Tianjin Research Articles

Analysis of allergen-specific IgE in children with atopic dermatitis from 2021 to 2023 in a hospital of pediatric in Tianjin City

Objective: To explore the distribution of allergen-specific IgE (sIgE) for children with atopic dermatitis in Tianjin City and provide the evidences of clinical diagnosis and treatment. Methods: A retrospective cross-sectional study was conducted to analyze the children who were suspected of atopic dermatitis and tested for serum sIgE in the Tianjin Children's Hospital from March 2021 to February 2023. Using first detection results only, a total of 1 841 serum samples were tested for twenty common allergens. The method was the enzyme-linked immune capture assay. The allergen epidemiological characteristics were statistically analyzed by Chi square test based on the children's characteristics and factors such as different sexes, ages and seasons by the mass data. Results: Among the 1 841 cases, the results showed that 1 247 (67.73%) were sensitized to at least 1 allergen-sIgE, comprising to 49.86% (918/1 841) to food allergen-sIgE and 47.96% (883/1 841) to aeroallergen-sIgE. The top three food allergens-sIgE were egg 32.10% (591/1 841), milk 25.91% (477/1 841) and wheat flour 14.61% (269/1 841); the top three positive rates of aeroallergens-sIgE were house dust 24.33% (448/1 841), alternaria 20.59% (379/1 841) and dermatophagoides farinae 14.83% (273/1 841). The positive rates of food allergens-sIgE were the highest in the 1-3 years old group (64.11%, 434/677) (χ2=122.854, P<0.001), while the positive rates of aeroallergens-sIgE were higher in the 11-14 years old group (71.26%, 62/87) (χ2=134.968, P<0.001). No seasonal difference was revealed in the overall positive rate of food allergen-sIgE and aeroallergen-sIgE (χ2=4.047, P=0.256; χ2=7.549, P=0.056). The positive rates of soybean-sIgE and milk-sIgE were the highest in summer (χ2=11.329, P=0.010; χ2=28.720, P<0.001), whereas alternaria-sIgE and mugwort-sIgE were the highest in summer and autumn, respectively (χ2=8.462, P=0.037; χ2=10.641, P=0.014). Among the 1 841 cases, 32.21% were sensitized to three or more allergens-sIgE. The sIgE concentration levels of egg, milk and house dust were mainly level 1 to 2, and the proportions of level 3 and above were all under 15%; although the positive rates of crab, shrimp, and peanut were low, the proportions of grade 3 and above were all beyond 30%. Children sensitized to alternaria, dermatophagoides farinae, mugwort, and cat dander had higher sIgE concentration levels, which were 68.07%, 49.45%, 56.57% and 47.83% respectively. Conclusions: This study can reflect the epidemic characteristics of allergen-sIgE in children with atopic dermatitis in Tianjin region to a certain extent. Allergen-sIgE positivity in patients differed by age, and there were seasonal differences and grade distribution differences in the positive rates of some allergens-sIgE. It is necessary to reasonably avoid the high-risk allergens according to the epidemiological characteristics and clinical symptoms, which provide valuable information for the prevention, diagnosis and treatment of atopic dermatitis.

High-throughput 16S rRNA gene-based amplicon sequencing reveals the functional divergence of halophilic bacterial communities in the Suaeda salsa root compartments on the eastern coast of China

