Recovery Time Period Research Articles

The effect of cold water on the transitional speed and agility of basketball players

In recent years the researches focus on recovery strategies to boost the rebuild of physiological processes and improving performance in training and competition, and ice-bath is one of the modern scientific methods to fatigue phenomenon and refresh athletes in addition to active neuromuscular cells. The game of basketball features by rapid and intense movements such as jump, footwork, sprint and intense motion repetition with short recovery time periods. Therefore, players need speed, power and motion endurance such as (sprint, jump, changing direction and footwork) despite the ability of maintaining high level performance during the game. The study aims to identify the effect of ice-bath on speed and agility of basketball players. The research sample consists of Qala sport club players in Erbil province numbered (10) players divided into to equal groups of (5) participants (control group and experimental group). The statistical package of social sciences (SPSS) used for data analysis. The results show no significant differences in speed and agility tests, as speed require long resting periods to be fully recovered. The researchers recommend conducting further researches and studies on ice-bath in different sports to determine the its advantages for muscle recovery after trainings and games.

Impact of anabolic steroids on male fertility and the role of post-cycle therapy in recovery

Impact of anabolic steroids on male fertility and the role of post-cycle therapy in recovery

Endoscopic vs microscopic facial nerve decompression for traumatic facial nerve palsy: a randomized controlled trial.

To explore a minimally invasive trans-canal endoscopic facial nerve decompression for traumatic facial nerve palsy and compare it with microscopic facial nerve decompression. 35 and 38 patients underwent endoscopic and microscopic facial nerve decompression, respectively, for traumatic facial nerve palsy. Onset of symptoms, type of temporal bone fracture, day of surgical intervention following trauma, ossicular chain status and nature of insult to facial nerve were observed. Time period for recovery (House Brackmann grade ≤ 3), long term recovery rates, pre- and post-operative hearing status, surgical time and post-operative pain were compared between groups. Maximum patients in endoscopic and microscopic groups (77.1% and 76.3%, respectively) had acute onset of symptoms. 57.1% (20/35) had longitudinal, 17.1% (6/35) had transverse and 25.7% (9/35) had mixed fractures in endoscopic group. In the microscopic group, 57.9% (22/38) had longitudinal, 18.4% (7/38) had transverse and 23.7% (9/38) had mixed fractures. The mean (± S.D.) post-operative air-bone gap in endoscopic and microscopic group were 16.47 ± 4.5dB and 19.4 ± 5.2dB, respectively, which was statistically significant. The mean (± S.D.) time period for recovery of endoscopic and microscopic groups were 14.4 ± 5days and 22.5 ± 7days, respectively (p value < 0.05). The difference in post-operative pain between the two groups was also statistically significant. The difference in long term recovery rates was not statistically significant (p > 0.05). Endoscopic facial nerve decompression results in early recovery, less post-operative pain and better post-operative air-bone gap closure when compared to conventional microscopic technique.

Performance measurement system for circular supply chain management

Circular supply chain management is characterized by multiple interdependencies between various performance objectives for circularity, economic, environmental and social performance. A performance measurement system which takes these interdependencies into account is currently not available, however, is needed to identify effective actions, involve stakeholders and prevent unintended consequences of actions. The objective of this paper is to develop this performance measurement system. Using a methodology of multiple case studies, we identify the interdependencies between the various performance objectives and combine these in a causal loop diagram and a system dynamics model. We then evaluate the usability of these models in two companies which are in transition to circular supply chain management. The companies confirm the relevance of performance objectives, their interdependencies and the validity of the outputs. This results in the following contributions: Service lifetime - the time period of use, recovery and reuse until incineration - is as relevant to circularity as the much-mentioned product lifetime. The maturity of circularity follows four phases: virgin materials only, combination, recovered materials only, deterioration. Shortening the supply chain leads to a rebound effect and increases the environmental impact. The circular premium can relate to shareholders as well as to customers.

