Tonsillitis In Children Research Articles

Role of OM-85 BV in the prevention of recurrent acute tonsillitis: a retrospective study and literature review

BackgroundThis study aims to assess the effectiveness of OM-85 BV in treating recurrent acute tonsillitis in children and adults during the first year after treatment, as well as to identify response predictors.ResultsThe study included 92 patients, and there was a significant decrease in the number of acute tonsillitis cases after OM-85 BV treatment (p < 0.001). Exposure to tobacco smoke predicts non-response or partial response to treatment (OR 5.24, p = 0.005, 95% CI 1.646–16.671/OR 4.57, p = 0.014, 95% CI 1.362–15.339).ConclusionsThe study concludes that OM-85 BV is effective in preventing new episodes of tonsillitis in patients with a history of recurrent acute tonsillitis. Patients exposed to tobacco smoke tend to have a poorer response to treatment.

Еffectiveness of immunocorrective therapy for frequently ill children

Introduction. All acute respiratory infections are characterized by damage to the mucous membrane of the respiratory tract, a decrease in local immune defense and a weakening of nonspecific protective factors.Aim. To characterize the clinical effectiveness of the use of the immunocorrective drug in frequently ill children.Materials and methods. The article assessed the microbiological spectrum of the rhinopharyngeal landscape in 65 children: 33 children took an immunocorrective drug in addition to conventional therapy – the main group; 32 children received conventional therapy (the comparison group), and also investigated the possibility of regulating their polypathogenic microbiota using topical bacterial lysates.Results and discussion. The result of the therapy was a clinical improvement characterized by the relief of pharyngoscopic signs of chronic tonsillitis in children while taking topical bacterial lysates in form of lozenges. Analysis of the microbiota of the oropharyngeal mucosa in the studied patients of both groups before the start of therapy revealed the species diversity of opportunistic flora, among which Streptococcus pyogenes, Staphylococcus aureus, the family Enterobacteriaceae and Candida albicans were identified in all patients in diagnostic significant titers of 105–1010. After treatment in the main group, the ratio of the microbiota of the nasopharynx significantly changed, stimulation of the production of local immunity components was noted, which was confirmed by a decrease in the intensity of contamination of microbiota with polypathogenic functions to diagnostically insignificant titers. When comparing the species composition of the microbiota in the studied groups after treatment with topical bacterial lysates, a statistically significant positive effect was found without additional use of antibacterial drugs.Conclusions. It has been shown that the immunocorrective drug eliminates pharyngoscopic signs of rhinopharyngeal dysbiosis in children who are often and long-term ill.

CHARACTERISTICS OF TONSILLITIS PATIENTS IN CHILDREN AT UNIVESITAS KRISTEN INDONESIA HOSPITAL, 2010-2017

Tonsillitis is a common disease in Ear Nose Throat (ENT) clinic, especially in the age of children and adolescents. Tonsillitis is inflammation of the palatine tonsils caused by bacteria, viruses or other immunological factors. The research is to find the characteristic of patients tonsillitis at Christian University of Indonesia Hospital. Method: This research uses descriptive method with retrospective approach done at Christian University of Indonesia General Hosipital with sample number of 40 patient. Statistical data checks using SPSS version 25. Result: Based on the medical record data obtained patients tonsillitis in children most often in the age group 0-6 62.5%, male gender 55%, have good nutrition status 57.5%, the main complaints of sorethroat 60%, size of T2-T2 tonsils 40%, medical diagnosis is acute tonsilitis 75%, medical treatment 77.5%. Conclusion: The profile of patients with tonsillitis in children was predominantly in the age group 0-6 years, male gender with good nutritional status had major complaints was swallowing pain, tonsils size T2-T2 and diagnosed acute tonsillitis. Medicamentous administration was an option in the treatment of tonsillitis.

