This paper experimentally investigates the effectiveness and applicability of the time delay control (TDC) algorithm, which is simple and robust to unknown system dynamics and disturbance, for an active mass damper (AMD) system to mitigate the excessive vibration of a building structure. To this end, the theoretical background including the mathematical formulation of the control system is first described; and then, a thorough experimental study using a shaking table system with a small-scale three-story building structural model is conducted. In the experimental tests, the performance of the proposed control system is examined by comparing its structural responses with those of the uncontrolled system in the free vibration and forced vibration cases. It is clearly verified from the test results that the TDC algorithm embedded AMD system can effectively reduce the structural response of the building structure.