Analysis of Semen Parameters of Recovered Patients after COVID-19

Aim: The COVID-19 has spread rapidly around the world. Apart from primarily targeting the lungs and causing acute respiratory distress syndrome with severe respiratory symptoms and high risk of death, the disease can also cause damage to other organs such as the heart, kidney, and testis. Studies have shown that men are more likely to get infected by the disease than women and the death rate due to the disease is found to be higher in men. We aimed to show the effects of COVID-19 on sperm parameters. Materials and Methods: In the study, semen analyzes of COVID-19 patients and healthy control groups were compared according to the presence or absence of PCR-confirmed SARS-CoV-2 positivity in hospital records. Patients with COVID-19 (+) were the patients who had mild disease. A total of 510 participants, 53 COVID-19 patients and 457 healthy control groups. After positivity confirmation of recovered COVID-19 patients using PCR, semen analysis was performed after an average of 157 (24-355) days. Also, in order to evaluate the short-term and long-term effects of the disease, patients were grouped as those with less than 90 days and more than 90 days after receiving the positive PCR result. Results: While the mean progressive motility of sperm was 41.45 (19.21) in the recovered COVID-19 patients, it was 38.35 (21.74) in the control group. The mean total motility was 55.74 (19.34) in recovered COVID-19 patients, where as it was 51.84 (22.45) in control group. The percentage of normal sperm morphology was 11.45 (5.97) in recovered COVID-19 patients, however it was 11.19 (8.08) in control group. The sperm concentration was found to be 68.60 (56.22) x 106/ml in recovered COVID-19 patients, but it was 74.10 (61.72) x 106/ml in control group. Finally, the mean sperm immobility was 44.26 (19.34) in recovered COVID-19 group, however it was 48.16 (22.45) in control group. Conclusion: In the study, when the semen analysis results of patients who recovered after COVID-19 and healthy control groups were compared in terms of semen parameters according to the recovery time period, no statistically significant difference was found. More studies are needed to fully understand the effects of COVID-19 on the reproductive system.

Effects of perioperative use of two doses of magnesium sulfate infusion on intraoperative blood loss in patients undergoing lumbar spinal fusion surgery

Objective: In general, spinal fusion surgery causes heavy bleeding. The purpose of this study was to evaluate the use of two different doses of magnesium sulfate to control the bleeding in lumbar fusion surgery. Methods: This study was carried out as a randomized double-blinded clinical trial in 2020 in Al-Zahra hospital in Isfahan. The participants were 60 patients selected using inclusion and exclusion criteria and were randomly allocated into three groups. In the first group, 50 mg/kg and in the second group, 40 mg/kg magnesium sulfate was infused. The third group received normal saline. From the beginning of anesthesia, heart rate, diastolic and systolic blood pressure, respiratory rate and blood oxygen saturation percentage were monitored and logged every 30 minutes during the operation and recovery. The volume of bleeding during the operation was calculated by counting the number of gauzes used and the amount of suctioned blood during the operation. Other required information such as the duration of operation, duration of anesthesia, time of intubation and the time period of hospitalization and recovery were determined and recorded in all patients. We used independent t-test and repeated measure ANOVA tests to compare data between different time lines and also different groups. P value&lt;0.05 was considered as significance threshold. The collected data were analyzed by using SPSS software version 23. Results: The group receiving 50 mg/kg magnesium sulfate had a significantly lower systolic blood pressure compared to other groups within 15, 30 and 45 minutes after the injections (P=0.04 for all). The pulse rate was significantly lower in the 50 mg/kg magnesium sulfate group compared to other groups within 15, 30 and 45 minutes after the injections (P&lt;0.05 for all). Patients that received 50 mg/kg magnesium sulfate had a lower duration of surgery (P=0.007), lower duration of anesthesia (P=0.007), lower bleeding volume (P&lt;0.001), lower fluid intake (P=0.01) and also lower transfused blood (P=0.01). The surgeons also had a significantly higher satisfaction with these patients (P=0.001). Conclusion: Injection of 50 mg/kg magnesium sulfate had a correlation with reduced blood pressure as well as bleeding volume compared to 40 mg/kg magnesium sulfate.