The rhizosphere environment of plants, which harbors halophilic bacterial communities, faces significant challenges in coping with environmental stressors, particularly saline soil properties. This study utilizes a high-throughput 16S rRNA gene-based amplicon sequencing to investigate the variations in bacterial community dynamics in rhizosphere soil (RH), root surface soil (RS), root endophytic bacteria (PE) compartments of Suaeda salsa roots, and adjoining soils (CK) across six locations along the eastern coast of China: Nantong (NT), Yancheng (YC), Dalian (DL), Tianjin (TJ), Dongying (DY), and Qingdao (QD), all characterized by chloride-type saline soil. Variations in the physicochemical properties of the RH compartment were also evaluated. The results revealed significant changes in pH, electrical conductivity, total salt content, and ion concentrations in RH samples from different locations. Notably, the NT location exhibited the highest alkalinity and nitrogen availability. The pH variations were linked to HCO3− accumulation in S. salsa roots, while salinity stress influenced soil pH through H+ discharge. Despite salinity stress, enzymatic activities such as catalase and urease were higher in soils from various locations. The diversity and richness of bacterial communities were higher in specific locations, with Proteobacteria dominating PE samples from the DL location. Additionally, Vibrio and Marinobacter were prevalent in RH samples. Significant correlations were found between soil pH, salinity, nutrient content, and the abundance and diversity of bacterial taxa in RH samples. Bioinformatics analysis revealed the prevalence of halophilic bacteria, such as Bacillus, Halomonas, and Streptomyces, with diverse metabolic functions, including amino acid and carbohydrate metabolisms. Essential genes, such as auxin response factor (ARF) and GTPase-encoding genes, were abundant in RH samples, suggesting adaptive strategies for harsh environments. Likewise, proline/betaine transport protein genes were enriched, indicating potential bioremediation mechanisms against high salt stress. These findings provide insight into the metabolic adaptations facilitating resilience in saline ecosystems and contribute to understanding the complex interplay between soil conditions, bacterial communities, and plant adaptation.

Physicochemical Properties and Fine Structure of Starch in Jinong Xiangruan 1 and DGR1 Soft Rice Varieties Cultivated in Different Regions of China

Rice, a staple food for billions around the globe, is cultivated in numerous forms. Among them, soft rice is well known, which is characterized by its tender, creamy consistency and desirable texture. In this study, we examined the physicochemical properties and fine structure of starch from two soft rice varieties, Jinong Xiangruan 1 and DGR1, cultivated in different regions in China (Baodi District, Tianjin City; Liaoning Province; and Fengyang City, Anhui Province). The aim was to understand how amylopectin content (AC) influences rice quality. This research aims to bridge the knowledge gap regarding the role of amylopectin in determining rice’s adhesive consistency and viscosity. Significant regional differences were observed in yield components such as the number of grains per panicle, seed setting rates and 1000-grain weight, with Liaoning generally showing higher performance metrics compared to other regions. Physicochemical analysis highlighted that though glue consistency and taste values showed little regional variation, AC significantly influenced rice hardness and viscosity. Rapid Visco Analyzer (RVA) profile analysis further demonstrated distinct differences in viscosity characteristics, underscoring the regional impacts on starch behavior. Additionally, molecular weight distribution and amylopectin chain length analysis, conducted via SEC-MALLS-RI and ICS ion chromatography, revealed notable differences in starch composition across varieties and locations. The findings suggest that environmental conditions play a crucial role in defining starch characteristics and, consequently, the eating quality of rice. This provides valuable insights for breeding high-quality japonica rice with broad adaptability.

Environmental adaptation, growth performance and nutrient content of the clam Cyclina sinensis from different geographic locations

The clam Cyclina sinensis is an economically important marine species in China. However, overfishing, habitat destruction, and inbreeding have led to the destruction of genetic resources. In this study, five natural populations [Dandong (DD), Dongying (DY), Tianjin (TJ), Wenzhou (WZ), and Yancheng (YC)] from different geographical locations were relocated and cultured homogeneously to study their potential for translocation and environmental adaptation by observing growth performance and nutrient content. There were significant differences in the growth rates of shell length (SL), shell height (SH), and shell width (SW) among the five populations (P&amp;lt;0.05). The DD, TJ, and YC populations exhibited the highest SL and SH growth rates, whereas these were lowest in the WZ population. The survival rate was highest in the YC population and lowest in the WZ population, which was significantly lower than the other four populations (P&amp;lt;0.05). The DD population exhibited superior plumpness and glycogen content, and the overall glycogen content in male C. sinensis was higher compared with that in females (P&amp;lt;0.05). All populations displayed a high total amino acid content and the essential amino acid/Total Amino Acid (EAA/TAA) and Non-essential amino acid/Total Amino Acid (NEAA/TAA) ratios in the soft tissue of all five populations aligned with the FAO/WHO ideal protein evaluation standards. Despite the same aquaculture environment, however, the nutrient composition of C. sinensis sampled from different populations varied significantly (P&amp;lt;0.05).Therefore, ex situ conservation did not eliminate nutritional differences between the different populations of C. sinensis. These findings highlight the importance of considering environmental and ecological factors in the nutritional assessment and cultivation of shellfish. In addition, C. sinensis from sampling sites closer to the transplantation sites had higher survival rates and growth rates, and the gonadal development of all populations showed adaption to the local environment, resulting in synchronization of the reproductive period.