Expert consensus-based clinical recommendation for an integrative anthroposophic treatment approach to acute tonsillitis in childhood

BackgroundMedical guidelines are an important basis for qualitative and cost-effective patient care. However, there is a lack of clinical recommendations in anthroposophic medicine (AM), an integrative medicine approach frequently practised in Europe. Acute tonsillitis, which includes tonsillopharyngitis, is a common childhood disease. that is mostly caused by a viral infection. Symptomatic treatment is therefore of high importance, and AM can offer several therapy options. Methods53 physicians from Germany, Spain, Netherlands, Switzerland, Austria, and Hungary with at least one year of experience in anthroposophic paediatric medicine were invited to participate in an online Delphi process. The process comprises five survey rounds starting with open-ended questions and ending with final statements, which need 75% agreement of experts to reach consensus. Expert answers were evaluated by two independent reviewers using MAXQDA and Excel. ResultsResponse rate was between 28% and 45%. The developed recommendation included 15 subtopics. These covered clinical, diagnostic, therapeutic and psychosocial aspects of acute tonsillitis. Six subtopics achieved a high consensus (>90%) and nine subtopics achieved consensus (75–90%). ConclusionThe clinical recommendation for acute tonsillitis in children aims to simplify everyday patient care and provide decision-making support when considering and prescribing anthroposophic therapies. Moreover, the recommendation makes AM more transparent for physicians, parents, and maybe political stakeholders as well.

Effect of Vyaghri Haritaki Lehya in Chronic Tonsillitis in Children of the Age Group 3-12 Years

Tonsillitis is the inflammation of the tonsils. The tonsils are two small glands on either side of the throat. The tonsils play a key role in helping the body to protect against infection. This is especially in young children, whose immune system is still developing. The tonsils act as a barrier, trapping an infection and stopping it spreading to other parts of the body. In Ayurveda tonsillitis is correlated with Tundikeri, the disease of Talu (palate) and Kantha (throat), both of which are the Avaranas (establishment) of Mukharoga (diseases of mouth). Although no specific formulation for Tundikeri is given and surgical treatment is described for the disease, many formulations for Mukharogas (mouth disorders) are effective in Tundikeri. Vyaghri haritaki lehya is described by Bhaishajya Ratnavali and Chakrvadatta. It is also included in Bhava Prakasha, Yoga Ratnakara, Gada Nigraha, Vanga Sena samhita and Bharat Bhaishajya Ratnakar. A case study of 20 children on chronic tonsillitis done using Ayurveda medicine to improve general health.. Internal administration of Vyaghri haritaki lehya, the dose was 5gm for children between 3 to 6 years and 10gm for children between 7 to 12 years with lukewarm water as adjuvant, for a period of 60 days given. Follow up done after a period of 30 days.

Immunotherapy in the treatment of chronic tonsillitis

Chronic tonsillitis is one of the most common diseases in children. The aim of the work was to study the feasibility of using OM-85 for the treatment of chronic tonsillitis in children. The study was conducted on the basis of four polyclinics in Rostov-on-Don. We studied 126 children aged 3 to 6 years with chronic tonsillitis. The control group consisted of 15 healthy children of the same age. All children underwent a course of preventive treatment with OM-85 according to the standard scheme. The results of treatment were assessed by indicators of local and systemic immunity, as well as clinically, i. e. observing the change in frequency of acute tonsillitis. As a result of the treatment, both clinical and immunological signs of improvement were registered.

Efficacy of Tonsenorm Compound in the management of Tundikeri with special reference to Chronic Tonsillitis in Children

Introduction: Tonsillitis is one of the most common infectious conditions in the paediatric age group. Symptoms such as pain or tenderness in the throat, fever, tonsillar swelling with a white or yellow coating, painful blisters or ulcers on the throat, headache, loss of appetite, ear pain, trouble swallowing, bad breath, a scratchy or muffled voice, and a stiff neck mentioned in this disease. Ayurveda addresses the problem of Tundikeri, similar to chronic tonsillitis with internal medicines and external therapies. Tonsenorm compound is such a herbomineral formulation formulated with extract a set of nine drugs. Aim of the proposed study is to evaluate the efficacy of the Tonsenorm compound in Tundikeri. Material and Methods: The present study is planned to be conducted under the strict protocol of an open-label clinical trial, in 40 patients. Tonsenorm compound will be given for 60 days at 250 mg thrice a day. Assessment of the patients will be done on the basis of subjective parameters with a grading/scoring system on every 15th day during the study, with a post-intervention follow-up after 1 month. Results: The result will show the effectiveness of the trial drugs, which will be economical and safe for long-term use in the patients of Tundikeri. Discussion &amp; Conclusion: The outcome of this herbomineral drug change in scoring/ grading of symptoms of Tundikeri /chronic tonsillitis (will be assess after the completion of the trial work).

