Time Research Articles

Time-Controllable Keyword Search Scheme With Efficient Revocation in Mobile E-Health Cloud

Electronic health (e-health) systems may outsource data such as patient e-health records to mobile cloud servers for efficiency gains (e.g., minimizing local storage and computation costs). However, such a move may result in privacy implications in the presence of semi-honest cloud servers. Searchable Encryption (SE) can potentially facilitate privacy-preserving searches based on keywords for encrypted data stored in the mobile cloud, but most existing SE solutions do not support temporal access control (i.e., a mechanism that grants access permissions to users for specified time ranges). Hence, in this paper we design a time-controllable keyword search scheme by using an attribute-based comparable access control. This allows users to match indexes encrypted at specified time intervals. Then, we improve the basic framework to support efficient user revocation using secret sharing. We then formally prove the security of our proposed frameworks against chosen-keyword attack and key collusion attack, as well as achieving keyword secrecy. We also evaluate the performance of our proposed approach using a real-world dataset to demonstrate their practical utility.

Effectiveness of the Sanofi/GSK (VidPrevtyn Beta) and Pfizer-BioNTech (Comirnaty Original/Omicron BA.4-5) bivalent vaccines against hospitalisation in England

The Sanofi/GSK AS03-adjuvanted (VidPrevtyn Beta) vaccine and the Pfizer-BioNTech mRNA (Comirnaty Original/Omicron BA.4-5) bivalent vaccine were offered to adults aged 75 years and over in England from 3rd April 2023. This is the first time an adjuvanted COVID-19 vaccine has been administered as part of a UK COVID-19 vaccination programme. In clinical trials, antibody levels generated were comparable with mRNA vaccines but there are no real-world data on the effectiveness or duration of protection. We used a test-negative case-control study design to estimate the incremental vaccine effectiveness of the Sanofi/GSK and Pfizer bivalent BA.4-5 boosters against hospitalisation amongst those aged 75 years and older in England. Cases (those testing positive) and controls (those testing negative) were identified from the national COVID-19 PCR testing data undertaken in hospital settings. The study period included tests from 3rd April 2023 to 27th August 2023. Tests were linked to the COVID-19 vaccination register and to the national hospital admission database, restricting to those with an acute respiratory infection coded in the primary diagnosis field. Vaccine effectiveness was estimated using multivariable logistic regression amongst those who had last received an autumn 2022 booster given at least 3 months prior. The test result was the outcome and vaccination status the exposure. Analyses were adjusted for week of test, gender, age, clinical risk group status, care home resident status, region, index of multiple deprivation, ethnicity, influenza vaccination status and recent COVID-19 positivity. There were 14,169 eligible tests from hospitalised individuals aged 75 years and older; 3005 cases (positive tests) and 11,164 controls (negative tests). Effectiveness was highest in the period 9-13 days post vaccination for both manufacturers at about 50%; 43.7% (95% CI, 20.1-60.3%) and 56.1% (95% CI, 25.2-74.2%) for Sanofi/GSK and Pfizer BA.4-5, respectively. There was evidence of waning with a reduction to about 30% for both manufacturers after 5-9 weeks. The longest time interval post vaccination for which we were able to estimate effectiveness was 10+ weeks post vaccination, at which point vaccine effectiveness was 17.6% (95% CI,-3.6 to 34.5%) and 37.9% (95% CI, 13.2-55.5%) for the Sanofi/GSK and Pfizer BA.4-5 boosters, respectively. Both boosters provided good protection against hospitalisation amongst older adults. The finding that the adjuvanted vaccine targeting the distant Beta strain had similar effectiveness to the bivalent mRNA vaccine targeting more closely matched Omicron sub-lineages is notable and highlights the need for further real-world studies into the effectiveness of vaccines from different vaccine platforms and formulations in the presence of matched and unmatched strains. No external funding.