Biomechanical assessment and quantification of femur healing process using fibre Bragg grating strain sensors

Femur diaphysis fractures almost always require surgery to heal. The femur recovery process may take 3–6 months or even longer. The current femur recovery assessment methods are qualitative and mainly rely on physicians' clinical experience. A better methodology to quantify the healing status will help the physicians counsel their patients on the appropriate load-bearing activities accordingly. This paper numerically and experimentally demonstrates a femur healing assessment methodology using fibre Bragg grating (FBG) sensors. Finite Element (FE) analysis was conducted to confirm the feasibility of the used epoxies. For the experiments, a fourth-generation composite femur (4GCF) sample fixated with an implant plate was prepared. The sample was instrumented with a total of six FBGs on the proximal and distal posterior, mid-shaft, and implant surfaces. The prepared sample was then subjected to cyclic loading on a hydraulic tensile machine in various situations including (1) intact, (2) fractured (mid-shaft transverse and wedge), and (3) epoxy-healed. Epoxies with different curing times were applied on the fractured femur to mimic bone regeneration stages as they harden. FBGs were used to monitor the alterations in the strain values during the healing stages. The results demonstrated that the strain values measured by FBGs were able to justify the non-union, mal-union, delayed union, and fully union conditions on the femur shaft compared to the intact and fractured conditions. The proposed assessment technique can potentially be used on long bones with various fracture types and for patients of different ages and recovery rates. • Fractured femur healing process was quantitatively monitored and assessed. • Epoxies were applied on fractured femur to mimic bone regeneration stages as they cure. • Finite element analysis was used to investigate the utilised epoxies feasibility. • The healing extent of the femur is shown at each stage during the recovery time period.

Reestablishing a foundational species: Limitations on post‐wildfire sagebrush seedling establishment

AbstractImproving post‐wildfire restoration of foundational plant species is crucial for conserving imperiled ecosystems. We sought to better understand the initial establishment of sagebrush (Artemisia sp.), a foundational shrubland species over a vast area of western North America, in the first 1–2 years post‐wildfire, a critical time period for population recovery. Field data from 460 sagebrush populations sampled across the Great Basin revealed several patterns. Sagebrush seedlings were uncommon in the first 1–2 years after fire, with none detected in 69% of plots, largely because most fires occurred in areas of low resistance to invasive species and resilience to disturbance (hereafter, R&amp;R). Post‐fire aerial seeding of sagebrush dramatically increased seedling occupancy, especially in low R&amp;R areas, which exhibited a 3.4‐fold increase in occupancy over similar unseeded locations. However, occupancy models and repeat surveys suggested exceptionally high mortality, as occupancy rates declined by as much as 50% between the first and second years after fire. We found the prevalence of “fertile island” microsites (patches beneath fire‐consumed sagebrush) to be the best predictor of seedling occupancy, followed by aerial seeding status, native perennial grass cover, and years since fire. In populations where no sagebrush seeding occurred, seedlings were most likely to occur in locations with a combination of high fertile island microsite cover and close proximity to a remnant sagebrush plant. These important attributes were only present in 13% of post‐fire locations, making them rare across the Great Basin. Finally, in the absence of fertile islands and remnant plants, seedling establishment was not observed in any unseeded areas, and rarely in seeded locations. Thus, local extirpation of sagebrush could have important, long‐term implications for sagebrush reestablishment following future fires if there are no mature individuals to leave behind fertile islands or serve as remnant individuals. These findings highlight the importance of landscape legacy effects and could help guide where and how big sagebrush restoration is conducted in the future.

