Initial Time Research Articles

Effect and mechanism of iron-carbon micro-electrolysis pretreatment of organic peroxide production wastewater.

The wastewater from organic peroxide production has high chemical oxygen demand (COD) concentration and poor biodegradability, so it is necessary to find a cost-effective treatment method. The iron-carbon microelectrolysis (IC-ME) technology was used to pretreat the organic peroxide production wastewater, and the influence of reaction conditions on the removal effect of pollutants and the degradation mechanism were studied. The effects of initial pH, iron filings, iron-carbon ratio, and reaction time on the wastewater treatment were investigated by single-factor and response surface optimization experiments, and the degradation mechanism was analyzed by three-dimensional fluorescence spectroscopy, UV-Vis, and gas chromatography mass spectrometry (GC-MS). The experimental results showed that the COD removal efficiency was 35.67% and the biodegradability of wastewater was increased from 0.113 to 0.173 under the conditions of initial pH of 3.1, the dosage of iron filings of 30.5g/L, the ratio of iron-carbon of 1.01, and the reaction time of 122.8min, and the process of IC-ME for degrading COD of wastewater from the production of organic peroxide was consistent with the secondary reaction. The IC-ME process could decompose macromolecular organic compounds such as tyrosine proteins and aromatic proteins, and improve the biodegradability of wastewater. It provides a theoretical reference for the practical application of IC-ME to treat this type of wastewater.

Understanding distracted pedestrians’ risky behaviour: The role of walking and visual characteristics through a field study

Use of mobile phones while crossing the road has become a growing safety concern among pedestrians. Though recently, some studies have attempted to understand risky behaviour of distracted pedestrians by analyzing impacts of distraction on pedestrians’ walking and visual characteristics, the impacts were measured individually. Moreover, most of the existing findings are based on lab-based experiments, whereas the real-world conditions are quite dynamic in nature. Hence, to overcome these gaps, the current study aims to understand to what extent different potential factors (such as distraction, walking characteristics, visual behaviour, etc.) affect the risk of unsafe pedestrian-vehicle interactions in real-world settings. For this purpose, a field experiment was designed to understand the impact of distraction on pedestrians’ risky behaviour using an eye-tracker at an unsignalized intersection in Delhi. The risk assessment was done using Post-Encroachment Time (PET) measure. The results indicate that the use of mobile phone while crossing the road increased the chances of unsafe (PET < 1.5 s) pedestrian-vehicle interactions by approximately eight folds. Surprisingly, pedestrians who crossed the intersection at high speed had higher chances of unsafe interactions, whereas their increased crossing initiation time reduced the probability of unsafe interactions. Moreover, increased pupil diameter and fixating more on vehicles approaching from the right side resulted in a reduced probability of unsafe interactions. However, the high frequency of saccades and higher fixations on the crosswalk's right side negatively affected unsafe interactions. This study highlights that it is important to consider visual characteristics along with demographic and walking and traffic characteristics as they can provide in-depth insights into pedestrians’ road crossing behaviour that are required to design and implement effective countermeasures and policies.

Simulation of four-point bending tests for the viscoelastic fracture properties of concrete

Understanding the fracture properties of concrete, such as crack propagation behavior and fracture energy, is crucial for designing and evaluating concrete structures. Experimental results are insufficient and cannot be directly employed for a comprehensive analysis of the fracture behavior of concrete structures under load, particularly when considering concrete as viscoelastic with the presence of cracks. Recognizing the time and cost constraints of traditional experimental testing, this research leverages numerical simulations as a cost-effective alternative to determine viscoelastic material parameters. Thus, the critical evaluation of concrete fracture properties, fundamental for the design and assessment of concrete structures, is addressed. Employing a finite element method for four-point bending tests, the study systematically investigates parameters such as initial crack depth, displacement acceleration, and time step. The material properties of concrete are described using viscoelastic models. The findings provide valuable insights into crack propagation behavior and deformation characteristics, emphasizing the significant influence of the modulus of elasticity on both maximum load values and displacement. These findings contribute to a deeper understanding of the structure's response and underscore the importance of considering these parameters in similar simulations. The study highlights the importance of considering these parameters in simulations to enhance the understanding of concrete fracture behavior. The paper's contributions can extend to optimizing concrete mixtures, formulating repair strategies, and improving structural assessments. Further research is suggested to improve the accuracy of simulations and investigate material properties under various conditions.