High precision low jitter pulse generator implemented with FPGA transceiver

Precisely controlled digital pulse plays a crucial role in various cutting-edge testing applications. This paper introduces an innovative approach to digital pulse generation utilizing an FPGA transceiver, with the AMD evaluation board ZCU102 serving as a demonstrative platform. In the normal mode, the transmitter generates a serial bit stream, enabling the generation of single or repeated pulses with configurable width and period. In the high precision mode, an internal dedicated phase interpolator enhances the configuration step size for width and period by up to 64 times, providing finer phase shift capability. The demonstration system operates at a line rate of 10Gbps, achieving a resolution of 100ps in normal mode and 1.5625ps in high precision mode. This paper details the design methodology, presents test results for pulse width uncertainty and non-linearity, and showcases achieved period jitter and time interval error jitter as small as around 1ps.

Anticancer Activity and Green Synthesized TiO2 Nanoparticles From Calotropis Gigantea Leaves Extract

Abstract: Aim & Objective: Research the Anticancer Abilities of TiO2 Nanoparticles Obtain using Calotropis Gigantea by liver cells (HepG2). Materials & Methods: Various plant materials for the synthesis of nanoparticles are considered in green technology. In this present study, reports the synthesis of Tio2 nanoparticles that were synthesized from Calotropis gigantea leaf, and the formation of Tio2 nanoparticles was observed with different time intervals. The characterization was recorded from scanning electron microscope, X-ray diffraction, Fourier transfer infrared spectra, DLS, UV-Vis spectrum. The supporting green synthesis and characterization of Tio2 nanoparticles. Result: The result is recorded from MTT assay and ETBR/AO Staining.

Dynamic relationship between workplace friendship and knowledge-sharing behavior: formation, development and decline

Purpose The purpose of this study is to empirically examine the cause–effect relationships between workplace friendship and knowledge-sharing behavior, from a static perspective. Furthermore, it investigates the bi-directional relationship between the increase in both workplace friendship and knowledge-sharing behavior over same time periods, and also endeavors to identify whether there is a significant negative lagged effect of the increase in both workplace friendship on knowledge-sharing behavior, and vice versa, across time from a dynamic perspective. Design/methodology/approach The study conducts a three-wave questionnaire survey to test the research model. A latent change score approach was used to test the direct relationship between changes in workplace friendship and changes in knowledge-sharing behavior. Findings The findings reveal that knowledge-sharing behavior fosters workplace friendship and workplace friendship promotes the emergence of knowledge-sharing behavior. An increase in workplace friendship promotes an increase in knowledge-sharing behavior over same time periods. However, an increase in workplace friendship will lead to a lagged decrease of knowledge-sharing behavior across time, and vice versa. Research limitations/implications The time interval in this study is a little short to capture the full changes in workplace friendship. Some important control factors and mediating mechanisms are not included in the research model. Practical implications This study guides managers to focus on various motivators to better strengthen workplace friendship and knowledge-sharing behavior and to consider and effectively respond to the negative side of workplace friendship and knowledge-sharing behavior across time. Originality/value This study emphasizes the predictivity of one important interaction patterns, namely, knowledge-sharing behavior on friendship at the workplace, from a static perspective. This study also shows the benefits of an increase in workplace friendship for the development of knowledge-sharing behavior in the same time period. Furthermore, the study presents a counterintuitive finding when taking the lag effect into consideration in exploring the relationship between changes both in workplace friendship and knowledge-sharing behavior, and identifies a negative side of both when viewed over longer periods.

The Reinforced Treat-and-Extend Protocol for Exudative Age-Related Macular Degeneration: Retrospective Assessment of 24-Month Real-World Outcomes in France.