A paradox of economic benefit and social equity of green space in megacity: Evidence from Tianjin in China

Urban green space (UGS) plays a crucial role in socio-ecological systems and has been recognized as an important factor in promoting sustainable cities and communities. Although a few studies have proposed a paradox of the incompatibility of economic benefit and social equity in UGS, the mechanisms through which the economic benefits of UGS interact with social equity have not been adequately demonstrated in developing countries. Here, we employ multi-source geographic information and 1559 residents survey data to investigate not only the economic benefit of UGS in the housing prices market from a macro perspective, but also the social inequity issues resulting from the housing choices of different social classes under "UGS economic benefit" from a micro perspective. Results reveal that the economic value premium of UGS in the housing market triggered a differentiation effect in housing prices, subsequently influencing housing preferences among various social classes, thus intensifying social residential segregation. This phenomenon underscores the emergence of the green space paradox. Moreover, the phenomenon of the UGS paradox has emerged in megacities of developing countries, where UGS is gradually being occupied by social elites, while vulnerable groups remain marginalized. These findings provide valuable insights into the planning layout of UGS in global high-density built-up areas that a small and decentralized UGS layout will be more economically efficient and socially equitable than a large and centralized UGS layout.

Resisting the heat wave: Revealing inequalities in matching between heat exposure risk and healthcare services in a megacity

Climate warming and the growing urban heat island effect are exacerbating the unequal public health crisis in megacities, and thus it is important to assess the equity of matching relationship between the healthcare services and the heat exposure risk. We selected 255 census units in Tianjin city for the study, and calculated a heat exposure index based on the universal thermal climate index (UTCI) and constructed a comprehensive urban healthcare services evaluation system to measure the degree of mismatch between the two. The results showed the following. (1) The heat exposure risk and healthcare services followed an increasing pattern from the Outer suburb area (OSA) to the Metropolitan development area (MDA) and then to the Main urban area (MUA). (2) The overall imbalance in matching was low in the OSA, whereas the healthcare services were relatively insufficient in the MDA, and the heat exposure risk and healthcare services were relatively balanced in the MUA. (3) The degree of matching between the core and peripheral parts of the MUA was severely polarized, with an overall pattern of excess healthcare in the core area and a high risk of heat exposure in the peripheral areas. The results can provide effective guidance for rationalizing the allocation of healthcare resources from a heat exposure perspective, and provide a policy basis for risk management and fund investment.

Evaluation Methods and Application of Adaptability of Ecological Product Development and Utilization—Taking Jizhou District, Tianjin City, as an Example

Evaluation Methods and Application of Adaptability of Ecological Product Development and Utilization—Taking Jizhou District, Tianjin City, as an Example

Genetic diversity of vector-borne zoonotic pathogens in companion dogs and cats, Tianjin, China.

