The current paper aims to investigate the stress distribution developed in Kennedy Class II mandibular distal extension removable partial dentures due to applying a unilateral load condition in both vertical and lateral oblique directions. 3D models of mandible bone and RPD framework were first built based on actual patient data and later exported to ANSYS software to implement the numerical analysis. For realistic analysis, the model considered the frictional contact between the RPD retainers with the teeth and mucosa with the resin denture base by applying the feature of small sliding. To ensure maximum longevity and suitability of restoration, two different metallic RPDs constructed from commercially pure titanium (CP Ti) and cobalt–chromium (Co-Cr) base materials were investigated within the proposed model. It was found that the highest stress value was seen within the Co-Cr framework followed by the titanium framework, particularly within the bar clasp under both loading directions. The principle abutment of the distal extension side carried the highest stress value under both RPD models in both loading cases. Also, it was found that the captured von Mises stress levels within the titanium bar clasps were lower than that in Co-Cr demonstrating both long durability and high flexibility of Ti clasps.