Early strength enhancement of high-volume fly ash mortar using accelerating admixtures

High-volume fly ash mortar is considered a "green" material, a sustainable development solution for the construction industry, in which the fly ash replacement Portland cement content is over 50%. However, this material has the major disadvantage of slow strength development, especially at an early age, which limits its applicability. To overcome the above disadvantage, the individual or combined addition of lime Ca(OH)2, silica fume, and/or accelerating admixtures including sodium thiocyanate (NaSCN), diethanolamine (DEA), and glycerol (Gly), etc. have been interested recently. In this study, to enhance the early strength of mortars with fly ash content to replace 60÷80% of Portland cement, a three-component accelerating admixture of NaSCN, DEA, and Gly (2:1:0.5 by the mass) was used with different ratios of 0.21÷0.49 % by the total powder mass, combined with a reasonable amount of lime, silica fume supplement as presented in previous research. Experimental results showed that the optimal accelerating admixture content is 0.35% by weight of powder, combined with 6% silica fume and the additional amount of lime is 5%; 10%; and 15% corresponding to mortars using fly ash of 60%; 70% and 80%, respectively to improve early strength of mortars that are suitable for structural use (R3 ≥ 13MPa, 3 days old). In addition, the influence of the additives used on the initial setting time of high-volume fly ash mortars was also discussed.

A new MIB-based time integration method for transient heat conduction analysis of discrete and continuous systems

By incorporating the matched interface and boundary (MIB) method into time integration computation, a new MIB-based time integration (MIBTI) approach is proposed for solving transient heat conduction problems in this work. Indeed, this is a truly effective time-domain MIB method that can directly discretize space and time derivatives, and the transient heat conduction problem (an initial-value problem) is transformed into a pseudo-space boundary-value problem. The initial and final time points are regarded as boundary points in the transformed space domain. Two algorithms are developed to deal with the final time point. Unlike conventional recursive schemes for time integration, all unknown variables can be determined by solving the transformed boundary-value problem in the present approach. Various discrete and continuous systems without and with internal heat sources under different boundary conditions are considered to examine the working performance of the proposed method. The applicability of the time stability criterion in the conventional recursive schemes to the proposed method is also discussed. It is found that excellent numerical stability and convergence can be achieved by using the present MIBTI method for solving transient heat conduction problems.

Cardiovascular Events and Mortality in Patients on Hemodialysis: The Prognostic Value of the CHA2DS2-VASc Score.

Background and Objectives: Cardiovascular events are the major cause of morbidity and mortality in patients on hemodialysis (HD). Identifying risk factors can help in the effort to reduce cardiovascular risk and improve life expectancy. The objective of this study was to evaluate the ability of the CHA2DS2-VASc score-the risk index of stroke in atrial fibrillation (AF)-to predict strokes, major cardiovascular events, and mortality in patients with end-stage kidney disease. Materials and Methods: The CHA2DS2-VASc and HAS-BLED scores (the bleeding risk from the use of anticoagulation in AF) were calculated in 237 HD patients, 99 women with a median age of 76 (15) years, at the time they commenced HD. The scores' ability to predict long term cardiovascular morbidity and mortality was estimated, both in those with and without AF. Among the exclusion criteria were the change of dialysis method or loss of follow-up, HD due to acute renal failure, and incompliance with medical instructions, thus the sample is not representative of a broader population. Results: The CHA2DS2-VASc score was higher in AF (n = 69) compared to non-AF (n = 168) patients, 5 (2.5) vs. 4 (2), p < 0.0001, respectively. An increased CHA2DS2-VASc score was correlated with cardiovascular events, namely, heart failure (p = 0.007, p = 0.024), stroke (p < 0.0001, p < 0.0001), and risk of all-cause mortality (p < 0.0001, p < 0.0001) in AF and non-AF groups, respectively. The C statistics indicated that the referred score showed modest discrimination in AF and non-AF patients on HD for heart failure, stroke, and all-cause mortality, however for cardiovascular mortality this was found only in the AF group. Conclusions: An increased CHA2DS2-VASc score at the time of HD initiation can predict strokes, heart failure, and all-cause mortality in HD patients independent of the presence of AF. The risk of cardiovascular mortality could only be predicted in patients with AF.