The aim of this work is to evaluate the real-world outcomes of the reinforced treat-and-extend (RTE) protocol for the treatment of exudative age-related macular degeneration with intravitreal injections of aflibercept or ranibizumab (anti-vascular endothelial growth factor therapies). This was a retrospective review of patients from two tertiary ophthalmology centers in France initiating the RTE protocol between February 2018 and June 2021. The primary outcome was change in best-corrected visual acuity (BCVA) after 24months. Secondary outcomes were change in central retinal thickness (CRT), recurrence, and management-related factors (injection interval, number of injections/consultations). Outcomes were additionally evaluated after protocol changes (strict versus modified RTE protocol groups). Sixty-eight patients (72 eyes) were included (68% females; mean age 82.2 ± 7.8years). After 24months, mean BCVA significantly improved (65.22 ± 14 vs. 71.96 ± 13 Early Treatment Diabetic Retinopathy Study letters; p < 0.001) and CRT significantly decreased (388.6 ± 104 vs. 278.8 ± 51μM; p < 0.001) with 21% of eyes showing signs of exudation. Over the 24months, a mean total of 14.9 ± 4.0 injections and 8.6 ± 1.4 consultations were performed. Mean 24-month injection interval was 7.9 ± 2.3weeks. Initial and 24-month ophthalmic outcomes for eyes in the strict (47%) versus modified (53%) groups were not significantly different, but mean time interval to first recurrence of disease activity was significantly shorter for the modified group (7.3 ± 2.4 vs. 9.9 ± 2.5weeks; p < 0.001). Patients in the strict RTE group received significantly less injections (13.9 ± 3.6 vs. 16.5 ± 3.9; p = 0.006) and mean 24-month injection interval was significantly longer (9.5 ± 2.7 vs. 6.5 ± 2.1weeks; p < 0.001). Consultation number was similar (8.5 ± 1.9 vs. 8.8 ± 1.6; p = 0.93). Treatment with aflibercept versus ranibizumab did not influence ophthalmic or management outcomes. The RTE protocol, even when modified, reduced consultations but improved ophthalmic outcomes. The RTE protocol could reduce hospital visits and overall burden while also encouraging better patient compliance. Video Abstract available for this article. Vincent Soler and François-Philippe Roubelat summarize the Reinforced Treat-and-Extend Protocol and main results (MP4 225022 KB).

Fraud risk implications of celebrity SPACs

Purpose The purpose of this study is to extend the Fraud Diamond Theory to celebrity Special Purpose Acquisition Companies (SPACs) and investigate their post-Initial Public Offering (IPO) stock market performance. Design/methodology/approach After obtaining a sample of celebrity SPACs from the Spacresearch.com database, fraud risk characteristics were obtained from Lexis Nexus searches. Buy and hold abnormal returns were calculated for celebrity SPACs versus a small-cap equity benchmark for time intervals after IPO, and multiple regression analysis was performed to examine the relationship between fraud risk features and post-IPO returns. Findings Celebrity SPACs exhibit Fraud Diamond characteristics and significantly underperform a small-cap stock portfolio on a risk-adjusted basis after IPO. Research limitations/implications This study only examines celebrity SPACs that conducted IPOs on the NYSE and NASDAQ/AMEX and does not include those that are traded on the Over the Counter Bulletin Board (OTCBB). Practical implications Celebrity endorsement of SPAC vehicles attracts investors who may not be properly informed regarding the risk characteristics of SPACs. Accordingly, investors should be warned that celebrity SPACs underperform a small-cap equity portfolio and exhibit significant elements of fraud risk. Social implications The use of celebrity endorsement as a marketing device to attract investment in SPACs has regulatory implications. Originality/value To the best of the authors’ knowledge, this paper is the first to examine the fraud risk characteristics and post-IPO performance of celebrity SPACs.