Dogs and cats are the hosts of many vector-borne human pathogens that can be transmitted to humans. Given their direct and intimate contact with humans, companion dogs and cats are considered direct sentinels of vector-borne human pathogens. However, limited information is currently available regarding canine and feline zoonotic pathogens in China. This study detected canine and feline vector-borne human pathogens to better understand the potential risk to humans. Blood samples were collected from 275 domestic companion animals (117 dogs and 158 cats) living in Tianjin city, China, and the presence of DNA from Anaplasma, Babesia, Bartonella, and Rickettsia was detected by semi-nested polymerase chain reaction (PCR). The PCR products of the expected size were sequenced, and these newly generated sequences were subjected to BLASTN, nucleotide identity, and phylogenetic analyses. A total of 24 blood samples tested positive for vector-borne pathogens in companion dogs and cats in Tianjin city, China, with a relatively low positive rate of 8.7%. Specifically, seven human pathogens, including Rickettsia raoultii, Candidatus Rickettsia jingxinensis, Rickettsia sibirica, Rickettsia felis, Babesia venatorum, Bartonella tribocorum, and Bartonella Henselae, were identified. In addition, Anaplasma ovis with zoonotic potential and Candidatus A. cinensis were detected. Our results indicate substantial genetic diversity in the vector-borne human pathogens circulating in companion dogs and cats. Interventions based on "One Health" should be taken to reduce the potential risks of contracting infection from companion dogs and cats in Tianjin, China.

Occurrence and exposure evaluation of 2- and 3-monochloropropanediol (MCPD) esters and glycidyl esters in refined vegetable oils marketed in Tianjin of China

2-and 3-monochloropropanediol esters (2-/3-MCPDE) and glycidyl esters (GE) with high toxicity have drawn global concerns due to their widespread occurrence in refined vegetable oils and oil-based foods. In this study, we investigated the contamination level and human health risks of 2-MCPDE, 3-MCPDE and GE in refined vegetable oils marketed in Tianjin of China. Results showed that the concentrations of 2-MCPDE, 3-MCPDE and GE in the 137 vegetable oil samples were in the range of not detected (ND) −6.95 mg/kg, ND-8.39 mg/kg and ND-5.46 mg/kg, respectively. The mean, 50th percentile and 95th percentile concentrations of 3-MCPDE were higher than the corresponding concentration of 2-MCPDE and GE in different types of oils samples. Among the samples analyzed, 29 samples (21.2%) exceeded the maximum levels (2.5 mg/kg) for 3-MCPDE, while 25 samples (18.2%) exceeded the maximum levels (1.0 mg/kg) for GE. The estimated intakes of 3-MCPDE of high consumers of children (7–10 years), adolescents (11–13 years) exceeded the tolerated daily intake (TDI) value of 2 µg/kg bw per day established by EFSA, suggesting a potential concern. The Margin of Exposure (MoE) values for glycidol exposure via vegetable oils consumption in all age groups indicated there is a human health concern.

Genomic surveillance of emerging SARS-CoV-2 Omicron variations in Tianjin Municipality, China 2022

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted public health. In 2022, the Omicron variant of SARS-CoV-2 rapidly became the dominant circulating variant in the local COVID-19 outbreaks in Tianjin Municipality, China. To gain a deeper understanding of the genetic variations of the Omicron variant in Tianjin, specimens from individuals who tested positive for SARS-CoV-2 between December 2021 and November 2022 were used for virus whole genome sequencing and phylogenetic analysis. A total of 1,674 high-quality Omicron sequences were obtained, consisting of 1,339 sequences from local cases belonging to 20 Phylogenetic Assignment of Named Global Outbreak (PANGO) lineages and 335 sequences from imported cases belonging to 70 lineages. Tianjin experienced five waves of local outbreaks, accompanied by multiple substitutions among subvariants, ranging from the initial BA.1.1 lineage to the subsequent BA.2, BF.7, and BA.5.2 lineages. The evolutionary rate of local strains, estimated to be 28.999 substitutions per year, and the evolutionary rate of imported strains, estimated to be 24.946 substitutions per year, were lower than that of the strains circulating globally. The additional substitutions and deletions of local strains have been used to identify and disrupt the virus transmission chains. The subvariants such as BA.5.2.48, BA.5.2.49, BF.7.14, and XBB.1 circulating in the fifth epidemic wave presented criterial immune escape mutations including S: R346T, S: L452R and S: F486V. It is essential to implement genomic surveillance strategies to investigate further the development of genomic mutation characteristics in the SARS-CoV-2 variant. This ongoing monitoring will contribute to a better understanding of the virus's genetic changes and aid in effective control measures.