Synthesis, characterization and isothermal studies of Mg-Fe Layered hydroxide with bentonite clay for the removal of alizarin blue dye from aqueous solution

This research aimed to prepare and characterize Mg-Fe layered Hydroxide clay for removal of alizarin blue dye from aqueous media using batch adsorption technique. The Mg-Fe layered Hydroxide prepared was characterized by SEM, FT-IR and XRD before and after adsorption. The result obtained from SEM shows a large surface area before and a rough and filled surface after adsorption. The presence of OH, C=O and N-CH stretching at 3644 cm-1, 1771 cm-1 and 2884 cm-1 respectively was analyzed by FT-IR. It was verified that the crystalline structure was not altered during the pillaring process as evidenced by XRD. Various parameters such as initial dye concentration (10 – 50 mg/l), contact time (10 – 50 mins), adsorbent dose (0.1 – 0.5 g) and Temperature (30 – 70oC) were investigated. The experiments showed the following results; dye concentration decreased from 95.70% - 72.6%, contact time increased from 87.70% - 98.0% and adsorbent dose showed 87.7% - 92.3% removal respectively. The Adsorption isotherms of Freundlich, Langmuir, Temkin and Harkin’s-Jura Isotherms were used to observe the adsorption condition. Freundlich adsorption Isotherm fitted best with maximum removal of 6.97 mg/g and R2 value of 0.999. In this work, Mg-Fe layered hydroxide with bentonite clay which is low cost became effective adsorbent for the removal of Alizarin blue dye.

External validation of the GETTEC algorithm for elective neck dissection in patients candidates for salvage total laryngectomy

ObjectiveTo perform an external validation of the algorithm for elective treatment of the lymph node areas proposed by GETTEC for patients candidates to salvage total laryngectomy after radiotherapy. This algorithm is based on the initial lymph node status, local extension of the recurrence and time to recurrence. Material and methodsRetrospective study performed in 151 patients treated with salvage total laryngectomy without clinical or radiological evidence of regional involvement at the time of diagnosis of recurrence (rcN0). The percentage of patients with occult lymph node metastases was calculated according to the algorithm proposed by GETTEC. ResultsA total of 14.6 % (n = 22) of the patients had occult lymph node metastases. Patients with locally advanced recurrences (rcT4) had a higher risk of occult lymph node metastases. There were no significant differences in the risk of occult lymph node metastases according to initial lymph node status or time to recurrence. When applying the algorithm proposed by GETTEC, there were no significant differences in the percentage of occult lymph node metastases between the group of patients who were candidates for follow-up (14.4 %) and those candidates for elective neck dissection (14.9 %) (P = 0.940). According to our results, patients who were candidates for an elective neck dissection were those with tumors located in the supraglottis or rcT4 glottic tumors. ConclusionOur results do not validate the algorithm proposed by GETTEC for the management of the lymph nodes in rcN0 patients who are candidates for salvage total laryngectomy after radiotherapy.

Multi-effect of fineness and replacement ratio of binders on thixotropic and some fresh state properties of cementitious systems, a comparative study

Effects of cement fineness, fly ash replacement ratio and fineness changes on some fresh state and rheological properties of mixtures were investigated in this study. Two different Blaine finenesses of portland cement (4000, 5000 cm2/g) and 4 different finenesses of fly ash (4000, 5000, 6000 and 7000 cm2/g) were used. 26 different paste mixtures were prepared by substituting fly ash in 3 different ratios (10%, 20%, and 30%) by weight. Marsh-funnel flow time, mini-slump, setting time, dynamic yield stress (DYS), viscosity and thixotropic behavior of mixtures were investigated. 4 different thixotropy measurement methods were used; dynamic yield stress ratio (DYSR), viscosity ratio (VR), shear stress-structural build-up area (SBUshr) and viscosity-structural build-up area (SBUvis). There was no notable change in the initial setting time results of the mixtures with the increase in portland cement fineness. The rheological parameters and thixotropic behavior of the mixtures increased significantly. Vicat-water requirement and setting-time-value decreased with the increase of fly ash fineness in cementitious mixtures with low fineness. The structural build-up of the mixtures decrease with the rise of the F class FA replacement ratio. It was determined that the methods with the highest correlation among thixotropy measurement methods were SBUshr-SBUvis, DYSR-SBUshr and DYSR-Athix, respectively.

