<h3>BACKGROUND CONTEXT</h3> Postoperative recovery is a common discussion topic during their preoperative counseling. Studies have reported return to activities with open techniques, with recent literature focusing on minimally invasive techniques. However, the precise timing of when patients return to these activities after certain procedures remains uncertain. <h3>PURPOSE</h3> The purpose of this study was to evaluate the timing of return to commonly performed activities, including driving, working and discontinuing opioids, as well as to identify preoperative factors associated with these outcomes. <h3>STUDY DESIGN/SETTING</h3> This was a single-center, multi-surgeon, retrospective review. Patients in this study had lumbar stenosis and underwent either minimally invasive lumbar laminectomy (MIS-L) or minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) between 7/2018 and 10/2021. <h3>OUTCOME MEASURES</h3> In addition to time to return to drive, return to work and discontinuation of opioids, patient reported outcome measures (PROMs) including Oswestry Disability Index (ODI), Visual Analog Scale (VAS) for back and leg pain, Short Form-12 physical and mental score components (SF-12 PCS and SF-12 MCS), and Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF) were collected preoperatively. <h3>METHODS</h3> Descriptive statistics were calculated for demographic variables, PROMs and return-to-activity measures. Logistic regression was conducted to identify factors associated with return to driving by 15, work by 30 days and for discontinuing opioids by 15 days. A composite group was also created for patients who returned to all three activities, and regression was performed for return to all activities by 30 days. <h3>RESULTS</h3> Seventy-one patients (88.8%) (Median 11 days; IQR 5-25) in the MIS-L group and 80 (96.4%) (Median 18.5 days; IQR 14-30) in the MIS-TLIF group returned to driving. Fifty-seven patients (91.9%) (Median 14 days; IQR 4.5-32) in the MIS-L group and 54 (85.7%) (Median 25 days; IQR 14-49.75) in the MIS-TLIF returned to work. Sixty-three patients (88.7%) (Median 7 days; IQR 4-17) in the MIS-L group and 87 (92.6%) (Median 11 days; IQR 5-18) in the MIS-TLIF group discontinued opioids. Twenty-five (96.2%) subjects in the MIS-L group and 45 (100%) of the MIS-TLIF group returned to all three activities, with a median of 27 days [IQR 14-53.5] and 31 days [IQR 18.5-49], respectively. Male gender (OR 3.57, 95 CI [1.64, 7.69], p=0.001) and a higher preoperative SF-12 PCS score (OR 1.08, 95 CI [1.02, 1.12], p=0.004) predicted return to driving by 15 days. Male gender (OR 3.23, 95 CI [1.27, 8.2], p=0.014) and a higher preoperative SF-12 PCS score (OR 1.07, 95 CI [1.01, 1.13], p=0.029) predicted return to work by 30 days. A higher preoperative VAS back was correlated with decreased odds of discontinuing opioids by 15 days (OR 0.84, 95 CI [0.73, 0.96], p=0.011). <h3>CONCLUSIONS</h3> Minimally invasive techniques seem to narrow the gap in postoperative recovery between a laminectomy and TLIF in this relatively homogenous patient population. While our data do not provide guidance on surgical indication, they do suggest that patients undergoing MIS TLIF are highly likely to return to work, driving and discontinue opioids. Additionally, the difference between the two procedures is less than 2 weeks for most activities and similar when examining composite success. These findings serve as an important compass for preoperative counseling. <h3>FDA DEVICE/DRUG STATUS</h3> This abstract does not discuss or include any applicable devices or drugs.