Time Bisection Task Research Articles

Time perception in stimulant-dependent participants undergoing repetitive transcranial magnetic stimulation

BackgroundThe dopaminergic (DA) system is an important neural system for the modulation of time perception and the timing of motor actions. Dysregulation of the DA system is related to chronic use of stimulant drugs, which lead, among others, to executive dysfunctions. Little is known instead about the potential deficiencies in temporal processing of stimulant-dependent individuals. The present study aimed to investigate temporal processing using a time bisection task with different temporal intervals in chronic cocaine users undergoing repetitive transcranial magnetic stimulation (rTMS). MethodStudy 1: A time bisection task with short temporal intervals range (480/1920 ms) was administered to 18 cocaine use disorder (CocUD) patients and 20 healthy control before and after the intensive phase of rTMS treatment (5 days apart). Study 2: 22 CocUD participants and 23 control participants completed two temporal tasks (time bisection and time reproduction) with long temporal intervals range (1200/2640 ms) at baseline and immediately after the intensive phase of rTMS treatment. ResultsStudy 1: A shift in the psychometric function consistent with temporal overestimation in CocUD patients compared to controls was observed. However, no temporal impairment in CocUD patients at test session was found. Study 2: The analysis of temporal variability indices showed a significant difference between groups at baseline but not at Day 5 due to a significant difference between time points only in the CocUD group. ConclusionsThis study report a temporal overestimation in CocUD patients and a temporal variability reduction after an rTMS protocol in CocUD patients.

Explicit Timing Differently Predicts Implicit Timing Performance in Younger and Older Adults

Abstract Temporal processing can be divided into explicit timing and implicit timing. Explicit timing tasks require participants to attend to the temporal aspects of the task, whereas in implicit timing tasks, temporal information affects performance without explicit instruction to process time. Compared to younger adults, older adults have been shown to exhibit greater variability in explicit timing, while in implicit timing, they have been shown to rely more on temporal predictions formed by the hazard function. However, the relationship between explicit and implicit timing and its age-related changes have yet to be explored. To address this issue, we collected data in which younger and older adults performed a time bisection task (i.e., explicit timing task) and a foreperiod task (i.e., implicit timing task) in a within-subjects design. Based on a Bayesian optimization framework, we hypothesized that individuals with higher variability in explicit timing would show a stronger foreperiod effect, which is an index of the degree of reliance on temporal predictions. Results showed a different relation between explicit and implicit timing in younger and older adults. In older adults, results were consistent with the hypothesis that increased variability in explicit timing was associated with a stronger foreperiod effect. In contrast, bias in the temporal representation but not variability was associated with the foreperiod effect in younger adults. Implications for the age-related difference in the relation between explicit and implicit timing are discussed.

The effect of modality and order presentation of emotional stimuli on time perception.

Despite human accuracy in perceiving time, many factors can modulate the subjective experience of time. For example, it is widely reported that emotion can expand or shrink our perception of time and that temporal intervals are perceived as longer when marked by auditory stimuli than by visual stimuli. In the present study, we aimed at investigating whether the influence of emotion on time perception can be altered by the order in which emotional stimuli are presented and the sensory modality in which they are presented. Participants were asked to complete a time bisection task in which emotional stimuli were presented either acoustically or visually, and either before or after interval to be estimated. We observed a main effect of modality (longer perceived duration and lower variability in the auditory than in the visual modality) as well as a main effect of emotion (temporal overestimation for negative stimuli compared to neutral). Importantly, the effects of modality and emotion interacted with the order of presentation of the emotional stimuli. In the visual condition, when emotional stimuli were presented after the temporal intervals, participants overestimated time, but no differences between negative and neutral stimuli were observed when emotional stimuli were presented first. In the auditory condition, no significant effect of emotion on perceived duration was found. Results suggest that negative emotions affect our perception of durations acting at the decision-making stage rather than at the pacemaker one. No effect on time perception was observed for emotional auditory stimuli.

Psychophysiological stress influences temporal accuracy.

Distortions of duration perception are often observed in response to highly arousing stimuli, but the exact mechanisms that evoke these variations are still under debate. Here, we investigate the effect of induced physiological arousal on time perception. Thirty-eight university students (22.89 ± 2.5; 28 females) were tested with spontaneous finger-tapping tasks and a time bisection task (with stimuli between 300 and 900ms). Before the time bisection task, half of the participants (STRESS group) performed a stress-inducing task, i.e., the Paced Auditory Serial Addition Test (PASAT), whereas the other participants (CONTROL group) performed a control task, the Paced Auditory Number Reading Task (PANRAT). The PASAT induced a greater heart rate, but not electrodermal, increase, as well as a more unpleasant and arousing state compared to the PANRAT. Moreover, although the two groups presented a similar performance at the finger-tapping tasks, participants in the STRESS group showed better temporal performance at the time bisection task (i.e., lower constant error) than the controls. These results indicate that psychophysiological stress may alter the subsequent perception of time.