Climatology of Synoptic Non-Gaussian Meteorological Anomalies in the Northern Hemisphere during 1979–2018

The analysis of spatial and temporal variability in the number of non-Gaussian extreme anomalies of climatic parameters was carried out for both the initial time series and synoptic variability in the troposphere of the Northern Hemisphere over the period 1979–2018, based on ERA-Interim reanalysis data. There are predominantly three types of empirical distribution densities at 850 hPa, each characterizing the processes of advective and convective heat transfer. At the beginning of the 21st century, compared to the end of the 20th century, there was an increase in the number of anomalies in vertical wind speed and specific humidity for the Northern Hemisphere. Additionally, there is an increase in the number of zonal wind speed anomalies in the low and middle latitudes. Regions with the maximum number of anomalies are primarily located over the continents, while for vertical wind speed anomalies, they are predominantly over the oceans. The application of R/S analysis and multifractal analysis has established that the identified tendencies (which are persistent processes) will continue in the identified regions. The time series of non-Gaussian anomalies (both initial and synoptic scales) exhibit a long-term memory of approximately four years, and synoptic extreme anomalies were found to be more predictable.

Functional electrical stimulation to enhance reactive balance among people with hemiparetic stroke.

Individuals with stroke demonstrate a twofold higher fall incidence compared to healthy counterparts, potentially associated with deficits in reactive balance control, which is crucial for regaining balance from unpredictable perturbations to the body. Moreover, people with higher stroke-related motor impairment exhibit greater falls and cannot recover balance during higher perturbation intensities. Thus, they might need supplemental agents for fall prevention or even to be included in a perturbation-based protocol. Functional electrical stimulation is a widely used clinical modality for improving gait performance;however, it remains unknown whether it can enhance or interfere with reactive balance control. We recruited twelve ambulatory participants with hemiparetic stroke (61.48 ± 6.77years) and moderate-to-high motor impairment (Chedoke-McMaster Stroke Leg Assessment ≤ 4/7). Each participant experienced 4 unpredicted paretic gait-slips, with and without functional electrical stimulation (provided 50-500ms after perturbation) in random order. The paretic quadriceps muscle group was chosen to receive electrical stimulation, considering the role of support limb knee extensors for preventing limb-collapse. Outcomes includingprimary (laboratory falls), secondary (reactive stability, vertical limb support) and tertiary (compensatory step length, step initiation, execution time) measureswere compared between the two conditions. Participants demonstrated fewer falls, higher reactive stability, and higher vertical limb support (p < 0.05) following gait-slips with functional electrical stimulation compared to those without. This was accompanied by reduced step initiation time and a longer compensatory step (p < 0.05). The application of functional electrical stimulation to paretic quadriceps following gait-slips reduced laboratory fall incidence with enhanced reactive balance outcomes among people with higher stroke-related motor impairment. Our results lay the preliminary groundwork for understanding the instantaneous neuromodulatory effect of functional electrical stimulation in preventing gait-slip falls, future studies could test its therapeutic effect on reactive balance. Clinical registry number: NCT04957355.

Trapping and guiding soliton through Airy pulse

We show that Airy soliton interaction in anomalous dispersion and focussing nonlinear regime provides an effective control on the co-propagating sech soliton dynamics. Cross phase modulation (XPM) induced nonlinear phase results varying group velocity of the sech soliton which leads to its temporal shift towards leading edge. The soliton could be made either advanced or delayed by choosing an appropriate initial time delay between the two co-propagating pulses. The effect of the initial time delay on trapping efficiency is also disclosed. Additionally, we have studied the effect of temporal chirp in Airy pulse on sech soliton dynamics. It is found that introduction of positive chirp inhibits the XPM-induced temporal shift of the soliton, while negative chirp boosts the XPM-induced acceleration. Further, the effect of group delay on the trapping and guiding of the soliton has been investigated. Moreover, the role of relative dispersion and nonlinear length on the soliton pulse acceleration are investigated. These results are expected to provide a better understanding on manipulation of light by light that could be useful in all-optical switching and signal control.