Study on the Development Efficiency of Leisure Agriculture in Suburban Towns: An Empirical Analysis Based on the Case of Xinkou Town, Tianjin City

The leisure agriculture in suburban towns provides important space for citizens to carry out leisure activities. This paper takes Xinkou town in Tianjin city as an example to analyze the development efficiency of leisure agriculture in suburban towns. On the premise of establishing the indicators for evaluating the development efficiency of leisure agriculture in Xinkou town, this paper first uses the data envelopment analysis (DEA) to measure the input and output indicators of leisure agriculture in 18 natural villages in Xinkou town, and calculates the comprehensive technical efficiency, target values, redundancy and returns to scale of leisure agriculture, and then evaluates the development efficiency of leisure agriculture in Xinkou town. Furthermore, by using the high/low clustering tool under the ArcGIS spatial statistics module, this paper conducts a high/low clustering analysis of the development efficiency of leisure agriculture in 18 natural villages of Xinkou town, and figures out the reasons for the high/low clustering of natural villages in Xinkou town spatially. After the research and analysis, the following conclusions are drawn: From the input–output perspective, except for Zhengzhuangzi village, Diliubu village, Yuejiakai village, and Dangcheng village, the development efficiency of leisure agriculture in other villages is relatively low due to their poor resource foundations, or deficiencies in management experience and transportation location. The development of leisure agriculture in Xinkou town is unbalanced, showing a pattern of polarized clusters: Diliubu village and Shuigaozhuang village form the most obvious high-value cluster, while Xiaoshawo village, Bijia village and Xuanjiayuan village form the most obvious low-value cluster, where the southeast corner of Xinkou town registers the lowest development efficiency value of leisure agriculture because it is far away from the town center and the main transportation arteries, and falls short of high-quality pastoral scenery. For the future development of leisure agriculture in Xinkou town, it is supposed to optimize the land use policy, provide active support to the competitive industrial and commercial capital, non-governmental capital, rural collective economic organizations, farmers’ cooperatives, and family farms, strengthen the in-depth integration of industries, improve the support system for new-type leisure agriculture, and build leisure agriculture brands with local features.

Liver impairment status toward workers exposed to vinyl chloride under different techniques