PO-630-08 INFLUENCE OF TWO NARCOSIS REGIMENS ON CARDIAC ELECTROPHYSIOLOGY IN MICE

Mouse models are commonly used to study arrhythmia mechanisms in vivo. Different narcosis regimens have proven feasibility in rodents with medetomidine (0.5 mg/kg), midazolam (5 mg/kg) and fentanyl (0.005 mg/kg) (MMF) and isoflurane (1-3 %)/fentanyl (0.05 mg/kg) (IF) among the most commonly used regimens, but little data is available regarding their effects on cardiac electrophysiology. To investigate the effects of MMF and IF narcosis in C57BL/6 wildtype mice on cardiac electrophysiology in vivo. Telemetry transmitters were implanted in 4 C57/BL6 mice which served as controls for ECG analysis without narcosis. In 22 mice ECG and invasive electrophysiology studies were performed under narcosis (n=10 MMF, n=12 IF). We assessed ECG, heart rate variability (HRV), sinus node recovery time (SNRT), atrial, atrioventricular and ventricular refractory periods (AERP, AVERP and VERP), Wenckebach point, VA conduction and arrhythmia inducibility by burst stimulation. MMF causes significant bradycardia (452 bpm baseline vs. 271 bpm MMF, ****p < 0.0001), affects HRV indicated by increased pRR50 (1.6 % baseline vs. 67.4 % MMF, ****p < 0.0001), reduced LF/HF ratio (0.62 baseline vs. 0.16 MMF, *p = 0.019) and both increased SD1 (15 ms baseline vs. 94 ms MMF, ****p < 0.0001) and SD2 (19.6 ms baseline vs. 48.5 ms MMF *p =0.017), and prolongs QRS duration (8.1 ms baseline vs. 11.6 ms MMF, *p = 0.015) and QT interval (50 ms baseline vs. 68 ms MMF, ****p < 0.0001). MMF prolongs SNRT (at 120 ms basic cycle length 234 ms MMF vs. 145 ms IF, ***p < 0.001), antegrade (69 ms MMF vs. 56 ms IF, ****p < 0.0001), and retrograde conduction in the AV node (118 ms MMF vs. 89 ms IF, ***p < 0.001), AVERP (67 ms MMF vs. 50 ms IF, **p < 0.01) and ultimately leads to increased susceptibility for ventricular arrhythmias (1.3 % MMF vs. 0 % IF, **p < 0.01) compared to IF. Our results highlight a significant impact of MMF narcosis on cardiac electrophysiology in mice. While IF only moderately reduces heart rate, MMF leads to significant bradycardia, QRS/QT prolongation and HRV alterations as well as impaired sinus node and AV node function, ultimately resulting in an increased inducibility of ventricular arrhythmias. Based on these effects we suggest using IF narcosis to study cardiac electrophysiology in mice.

Impact of Maternal Hyperoxygenation on Myocardial Deformation and Loading Conditions in Fetuses with and without Left Heart Hypoplasia

Maternal hyperoxygenation (MHO) is used in a variety of clinical applications, but its impact on fetal cardiovascular physiology is poorly understood. Our aims were to describe the effects of MHO on myocardial deformation parameters and on ultrasound-based metrics of preload and afterload and to assess the differential effect of MHO on fetuses with left heart hypoplasia (LHH). We hypothesized that the effects of MHO would be modulated by loading conditions and that fetuses with LHH would be more sensitive to changes in preload and afterload induced by MHO. We performed a post hoc analysis of 36 fetal echocardiograms performed as part of a pilot study of MHO in LHH (n=9) and control (n=9) fetuses. Oxygen was administered via 8L face mask for 10minutes. Right ventricular (RV) and left ventricular (LV) longitudinal strain and strain rate, estimated aortic and pulmonary cardiac output, pulmonary vein velocity-time integral (VTI) and pulsatility indices (PI) of the middle cerebral artery (MCA), pulmonary arteries (PA), and umbilical artery (UA) were measured at three time points: baseline, during MHO, and 10minutes after removal of MHO. Maternal hyperoxygenation induced decreases in LV strain and strain rate and increases in RV strain and strain rate. Pulmonary artery PI decreased and pulmonary vein VTI increased, suggesting decreased pulmonary vascular resistance and increased pulmonary venous return. Most findings did not return to baseline after removal of MHO. We found no significant effect of MHO on MCA or UA PI. Left heart hypoplasia cases demonstrated similar effects of MHO in control cases, with larger changes in pulmonary vein VTI and LV strain rate. The effects ofMHOon LV and RV mechanics suggest that changes in deformation indices may be explained by increases in LV preload and decreases in RV afterload. The time period for recovery of fetal hemodynamics from MHO is ill-defined.