Time bisection and reproduction: Evidence for a slowdown of the internal clock in right brain damaged patients

Previous studies show that the right hemisphere is involved in time processing, and that damage to the right hemisphere is associated with a tendency to perceive time intervals as shorter than they are, and to reproduce time intervals as longer than they are. Whether time processing deficits following right hemisphere damage are related and what is their neurocognitive basis is unclear. In this study, right brain damaged (RBD) patients, left brain damaged (LBD) patients, and healthy controls underwent a time bisection task and a time reproduction task involving time intervals varying between each other by milliseconds (short durations) or seconds (long durations). The results show that in the time bisection task RBD patients underestimated time intervals compared to LBD patients and healthy controls, while they reproduced time intervals as longer than they are. Time underestimation and over-reproduction in RBD patients applied to short but not long time intervals, and were correlated. Voxel-based lesion-symptom mapping (VLSM) showed that time underestimation was associated with lesions to a right cortico-subcortical network involving the insula and inferior frontal gyrus. A small portion of this network was also associated with time over-reproduction. Our findings are consistent with a slowdown of an ‘internal clock’ timing mechanism following right brain damage, which likely underlies both the underestimation and the over-reproduction of time intervals, and their (overlapping) neural bases.

Temporal visual representation elicits early auditory-like responses in hearing but not in deaf individuals

It is evident that the brain is capable of large-scale reorganization following sensory deprivation, but the extent of such reorganization is to date, not clear. The auditory modality is the most accurate to represent temporal information, and deafness is an ideal clinical condition to study the reorganization of temporal representation when the audio signal is not available. Here we show that hearing, but not deaf individuals, show a strong ERP response to visual stimuli in temporal areas during a time-bisection task. This ERP response appears 50–90 ms after the flash and recalls some aspects of the N1 ERP component usually elicited by auditory stimuli. The same ERP is not evident for a visual space-bisection task, suggesting that the early recruitment of temporal cortex is specific for building a highly resolved temporal representation within the visual modality. These findings provide evidence that the lack of auditory input can interfere with typical development of complex visual temporal representations.

Time Perception in Cocaine-Dependent Patients.

The involvement of the dopamine system in modulating time perception has been widely reported. Clinical conditions (e.g., Parkinson’s disease, addictions) that alter dopaminergic signaling have been shown to affect motor timing and perceived duration. The present study aimed at investigating whether the effects of chronic stimulant use on temporal processing are time-interval dependent. All participants performed two different time bisection tasks (480/1920 ms and 1200/2640 ms) in which we analysed the proportion of long responses for each stimulus duration as well as an index of perceived duration and one of sensitivity. Regarding the proportion of long responses, we found no differences between groups in either time bisection task but patients had more variable results than controls did in both tasks. This study provides new insight into temporal processing in stimulant-dependent patients. Regardless of the time interval tested, the results showed comparable temporal ability in patients and controls, but higher temporal variability in patients. This finding is consistent with impairment of frontally-mediated cognitive functions involved in time perception rather than impairment in time processing per se.

Do I dislike what you dislike? Investigating the effect of disgust on time processing.

Time perception can be distorted by emotional stimuli. The present study aims to investigate the effect of disgust on time perception in young adults. Here, we report two experiments in which a time bisection task was used with intervals lasting 400ms (short standard) to 1600ms (long standard). In Experiment 1, temporal intervals were marked by neutral images or images from food (rotten, joyful), and facial (disgust, happy) categories. In Experiment 2, disgust-eliciting and neutral stimuli belonging to seven different domains were used: faces, food, animals, body products, injury/infections, death and hygiene. Results showed temporal overestimations when, compared to neutral conditions, disgusted faces (Experiments 1 and 2) and disgusting death and hygiene stimuli (Experiment 2) were used, and a temporal underestimation when images of rotten food (Experiment 1) were used. Results are discussed in terms of arousal-based and attention-based processes and showed that the degree of the emotional component influences time perception.

