Integration Time Research Articles

Nano-optomechanical fiber-tip sensing

Nano-optomechanical sensors exploit light confinement at the nanoscale to enable very precise measurements of displacement, force, acceleration, and mass. Their application is hampered by the complex optical set-ups or packaging schemes required to couple light to and from the nano-optomechanical resonator. In this work, we present a fiber-coupled nano-optomechanical sensor that requires no coupling optics. This is achieved by directly placing a nano-optomechanical structure, a double membrane photonic crystal (DM-PhC), on the facet of a fiber, using a simple and scalable wafer-to-fiber transfer method. The device is probed in reflection and has a resonance at telecom wavelengths with a relatively broad spectral width of 3–10 nm, which is advantageous for a simple read-out and achieves a displacement imprecision of 10fm/Hz\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$10\\,{{\\rm{fm}}}/{\\sqrt{{\\rm{Hz}}}}$$\\end{document}. Using resonant driving and a ringdown measurement, we can induce and monitor mechanical oscillations with an nm-scale amplitude via the fiber, which allows for tracking the mechanical resonant frequency and the mechanical linewidth with imprecisions of 79 and 12 Hz, respectively, at integration times of 4.5 s. We further demonstrate the application of this fiber-tip sensor to the measurement of pressure, using the effect of collisional damping on the mechanical linewidth, leading to the imprecision of 9×10−4mbar\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$9\ imes {10}^{-4}\\,{\\rm{mbar}}$$\\end{document} with an integration time of 290 s. This combination of optomechanics and fiber-tip sensing may open the way to a new generation of fiber sensors with unprecedented functionality, ultrasmall footprint, and low-cost readout.

A novel artificial hummingbird algorithm improved by natural survivor method

The artificial hummingbird algorithm (AHA) has been applied in various fields of science and provided promising solutions. Although the algorithm has demonstrated merits in the optimization area, it suffers from local optimum stagnation and poor exploration of the search space. To overcome these drawbacks, this study redesigns the update mechanism of the original AHA algorithm with the natural survivor method (NSM) and proposes a novel metaheuristic called NSM-AHA. The strength of the developed algorithm is that it performs population management not only according to the fitness function value but also according to the NSM score value. The adopted strategy contributes to NSM-AHA exhibiting powerful local optimum avoidance and unique exploration ability. The optimization ability of the proposed NSM-AHA algorithm was compared with 21 state-of-the-art algorithms over CEC 2017 and CEC 2020 benchmark functions with dimensions of 30, 50, and 100, respectively. Based on the Friedman test results, it was observed that NSM-AHA ranked 1st out of 22 competitive algorithms, while the original AHA ranked 8th. This result highlights that the NSM update mechanism provides a remarkable evolution in the convergence performance of the original AHA algorithm. Furthermore, two constrained engineering problems including the optimization of single-diode solar cell model (SDSCM) parameters and the design of a power system stabilizer (PSS) are solved with the proposed algorithm. The NSM-AHA algorithm provided better results compared to other algorithms with a value of 9.86E − 04 root mean square error for SDSCM and 1.43E − 03 integral time square error for PSS. The experimental results showed that the proposed NSM-AHA is a competitive optimizer for solving global and engineering problems.

Disturbance rejection based consensus controller for swarm system

This article introduces a robust controller designed to facilitate consensus among leader-follower agents in a swarm system. The method employs algebraic graph theory to establish a consensus framework and incorporates a sliding surface-based uncertainty and disturbance estimator (SUDE) to mitigate the effects of nonlinearities, external disturbances, and parametric uncertainty inherent in swarm systems. The stability of the SUDE controller is examined using Lyapunov theory. Importantly, this approach operates without prior knowledge of disturbance bounds, relying instead on the dynamics of disturbance error. Simulation studies demonstrate the effectiveness of the proposed control methodology, showing that the SUDE controller expedites consensus achievement while ensuring smooth and non-chattering control behavior. The proposed SUDE controller demonstrates a notable improvement in achieving position and velocity consensus in both the X and Y directions, with a 75% and 66% faster convergence rate, respectively, when compared to the conventional sliding mode controller (SMC). Additionally, the performance of the proposed controller is assessed under various external disturbances and parametric uncertainty conditions. Comparative analyses using root mean square error (RMSE) and integral absolute time error (IATE), both based on consensus error, confirm the effectiveness of the proposed SUDE consensus controller.