Semianalytical model of complex fracture growth in vertical wells based on boundary element theory

The recent developments in low-permeability oil and gas reservoir mining technology have led to the application of various forms of well fracturing models to determine the physical formation parameters and flow laws in porous media. However, most related studies have been aimed at conducting a pressure transient analysis after the formation of fractures, ignoring the pressure change characteristics during fracture formation. In this study, a fracture growth model based on vertical fractured wells was established and solved using the source function theory and boundary element method. The rationality of the model calculation method was verified by the superposition principle. The pressure change laws before and after fracture growth were analyzed, and the model was subjected to hydraulic fracturing experiments. The results showed that with the increase in the local pressure at the bottom of the well, main fractures, branch fractures, and microfractures were generated in three stages. When the fracture was formed, the pressure and pressure derivative curves fluctuated but gradually returned to a stable state under the fracture shape with the extension of the flow time. Moreover, from the main fracture to the microfracture stage, the pressure recovery time period was gradually shortened. The fitting results of the analysis model and fracturing experiment were found to be accurate, providing a theoretical support for analyzing the transient pressure changes during the formation of complex fractures. The different curve characteristics also provide a new reference basis for evaluating the fracture propagation behavior and predicting the fracture conductivity.

Radiology Imaging Volume Changes During Discrete COVID-19 Pandemic Waves: Implications for the Delta Variant of Coronavirus and Future Pandemics.

PurposeThe aim of this study was to evaluate radiology imaging volumes at distinct time periods throughout the coronavirus disease 2019 (COVID-19) pandemic as a function of regional COVID-19 hospitalizations.MethodsRadiology imaging volumes and statewide COVID-19 hospitalizations were collected, and four 28-day time periods throughout the COVID-19 pandemic of 2020 were analyzed: pre–COVID-19 in January, the “first wave” of COVID-19 hospitalizations in April, the “recovery” time period in the summer of 2020 with a relative nadir of COVID-19 hospitalizations, and the “third wave” of COVID-19 hospitalizations in November. Imaging studies were categorized as inpatient, outpatient, or emergency department on the basis of patient location at the time of acquisition. A Mann-Whitney U test was performed to compare daily imaging volumes during each discrete 28-day time period.ResultsImaging volumes overall during the first wave of COVID-19 infections were 55% (11,098/20,011; P < .001) of pre–COVID-19 imaging volumes. Overall imaging volumes returned during the recovery time period to 99% (19,915/20,011; P = .725), and third-wave imaging volumes compared with the pre–COVID-19 period were significantly lower in the emergency department at 88.8% (7,951/8,955; P < .001), significantly higher for outpatients at 115.7% (8,818/7,621; P = .008), not significantly different for inpatients at 106% (3,650/3,435; P = .053), and overall unchanged when aggregated together at 102% (20,419/20,011; P = .629).ConclusionsMedical imaging rebounded after the first wave of COVID-19 hospitalizations, with relative stability of utilization over the ensuing phases of the pandemic. As widespread COVID-19 vaccination continues to occur, future surges in COVID-19 hospitalizations will likely have a negligible impact on imaging utilization.

Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

The biological processes associated with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown. We measured soluble markers of inflammation in a SARS-CoV-2 recovery cohort at early (<90 days) and late (>90 days) timepoints. We defined PASC as the presence of 1 or more coronavirus disease 2019 (COVID-19)-attributed symptoms beyond 90 days. We compared fold-changes in marker values between those with and without PASC using mixed-effects models with terms for PASC and early and late recovery time periods. During early recovery, those who went on to develop PASC generally had higher levels of cytokine biomarkers including tumor necrosis factor-α (1.14-fold higher mean ratio [95% confidence interval {CI}, 1.01-1.28]; P = .028) and interferon-γ-induced protein 10 (1.28-fold higher mean ratio [95% CI, 1.01-1.62]; P = .038). Among those with PASC, there was a trend toward higher interleukin 6 levels during early recovery (1.29-fold higher mean ratio [95% CI, .98-1.70]; P = .07), which became more pronounced in late recovery (1.44-fold higher mean ratio [95% CI, 1.11-1.86]; P < .001). These differences were more pronounced among those with a greater number of PASC symptoms. Persistent immune activation may be associated with ongoing symptoms following COVID-19. Further characterization of these processes might identify therapeutic targets for those experiencing PASC.

Suture-button Fixation and Arthroscopic Dorsal Ligamento-capsulodesis in Chronic Scapholunate Dissociation.

