The subject of study of this article is one of the key tasks that arises during the development and operation of aviation gas turbine engines, namely ensuring the strength of their parts. The turbine blade is one of the most heavily loaded parts of an aircraft engine. Therefore, at the stage of designing these blades, it is necessary to be able to identify and avoid possible resonance modes that appear during the flight cycle of an aircraft gas turbine engine. Such resonant oscillations of gas turbine blades can occur due to time-varying gas-dynamic forces from the action of the gas flow and are periodic in nature, as they are determined by the frequency of rotation of the rotor. In order to regulate the frequency characteristics of the blades to prevent dangerous resonant forms of oscillations that arise under the action of various harmonics of the exciting force during variable modes of operation of the aircraft engine, it is necessary to carry out a complex of various technological or structural changes. At the current stage, turbine blades of aircraft engines are manufactured by the method of single-crystal casting. As is known, single crystals have anisotropic properties, namely they manifest themselves as materials with the characteristics of cubic symmetry. A very urgent task is to investigate the effect of the anisotropy of the elastic characteristics of monocrystalline blades on their natural frequencies and forms of oscillations. In this research, the authors developed a method for determining the elastic characteristics of a single crystal, namely Young's modulus of elasticity, Poisson's ratio and pure shear modulus, which is based on available experimental data for typical heat-resistant alloys. With the help of finite element analysis on the example of a typical model of a cooled blade of a gas turbine, its modal analysis was carried out and its resonance diagram was constructed. The trend of changing the natural frequencies and forms of blade oscillations when the elastic constants of the single crystal change due to the rotation of the crystallographic system of directions was also investigated. The three-dimensional model of the blade was built using the capabilities of the NX graphics complex, all calculations were performed in the Maple computing complex, and the capabilities of the ANSYS software complex were used for finite element analysis.