In spite of the contemporary interest in renewable power plants, thermal power plants are still inevitable. Various electric equipment and apparatus are grounded via a large-scale grounding system in thermal power plants. In this paper, the three-dimensional finite-difference time-domain method has been employed to study the performance of such a large-scale grounding system against a lightning strike to a nearby transmission tower. The study has emphasized how a nearby sea, which is utilized for cooling purposes in thermal power plants, influences the ground potential rise on the large-scale grounding system considering soil ionization. The results show that the distribution of the ground potential rise on the large-scale grounding system is quite dependent on the alignment of sea with the large-scale grounding system. In addition, the extent that soil ionization affects the ground potential rise is dependent on the distance between the struck tower and the large-scale grounding system.