Optical variability of the blazar 3C 371: From minute to year timescales

The BL Lac object 3C 371 was observed by the Transiting Exoplanet Survey Satellite (TESS) for approximately a year, between July 2019 and July 2020, with an unmatched two-minute imaging cadence. In parallel, the Whole Earth Blazar Telescope (WEBT) Collaboration organized an extensive observing campaign, providing three years of continuous optical monitoring between 2018 and 2020. These datasets allow for a thorough investigation of the variability of the source. The goal of this study is to evaluate the optical variability of 3C 371. Taking advantage of the remarkable cadence of TESS data, we aim to characterize the intra-day variability (IDV) displayed by the source and identify its shortest variability timescale. With this estimate, constraints on the size of the emitting region and black hole mass can be calculated. Moreover, WEBT data are used to investigate long-term variability (LTV), including in terms of the spectral behavior of the source and the polarization variability. Based on the derived characteristics, we aim to extract information on the origin of the variability on different timescales. We evaluated the variability of 3C 371 by applying the variability amplitude tool, which quantifies variability of the emission. Moreover, we employed common tools, such as ANOVA (ANalysis Of VAariance) tests, wavelet and power spectral density (PSD) analyses to characterize the shortest variability timescales present in the emission and the underlying noise affecting the data. We evaluated the short- and long-term color behavior to understand to understand its spectral behavior. The polarized emission was analyzed, studying its variability and possible rotation patterns of the electric vector position angle (EVPA). Flux distributions of the IDV and LTV were also studied with the aim being to link the flux variations to turbulent and/or accretion-disk-related processes. Our ANOVA and wavelet analyses reveal several entangled variability timescales. We observe a clear increase in the variability amplitude with increasing width of the time intervals evaluated. We are also able to resolve significant variations on timescales of as little as sim 0.5 hours. The PSD analysis reveals a red-noise spectrum with a break at IDV timescales. The spectral analysis shows a mild bluer-when-brighter (BWB) trend on long timescales. On short timescales, mixed BWB, achromatic and redder-when-brighter (RWB) signatures can be observed. The polarized emission shows an interesting slow EVPA rotation during the flaring period where a simple stochastic model can be excluded as the origin with a 3sigma significance . The flux distributions show a preference for a Gaussian model for the IDV, and suggest it may be linked to turbulent processes, while the LTV is better represented by a log-normal distribution and may have a disk-related.

Efficacy and safety of cangrelor as compared to ticagrelor in patients with ST-elevated myocardial infarction (STEMI): a systematic review and meta-analysis.

This systematic review and meta-analysis aimed to compare the efficacy and safety of cangrelor as compared to ticagrelor in patients with ST-elevated myocardial infarction (STEMI) who underwent percutaneous intervention. PubMed, Embase, Scopus, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov databases were searched for relevant head-on-comparison or swapping studies. The primary outcome was the rate of high platelet reactivity (HPR) at specific time intervals after stopping cangrelor infusion during the first 24h. Secondary outcomes were the risks of thrombosis, all-cause mortality and bleeding. Pooled odds ratios (ORs) were calculated using random-effects models. A total of 1018 studies were screened and eight were included in the analysis. There were four head-on-comparison studies and four swapping studies. There was no significant difference in the proportion of patients achieving a high platelet reactivity in swapping studies [OR, 0.71 (95% CI 0.04, 13.87), p = 0.82, i2 = 88%]. In head-on-comparison studies, PRU from Fig.2B shows there was no significant reduction in high platelet reactivity [mean difference - 77.83 (95% CI - 238.84, 83.18), p < 0.001, i2 = 100%]. PRU results from (Fig.2C) show a mean difference of 7.38 (95% CI - 29.74, 44.51), p < 0.001, i2 = 97%. There was no significant difference in the risks of thrombosis [OR, 0.91 (95% CI 0.20, 4.13), p = 0.81, i2 = 0%], all-cause mortality [OR, 3.52 (95% CI 0.44, 27.91), p = 0.24, i2 = 26%] and bleeding [OR, 0.89 (95% CI 0.37, 2.17), p = 0.93, i2 = 0%] between the two groups as revealed in the head-on-comparison studies. The efficacy and safety profiles of cangrelor and ticagrelor were similar in patients with STEMI.