Highly selective and sensitive detection of volatile organic compounds using long wavelength InAs-based quantum cascade lasers through quartz-enhanced photoacoustic spectroscopy

The precise detection of volatile organic compounds plays a pivotal role in addressing environmental concerns, industrial safety, and medical diagnostics. The accurate identification and quantification of these compounds because of their ubiquity and potential health hazards has fueled the development of advanced sensing technologies. This work presents a sensing system in the realm of long-wavelength infrared spectroscopy for achieving enhanced selectivity and sensitivity of benzene, toluene, and propane detection through quartz-enhanced photoacoustic spectroscopy. High-resolution gas spectroscopy is made possible by the use of specially designed InAs/AlSb-based quantum cascade lasers, emitting in the wavelength range 13–15 μm, and quartz tuning forks. The sensor system, characterized by its robustness and precision, demonstrates exceptional capabilities in benzene, toluene, and propane detection. The system's capacity for practical applications in environmental monitoring and medical diagnostics is demonstrated by its ability to distinguish these volatile organic compounds with a minimum detection limit of 113 ppb, 3 ppb, and 3 ppm for toluene, benzene, and propane at an integration time of 10 s, even in complex gas matrices. This work advances gas sensing technology while also offering insightful information on spectral interferences, a persistent problem in the field. The results usher in a new era of sophisticated and reliable gas sensing techniques meeting the growing demand for precise volatile organic compounds detectors for environmental monitoring purposes.

Long-term Integration Ability of the Submillimeter Wave Astronomy Satellite (SWAS) Spectral Line Receivers

The Submillimeter Wave Astronomy Satellite (SWAS) was the first space telescope capable of high spectral resolution observations of terahertz spectral lines. We have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit operation. The C i , O2, H2O, and 13CO spectra taken toward all observed Galactic sources were analyzed. The present results are based on spectra with a total integration time of up to 2.72 × 104 hr (≃108 s). The noise in the spectra is generally consistent with that expected from the radiometer equation, without any sign of approaching a noise floor. This noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

Atmospheric Limitations for High-frequency Ground-based Very Long Baseline Interferometry

Very long baseline interferometry (VLBI) provides the highest-resolution images in astronomy. The sharpest resolution is nominally achieved at the highest frequencies, but as the observing frequency increases, so too does the atmospheric contribution to the system noise, degrading the sensitivity of the array and hampering detection. In this paper, we explore the limits of high-frequency VLBI observations using ngehtsim, a new tool for generating realistic synthetic data. ngehtsim uses detailed historical atmospheric models to simulate observing conditions, and it employs heuristic visibility detection criteria that emulate single- and multifrequency VLBI calibration strategies. We demonstrate the fidelity of ngehtsim’s predictions using a comparison with existing 230 GHz data taken by the Event Horizon Telescope (EHT), and we simulate the expected performance of EHT observations at 345 GHz. Though the EHT achieves a nearly 100% detection rate at 230 GHz, our simulations indicate that it should expect substantially poorer performance at 345 GHz; in particular, observations of M87* at 345 GHz are predicted to achieve detection rates of ≲20% that may preclude imaging. Increasing the array sensitivity through wider bandwidths and/or longer integration times—as enabled through, e.g., the simultaneous multifrequency upgrades envisioned for the next-generation EHT—can improve the 345 GHz prospects and yield detection levels that are comparable to those at 230 GHz. M87* and Sgr A* observations carried out in the atmospheric window around 460 GHz could expect to regularly achieve multiple detections on long baselines, but analogous observations at 690 and 875 GHz consistently obtain almost no detections at all.