Perceived Control in the Lab and in Daily Life Impact Emotion-Induced Temporal Distortions

Abstract Prior research has shown that the arousal and valence dimensions of emotional images distort the perceived duration of those images. Further, these time distortions are eliminated when observers feel in control over the events in the experiment. The present study had two goals. The first goal was to replicate the effect of perceived control on time perception, using a design where perceived control was manipulated within subjects. The second goal was to evaluate whether the experimental manipulation of perceived control was related to feelings of control experienced in daily life, as assessed by the Desire for Control and Locus of Control scales. In all, 109 participants completed a time bisection task and evaluated the same emotional images under low and high levels of perceived control over the events. The results replicated the finding that the temporal distortions by emotional events observed under low perceived control were eliminated under high perceived control. Furthermore, individual differences regarding control in daily life modulated the effects of perceived control on time perception. Individuals with a high desire for control and a high degree of internality seemed to have an enhanced experience of positive events. These same individuals also benefited more from the experimental control manipulation, speeding the passage of time and perhaps making the task more enjoyable. The results are discussed in the context of current models of time perception.

Lack of Temporal Impairment in Patients With Mild Cognitive Impairment.

In the present study, we investigate possible temporal impairment in patients with mild cognitive impairment (MCI) and the amount of temporal distortions caused by the presentation of emotional facial expressions (anger, shame, and neutral) in MCI patients and controls. Twelve older adults with MCI and 14 healthy older adults were enrolled in the present study. All participants underwent a complete neuropsychological evaluation. We used three timing tasks to tap temporal abilities, namely time bisection (standard intervals lasting 400 and 1600 ms), finger-tapping (free and 1 s), and simple reaction-time tasks. The stimuli used in the time bisection task were facial emotional stimuli expressing anger or shame to investigate a possible contribution of emotional information as previously observed in healthy adults. MCI patients showed temporal abilities comparable to controls. We observed an effect of facial emotional stimuli on time perception when data were analyzed in terms of proportion of long responses, and this result was mainly driven by the temporal overestimation when a facial expression of anger was presented in controls. Results seem to suggest that the severity of the cognitive dysfunction accounts more for subjective temporal impairment than a compromised internal clock.

Time perception in childhood absence epilepsy: Findings from a pilot study

ObjectivesWith this explorative study, we aimed to examine time perception in children with childhood absence epilepsy (CAE) and to compare those children with a matched control group. The study also investigated the association between the neuropsychological performance of the group with CAE and time judgment. We hypothesize that children with CAE could fail in time perception and that this may be because of a common underlying substrate with executive impairments. MethodsThirteen children with CAE, aged 6–13 years, and 17 healthy children were recruited. All children performed the time bisection task; the children with CAE also performed a cognitive and neuropsychological assessment. We performed a univariate analysis using each parameter of the bisection task (bisection point [BP]) and Weber ratio (WR) as dependent variables, the group (patients vs. controls) as fixed factors and age at evaluation and vocabulary scores as covariates. In the subgroup of patients, we correlated bisection task parameters with neuropsychological tests using a nonparametric partial correlation; the analysis has corrected for age at evaluation. ResultsThe BP and WR measures differed between controls and patients with CAE. In the subgroup of patients also performing a neuropsychological assessment, we found a correlation between the WR measure and performance on the inhibition test (r = −0.641, p = .025), coding test (r = −0.815, p = .014), and Trail Making Test B (TMT B) (r = 0.72, p = .042). ConclusionsWe found an altered time perception in a pilot study of a small group of children with CAE. A neurophysiological mechanism underlying CAE seems to influence cognitive and behavioral deficits and time sensibility.

Spatial Cues Influence Time Estimations in Deaf Individuals.

SummaryRecent studies have reported a strong interaction between spatial and temporal representation when visual experience is missing: blind people use temporal representation of events to represent spatial metrics. Given the superiority of audition on time perception, we hypothesized that when audition is not available complex temporal representations could be impaired, and spatial representation of events could be used to build temporal metrics. To test this hypothesis, deaf and hearing subjects were tested with a visual temporal task where conflicting and not conflicting spatiotemporal information was delivered. As predicted, we observed a strong deficit of deaf participants when only temporal cues were useful and space was uninformative with respect to time. However, the deficit disappeared when coherent spatiotemporal cues were presented and increased for conflicting spatiotemporal stimuli. These results highlight that spatial cues influence time estimations in deaf participants, suggesting that deaf individuals use spatial information to infer temporal environmental coordinates.