Mitigating commutation failures in HVDC systems with SFCL deployment

Commutation failures represent a prevalent issue encountered in line-commutated-converter high voltage direct current (LCC-HVDC) systems. As the widespread deployment of HVDC systems continues, the risk associated with commutation failures increases, posing a growing threat to power grids due to their potential to trigger severe consequences, including cascading failures and widespread blackouts. This research paper aims to address the significant issue of commutation failure within direct current (DC) systems through advocating for the use of resistive-type Superconducting Fault Current Limiters (R-SFCLs). To substantiate the efficacy of this proposed strategy, an array of simulations are executed using the PSCAD/EMTDC software. This comprehensive study investigates the performance characteristics of R-SFCLs configured with varying resistance values, scrutinizing their response under diverse fault resistance scenarios and distinct fault initiation times within the LCC-HVDC system. The outcomes of these simulations are that SFCLs confer significant advantages for mitigating commutation failures, surpassing traditional mitigation methods in terms of effectiveness. Consequently, SFCLs emerge as an optimal solution to prevent commutation failures in the HVDC systems.

Appropriate timing of veno-arterial extracorporeal membrane oxygenation initiation after cardiac surgery

BackgroundVeno-arterial extracorporeal membrane oxygenation (VA-ECMO) can be initiated during cardiac surgery or later in ICU according to the hemodynamic profile and organ perfusion. Our aim was to study the appropriate timing of post-cardiotomy ECMO (PC-ECMO) initiation. We retrospectively analyzed 152 adult patients supported with PC-ECMO in our cardiac center between 2016 and 2022. The patients were divided into two groups: the intra-operative ECMO and the postoperative ECMO groups. The primary outcome was all-and-on-ECMO hospital mortality. The secondary outcomes included ECMO duration, new need for dialysis, cerebrovascular stroke, and length of ICU stay.ResultsOur cohort analysis revealed that 81(53.3%) patients were intra-operatively supported with VA-ECMO while 71(46.7%) patients were postoperatively supported in ICU. The postoperative ECMO group had significantly lesser SAVE score (p = 0.001), higher SAVE risk classes (p < 0.001), and higher SOFA score (p = 0.008) compared to the intra-operative ECMO group. The postoperative ECMO group had significantly more frequent hospital mortality (p = 0.003), on-ECMO mortality (p = 0.006), cerebrovascular stroke (p = 0.034), acute renal failure requiring dialysis (p < 0.001), and lesser lactate clearance at 12 h (p = 0.016) and at 24 h (p = 0.023) compared to the intra-operative group. There were statistically insignificant differences between the two groups regarding post-ECMO hospital mortality, cerebral bleeding, limb ischemia, ECMO, and ICU duration. Postponed postoperative ECMO insertion was associated with an increased risk of death (HR 1.628, 95%CI 1.102–2.403, p =0.014) with cox-proportional hazard regression. Logistic multivariable regression showed that atrial fibrillation (OR 6.2, 95% CI 2.71–61.84, p = 0.002), initial SOFA score (OR 1.46, 95% CI 1.041–3.83, p = 0.001), and postoperative ECMO insertion (OR 1.93, 95% CI 1.04–8.73, p = 0.031) were the predictors of hospital mortality.ConclusionsPostponed ECMO insertion in critically sick patients was associated with increased mortality after cardiac surgery. Early intra-operative initiation of PC-ECMO may have the potential to improve outcomes after cardiac surgeries.

Evaluating the photocatalytic performance of MOF coated on glass for degradation of gaseous styrene under visible light

Styrene is a volatile organic compound with various applications, especially in the plastics and paint industries. Exposure to it leads to symptoms such as weakness, suppression of the central nervous system, and nausea, and prolonged exposure to it increases the risk of cancer. Its removal from the air is a topic that researchers have considered. Various methods such as absorption, membrane separation, thermal and catalytic oxidation, biofiltration have been used to remove these compounds. The disadvantages of these compounds include the need for high energy, production of secondary pollutants, large space, providing environmental conditions (temperature and humidity) and long time. The photocatalyst process is considered as an advanced process due to the production of low and safe secondary pollutants. MOFs are nanoparticles with unique photocatalytic properties that convert organic pollutants into water and carbon dioxide under light irradiation and in environmental conditions, which prevent the production of secondary pollutants. The present study aimed to investigate the efficiency of MIL100 (Fe) nanoparticles coated on glass in removing styrene vapor from the air. Surface morphology, crystal structure, pore size, functional groups, and chemical composition of the catalyst were analyzed by SEM, XRD, BET, FTIR, and EDX analysis. The effect of parameters such as initial pollutant concentration, temperature, time, relative humidity, and nanoparticle concentration was evaluated as effective parameters in the removal process. Based on the results, MIL100 (Fe) 0.6 g/l with an 89% removal rate had the best performance for styrene removal. Due to its optimal removal efficiency, it can be used to degrade other air pollutants.