Simulation and modeling for controlling stepper motor with tuned PID by GWO: comparative study

The current work aims to simulate the operation of the electric motor in one of the most important industrial applications, which is printers, by adopting stepper motors (SM). The performance of the motor is also improved by adopting traditional control systems and adjusting them using the gray wolf optimization (GWO) advanced algorithm. It works to adjust the parameters of a conventional controller. Simulation to reach an appropriate design with high performance, which is obtained by adopting the integral time absolute error (ITAE) function to get rid of the error for transient cases. Transfer function was adopted to represent the engine and two methods of control were used, traditional and advanced optimization. Results demonstrated the possibility of improving performance by adopting both methods with a clear superiority of advanced optimization. Response of SM without controller for close loop shows the values of each rising time equal 130.440 ms, overshoot equal 0.505%, and undershoot equal 1.077%. Response of SM for close loop with proportional-integral-derivative controllers (PIDC) shows the parameters, performance, and robustness of PIDC also the values of overshoot=9.16%, settling time=0.406, and rise time=0.0628 s. Results were developed by using GWO-PID over the previous cases by reducing values of overshoot to zero, rise time, and settling time to 0.00145 and 0.0027 respectively.

Dynamic interaction of inflow and rotor time scales and impact on single turbine wake recovery

The entrainment and recovery of wind turbine wakes are highly dependent on atmospheric inflow conditions, which has typically been quantified through the turbulent intensity. However, recent studies have shown that the integral time scales of the inflow has significant impact on the wake recovery. Concurrently, increased power production can also be achieved through intentionally introducing beneficial time scales by altering the control of the individual wind turbines. This study studies the combined impact of the dynamic interaction between dominant inflow and rotor time scales. The results show increased power production of a downstream wind turbine of more than 50% for the largest thrust coefficients and tip-speed ratios (TSR). However, the peak power gain occurs at different downstream positions indicating that combinations of inflow time scales and TSR = 6 result in faster near wake breakdown compared to the same inflow time scales combined with higher thrust coefficient of TSR = 8.

A zinc oxide resonant nano-accelerometer with ultra-high sensitivity

Nanoelectromechanical system accelerometers have the potential to be utilized in next-generation consumer electronics, inertial navigation, and seismology due to their low cost, small size, and low power consumption. There is an urgent need to develop resonant accelerometer with high sensitivity, precision and robustness. Here, a zinc oxide resonant nano-accelerometer with high sensitivity has been designed and prototyped using zinc oxide nanowires. Within a device two nanowires were symmetrically placed close to a notched flexure to evaluate acceleration based on differential resonant frequencies. Additionally, microleverages were integrated in the accelerometer to enhance its sensitivity by amplifying the inertial force. High performance of the accelerometer has been demonstrated by the measured absolute sensitivity (16.818 kHz/g), bias instability (13.13 μg at 1.2 s integration time) and bandwidth (from 4.78 to 29.64 kHz), respectively. These results suggest that zinc oxide nanowires could be a candidate to develop future nanoelectromechanical resonant accelerometer potentially used for inertial navigation, tilt measurement, and geophysical measurements.

Метод определения эффективности вариантов организации перевозок барже-буксирными составами

A study has been conducted on the method of evaluating options for organizing cargo transportation by barge-tow trains based on determining their effectiveness. Using the methods of the classical theory of transport processes, this problem has no quantitative solution, since it is not possible to take into account the regrouping of the composition during the passage of the route. To overcome this problem, additional mathematical tools have been developed for constructing integral time and velocity matrices, an objective function and graphs of the ratios of the total volume of transported cargo to the time it was en route. The consistent implementation of the proposed tools ensures the coherence of the calculation methods for determining the effectiveness of a flight with and without regrouping on the route, and also makes it possible to select the most appropriate option for organizing transportation. The cumulative result allows us to reflect the method of evaluation, comparison and selection of the most effective option for organizing a flight / group of flights, taking into account the ability to set individual parameters for the movement of the train and cargo. An example of approximation of the coordinate points of the route from the Nizhne-Svirsky shipping lock to Lake Ladoga is illustrated, as well as an example of discretization of an inland waterway section according to a three-level model. The parameters of equalization of the objective function of determining the efficiency of cargo transportation are considered. It is concluded that the optimal transportation option can be carried out on the basis of a combined approach, when several parameters are taken into account or sequentially set in the process of modeling the operation of ships. Graphs have been built that demonstrate the differences between the ways of organizing flights.