To analyse potential differences towards liver impairment status on vinyl chloride monomer(VCM) exposed population from technique under acetylene hydrochlorination to the one of ethylene oxychlorination respectively and to explore the possible reasons, which will pave the way for occupational health promotion in terms of hazard reduction. a cross-sectional study was initiated between June and September in 2022 towards 2 groups of VCM exposed population from the facility of acetylene hydrochlorination(n=78) and the one of ethylene oxychlorination(n=69) in a PVC petrochemical complex enterprise(abbreviation of H) in Tianjin City. The demographic information concerning age, gender, messages on occupational history, field investigation were inquired through questionnaire interview. Then, venous blood(4 mL/person) and urine(10-50 mL/person) were collected during the physical exam phase and indices of 8-hydroxy-2 deoxyguanosine(8-OHdG) in blood and thiodiglycolic acid(TDGA) in urine were detected through ELISA and solid phase extraction-ion chromatography respectively. The 2 groups of population were matched well in terms of average age distribution and gender composition ratio, with significant differences on population composition ratio were found on variables of working years, alcohol consumption and daily sleeping duration(P&lt;0.01 or P&lt;0.05). It was found that the average content of TDGA in acetylene hydrochlorination group was(0.81±0.05)mg/L while the content in ethylene oxychlorination group reached to(0.83±0.06)mg/L, noteworthy differences were only found among 6 posts in the acetylene hydrochlorination group and 5 others in the ethylene oxychlorination group after classification for specific posts, however, the average concentration of 8-OHdG in acetylene hydrochlorination group(122(78.3, 168.8) μg/m~3) was different from the one in ethylene oxychlorination group(101.7(79.6, 149.7) μg/m~3)(Z=6.82, P&lt;0.05). Moreover, a series of positive correlations in moderate intensity between 8-OHdG concentration and TDGA content were observed among posts of polymerization cleaners(r=0.53), aggregation operators(r=0.47), maintenance repairers(r=0.45), sampling operators(r=0.41) in acetylene hydrochlorination group(P&lt;0.05) and posts of cracking reactants(r=0.64), DCS operators(r=0.51), oxychlorination operators(r=0.50) and chemical loaders(r=0.44) in ethylene oxychlorination group(P&lt;0.05). Liver function indices such as content on ALT(χ~2=15.41, P&lt;0.01), AST(χ~2=9.95, P&lt;0.01) and ALP(χ~2=3.79, P&lt;0.01) were different in the 2 groups population with statistical significance, then proportions on population composition ratio that exceeded normal ranges of indices on ALT, AST, AST/ALT ratio, ALP and Alb/Glb ratio were higher in acetylene hydrochlorination group than ones in ethylene oxychlorination group with great significance(P&lt;0.05), so as to the abnormalities in liver B altrosonography test between groups(χ~2=17.33, P&lt;0.01). Binary logistic regression model indicated that 8-OHdG concentration in blood that exceed 90 μg/m~3, TDGA content in urine that exceed 0.60 mg/L, working years that were over 10a, alcohol consumption, sleeping duration less than 6 h per day and male workers were potential risky factors for liver impairment(P&lt;0.05). The degree on liver impairment status was higher in acetylene hydrochlorination group than ones in in ethylene oxychlorination group under the same PVC factory, which might be associated with the oxidative stress injury induced from the combination of higher VCM concentration at workplaces, longer cumulative exposure time, longer working years, alcohol consumption habits and sleep shortage caused by shift work patterns.

Spatial Relationships between Population, Employment Density, and Urban Metro Stations: A Case Study of Tianjin City, China

Spatial Relationships between Population, Employment Density, and Urban Metro Stations: A Case Study of Tianjin City, China

Contradictions in human-nature relationships threaten coastal resilience and sustainability in the Bohai Rim Region, China.

Under the challenge of global environmental change and rapid development, tremendous risks brought about by natural disasters and human activities have increased environmental pressures for sustainable development. How to improve coastal resilience in the process of urban development has become an important topic in academia. In this study, a variable fuzzy recognition model was used to measure the level of coastal resilience in 17 cities in the Bohai Rim region, and then the kernel density, thiel index, and random forest model were used to explore the spatiotemporal characteristics and influencing factors of coastal resilience. The results show that (1) The overall resilience level of the Bohai Rim region is increasing over time, but at a relatively slow rate. (2) Coastal resilience has significant spatial unevenness, with high-level cities dominated by Tianjin, Qingdao, Yantai, etc. and low-level cities dominated by Cangzhou, Panjin, Yingkou, Binzhou, etc. (3) The influence of economic development, infrastructure, innovation ability, technology investment, and government regulation on coastal resilience decreases in order. Based on the research findings, the study can not only make suggestions for the actual regulation strategy but also provide empirical and theoretical experience for other coastal countries.

Variations of the atmospheric polycyclic aromatic hydrocarbon concentrations, sources, and health risk and the direct medical costs of lung cancer around the Bohai Sea against a background of pollution prevention and control in China