Analysis of clinical and paraclinical findings in children with community-acquired pneumonia and comorbid chronic tonsillitis

Background. Respiratory morbidity is the most frequent cause for children consulting a doctor, accounting for about one-quarter of primary care consultations. The current research aimed to analyze the clinical and paraclinical features of community-acquired pneumonia (CAP) with comorbid chronic tonsillitis in children and to assess the prognostic value of the proposed diagnostic procedures to optimize the management of patients. Materials and methods. The study was conducted at the Pulmonology and Allergology and Infectious Department of the Municipal Medical Establishment “Chernivtsi Regional Children’s Clinical Hospital”, Ukraine. Clinical group I included 20 children (mean age 9.40 ± 1.56 years) with uncomplicated community-acquired pneumonia and concomitant chronic tonsillitis, and the clinical group II consisted of 16 patients (mean age 9.60 ± 1.13 years) with CAP without concomitant pathology of the upper respiratory tract. Results. Community-acquired pneumonia in children with comorbid chronic tonsillitis is characterized by an intense proinflammatory response in the airways, which manifests itself in fever (odds ratio (OR) 6.0), malaise and fatigue (OR 14.3), persistent cough and dyspnea (OR 3.7), leukocytosis (OR 2.0), high levels of acute phase proteins (OR 4.5), activation of the oxidative protein modification according to the exhaled breath condensate examination (OR 6.0–30.0), and more frequent fungal-bacterial association according to the microbiological examination of sputum and oropharyngeal swab (OR 11.1). The obtained data suggest that parenteral antibiotic therapy was used in 20 % of patients from group I and 12.5 % from group II, while 6.3 % of children from group II received only oral antibiotics. In children with CAP and chronic tonsillitis versus comparison group, the ОR of receiving parenteral antibiotic therapy for longer than 7 days reached 10.0, and the OR of oral antibiotic therapy for longer than 5 days reached 4.0. Conclusions. The results obtained from the study show that children with CAP and comorbid chronic tonsillitis have more pronounced clinical symptoms, accompanied by paraclinical signs of inflammation that last longer during hospital treatment and require comprehensive therapy (OR 3.3) of longer duration (OR 4.0–10.0).

Complementary and alternative medicine in the (symptomatic) treatment of acute tonsillitis in children: A systematic review.

Acute tonsillitis (including tonsillopharyngitis) in childhood is a common disease with a peak of illness in school-age. Most of these cases have a viral origin and antibiotic therapy is not indicated, therefore, effective symptomatic therapy is required. For this reason, complementary, alternative and integrative medicine therapies might be a solution. The aim of this review is to demonstrate study status of such therapies. The databases PubMed, Cochrane Library, OVID, CAMbase, CAM-QUEST® and Anthromedics were systematically screened for studies investigating complementary, alternative and integrative therapy approaches in paediatric cohorts. Studies were analyzed by therapy approach, study design, cohort and outcome, using the PRISMA 2020 checklist. The systematic literature search resulted in 321 articles. Five publications corresponded to the search criteria and were assigned to the following specific therapeutic categories: herbal medicine (3), homeopathy (1) and ayurvedic medicine (1). Clinical trials were found for the herbal compounds BNO 1030 (Impupret®) and EPs® 7630 (Umckaloabo), the homeopathic complex Tonzolyt® and the ayurvedic medicine Kanchnara-Guggulu and Pratisarana of Tankana‑Madhu. Antimicrobial effects of essential oils and carvacrol as single agents as well as in combination with erythromycin were analysed in an in vitro study. Clinical studies indicate an improvement of symptoms and a good tolerability of all investigated remedies of complementary, alternative and integrative medicine in the treatment of tonsillitis in childhood. Nevertheless, quality and quantity of the studies were insufficient to make a reliable conclusion regarding effectiveness. Therefore, more clinical trials are urgently needed to achieve a meaningful result.