Comprehensive Identification and Characterization of HML-9 Group in Chimpanzee Genome.

Endogenous retroviruses (ERVs) are related to long terminal repeat (LTR) retrotransposons, comprising gene sequences of exogenous retroviruses integrated into the host genome and inherited according to Mendelian law. They are considered to have contributed greatly to the evolution of host genome structure and function. We previously characterized HERV-K HML-9 in the human genome. However, the biological function of this type of element in the genome of the chimpanzee, which is the closest living relative of humans, largely remains elusive. Therefore, the current study aims to characterize HML-9 in the chimpanzee genome and to compare the results with those in the human genome. Firstly, we report the distribution and genetic structural characterization of the 26 proviral elements and 38 solo LTR elements of HML-9 in the chimpanzee genome. The results showed that the distribution of these elements displayed a non-random integration pattern, and only six elements maintained a relatively complete structure. Then, we analyze their phylogeny and reveal that the identified elements all cluster together with HML-9 references and with those identified in the human genome. The HML-9 integration time was estimated based on the 2-LTR approach, and the results showed that HML-9 elements were integrated into the chimpanzee genome between 14 and 36 million years ago and into the human genome between 18 and 49 mya. In addition, conserved motifs, cis-regulatory regions, and enriched PBS sequence features in the chimpanzee genome were predicted based on bioinformatics. The results show that pathways significantly enriched for ERV LTR-regulated genes found in the chimpanzee genome are closely associated with disease development, including neurological and neurodevelopmental psychiatric disorders. In summary, the identification, characterization, and genomics of HML-9 presented here not only contribute to our understanding of the role of ERVs in primate evolution but also to our understanding of their biofunctional significance.

Hybrid minigrid system comprising energy storage systems with optimal frequency control empowering the new Egypt large optical telescope site

Proposed hybrid minigrid two area system simulation model encompassing Photo Voltaic (PV) system, Wind Turbines (WT), diesel generators and Energy Storage Systems with intelligent based optimal Frequency Controllers (FCs) empowering the new Egypt large optical telescope (ELOT) site is presented in this research. Technical study and specifications for a PV solar system of 1000 Kw is introduced. Intelligent fine optimized Proportional Integral Derivative (PID) and Fuzzy self-tuned PID (FSTPID) controllers are designed through applying Harris Hawk optimizer (HHO). The proposed HHO employed method performance is validated under number of eventualities which include vacillations of load, sun radiation and wind speed. The objective function and control parameters are the integral time summation of absolute deviations and the parameters of controllers, consecutively. The system dynamic response and simulation results show that the proposed HHO based FSTPID type FCs are effective in reducing frequency and tie line power signals’ deviations in a diminutive time for such minigrid hybrid system. For supplemental validations, simulation results obtained are compared with genetic algorithm to get the proposed controllers’ gains.

Natural Orbitals and Targeted Non-Orthogonal Orbital Sets for Atomic Hyperfine Structure Multiconfiguration Calculations