Comparative evaluation of effects of manual and powered tooth brushing on biofilm formation on metal orthodontic brackets and on gingival and periodontal health- an in-vivo study

To evaluate and compare the effects of manual tooth brushing and powered tooth brushing on biofilm formation on metal orthodontic brackets and on gingival and periodontal health of the patient undergoing orthodontic treatment.This randomized controlled clinical trial comprised a total of 36 patients in the age group 15-25 years, coming to Outpatient Department (OPD) of Orthodontics and Dentofacial Orthopedics and undergoing orthodontic treatment. Periodontal evaluation was performed for each patient at four intervals of time, before oral prophylaxis, 1 week after oral prophylaxis, after 3 months of bonding and after 6 months of bonding which constituted the readings at T, T, T and T, respectively. Patients were instructed to use manual toothbrushes for 3 months after bonding. Post 3 months, the patients were divided into two groups- Group I and II as Group I- patients using powered toothbrush and Group II- patients using manual toothbrush, for next 3 months. At both the intervals (T and T), two brackets were debonded from central incisors and second premolars from each patient and studied under scanning electron microscope for biofilm formation.Powered toothbrushing was more effective in reducing API and SBI scores, statistically high significant difference was seen in API score (P = .004) and SBI score (P &amp;#60; .001) between T &amp; T time intervals on comparing both the groups. Both the manual and powered toothbrushing had equal effect on GI scores, no significant difference was seen in GI score (P = .540) between T &amp; T time intervals on comparing both the groups. On inter group comparison of amount of biofilm formation between T2 &amp; T3 time intervals in anterior and posterior region, higher amount of biofilm formation in both the anterior and posterior regions in group II patients (Anterior region= 12.05±6.90, P = .001, posterior region= 10.32±9.75, P = .001).Powered toothbrushes are more effective in removing plaque and thus reducing gingival inflammation in patients with fixed orthodontic appliances.

Thermostability study of virulent Newcastle disease viruses isolated in Southern Angola

Newcastle disease (ND) is endemic in Angola. Several outbreaks of ND occurred in small backyard flocks and village chickens with high mortality in the southern provinces of the country, Cunene, Namibe and Huíla, in 2016 and 2018. In those years, 15 virulent ND virus (NDV) strains were isolated and grouped within subgenotype 2 of genotype VII (subgenotype VII.2). We now present a study on the thermostability of the isolates, aiming at the selection of the most thermostable strains that, after being genetically modified to reduce their virulence, can be adapted to the production of vaccines less dependent on cold chain and more adequate to protect native chickens against ND. Heat-inactivation kinetics of haemagglutinin (Ha) activity and infectivity (I) of the isolates were determined by incubating aliquots of virus at 56 °C for different time intervals. The two isolates from Namibe province showed a decrease in infectivity of 2 log10 in ≤ 10 min, therefore belonging to the I-phenotype, but while the NB1 isolate from 2016 maintained the Ha activity up to 30 min and was classified as thermostable virus (I−Ha+), the Ha activity of the 2018 NB2 isolate decreased by 2 log2 in 30 min, being classified as a thermolabile virus (I−Ha−). Of the 13 NDV isolates from Huíla province, 10 isolates were classified as thermostable, eight with phenotype I+Ha+ and 2 with phenotype I−Ha+. The other three isolates from this province were classified as thermolabile viruses (I−Ha−).Contribution: This study will contribute to the control and/or eradication of Newcastle disease virus in Angola. The thermostable viral strains isolated from chickens in the country can be genetically manipulated by reverse genetic technology in order to reduce their virulence and use them as a vaccine in the remote areas of Angola.

Effects of Cutting Planes on Costal Cartilage Warping.

