pace of cancer data science. The GenePattern ecosystem, first introduced in 2004 and updated continually to support the changing needs of cancer genomics research, supports the analytical, computational, and reproducibility needs of the world-wide cancer analysis community.The GenePattern server, available at www.genepattern.org, provides hundreds of analysis methods for scientists at all levels of computational sophistication, with the only requirement for use being a web browser. The GenePattern server offers bulk and single-cell RNA-seq, copy number variation, flow cytometry, network analysis, general machine learning, gene set enrichment analysis, proteomics, and many other modalities. Analysis steps can be linked together into pipelines that can then be edited, shared, and made public. All parameters of an analysis, including the code version, are recorded so that an analytical result can be reproduced at any point in the future.The GenePattern Notebook system, notebook.genepattern.org, is an integration of the Jupyter Notebook environment with the GenePattern server. It combines the research narrative capabilities of Jupyter with the non-programming approach and breadth of analyses available in GenePattern. Scientists using GenePattern Notebook can create documents that include richly-formatted text and multimedia, executable code, and GenePattern analyses. A single GenePattern notebook can therefore comprise a sophisticated analytical workflow that runs on multiple remote servers.We have recently expanded GenePattern Notebook into a new notebook environment, Genomics to Notebook, g2nb.org, which adds the ability to include analyses on any public Galaxy server as well as using the Integrative Genomics Viewer (IGV) and Cytoscape within notebooks. Each analysis or visualization appears a cell within a notebook, preserving the accessibility and ease of use of the notebook metaphor while retaining the essential aspects of each tool’s user interface. When run, the entire analysis appears to execute seamlessly within the notebook. The online workspace also includes a library of featured genomic analysis notebooks, including templates for common analysis tasks as well as cancer-specific research scenarios and compute-intensive methods. Scientists can easily copy these notebooks, use them as is, or adapt them for their research purposes. Citation Format: Michael M. Reich, Thorin Tabor, John Liefeld, Edwin Huang, Forrest Kim, Jill P. Mesirov. The GenePattern ecosystem for cancer bioinformatics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7426.

Abstract 920: Insights from the National Cancer Institute’s request for information on existing data sharing processes for NIH-funded research

Abstract Data sharing plays a crucial role in accelerating biomedical research discoveries, promoting rigorous and reproducible research, enabling research data reuse, and fostering public trust. To facilitate data sharing, a coordinated, sustainable, and streamlined infrastructure is required to store, preserve, retrieve, and make data findable, accessible, interoperable, and reusable. Starting January 25, 2023, researchers funded by the National Institutes of Health (NIH) are required to comply with the NIH Data Management and Sharing Policy (https://sharing.nih.gov/data-management-and-sharing-policy/about-data-management-and-sharing-policies/data-management-and-sharing-policy-overview) and indicate how research data funded by the NIH will be managed and broadly shared. As institutions prepare to meet these requirements, the National Cancer Institute (NCI) is looking to understand the existing processes of data storage, preservation, and sharing including what infrastructure and services are available to facilitate data sharing. To carry out this goal, the NCI’s Office of Data Sharing (ODS), dedicated to promoting responsible and efficient sharing of cancer research data, issued a Request for Information (RFI) to understand the existing data sharing processes for NIH-Funded Research. The RFI was designed to collect information on services (e.g. guidance on data standards and file formats), technologies (e.g. storage, compression, retrieval, archival, analysis tools, workbenches), and processes (e.g. governance, communication, education, outreach) that promote data sharing. ODS utilized the RFI to gather input from stakeholders involved in facilitating data sharing. This included personnel from various fields such as research laboratories, scientific instrumentation core facilities, offices of research and/or sponsored programs, provost offices or other research administration, libraries, information technology, and institutional review boards. We also engaged with bioinformaticians and data scientists who are actively contributing to data curation, formatting, and analysis. Here, we present analysis of the responses received, including insights relating to gaps and challenges in data sharing, and proposed next steps and recommendations. Citation Format: Mousumi Ghosh, Nathan Boyd, Subhashini Jagu. Insights from the National Cancer Institute’s request for information on existing data sharing processes for NIH-funded research [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 920.