RSM approach for process optimization of the photodegradation of congo red by a novel NiCo2S4/chitosan photocatalyst

The current study reported a facile co-precipitation technique for synthesizing novel NiCo2S4/chitosan nanocomposite. The photocatalytic activity of the prepared nanocomposite was evaluated using congo red (CR) dye as a target pollutant. The central composite design was employed to examine the impact of different reaction conditions on CR dye degradation. This study selected the pH, photocatalyst loading, initial CR concentration and reaction time as reaction parameters, while the degradation efficiency (%) was selected as the response. A desirability factor of 1 suggested the adequacy of the model. Maximum degradation of 93.46% of 35 ppm dye solution was observed after 60 min of visible light irradiation. The response to surface methodology (RSM) is a helpful technique to predict the optimum reaction conditions of the photodegradation of CR dye. Moreover, NiCo2S4/Ch displayed high recyclability and reusability up to four consecutive cycles. The present study suggests that the prepared NiCo2S4/chitosan nanocomposite could prove to be a viable photocatalyst for the treatment of dye-contaminated wastewater.

Improvement on engineering properties and volumetric stability of alkali-activated slag-based composite cementitious material with rice husk ash and magnesium oxide

This study used rice husk ash (RHA) and magnesium oxide (MgO) to improve the engineering properties and volumetric stability of alkali-activated slag-based cementitious material. Experimental results found that when the amount of slag substituted by RHA increased from 0% to 20%, the initial setting time was extended from 15 to 20 min, and the final setting time was shortened from 35 to 30 min for the paste without MgO. The optimal substitution amount of RHA was 10%, which had the maximum compressive strengths at ages of 28 and 56 days to achieve 104.44 and 102.43 MPa for the paste without MgO, respectively. The drying shrinkage of paste without MgO increased with both the increase of RHA from 0% to 20% and ages from 3 to 56 days. With RHA, the drying shrinkage substantially decreased with the substitutions of MgO from 0% to 2.0% and almost remained steady after ages of 7 or 14 days. The optimal amount of RHA to replace slag was less than 10% and the optimal content of MgO was less than 1%, which can effectively improve the volumetric stability and reduce the heat of hydration of paste.

Concurrent Olaparib and Radiation Therapy in Older Patients With Newly Diagnosed Glioblastoma: The Phase 1 Dose-Escalation PARADIGM Trial

Background: Patients with glioblastoma who are elderly or have poor performance status (PS) experience particularly poor clinical outcomes. At the time of study initiation, these patients were treated with short-course radiotherapy (40 Gy in 15 fractions). Olaparib is an oral inhibitor of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) that is well tolerated as a single agent but exacerbates acute radiation toxicity in extracranial sites. Preclinical data predicted that PARP inhibitors would enhance radiosensitivity in glioblastoma without exacerbating adverse effects on the normal brain. Methods: Phase I of the PARADIGM trial was a 3+3 dose escalation study testing olaparib in combination with radiotherapy (40 Gy 15 fractions) in patients with newly diagnosed glioblastoma who were unsuitable for radical treatment either because they were aged 70 or over (WHO PS 0-1) or aged 18-69 with PS 2. The primary outcome was the recommended phase 2 dose (RP2D) of olaparib. Secondary endpoints included safety and tolerability, overall survival (OS) and progression free survival (PFS). Effects on cognitive function were assessed by mini-mental state examination (MMSE). Results: Of 16 eligible patients (56.25% male, median age 71.5 [range 44-78 years], 75% PS 0-1), one dose-limiting toxicity was reported (grade 3 agitation). Maximum tolerated dose was not reached and the RP2D was determined as 200 mg twice daily. Median OS and PFS were 10.8 months (80% CI: 7.3-11.4) and 5.5 months (80% CI: 3.9-5.9) respectively. MMSE plots indicated that cognitive function was not adversely affected by the olaparib-radiotherapy combination. Conclusions: Olaparib can be safely combined with hypofractionated brain radiotherapy and is well tolerated in patients unsuitable for radical chemoradiation. These results enabled initiation of a randomised phase II study and support future trials of PARP inhibitors in combination with radiotherapy for patients with brain tumors.