Autogenous costal cartilage becomes a favorable choice for nasal reconstruction and complicated aesthetic rhinoplasty, due to its ample supply, sufficient for most patients. However, a notable drawback is the potential for warping. Our study aims to identify cutting planes that minimize warping. Two hundred and seven costal cartilage grafts were obtained by slicing the extracted costal cartilages from 10 fresh cadavers, along three main planes: cephalocaudal, anteroposterior, and parallel to the synchondrosis plane. Each of these major planes was further divided into grafts taken from both the central and peripheral portions. Furthermore, both subgroups were categorized into three thicknesses: 1mm, 2mm, and 3mm. The warping angles of all grafts were then compared at various time intervals after the initial cutting. Cephalocaudal cuts exhibited significantly greater warping than other planes. Anteroposterior cuts displayed the least warping, although this difference lacked statistical significance. Peak warping occurred at 30 minutes. Certain grafts continued to warp even at 1 month. Central grafts had less warping than peripheral ones, though not statistically significant. Cephalocaudal cuts yielded the highest warping angle. Surgeons seeking thin (< 3 mm) straight grafts should opt for anteroposterior or parallel to synchondrosis planes. Thicker grafts (> 3 mm) can be cut in the cephalocaudal plane with an acceptable warping angle, close to parallel with the synchondrosis plane. For curved cartilage, thin cephalocaudal cut is recommended. Additionally, we suggest placing the cartilage in normal saline for at least 30 minutes, allowing for maximum warping to occur.

Unveiling The Biomedical Applications Of Novel Coumarins Isolated From Capsicum Annuum L. Seeds By A Multivariate Extraction Technique.

For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90-minute extraction duration and a 55°C extraction temperature. To enable their coumarin contents to be chemically separated and chromatographically purified, two of these extracts containing coumarin were chosen. Four new phytocoumarins have been identified and their molecular structures distinguished using FTIR spectra, 1H-NMR, 13C-NMR, and mass analysis.The results demonstrated that the extracted phytocoumarins have exceptional oxidative stress-mitigating characteristics, ranging from 71.51 to 81.48%, when compared to a positive control. Furthermore, they showed excellent cytotoxicity against the test malignant populations (IC50 values of 46.76-81.45 μg/ml). The isolates need to be taken into account as dual COX-2/5-LOX antagonists because they also showed aselective anti-inflammatory effect.

Clinical analysis of multiple primary gastrointestinal malignant tumors: A 10-year case review of a single-center

BACKGROUND Multiple primary malignant tumors (MPMTs) was first described by Billroth as early as 1889, with the first report published by Warren and Gates in 1932. Since then, numerous cases have been reported. A literature review of 1104269 patients with cancer revealed that the incidence of MPMTs ranged from 0.73 to 11.7%. In recent years, however, there has been a significant upward trend in the incidence of this phenomenon, which may be associated with many different factors, including the advancement of modern diagnostic procedures facilitating the examination and diagnosis of more MPMTs, increased exposure to chemotherapy and radiotherapy that exacerbate the risk of new malignant tumors in patients with cancer, and prolonged survival of patients with cancer allowing sufficient time for the development of new primary cancers. AIM To analyze the incidence, clinical features, treatment factors, prevalence, and prognosis of patients with MPMTs in the gastrointestinal tract treated in a single center. Additionally, we analyzed the different tumor combinations, time interval between the occurrence of tumors, and staging. METHODS This retrospective cohort study analyzed 8059 patients with pathologically confirmed gastrointestinal malignant tumors treated at the Gansu Province Hospital in Lanzhou, Gansu, China between June 2011 and June 2020. Of these, 85 patients had MPMTs. The clinical features, treatment factors, prevalence, and prognosis of this latter cohort were analyzed. RESULTS The incidence of MPMTs in patients with gastrointestinal malignant tumors was 1.05% (85/8059), including 83 double primary malignant tumors and two triple primary malignant tumors of which 57 (67.06%) were synchronous MPMTs (SMPMTs) and 28 (32.94%) were metachronous MPMTs (MMPMTs). The most frequent associations were found between the rectum colon cancers within the SMPMT category and the gastric-colon cancers within the MMPMT category. For the MMPMTs, the median interval was 53 months. The overall 1-, 3- and 5-year survival rates from diagnosis of the first primary cancer were 91.36%, 65.41%, and 45.97%, respectively; those from diagnosis of the second primary cancer were 67.90%, 29.90%, and 17.37%, respectively. CONCLUSION MPMTs in the gastrointestinal tract have a high incidence and poor prognosis. Thus, it is necessary to perform both gastroscopy and colonoscopy in patients with gastrointestinal tumors. Multidisciplinary comprehensive diagnosis and treatment may improve the diagnosis rate and treatment efficiency of MPMTs.