A comparison of platelet indices in children with urinary tract and tonsillitis infection

Introduction and Aim: Platelet indices are used as diagnostic markers in many diseases and disorders. Urinary tract infections and tonsillitis are common among children. In this study we aimed to investigate whether platelet indices could be used as a marker of UTI and tonsillitis in children. Materials and Methods: This study included 120 children aged between 1-10 years, who were divided into 3 groups (G1-G3). The group G1 included children suffering from UTI (n=40), G2 with only tonsillitis (n=40) and G3 only healthy children (n=40). UTI and tonsillitis were diagnosed based on different parameters including C - reactive protein, erythrocyte sedimentation rate and complete blood counts. The platelet indices (PLT count, MPV, PDW, PCT, P-LCR, P-LCC) were measured using an automatic CBC blood counting and analysis machine. Results: The results in this study showed a high significant increase in (127.22), (7.179), (0.122) platelet count, PDW % and PCT% respectively and non-significant increase of P-LCC count. The results also revealed a high significant decrease in values of MPV, PDW and P-LCR (2.210), (2.315) and (6.427) respectively. Conclusion: Our study suggests the platelet indices could be used as a diagnostic marker in diagnosing urinary tract infection and tonsillitis in children.

Peritonsillar abscesses in children with non-angina form of chronic tonsillitis

In recent years, there has been a marked increase in the number of peritonsillar abscesses not only in adults, but also in children. The aim of the work was to study the frequency of PA in non-angina form of chronic tonsillitis in children. We observed 116 children with chronic tonsillitis who underwent tonsillectomy in the period from September 30, 2017 to September 8, 2020. A peritonsillar abscess was observed in 19 % of children subjected to tonsillectomy, and in 8 of 22 patients (36 %) there were no indications of anamnesis of acute tonsillitis, although histological signs of chronic inflammation were found in the removed tonsils, which makes it possible to characterize the existing pathology as a non-angina form of chronic tonsillitis.

Formulation and standardization of Peetha Saireyaka tablet – A novel Ayurvedic drug to combat Chronic tonsillitis in children

Introduction: Peetha Saireyaka tablet (PST) is a herbal formulation widely used in Ayurvedic clinical practice with multi fold benefits, specifically to combat chronic tonsillitis in children. There is no work on record on formulation and standardization aspect of herbal drug, Peetha Saireyaka tablet. This paper highlights the preparation, physico-chemical characterization, TLC and HPTLC densitogram profiling of Peetha Saireyaka tablet which can be applied for authentication of this herbal formulation. Methods: The roots of Peetha Saireyaka (Barleria prionitis Linn.) were authenticated botanically. The tablets were prepared at certified pharmacy and subjected for detailed physico-chemical and HPTLC analyses. Results: Set of standardization parameters were derived for Peetha Saireyaka tablet by physico-chemical characterization. The tests proposed would serve as diagnostic parameters for the identity of this herbal formulation. HPTLC fingerprint profile which can serve as a fingerprint for the identification of the formulation has been obtained. Conclusion: The proposed method of making tablet from roots of Peetha Saireyaka (Barleria prionitis Linn.) will aid in yielding concentrated medicament with the same efficacy as per the classically proposed drug dosage at lower dose. Standards for the herbal formulation has been developed for the quality check of the formulation.

Assessment of changes in Streptococcus pyogenes levels using N-acetylgalactosamine-6-sulfatase marker and pharyngeal airway space with appliance therapy in mouth breathers - An ELISA-based study.

