It is known that the well-posedness of time-fractional reaction–diffusion models with Mittag-Leffler kernel usually requires non-physical constraints on the initial data. In this paper, we propose a variable-order time-fractional reaction–diffusion equation with Mittag-Leffler kernel and prove that the aforementioned constraints could be eliminated by imposing the integer limit of the variable fractional order at the initial time, which mathematically demonstrates the physically-relevance of the variable-order modifications.
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