Hyperfine structure constants have many applications, but are often hard to calculate accurately due to large and canceling contributions from different terms of the hyperfine interaction operator, and also from different closed and spherically symmetric core subshells that break up due to electron correlation effects. In multiconfiguration calculations, the wave functions are expanded in terms of configuration state functions (CSFs) built from sets of one-electron orbitals. The orbital sets are typically enlarged within the layer-by-layer approach. The calculations are energy-driven, and orbitals in each new layer of correlation orbitals are spatially localized in regions where the weighted total energy decreases the most, overlapping and breaking up different closed core subshells in an irregular pattern. As a result, hyperfine structure constants, computed as expectation values of the hyperfine operators, often show irregular or oscillating convergence patterns. Large orbital sets, and associated large CSF expansions, are needed to obtain converged values of the hyperfine structure constants. We analyze the situation for the states of the {2s22p3,2s22p23p,2s22p24p} odd and {2s22p23s,2s2p4,2s22p24s,2s22p23d} even configurations in N I, and show that the convergence with respect to the increasing sets of orbitals is radically improved by introducing separately optimized orbital sets targeted for describing the spin- and orbital-polarization effects of the 1s and 2s core subshells that are merged with, and orthogonalized against, the ordinary energy-optimized orbitals. In the layer-by-layer approach, the spectroscopic orbitals are kept frozen from the initial calculation and are not allowed to relax in response to the introduced layers of correlation orbitals. To compensate for this lack of variational freedom, the orbitals are transformed to natural orbitals prior to the final calculation based on single and double substitutions from an increased multireference set. The use of natural orbitals has an important impact on the states of the 2s22p23s configuration, bringing the corresponding hyperfine interaction constants in closer agreement with experiment. Relying on recent progress in methodology, the multiconfiguration calculations are based on configuration state function generators, cutting down the time for spin-angular integration by factors of up to 50, compared to ordinary calculations.

Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration.

Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration.

Asymptotic profiles of mean zonal flows generated by thermal convection of Boussinesq fluid in a rapidly rotating thin spherical shell

The asymptotic behavior of the profiles of mean zonal flows generated by thermal convection of a Boussinesq fluid in a rapidly rotating thin spherical shell was studied by extending the integration time of the numerical experiments of a previous study under similar conditions. Calculations were performed for the whole globe, as well as for a one-eighth sector region, with various values of the hyper-diffusion parameters. For sufficiently weak hyper-diffusion, a prograde zonal jet and alternating narrow zonal jets appeared at the equator and in the middle and high latitudes, respectively, as reported in the previous study. However, further integrations showed that the middle and high latitude flows are asymptotically accelerated eastward, jet peaks merge, and the banded zonal flow structure eventually disappears. Thus, the rotating thin spherical shell convection model of a Boussinesq fluid used in the previous studies seems inadequate to explain the surface banded structures of Jovian planetary atmospheres without modification of the standard setups. To maintain the alternating jet structure in the middle and high latitudes over the long-term, some sort of scale-independent dissipation process should be specified that prevents the evolution of zonal flows toward the long-term asymptotic state.

Analysis of the interaction of antimalarial agents with Plasmodium falciparum glutathione reductase through molecular mechanical calculations.

Malaria remains a significant global health challenge with emerging resistance to current treatments. Plasmodium falciparum glutathione reductase (PfGR) plays a critical role in the defense mechanisms of malaria parasites against oxidative stress. In this study, we investigate the potential of targeting PfGR with conventional antimalarials and dual drugs combining aminoquinoline derivatives with GR inhibitors, which reveal promising interactions between PfGR and studied drugs. The naphthoquinone Atovaquone demonstrated particularly high affinity and potential dual-mode binding with the enzyme active site and cavity. Furthermore, dual drugs exhibit enhanced binding affinity, suggesting their efficacy in inhibiting PfGR, where the aliphatic ester bond (linker) is essential for effective binding with the enzyme's active site. Overall, this research provides important insights into the interactions between antimalarial agents and PfGR and encourages further exploration of its role in the mechanisms of action of antimalarials, including dual drugs, to enhance antiparasitic efficacy. The drugs were tested as PfGR potential inhibitors via molecular docking on AutoDock 4, which was performed based on the preoptimized structures in HF/3-21G-PCM level of theory on ORCA 5. Drug-receptor systems with the most promising binding affinities were then studied with a molecular dynamic's simulation on AMBER 16. The molecular dynamics simulations were performed with a 100ns NPT ensemble employing GAFF2 forcefield in the temperature of 310K, integration time step of 2fs, and non-bond cutoff distance of 6.0Å.

