The article traces the formation and development of the Northern Studies Collection at the Hokkaido University Library, the largest collection of Japanese written sources on the history of Sakhalin and the Kuril Islands in the 17th–19th cc. in Japan and beyond. This region was involved in trade relations with Japanese merchants under the control of the Matsumae clan, and later was partly administered by the Tokugawa shogunate. The Northern Studies Collection of the Hokkaido University Library is based on written sources that were collected and copied nationwide for the compilation of an official history of Hokkaido under the auspices of the island’s governorship in the 1910s–1930s. During the preparation of the catalog in the 1970s and 1980s, the collection was also enriched with copies of many sources from other collections in Japan. Thus, the Northern Studies Collection can be used to reconstruct a map of all the centers for storing sources on the history of the region in Japan. As this extensive collection is closely related to the history of the Northern Studies Collection Department and its predecessor, the Northern Cultures Research Department of the Hokkaido University, the history of these two branches is also traced in the article.