Abstract. The Bohai Sea (BS) region, an area of China that is severely polluted with atmospheric polycyclic aromatic hydrocarbons (PAHs), has received wide attention in recent decades. To characterize the variations of the concentrations and sources of PAHs from June 2014 to May 2019, 15 PAH congeners (Σ15PAHs) were measured in atmospheric samples (N = 228) collected at 12 sites around the BS, and the health risk and direct medical costs associated with lung cancer caused by exposure to PAHs were also estimated. The annual daily average concentration of Σ15PAHs was 56.78 ± 4.75 ng m−3, which was dominated by low molecular weight PAHs (LMW-PAHs) containing three rings (58.7 ± 7.8 %). During the 5-year sampling period, the atmospheric Σ15PAHs concentration reduced by 17.5 % for the whole BS region, with an especially large drop of 51.7 % observed in the tightly controlled area of Tianjin (TJ), which was mainly due to a decrease in the concentration of high molecular weight PAHs (HMW-PAHs) containing five or six rings. Generally, the concentration of Σ15PAHs was highest in winter and lowest in summer, which can mainly be attributed to the change in LMW-PAH concentration. Based on the positive matrix factorization (PMF) model, PAHs in the BS region were mainly ascribed to coal combustion and biomass burning. The PAH contributions of coal combustion and motor vehicles showed different trends for the BS region (PAHs from coal combustion rose by 7.2 % and PAHs from motor vehicles fell by 22.4 %) and for TJ (PAHs from coal combustion fell by 12.6 % and PAHs from motor vehicles rose by 6.9 %). The incidence of lung cancer (ILCR) caused by exposure to atmospheric PAHs decreased by 74.1 % and 91.6 % from 2014 to 2018 in the BS region and in TJ, respectively. This was mainly due to the decrease in the concentration of highly toxic HMW-PAHs and was reflected in USD 10.7 million of savings in direct medical costs of lung cancer caused by exposure to PAHs, which represent a decrease of 46.1 % compared to the corresponding costs before air pollution prevention and control was implemented around the BS. There was an even higher reduction in medical costs of 54.5 % in TJ. Hence, this study proves that implementing pollution prevention and control not only effectively reduced the concentration of pollutants and the risks caused by them, but it also significantly reduced the medical costs of diseases caused by the corresponding exposure.

Analysis of the Operational Efficiency of Public Hospitals in Tianjin City based on a Three-Stage Data Envelopment Analysis Model

The purpose is to analyze the operational efficiency of 132 public hospitals in Tianjin in 2021, providing reference for them to fully play the role of "leading institutions" and optimize resource allocation. We constructed an evaluation index system with multiple inputs, outputs, and environmental variables and utilized a three-stage DEA model to assess efficiency by removing the influence of random errors and environmental factors. The average comprehensive technical efficiency, pure technical efficiency, and scale efficiency of public hospitals were 0.865, 0.989, and 0.875, respectively. Among them, seven districts, including Heping, Hedong, and Hexi, had a comprehensive technical efficiency of 1. Among the remaining nine districts, except for Baodi, the rest showed an increasing trend in scale efficiency. Public hospitals in Tianjin City exhibit high operational efficiency, but significant variations exist among different districts, leading to uneven development. The main reason for this disparity is the presence of scale inefficiency. It is recommended to prioritize resource optimization and address the shortcomings that hinder efficiency improvement in a targeted manner. Emphasizing the "triple integration" of service capacity, efficiency, and quality in public hospitals is essential to maximize both social and economic benefits."

Optimization study on thermal performance of a novel dynamic phase change material wall

A new concept of dynamic phase change material (PCM) wall structure in building envelope is proposed to enhance the passive solar energy utilization, in which PCM wall position could be exchanged with insulation layer. The thermal performance of phase change materials in buildings is related to many factors. To ensure that the novel dynamic PCM wall structure could reach its full potential, the thermal performance of the structure was numerically simulated and optimized based on different climatic conditions, room sizes and the position of PCM layer in the wall. The results indicated that the suitable PCM was different when using the novel dynamic PCM wall in different climates. Among the four cities of Harbin, Tianjin, Jinan and Guangzhou, northern cities, like Tianjin, were more suitable for using PCM A16 than southern cities. In terms of room size design, when the volume of the room remained identical, the room size design formed a certain correlation with the indoor temperature. In addition, results showed that the location of the novel PCM wall system in the wall would cause a great difference in indoor temperature, which was related to heat dissipation at different locations.