The frequency of adenotonsillar hypertrophy in mouth-breathing children when compared to the average found in the general population is considered to be higher. Mouth breathing is considered as one of the causative factors for tonsillitis in children. Through continuous irritation on tonsillar wall, tonsils swell up and inflammation develops. The purpose of the study is to evaluate Streptococcus pyogenes count using colony-forming units (CFUs) and N-acetylgalactosamine-6-sulfatase side chain marker on ELISA (enzyme linked immunosorbent assay) in mouth breathers and to establish its correlation with pharyngeal airway space pre- and post-oral screen appliance therapy. A total number of 24 (n) mouth breathers aged between 5 and 12 years were included in the study and given oral screen appliance therapy. The subjects were evaluated for the various parameters before the delivery of a habit-breaking appliance and then reevaluated for the same parameters (presence of S. pyogenes and its counts, size of tonsils, and pharyngeal airway space dimensions) after 6 months of appliance usage. A statistically significant difference was seen in levels of S. pyogenes using ELISA and CFUs. Furthermore, statistically significant difference was observed in Friedman tonsil scoring and pharyngeal airway space and pre- and post-oral screen appliance therapy. Oral screen appliance therapy reduced the frequency of occurrence of tonsillitis in mouth breathers by decreasing the counts of S. pyogenes bacteria. Upper and lower pharyngeal airway space dimensions were increased after 6 months of appliance therapy in mouth breathers.

A clinical study of utility of kents repertory in the management of tonsillitis in children

Tonsillitis is the most common presenting complaint. Usually seen at the age of 5 years-15 years age group. Sore throat annual incidence of 100 in 1000 with tonsillitis. Tonsillitis is viral in majority of cases and bacterila in 10-30 percent cases.

Hubungan Pengetahuan Dan Pola Makan Dengan Kejadian Tonsilitis Pada Anak Di Puskesmas Tehoru Tahun 2022

Inflammation of the tonsils, lay people often call tonsils. Everyone has tonsils, for some reason the tonsils can become inflamed which should not be underestimated. Tonsillitis is inflammation of the palatine tonsils which are part of the Waldeyer ring (Suroso, 2019). Tonsillitis is an infectious disease that occurs quite often, especially in children aged 5-15 years compared to adults (Koes Irianto, 2019). This study aims to determine the relationship between knowledge and eating patterns with the incidence of tonsillitis in children at the Tehoru Health Center, Central Maluku Regency. This research uses an observational research design with analytical survey research methods and uses a cross sectional study approach. The population in this study were Tonsillitis patients aged 6-15 years who received treatment at the Tehoru Health Center, Central Maluku Regency from January – June 2022, totaling 280 patients. Sampling using the Purposive Sampling technique obtained 31 respondents according to the inclusion criteria. Data were collected using questionnaires and observation sheets, the data collected was then processed and analyzed using the SPSS computer program. Data analysis includes univariate analysis by looking for frequency distributions and bivariate analysis with the chi-square test (a&lt;0.05) to determine the relationship between variables. The results of the bivariate analysis showed a value of p=0.069 for the relationship between knowledge and the incidence of tonsillitis, and p=0.001 for the relationship between diet and the incidence of tonsillitis. So it can be concluded that there is no relationship between knowledge and the incidence of tonsillitis and there is a relationship between diet and the incidence of tonsillitis in children at the Tehoru Community Health Center, Central Maluku Regency in 2022.&#x0D;

Twenty-year observational study of paediatric tonsillitis and tonsillectomy

IntroductionTonsillectomy is now only indicated in the UK when specific criteria are met, as outlined by the Scottish Intercollegiate Guidelines Network (SIGN) and The National Institute for Health and Care...

Acute tonsillopharyngitis - a review

Introduction and purpose: Acute pharyngitis and tonsillitis is the most common reason why people want to visit their primary care physician. Viruses are the most common cause of acute pharyngitis and acute tonsillitis in children and adults. The patient complains about pain with sudden onset and throat irritation, pain on swallowing, fever and headache, and in children also abdominal pain, nausea and vomiting.&#x0D; Brief description of the state of knowledge: Most acute tonsillopharyngitis is due to rhinoviruses (35%), influenza (30%), RSV and parainfluenza. Bacteria causes 30% of the infections and S. pyogenes is the most common cause. Viral infections are seasonal. S.pyogenes infection is most often in winter and early spring. Changes in the pharyngeal mucosa look similar in both bacterial and viral etiologies. Because of that, scales have been developed to assess the probability of a bacterial infection. The most used is Centor / McIsaac scale. The gold standard of diagnostics is throat swab culture. In the treatment of streptococcal pharyngitis and tonsillitis, penicillins are used as first-line treatment. Antibiotic treatment reduces infectivity, lowers the risk of rheumatic fever and made symptoms disappear two days earlier. Tonsillectomy does not reduce the number of recurrent pharyngitis and tonsillitis, therefore it cannot be recommended.&#x0D; Conclusion: Acute tonsillopharyngitis can result in many complications, the most serious of them is rheumatic fever. Therefore, it is very important to properly diagnose and use antibiotic therapy when necessary.