Modulating Subjective Time Perception with Transcranial Random Noise Stimulation (tRNS)

Understanding the neural and cognitive mechanisms underlying time estimation remains a challenge. Transcranial electric stimulations, such as transcranial random noise stimulation (tRNS), are useful tools to interfere with brain activity and identifying brain areas involved in temporal processing. Here, the aim is to investigate the specific role of primary sensory cortices (either V1 or A1) in temporal processing and to further investigate if the stimulation acts on either perceived duration or temporal sensitivity. Forty-eight university students were included in the study. Twenty-four participants were stimulated over A1, and 24 participants were stimulated over V1. All participants performed a time bisection task, either in a visual or auditory modality, involving standard durations lasting 300 ms (short) and 900 ms (long). When tRNS was delivered over A1, an effect of stimulation was observed on perceived duration (temporal over-estimation) under random stimulation compared to sham in both visual and auditory modalities. When tRNS was delivered over V1, the effect of stimulation was observed only in the visual modality (temporal over-estimation). No effect of stimulation was observed on temporal sensitivity in any condition. Our results showed for the first time that tRNS acts on modulating an individual’s perceived duration, but not on temporal sensitivity.

A tRNS investigation of the sensory representation of time

The understanding of the mechanisms underlying the representation of temporal intervals in the range of milliseconds/seconds remains a complex issue. Different brain areas have been identified as critical in temporal processing. The activation of specific areas is depending on temporal range involved in the tasks and on the modalities used for marking time. Here, for the first time, transcranial random noise stimulation (tRNS) was applied over the right posterior parietal (P4) and right frontal (F4) cortex to investigate their role in intra- and intermodal temporal processing involving brief temporal intervals (<1 sec). Eighty University students performed a time bisection task involving standard durations lasting 300 ms (short) and 900 ms (long). Each empty interval to be judged was marked by two successive brief visual (V) or auditory (A) signals defining four conditions: VV, VA, AV or AA. Participants were assigned to one of these four conditions. Half of the participants received tRNS over P4 and half over F4. No effect of stimulation was observed on temporal variability (Weber ratio). However, participants that were stimulated over P4 overestimated temporal intervals in the random condition compared to the sham condition. In addition to showing an effect of tRNS on perceived duration rather than on temporal variability, the results of the present study confirm that the right posterior parietal cortex is involved in the processing of time intervals and extend this finding to several sensory modality conditions.

Dissociating Explicit and Implicit Timing in Parkinson's Disease Patients: Evidence from Bisection and Foreperiod Tasks.

A consistent body of literature reported that Parkinson’s disease (PD) is marked by severe deficits in temporal processing. However, the exact nature of timing problems in PD patients is still elusive. In particular, what remains unclear is whether the temporal dysfunction observed in PD patients regards explicit and/or implicit timing. Explicit timing tasks require participants to attend to the duration of the stimulus, whereas in implicit timing tasks no explicit instruction to process time is received but time still affects performance. In the present study, we investigated temporal ability in PD by comparing 20 PD participants and 20 control participants in both explicit and implicit timing tasks. Specifically, we used a time bisection task to investigate explicit timing and a foreperiod task for implicit timing. Moreover, this is the first study investigating sequential effects in PD participants. Results showed preserved temporal ability in PD participants in the implicit timing task only (i.e., normal foreperiod and sequential effects). By contrast, PD participants failed in the explicit timing task as they displayed shorter perceived durations and higher variability compared to controls. Overall, the dissociation reported here supports the idea that timing can be differentiated according to whether it is explicitly or implicitly processed, and that PD participants are selectively impaired in the explicit processing of time.

Effects of happy and sad facial expressions on the perception of time in Parkinson’s disease patients with mild cognitive impairment

ABSTRACTIntroduction: Parkinson’s disease (PD) is a movement disorder caused by deterioration of the dopaminergic system. Previous studies have demonstrated temporal as well as emotional facial recognition impairment in PD patients. Moreover, it has been demonstrated that emotional facial expressions alter temporal judgments. In the present study, we investigate the magnitude of temporal distortions caused by the presentation of emotional facial expressions (happiness, sadness, and neutral) in PD patients with mild cognitive impairment (PD-MCI) and controls.Method: Seventeen older adults with PD-MCI and 22 healthy older adults took part in the present study. Participants were tested with a time bisection task with standard intervals lasting 400 ms and 1600 ms. Moreover, a complete neuropsychological evaluation was conducted to characterize the sample.Results: Differences between groups were observed indicating a general underestimation of time in PD-MCI patients. Temporal impairments in PD-MCI patients seem to be caused mainly by a dysfunction at the level of reference memory. The effect of emotional facial expressions on time perception was evident in both PD patients and controls, with an overestimation of perceived duration when happiness was presented and an underestimation when sadness was presented.Conclusion: Overall, our results indicate that reduced cognitive abilities might be responsible for the lower temporal ability observed in PD-MCI patients. Moreover, similar effects of emotional stimuli were observed in both PD-MCI patients and controls.

