High-power laser welding processes involve intense interactions between the laser beam and the base material, resulting in severe welding defects such as humping, spattering, and undercutting. Utilizing side gas flow may provide an effective approach for minimizing these defects. However, the effects of side gas flow on the dynamic behavior and weld formation necessitate further investigation. In this study, an innovative analysis of metal vapor characteristics and keyhole/melt pool dynamics in high-power laser welding with side gas flow is presented, combining experimental and simulation results. A three-dimensional transient fluid flow model was developed, uniquely integrating an adaptive heat source, evaporation-condensation processes, and metal vapor energy attenuation to provide a novel perspective on the effects of side gas flow in high-power laser welding. The results display that side gas flow could suppress plasma, increase thermal input to the melt pool, and intensify the flow of liquid metal toward the pool bottom during high power laser welding, thereby enhancing weld seam penetration. The numerical results indicate that variations in flow rate significantly impact metal vapor morphology, with higher flow rates reducing both the average area and height of the metal vapor and effectively suppressing the size of metal vapor/plasma. When the side gas flow rate is 20 l/min, with the gas flow impact point located at the keyhole opening and the nozzle height set to 3 mm, the side gas flow significantly enhances the depth-to-width ratio of the weld seam in 316L stainless steel laser welding. This work can provide guidance for suppression of weld defects in high-power laser welding of medium-thick steel components, which has important theoretical significance and application value.