Adsorbents with hierarchical hollow architecture are proved to be promising in wastewater purification. Herein, hierarchical titanate microtube (HTMT) has been fabricated by simple alkaline hydrothermal. The obtained HTMT presented hollow structure with large interior voids and countless external nanosheets. HTMT exhibited superior adsorption performance to eliminate Pb(II) from wastewater due to the large specific surface area as 80.4 m2 g−1 and abundant exchangeable intercalated Na+. HTMT showed maximum adsorption capacity as 540.5 mg g−1 at 298 K, fast adsorption rate and good reusability to remove Pb(II). Moreover, HTMT could selectively remove Pb(II) in the environment containing high concentration of interference cations(Na+, K+, Ca2+, Mg2+, Al3+) and heavy metals (Cu2+, Cd2+, Zn2+, Ni2+) with high efficiency. Furthermore, the large micron size of HTMT ensured the feasibility and reliability for reclamation of adsorbents by 0.45 μm microfiltration membrane. The adsorption mechanism was mainly ions exchange and inner-sphere complexation. The high adsorption capacity, fast adsorption rate, strong selectivity and good reusability make HTMT attractive for practical removal of Pb(II) from contaminated water.