As time goes by: Oxytocin influences the subjective perception of time in a social context

Time perception depends on an event’s emotional relevance to the beholder; a subjective time dilation effect is associated with self-relevant, emotionally salient stimuli. Previous studies have revealed that oxytocin modulates the salience of social stimuli and attention to social cues. However, whether the oxytocin system is involved in human subjective time perception is unknown. The aim of the present study was to investigate whether increased oxytocin levels would induce a time dilation effect for self-relevant, positive social cues.In a double-blind, placebo-controlled, between-subject design, heterosexual men were administered intranasal oxytocin or placebo. After about 50min, participants completed a time-bisection task in which they estimated lengths of exposure to happy female faces (self-relevant positive stimuli, based on sexual orientation), emotionally neutral and negative female faces (control), and happy, neutral, and negative male faces (control). Oxytocin induced a subjective time dilation effect for happy female faces and a time compression effect for happy male faces.Our results provide evidence that oxytocin influences time perception, a primary form of human subjectivity.

The Remapping of Time by Active Tool-Use

Multiple, action-based space representations are each based on the extent to which action is possible toward a specific sector of space, such as near/reachable and far/unreachable. Studies on tool-use revealed how the boundaries between these representations are dynamic. Space is not only multidimensional and dynamic, but it is also known for interacting with other dimensions of magnitude, such as time. However, whether time operates on similar action-driven multiple representations and whether it can be modulated by tool-use is yet unknown. To address these issues, healthy participants performed a time bisection task in two spatial positions (near and far space) before and after an active tool-use training, which consisted of performing goal-directed actions holding a tool with their right hand (Experiment 1). Before training, perceived stimuli duration was influenced by their spatial position defined by action. Hence, a dissociation emerged between near/reachable and far/unreachable space. Strikingly, this dissociation disappeared after the active tool-use training since temporal stimuli were now perceived as nearer. The remapping was not found when a passive tool-training was executed (Experiment 2) or when the active tool-training was performed with participants’ left hand (Experiment 3). Moreover, no time remapping was observed following an equivalent active hand-training but without a tool (Experiment 4). Taken together, our findings reveal that time processing is based on action-driven multiple representations. The dynamic nature of these representations is demonstrated by the remapping of time, which is action- and effector-dependent.

Heart rate variability helps tracking time more accurately

Adequate temporal abilities are crucial for adaptive behavior. In time processing, variations in the rate of pulses’ emission by the pacemaker are often reported to be an important cause of temporal errors. These variations are often associated with physiological changes, and recently it has also been proposed that physiological changes may not just vary the pulses’ emission, but they can work as a timekeeper themselves. In the present study we further explore the relationship between temporal abilities with autonomic activity and interoceptive awareness in a group of thirty healthy young adults (mean age 24.18years; SD=2.1). Using electrocardiogram, impedance cardiography and skin conductance measures, we assessed the relationship between the autonomic profile at rest and temporal abilities in two temporal tasks (time bisection and finger tapping tasks). Results showed that heart rate variability affects time perception. We observed that increased heart rate variability (HRV) was associated with higher temporal accuracy. More specifically, we found that higher vagal control was associated with lower error in producing 1-s tempo, whereas higher overall HRV was related with lower error (measured by the constant error) in the time bisection task. Our results support the idea that bodily signals may shape our perception of time.

Effects of Emotional Facial Expression on Time Perception in Patients with Parkinson's Disease.

Previous studies have demonstrated that emotional facial expressions alter temporal judgments. Moreover, while some studies conducted with Parkinson's disease (PD) patients suggest dysfunction in the recognition of emotional facial expression, others have shown a dysfunction in time perception. In the present study, we investigate the magnitude of temporal distortions caused by the presentation of emotional facial expressions (anger, shame, and neutral) in PD patients and controls. Twenty-five older adults with PD and 17 healthy older adults took part in the present study. PD patients were divided into two sub-groups, with and without mild cognitive impairment (MCI), based on their neuropsychological performance. Participants were tested with a time bisection task with standard intervals lasting 400 ms and 1600 ms. The effect of facial emotional stimuli on time perception was evident in all participants, yet the effect was greater for PD-MCI patients. Furthermore, PD-MCI patients were more likely to underestimate long and overestimate short temporal intervals than PD-non-MCI patients and controls. Temporal impairment in PD-MCI patients seem to be mainly caused by a memory dysfunction. (JINS, 2016, 22, 890-899).