Performance analysis of an optimized PID-P controller for the position control of a magnetic levitation system using recent optimization algorithms

As industrial technology advances, there is an increasing need for very precise position control mechanisms for highly integrated and accurate products. Therefore, high precision positioning systems play an essential part in today's manufacturing processes. Piezoelectric actuators offer the requisite stiffness and positioning precision, but they have a limited traveling range. The combination of a linear motor with air bearings is a typical method for achieving long stroke movement at high speeds. However, to accomplish extensive and precise motion in several degrees of freedom with a linear motor and non-contact bearing, a sophisticated system setup is required. In this paper, a proportional-integral-derivative-proportional (PID-P) controller is presented for magnetic levitation system position control. Particle swarm optimization (PSO) and Black window optimization (BWO) algorithms are proposed for tuning the PID-P controller parameters. The PSO and BWO algorithms are employed by considering Integral Time Absolute Error (ITAE) as an objective function with rise-time and percentage peak overshoot as constraints. Furthermore, the performance of PSO and BWOA tuned PID-P controllers is compared to conventional PID-P and PID controllers using time response specifications such as rise time, settling time, and percentage peak overshoot. The graphical and numerical simulation results show that the PSO and BWOA tuned PID-P controller outperforms the conventional PID-P and PID controllers. The BWOA tuned PID-P controller outperformed the PSO tuned PID controller and the classical PID-P controller by 8.5 % in rise time, 46.77 % in settling time, and 86.6 % in percentage peak overshoot.

On the Performance of the Model-Free Adaptive Control For A Novel Moving-Mass Controlled Flying Robot

In this paper, the performance of Model-Free Adaptive Control (MFAC) has been investigated on a novel and specific moving-mass controlled (MMC) flying robot system. The novel one-degree-of-freedom (1 DOF) MMC flying robot test bed presented in this paper has highly nonlinear and slow dynamics with a variable center of gravity (CoG) and moment of inertia. This makes the control of this system a challenging problem. One of the solutions to this challenge is the use of data-driven control methods, in particular, MFAC. This controller uses a data-driven model to control the system using only input and output (I/O) data. This paper compares this data-driven controller with proportional-integral-derivative (PID) control, and Linear Quadratic Regulator (LQR) as two model-free and model-based controllers which are widely used controllers in industry. The results of the comparison show that in the various scenarios applied, MFAC has a clear superiority over the PID and LQR, and its adaptive structure gives more freedom of action in the implementation of different scenarios and the presented noise. The results are obtained using the Integral Time Absolute Error (ITAE) criteria and the mean maximum error has also been compared in a Monte Carlo analysis. For a more detailed study, the amount of control energy consumption was also compared, which showed a clear superiority of the MFAC. Also, the robustness of the controller was demonstrated by introducing uncertainty in the plant parameters and by running 100 Monte Carlo simulations with random initial conditions. Finally, despite the PID controller, the MFAC followed the desired scenarios well and compared to LQR consumed less energy. The results demonstrate that the MFAC outperformed the PID and LQR controllers in the presence of random initial conditions and noise in terms of mean maximum error (70.4%)\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$(70.4\\%)$$\\end{document}, mean ITAE (91%)\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$(91\\%)$$\\end{document}, and energy consumption (46%)\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$(46\\%)$$\\end{document}.

Comparison of in-shoe plantar pressure between Korean combat boots and running shoes

IntroductionCombat boots are special shoes designed for soldiers to wear during activities in rough terrain, such as long marches or military training. Combat boots have been known to cause high...

Contrast sensitivity is resilient to induced fast periodic defocus oscillations.

This study investigates the potential effects of periodic defocus oscillations on contrast sensitivity. Sinusoidal fluctuations at 5, 15, and 25 Hz, with defocus peak-to-valley values ranging from 0.15 to 3 D, were induced by means of a focus-tunable lens after calibrating its dynamic behavior. Monocular contrast sensitivity was measured on five young emmetropic subjects. The experimental data shows that contrast sensitivity loss due to defocus fluctuations is low for a wide range of frequencies and amplitudes. Only for the more severe case studied (25 Hz, ± 1.5 D) contrast threshold showed a clear increase in most subjects. Qualitative comparison of the empirical data with a simulation of modulation loss due to time integration of defocused retinal point spread functions, suggests a short integration time by the eye for defocus blur, around or even below a hundredth of a second.