Spatiotemporal variations in soil pollution by polycyclic aromatic hydrocarbons over a 20-year economic boom in different districts of a heavy industrial city in North China

Urbanization-related human activities, such as population aggregation, rapid industrial expansion, and intensified traffic, are key factors that impact local polycyclic aromatic hydrocarbon emissions and their associated health risks. Consequently, regions with varying degrees of urbanization within a megacity may exhibit diverse spatiotemporal patterns in the presence and distribution of soil polycyclic aromatic hydrocarbons, resulting in different levels of ecological risks for local inhabitants following the same period of development. In this study, we measured the concentrations of 16 polycyclic aromatic hydrocarbons in soil samples collected from industrial district and rural district in Tianjin (China) in 2018, and compared with polycyclic aromatic hydrocarbon data in 2001 from a previous study to characterize these regional variations in occurrence, source, and human risk of polycyclic aromatic hydrocarbons induced by urbanization with time and space. The results indicate the 20-year rapid urbanization and industrialization has differentially affected the composition, distribution and sources of polycyclic aromatic hydrocarbons in soils from different economic functional zones in Tianjin. Additionally, its impact on health risks in rural district appeared to be more significant than that in industrial district.

Effect of piperacillin sodium and sulbactam sodium on respiratory function in patients with acute respiratory distress syndrome

Purpose: To investigate the effect of the combination of piperacillin sodium and sulbactam sodium on respiratory function in patients with acute respiratory distress syndrome (ARDS).&#x0D; Methods: The clinical data for 151 ARDS patients admitted in Tianjin Hospital of ITCWM Nankai Hospital, Tianjin China from January 2020 to January 2021 were analyzed in this retrospective study. The patients were assigned to two groups based on different treatment regimens. Control group (COG) comprised 77 patients who received basic treatment (mechanical ventilation and drug treatment using oxazolidinones), while 74 patients who received basic treatment together with a combination of piperacillin sodium and sulbactam sodium (4 g of piperacillin and 0.5 g of sulbactam (for adults) through intravenous injection for 2 weeks continuously) were in study group (STG). Respiratory function was assessed in the two groups post-treatment using the basic dyspnea index (BDI) measurement. Mechanical ventilation time, intensive care unit (ICU) stay time and 28-day mortality rate after treatment, were also recorded.&#x0D; Results: Following treatment, patients in STG had significantly higher levels of partial pressure of arterial oxygen (PaO2) and oxygenation index (PaO2/FiO2), significantly lower partial pressure of carbon dioxide (PaCO2), markedly lower levels of pentraxin-3 (PTX-3) and procalcitonin (PCT), significantly higher score on BDI scale, and overtly lower mechanical ventilation time and ICU stay time, than COG (p &lt; 0.05).&#x0D; Conclusion: Piperacillin sodium and sulbactam sodium combination significantly relieves clinical symptoms of ARDS such as breathlessness and chest discomfort in patients, resulting in improved respiratory function. The effectiveness of this combination makes it a potential first-line treatment for further large-scale investigation in ARDS management.

Unraveling volatilomics profiles of milk products from diverse regions in China

To distinguish Chinese milks from different regions, 13 milk samples were gathered from 13 regions of China in this study: Inner Mongolia (IM), Xinjiang (XJ), Hebei (HB), Shanghai (SH), Beijing (BJ), Sichuan (SC), Ningxia (NX), Henan (HN), Tianjin (TJ), Qinghai (QH), Yunnan (YN), Guangxi (GX), and Tibet (XZ). Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS) combined with the electronic nose (E-nose) technology, was used to detect and analyze the volatile compounds in these milk samples. The qualitative and quantitative results identified 29 volatile chemicals, and we established a database of flavor profiles for the main milk-producing regions in China. E-nose analysis revealed variations in the odor of milk across different areas. Furthermore, results from partial least squares discriminant analysis (PLS-DA) and odor activity values (OAVs) suggested that seven volatile compounds: decane, 2-heptanone, 2-undecanone, 2-nonanone, 1-hexadecanol, 1-octen-3-ol, and (E)-2-nonenal, could be considered as key flavor compounds in Chinese milk products.