Multi-temporal Scale Wind Power Forecasting Based on Lasso-CNN-LSTM-LightGBM

Due to the increasingly severe climate problems, wind energy has received widespread attention as the most abundant energy on Earth. However, due to the uncertainty of wind energy, a large amount of wind energy is wasted, so accurate wind power prediction can greatly improve the utilization of wind energy. To increase the forecast for wind energy accuracy across a range of time scales, this paper presents a multi-time scale wind power prediction by constructing an ICEEMDAN-CNN-LSTM-LightGBM model. Initially, feature selection is performed using Lasso regression to identify the most significant variables affecting the forecast for wind energy across distinct time intervals. Subsequently, the ICEEMDAN is utilized to break down the wind power data into various scales to capture its nonlinear and non-stationary characteristics. Following this, a deep learning model based on CNN and LSTM networks is developed, with the CNN responsible for extracting spatial features from the time series data, and the LSTM designed to capture the temporal relationships. Finally, the outputs of the deep learning model are fed into the LightGBM model to leverage its superior learning capabilities for the ultimate prediction of wind power. Simulation experiments demonstrate that the proposed ICEEMDAN-CNN-LSTM-LightGBM model achieves higher accuracy in multi-time scale wind power prediction, providing more reliable decision assistance with the management and operation of wind farms.

Adaptive network traffic control with approximate dynamic programming based on a non-homogeneous Poisson demand model

ABSTRACT In this study, we develop a stochastic dynamic traffic-flow model subject to practical restrictions under the non-homogeneous Poisson vehicle arrival process. Using the cell transmission strategy, we establish traffic dynamics between two intersections. We also discuss simulating the random demand of source links from an estimated intensity function. Additionally, we propose an algorithm to optimize time interval division for aggregated data, aiming to enhance estimation performance. We explore applying our traffic flow model to the adaptive traffic network management problem, which is formulated as a Markov decision process. Leveraging approximate dynamic programming with recursive least squares-temporal difference learning, we achieve adaptive optimal policies. To validate our approach, we conduct a series of numerical experiments with random demands. The results of non-homogeneous Poisson demand conducted using random numbers and a real-word dataset indicate high efficiency with the piecewise constant, I-SMOOTH, and MNO-PQRS estimators. Compared to the Webster and Max-pressure control systems, our proposed approximate dynamic programming-based model exhibits superior stability and applicability.

Prevalence Patterns of Body Contouring Procedures Among Injectable Glucagon-Like Peptide-1 Receptor Agonist Users.

The introduction of injectable glucagon-like peptide-1 (GLP-1) receptor agonists like Ozempic and Wegovy has transformed weight loss in plastic surgery patients, often leading to excess skin and soft tissue amendable to body contouring procedures. This project aims to examine the relationship between injectable GLP-1 receptor agonist use and the growing need for body contouring surgeries, focusing on trunk and extremity procedures. A retrospective analysis was conducted using the PearlDiver database, examining prescription data for Ozempic, Wegovy, and liraglutide, and correlating these with body contouring procedures across 30 U.S. states from 2011-2022. Multimodal statistics were used to compare surgery rates and assess dosage and time interval patterns among GLP-1 receptor agonist users and non-users. Significant correlations between GLP-1 receptor agonist use (881 Ozempic, 59 Wegovy, and 4,655 liraglutide users) and increased body contouring surgeries were found. Ozempic showed weak correlations with brachioplasty (r = 0.23) and panniculectomy (r = 0.21), and Wegovy with breast procedures (r = 0.28), while liraglutide showed consistent correlations across surgeries. Time to surgery varied from 87 days (Wegovy) to 1,018 days (liraglutide), with higher surgery rates among users (p < 0.01) and dose-related differences, especially in Ozempic and Wegovy users. This study demonstrates a dose-dependent link between the use of GLP-1 receptor agonists and an increase in subsequent aesthetic body contouring surgeries, highlighting the need for surgeons to adapt to the merging of medicinal body transformation and aesthetic plastic surgery.