The Properties of Ultra-High-Performance Concrete with Assembly Unit of Secondary Aluminum Dross and Waste Fly Ash

Waste fly ash (WFA) and secondary aluminum dross (SAD) are common solid wastes inducing environmental pollution. These materials contain certain active substances that can be used in cement-based materials. Therefore, cement concrete can be used to solidify these solid wastes. In this study, the influence of the assembly unit of secondary aluminum dross (SAD) and waste fly ash (WFA) on the properties of ultra-high-performance concrete (UHPC) is investigated. The slump flow, the plastic viscosity, the yield shear stress, and the initial setting time of fresh UHPC are measured. Moreover, the flexural and compressive strengths and the dry shrinkage rate (DSR) are determined. The electrical resistance and reactance are tested. The electron microscopy spectroscopy (EDS), thermogravimetric analysis (TG), and X-ray diffraction spectrum (XRD) curves are obtained for revealing the mechanism of macroscopic performances. Results show that due to the optimal specific surface area and the volcanic ash effect, the UHPC with the assembly unit of 50% SAD and 50% WFA provides the highest slump flow, DSR, and mechanical strengths, while the corresponding plastic viscosity, yield shear stress, and electrical resistance are the lowest. The SAD can delay the setting time of UHPC. The relationship between the electrical resistance or the electrical reactance and the mass ratio of SAD accords with the quadratic function. The corresponding electrical resistance is the lowest. The relationship between the mechanical strengths and the electrical resistance fits with the cubic function. The leaching amounts of Zn and Cr increase in the form of cubic function with the immersing time. Meanwhile, the SAD can decrease the Zn and Cr by 0%–46.3% and 0%–45.2% respectively. As obtained from the EDS results, the element of Al is increased by adding SAD. The XRD curves show that the crystals of Al2O3 are increased and the SiO2 crystals are decreased by the added SAD. UHPC with 50% SAD exhibits the highest compact microstructures and the least Ca(OH)2 and 3CaO·SiO2 hydration products. The TG results show that UHPC with 50% SAD shows the lowest TG values of all the groups. This research will provide new UHPC materials and techniques applied in solidifying the WFA and SAD in the future.

Magnesium or bentonite modified almond kernel biochar for phosphate adsorption from contaminated water solutions

The potential of almond kernel, physically activated by nitrogen/steam, or chemically activated by Mg2+ or bentonite and then by nitrogen/steam, to adsorb phosphate from wastewaters was evaluated. The performance of biochar was studied as a function of initial phosphate concentration, adsorbent dose, contact time and solution pH. The mechanism of adsorption was investigated by carrying out structural, chemical and mineralogical analyses of the material before and after phosphate adsorption, as well as by applying two isotherm models, simulating the experimental data. The results showed that the specific surface area increased about 260 times after activation. Adsorption of phosphate was fast within 30 min, while reached equilibrium after 12 h. For Mg2+ modified material a higher ionic strength facilitated the uptake of phosphate by the biochar up to 59%, in contrast to the bentonite modified material, where adsorption of phosphate was complete (100%) at an initial concentration of 50 mg/L, declining thereafter. Mg2+ modified material was best fitted by the Freundlich model, while bentonite modified material was best fitted by the Langmuir model. For an adsorbent dose of 2 g/L maximum phosphate adsorption capacity after Mg2+ or bentonite modification was 82 mg/g and 54 mg/g, respectively. In the case of Mg2+ modification the potential mechanisms of adsorption were surface precipitation, electrostatic attraction, chemical complexation or electron coordination between the phosphate ion and the adsorbent. For bentonite modification, chemical complexation and π-π electron coordination were the potential adsorption mechanisms.