The treatment choice in scapholunate (SL) injury depends on the extent of the SL ligament tear, chronicity of injury, quality of the ligament remnants, reducibility of carpal malalignment, and cartilage status of the radiocarpal and midcarpal joints. In the absence of degenerative changes with chronic reducible dissociation, the optimal treatment would be the reconstruction of the SL interosseous ligament. Various SL reconstruction techniques via open or arthroscopic approaches have been described over the years; they include tendon reconstructions, volar/dorsal capsulodesis, SL allografts, bone-tissue-bone composite grafts, reduction and association of the scaphoid and lunate procedure, SL axis method, and SL internal brace technique. However, all of these techniques have their own shortcomings and disadvantages. The present study demonstrates a new technique using a suture-button device for the reduction and fixation of SL diastasis. The suture-button system is positioned between the scaphoid and the triquetrum, the direction of the system prevents scaphoid flexion and maintains continuity of the reduction. Arthroscopic dorsal ligamento-capsulodesis technique can be added to achieve biological healing during the stabilization process. The major advantages of this technique over others are a straightforward application with shorter operative time and lack of a need for harvesting a tendon graft. The technique is performed through mini-incisions, which enable a shorter postoperative recovery time and rehabilitation period and a quicker restoration of function which decreases the risk of joint stiffness. Furthermore, large bone tunnels which increase the risk of fracture are avoided.

Therapeutic management of demodicosis in golden hamsters: A review of 5 cases

Demodex spp is the most common ectoparasite recognized in golden hamsters (Mesocricetus auratus). Demodex criceti and Demodex aurati are the two distinct species causing demodicosis in hamsters. Five Golden hamsters belongs to different age groups were presented to Teaching Veterinary Clinical Complex, Mannuthy with alopecia and erythema on the dorsal aspect of the body. Physical conditions of animals were slightly below normal. Examination of deep skin scrapings revealed mites identified as Demodex spp. All the five hamsters were treated with subcutaneous administration of ivermectin @ 0.3mg/kg body weight. Topically amitraz dips were recommended at weekly intervals. Oral multivitamin supplements were also given as supportive therapy. The average time period for complete recovery was found to be five consecutive treatments at 2 weeks interval in all the cases. All the animals made an uneventful recovery by 10 weeks period.

Favorable Outcomes with Fludarabine, High Dose Cytarabine and Granulocyte Colony Stimulating Factor (FLAG) As Re-Induction for Residual Acute Myeloid Leukemia on Day 14 Bone Marrow

BACKGROUND:Initial response to standard induction therapy for acute myeloid leukemia (AML) is typically assessed by a bone marrow biopsy on day 14 (D14). However, there does not appear to be a consensus on who should receive re-induction therapy and what regimen to choose if treatment is given. Fludarabine, high dose cytarabine and granulocyte colony stimulating factor (FLAG) regimen has been used at our institution for re-induction in patients with residual disease on D14 marrow evaluation.METHODS:A retrospective chart review was performed to evaluate adult patients with AML who received re-induction with FLAG for residual leukemia on D14 marrow between September 2012 and July 2017 at our institution. All patients included in the analysis received standard induction chemotherapy with cytarabine and an anthracycline. Approval for the study was obtained from the IRB.RESULTS:We identified 27 patients that received FLAG as re-induction (Table 1). The median age at diagnosis was 61 years (range 19-77). Median WBC count at presentation was 5.8 X10^3/ml (range 0.6-132) and bone marrow blast % was 64 (range 30-95). Most patients (63%) had poor risk disease based on cytogenetics and molecular abnormalities (as per NCCN AML guidelines), one patient (4%) had favorable risk disease with the rest of the patients (33%) having intermediate risk disease. The D14 marrow had a minimum cellularity of more than 20% in 14 patients. The median blast % by morphology on the D14 marrow was 60% (range 9-95). The overall response rate (CR/CRp/CRi) was 78% with 17 out of 27 (63%) patients achieving complete remission (CR). Four patients (15%) had resistant disease after FLAG based on a bone marrow evaluation and 2 patients died of indeterminate cause. Of the 4 patients with resistant disease, 1 achieved CR with a second cycle of FLAG. Overall, three patients died in the hospital during re-induction.The median time period for neutrophil count recovery (ANC >500) from re-induction date was 19 days (range 15-33). The median length of hospital stay after re-induction for patients that were discharged was 22.5 days (range 17-41). Fifteen patients (56%) proceeded to hematopoietic stem cell transplant (HSCT). Out of the 15, 14 were in CR1 at the time of HSCT. At the last follow up, 16 patients were in remission. The median follow up time period after re-induction was 224 days (range 11-1,663). The median time to relapse for patients that achieved CR after initiating FLAG re-induction was 233 days (range 152-676). The 1 and 2 year overall survival (OS) rates were 72% and 62% respectively (Figure 1).CONCLUSION:We report favorable outcomes with FLAG as a re- induction regimen for patients found to have residual AML on D14 bone marrow biopsy following standard induction chemotherapy. The median age of our population was > 60 years and 63% of the patients had poor risk AML. Within the limitations of a small retrospective study, FLAG was well tolerated with 3 patients expiring during the initial hospitalization. For AML patients with residual disease 14 days after standard induction therapy and who are able to receive further treatment, FLAG is a reasonable salvage option. [Display omitted] DisclosuresErba:Celgene: Consultancy, Other: Chair, Scientific Steering Committee , Speakers Bureau; Incyte: all research support paid to University of Alabama, Consultancy, Speakers Bureau; Jazz: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau; Amgen: Consultancy, Other: all research support paid to University of Alabama, Research Funding; Daiichi Sankyo: Consultancy, Other: all research support paid to University of Alabama, Research Funding; ImmunoGen: Consultancy, Other: all research support paid to University of Alabama, Research Funding; MacroGen: Consultancy; Ono: Consultancy; Pfizer: Consultancy; Seattle Genetics: Consultancy, Other: all research support paid to University of Alabama, Research Funding; Sunesis: Consultancy; Millennium/Takeda: Consultancy, Other: all research support paid to University of Alabama, Research Funding; Agios: Other: all research support paid to University of Alabama, Research Funding; Juno: Other: all research support paid to University of Alabama, Research Funding; Astellas: Other: all research support paid to University of Alabama, Research Funding; Celator: Other: all research support paid to University of Alabama, Research Funding; Janssen: Other: all research support paid to University of Alabama, Research Funding; Glycomimetics: Other: Chair, Data and Safety Monitoring Committee.