Vitamin D Levels in Children with Recurrent Acute Tonsillitis in Jordan: A Case-Control Study.

Background: Vitamin D is essential for many functions of the body. In addition to its primary function of regulating the absorption of calcium in the small intestine, its role in the immune system has recently been studied. The current study aimed to test the impact of vitamin D deficiency on the rate of recurrent acute tonsillitis in children. Methods: According to Paradise criteria, two hundred forty-two children with recurrent acute tonsillitis were recruited. A group of healthy children (n = 262) was also recruited as controls. Poisson regression was run to predict the number of tonsillitis episodes per year based on vitamin D levels. The mean vitamin D level in the study group was lower than in the control group (p < 0.0001). Poisson regression of the rate of recurrent tonsillitis and vitamin D level (OR = 0.969 (95% CI, 0.962–0.975)) showed that for every single unit increase in vitamin D level, there was a 3.1% decrease in the number of tonsillitis episodes per year (p < 0.0001). Conclusions: Vitamin D deficiency is associated with higher rates of recurrent acute tonsillitis. Future controlled trials should investigate the role of vitamin D supplementation in reducing the rate of recurrent tonsillitis.

Some Pro and Anti-Inflammatory Cytokines in Children with Tonsillitis and their Correlations with Vitamin D Deficiency

Inflammation of the tonsils could be described as acute tonsillitis, mainly due to infection. Recurrent tonsillitis could be defined as 3-7 episodes during the first 3 years of age. Vitamin D, which is a neuro-hormone with pleiotropic biological activities may modulate the immune response by alleviation, and stimulation of Th1 and Th2 cell proliferation, respectively, that influence the stimulation, synthesis, and secretion of both pro and anti-inflammatory cytokines. In this study we aimed to shed light on the levels of vitamin D in children with different episodes of tonsillitis in association with levels of interleukins (TNFα, IL-2, IL-4, IL-10). Blood samples were collected from 48 participants in 3 groups: control, acute tonsillitis (1-2 episodes/year), chronic tonsillitis (more than 7 episodes/year), serum was separated and the levels of Vitamin D, TNFα, IL-2, IL-4 and IL-10 were estimated using ELISA technique. Vitamin D decreased significantly as the episodes of tonsillitis increased, with level of 16.38± 2.41ng/ml in acute and, 14.13± 2.15 ng/ml in chronic tonsillitis as compared to control (30.91± 2.31 ng/ml), while pro-inflammatory cytokines (TNFα and IL-2) significantly increased (46.88± 14.05 and 44.55± 9.24, 1267.25± 111.85 and 1191.72± 121.52 ng/ml, respectively) as compared to control (9.45 and 138.48 ng/ml respectively). Anti-inflammatory (IL-4, IL-10) cytokines in control group were (243.08± 28.72 and 24.27± 1.83 ng/ml, respectively), which increased non-significantly in acute and chronic tonsillitis (302.76± 38.93, 290.12± 44.69 and 28.16± 2.01, 26.29± 1.99 ng/ml, respectively). Significant direct correlation was observed between the levels of vitamin D and anti-inflammatory cytokines in chronic tonsillitis (P&lt;0.05). In conclusion, deficiency of vitamin D may affect the number of episodes of tonsillitis in children by modulation of the secretion of some cytokines.

An observational retrospective study on prevalence of tonsillitis in children below 15 years

An observational retrospective study on prevalence of tonsillitis in children below 15 years