A Biochemical and Histological Assessment of Postmortem Changes to the Eyes of Domestic Pigs: A Preliminary Study

The Postmortem Interval (PMI) is the time from the death of an animal to its discovery. From a veterinary forensic standpoint, an accurate estimation of the PMI is of particular importance, especially with the observed increase in deaths of domestic and wild animals. A preliminary study was conducted using the eyes of domestic pigs. A biochemical analysis was conducted on the vitreous humor of the eye, whilst a histological analysis was conducted on the retina. The eyes were stored at +4 °C and changes were assessed at time intervals of 0, 12, 24, 48, and 120 h. The biochemical analysis during the PMI established a decrease in sodium, chlorine, and glucose concentrations, and a rise in potassium concentration. Accordingly, a simple linear regression showed a significant correlation between changes in concentrations of sodium (Na+), potassium (K+), chloride (Cl−), and glucose, in relation to the PMI. The histological analysis showed evident morphological changes in the retina, which included homogenization of the rod and cone cells, pyknosis of the outer nuclear layer, homogenization of the outer plexiform layer, pyknosis of the inner nuclear layer, homogenization of the inner plexiform layer, and pyknosis of the nuclei of the ganglion layer of the retina.

Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review

Background: Malignant-associated abdominal wall endometriosis (AWE) is a rare pathology, likely to occur in 1% of scar endometriosis. The objectives of this study were to update the evidence on tumor degeneration arising from AWE to notify about the clinical characteristics, the different treatments offered to patients and their outcomes. Methods: A comprehensive systematic review of the literature was conducted. PubMed, Embase and Cochrane Library databases were used. Prospero (ID number: CRD42024505274). Results: Out of the 152 studies identified, 63 were included, which involved 73 patients. The main signs and symptoms were a palpable abdominal mass (85.2%) and cyclic pelvic pain (60.6%). The size of the mass varied between 3 and 25 cm. Mean time interval from the first operation to onset of malignant transformation was 20 years. Most common cancerous histological types were clear cell and endometrioid subtypes. Most widely accepted treatment is the surgical resection of local lesions with wide margins combined with adjuvant chemotherapy. The prognosis for endometriosis-associated malignancy in abdominal wall scars is poor, with a five-year survival rate of around 40%. High rates of relapse have been reported. Conclusions: Endometrial implants in the abdominal wall should be considered as preventable complications of gynecological surgeries. Special attention should be paid to women with a history of cesarean section or uterine surgery.

Reward positivity affects temporal interval production in a continuous timing task.

The neural circuits of reward processing and interval timing (including the perception and production of temporal intervals) are functionally intertwined, suggesting that it might be possible for momentary reward processing to influence subsequent timing behavior. Previous animal and human studies have mainly focused on the effect of reward on interval perception, whereas its impact on interval production is less clear. In this study, we examined whether feedback, as an example of performance-contingent reward, biases interval production. We recorded EEG from 20 participants while they engaged in a continuous drumming task with different realistic tempos (1728 trials per participant). Participants received color-coded feedback after each beat about whether they were correct (on time) or incorrect (early or late). Regression-based EEG analysis was used to unmix the rapid occurrence of a feedback response called the reward positivity (RewP), which is traditionally observed in more slow-paced tasks. Using linear mixed modeling, we found that RewP amplitude predicted timing behavior for the upcoming beat. This performance-biasing effect of the RewP was interpreted as reflecting the impact of fluctuations in reward-related anterior cingulate cortex activity on timing, and the necessity of continuous paradigms to make such observations was highlighted.