Analysing spatial interdependence among the 2011 Thailand flood-affected small and medium enterprises for reduction of disaster recovery time period

Natural disasters have been a significant hurdle in the economic growth of middle-income developing countries. Thailand has also been suffering from recurring flood disasters and was most which are severely affected during the 2011 floods. This paper aims to identify the various factors that impact the speed of disaster recovery among the Small and Medium Enterprises (SMEs) severely affected by the floods in Pathumthani province in central Thailand, and how it is related to its speed decision of neighbours SMEs. The methodology adopts a spatial econometric model, to analysis and understand each of the chosen factors’ impact. The findings include the impact of disaster resilience, mitigation and planning at the SME level as well as the government level. The absence of accurate perception of actual risk, flood insurance and disaster management planning before the 2011 floods had contributed to the severity of the impacts during the 2011 floods.

A multivariate comparative clinical pharmacotherapeutic efficacy and chronopharmacovigilance assessment study of ofloxacin, one of the commonplace, TGFβ1 inducing and telomerase impairing fluoroquinolones, in treating acute gastroenteritis, chronic obstructive pulmonary disease, new drug-sensitive tuberculosis, recurrent mixed cutaneous infections, and post-surgical refractory wound infections, among the global patients, with heterogenous pharmacogeographic and pharmacogenomic constitution

Background: Ofloxacin has an inhibitory effect on DNA gyrase, DNA topoisomerase IV and IL-1α, IL-6, IL-8, TNFa; and a superinducing effect on IL-2. Ofloxacin has profound bactericidal, anti-tubercular, anti-leprotic, anti-viral including anti-coronavirus, anti-fungal, anti-protozoal, comedolytic, anti-comedogenic, anti-inflammatory, immunomodulatory, and anti-malignant: pro-apoptotic and anti-proliferative potential, including TGFb1 targeted G2 phase cell cycle arrest and telomerase activity impairment. Objectives of the study were a comparative clinical pharmacotherapeutic efficacy and chronopharmacovigilance assessment study, of ofloxacin, one of the commonplace TGFb1 inducing and telomerase impairing fluoroquinolones, in treating heterogenous global patients, suffering from different diseases.Methods: A prospective, multivariate study of 100 patients, allotted into group A (acute gastroenteritis) =20, group B (chronic obstructive pulmonary disease) =20, group C (new drug-sensitive tuberculosis) =20, group D (recurrent mixed cutaneous infections) =20, and group E (post-surgical refractory wound infections) =20, was prescribed ofloxacin 200-400 mg twice daily, according to required prescribed regimens. A comparative pharmacotherapeutic efficacy assessment was made from the complete recovery time-periods, including the residual recovery time-periods. The chronopharmacovigilance assessment was made by adverse effects occurrence monitoring during treatment period or follow-up, with an Adverse Event Case Report Form. Results: The residual recovery time-periods, in group A=0 days, group B=2 days, group E=3 days, group D=3 days, and group C=7 days. Adverse effects were not statistically significant, with a predictable chronopharmacovigilance illustration.Conclusions: The pharmacotherapeutic efficacy of ofloxacin was more for treating group A, followed by group B, followed by group E and group D, and finally followed by group C. Ofloxacin was safe, without any pharmacogenomic or pharmacogeographic heterogeneity related fluctuation.

Клиническая эффективность анатомической пластики передней крестообразной связки коленного сустава

Purpose Evaluate clinical effectiveness of anatomical reconstruction of the anterior cruciate ligament (ACL) and determine the perspectives for practical health care. Material and methods The review included 706 patients who underwent arthroscopic reconstruction of the ACL and graft interference screw fixation between 2010 and 2018. ACL reconstruction was performed using either anteromedial portal (n = 396, Group I) or an isometric transtibial tunnel technique (n = 310, Group II). Outcomes were evaluated clinically and radiographically using the 2000 International Knee Documentation Committee (2000 IKDC) Subjective Knee Evaluation Form, the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Tegner Lysholm scoring scale. Clinical and economic outcome measures included surgical time, rehabilitation and disability periods and period of recovery for sports performance. Results The knee anterior drawer test was equally negative and showed no significant differences in the groups. The Lachman test and the pivot shift test showed better results in Group I (p &lt; 0.001). Contractures, atrophic femoral muscles (p &lt; 0.05), synovitis (p &lt; 0.01), vertical position of the femoral graft channels and pathologically extended bone channels with wind-wiper effect (p &lt; 0.001) were more common among patients of Group II. Although knee function returned to normal, as rated with the 2000 IKDC Subjective Knee Evaluation Form, in 91.3 % of cases pathological changes in the knee (C) and severely impaired function (D) were 2.5 and 5 times less common in group I than in Group II (p &lt; 0.05). Pain, symptoms and sport scores were significantly higher on the KOSS scale for Group I (p &lt; 0.05). Surgical time was longer in patients of Group I (p &lt; 0.05) who had shorter rehabilitation period (p &lt; 0.05). Conclusion Anatomical reconstruction of ACL using anteromedial portal was shown to be a more reliable technique as compared to transtibial approach to ensure overall knee stability arranging adequate bone channels. The technique is capable to protect the graft from injury, reduce the likelihood of pain, synovitis, contractures, muscle atrophy, providing shorter rehabilitation, disability period and recovery for sport performance.

Fire reduces riverine DOC concentration draining a watershed and alters post-fire DOC recovery patterns

The loading of dissolved organic carbon (DOC) from soils to inland waters and ultimate transport to the ocean is a critical flux pathway in the terrestrial biosphere carbon cycle. Fires can significantly affect this flux through biogeochemical processes related to oxidation and mobilization of DOC in the soil. Therefore, in order to accurately estimate and model terrestrial carbon storage and export to the marine environment, we need to better understand the effects of fire on DOC flux. In this analysis, we compiled available observational data sets from seven watersheds across the conterminous United States generally spanning the years 1999–2019. We used these data sets to examine the effects of fire on riverine DOC concentration draining a watershed to study both the immediate impacts and the post-fire recovery patterns. Our results suggest that these fires result in an immediate decrease in riverine DOC concentration draining the watershed by 26 ± 15%, and the time required for DOC concentrations to recover to pre-fire levels was estimated to be, on average, approximately 9 months. During recovery, DOC concentration was 24 ± 11% lower than the long-term average for the watershed. In addition, the larger the proportion of the watershed that burned, the greater the concentration decrease and the longer the time period for post-fire recovery.